公开(公告)号：HRP970441A2

公开(公告)日：1998-06-30

申请号：HRP970441

申请日：1997-08-11

Applicant: BASF AG

Inventor： HORNBERGER WILFRIED

IPC: A61K38/00 ,  A61K38/05 ,  A61P7/02 ,  A61P29/00 ,  A61P35/00 ,  A61P35/04 ,  C07K5/06 ,  C07K5/062 ,  C07K5/065

Abstract: PCT No. PCT/EP97/04104 Sec. 371 Date Feb. 10, 1999 Sec. 102(e) Date Feb. 10, 1999 PCT Filed Jul. 29, 1997 PCT Pub. No. WO98/06741 PCT Pub. Date Feb. 19, 1998Compounds of the formula where A, B, E and D have the meanings indicated in the description, and their preparation are described. The substances are suitable for controlling diseases.

公开(公告)号：HU9800263A2

公开(公告)日：1998-06-29

申请号：HU9800263

申请日：1996-02-12

Applicant: BASF AG

Inventor： BOEHM HANS-JOACHIM ,  HORNBERGER WILFRIED ,  HOEFFKEN HANS WOLFGANG ,  KOSER STEFAN ,  MACK HELMUT ,  PFEIFFER THOMAS ,  SEITZ WERNER ,  ZIERKE THOMAS

IPC: A61K31/00 ,  A61K38/55 ,  A61P7/02 ,  C07D205/04 ,  C07D207/16 ,  C07D213/53 ,  C07D213/63 ,  C07D213/72 ,  C07D213/78 ,  C07D213/79 ,  C07D239/28 ,  C07D241/14 ,  C07D241/24 ,  C07D401/12 ,  C07K5/06 ,  C07K5/062 ,  C07K5/078 ,  A61K31/40 ,  A61K31/445 ,  A61K31/495

Abstract: The invention relates to a compound of the formula I: or a salt thereof with a physiologically tolerated acid, or stereoisomers thereof, wherein R 1 , R 2 , A, B, C and D have the meanings described in the specification.

公开(公告)号：SI9620037A

公开(公告)日：1998-02-28

申请号：SI9620037

申请日：1996-02-12

Applicant: BASF AG

Inventor： BOEHM HANS-JOACHIM ,  HOEFFKEN HANS WOLFGANG ,  HORNBERGER WILFRIED ,  KOSER STEFAN ,  MACK HELMUT ,  PFEIFFER THOMAS ,  SEITZ WERNER ,  ZIERKE THOMAS

IPC: A61K31/00 ,  A61K38/55 ,  A61P7/02 ,  C07D205/04 ,  C07D207/16 ,  C07D213/53 ,  C07D213/63 ,  C07D213/72 ,  C07D213/78 ,  C07D213/79 ,  C07D239/28 ,  C07D241/14 ,  C07D241/24 ,  C07D401/12 ,  C07K5/06 ,  C07K5/062 ,  C07K5/078 ,  A61K31/40 ,  A61K31/445 ,  A61K31/495

Abstract: The description relates to compounds of formula (I) in which A, B, D, R1 and R2 have the meanings given in the specification. The compounds are suitable for the treatment of diseases. The novel compounds are produced via compounds of the formula H2N-CH2-G-M in which G and M have the meanings given in claim 4.

公开(公告)号：TR199700803T1

公开(公告)日：1998-02-21

申请号：TR9700803

申请日：1996-02-12

Applicant: BASF AG

Inventor： BOEHM HANS JOACHIM ,  HOEFFKEN HANS WOLFGANG ,  HORNBERGER WILFRIED ,  KOSER STEFAN ,  MACK HELMUT ,  PFEIFFER THOMAS ,  ZIERKE THOMAS ,  SEITZ WERNER

IPC: A61K31/00 ,  A61K38/55 ,  A61P7/02 ,  C07D205/04 ,  C07D207/16 ,  C07D213/53 ,  C07D213/63 ,  C07D213/72 ,  C07D213/78 ,  C07D213/79 ,  C07D239/28 ,  C07D241/14 ,  C07D241/24 ,  C07D401/12 ,  C07K5/06 ,  C07K5/062 ,  C07K5/078

Abstract: The invention relates to a compound of the formula I: or a salt thereof with a physiologically tolerated acid, or stereoisomers thereof, wherein R 1 , R 2 , A, B, C and D have the meanings described in the specification.

公开(公告)号：CA2263220A1

公开(公告)日：1998-02-19

申请号：CA2263220

申请日：1997-07-29

Applicant: BASF AG

Inventor： SEITZ WERNER ,  ZIERKE THOMAS ,  HOEFFKEN HANS WOLFGANG ,  MACK HELMUT ,  BAUCKE DORIT ,  HORNBERGER WILFRIED ,  LANGE UDO

IPC: A61K38/00 ,  A61K38/05 ,  A61P7/02 ,  A61P29/00 ,  A61P35/00 ,  A61P35/04 ,  C07K5/06 ,  C07K5/062 ,  C07K5/065

Abstract: Compounds having formula (I) wherein A, B, E and D have the m eanings indicated in the description, are described, in addition to the production thereof. The substances can be used to combat illnesses.

公开(公告)号：PL321759A1

公开(公告)日：1997-12-22

申请号：PL32175996

申请日：1996-02-12

Applicant: BASF AG

Inventor： BOEHM HANS-JOACHIM ,  HOEFFKEN HANS WOLFGANG ,  HORNBERGER WILFRIED ,  KOSER STEFAN ,  MACK HELMUT ,  PFFEIFFER THOMAS ,  SEITZ WERNER ,  ZIERKE THOMAS

IPC: A61K31/00 ,  A61K38/55 ,  A61P7/02 ,  C07D205/04 ,  C07D207/16 ,  C07D213/53 ,  C07D213/63 ,  C07D213/72 ,  C07D213/78 ,  C07D213/79 ,  C07D239/28 ,  C07D241/14 ,  C07D241/24 ,  C07D401/12 ,  C07K5/06 ,  C07K5/062 ,  C07K5/078 ,  A61K31/40 ,  A61K31/445 ,  A61K31/495

Abstract: The invention relates to a compound of the formula I: or a salt thereof with a physiologically tolerated acid, or stereoisomers thereof, wherein R 1 , R 2 , A, B, C and D have the meanings described in the specification.

公开(公告)号：NO973764L

公开(公告)日：1997-10-15

申请号：NO973764

申请日：1997-08-15

Applicant: BASF AG

Inventor： BOEHM HANS-JOACHIM ,  HOEFFKEN HANS WOLFGANG ,  HORNBERGER WILFRIED ,  KOSER STEFAN ,  MACK HELMUT ,  PFEIFFER THOMAS ,  SEITZ WERNER ,  ZIERKE THOMAS

IPC: A61K31/00 ,  A61K38/55 ,  A61P7/02 ,  C07D205/04 ,  C07D207/16 ,  C07D213/53 ,  C07D213/63 ,  C07D213/72 ,  C07D213/78 ,  C07D213/79 ,  C07D239/28 ,  C07D241/14 ,  C07D241/24 ,  C07D401/12 ,  C07K5/06 ,  C07K5/062 ,  C07K5/078 ,  A61K31/40 ,  A61K31/445 ,  A61K31/495

Abstract: The invention relates to a compound of the formula I: or a salt thereof with a physiologically tolerated acid, or stereoisomers thereof, wherein R 1 , R 2 , A, B, C and D have the meanings described in the specification.

公开(公告)号：HRP940968A2

公开(公告)日：1997-08-31

申请号：HRP940968

申请日：1994-12-01

Applicant: BASF AG

Inventor： SCHWEDEN JUERGEN ,  ECKES PETER ,  HORNBERGER WILFRIED ,  SUBKOWSKI THOMAS

IPC: A61K38/00 ,  A61K47/48 ,  A61P7/02

Abstract: PCT No. PCT/EP94/03901 Sec. 371 Date May 31, 1996 Sec. 102(e) Date May 31, 1996 PCT Filed Nov. 25, 1994 PCT Pub. No. WO95/15183 PCT Pub. Date Jun. 8, 1995The invention relates to novel hirudin conjugates formed from a hirudin and one or more lipophilic compounds, where the lipophilic compound has an octanol/water partition coefficient of more than 1.8 and is chemically linked to the hirudin, to the preparation thereof and to the use thereof.

公开(公告)号：BR9408195A

公开(公告)日：1997-08-26

申请号：BR9408195

申请日：1994-11-25

Applicant: BASF AG

Inventor： SCHWEDEN JURGEN ,  ECKES PETER ,  HORNBERGER WILFRIED ,  SUBKOWSKI THOMAS

IPC: A61K38/00 ,  A61K47/48 ,  A61P7/02

Abstract: PCT No. PCT/EP94/03901 Sec. 371 Date May 31, 1996 Sec. 102(e) Date May 31, 1996 PCT Filed Nov. 25, 1994 PCT Pub. No. WO95/15183 PCT Pub. Date Jun. 8, 1995The invention relates to novel hirudin conjugates formed from a hirudin and one or more lipophilic compounds, where the lipophilic compound has an octanol/water partition coefficient of more than 1.8 and is chemically linked to the hirudin, to the preparation thereof and to the use thereof.

公开(公告)号：FI973360A0

公开(公告)日：1997-08-15

申请号：FI973360

申请日：1997-08-15

Applicant: BASF AG

Inventor： BOEHM HANS-JOACHIM ,  HOEFFKEN HANS WOLFGANG ,  HORNBERGER WILFRIED ,  KOSER STEFAN ,  MACK HELMUT ,  PFEIFFER THOMAS ,  SEITZ WERNER ,  ZIERKE THOMAS

IPC: A61K31/00 ,  A61K38/55 ,  A61P7/02 ,  C07D205/04 ,  C07D207/16 ,  C07D213/53 ,  C07D213/63 ,  C07D213/72 ,  C07D213/78 ,  C07D213/79 ,  C07D239/28 ,  C07D241/14 ,  C07D241/24 ,  C07D401/12 ,  C07K5/06 ,  C07K5/062 ,  C07K5/078 ,  C07K

Abstract: The invention relates to a compound of the formula I: or a salt thereof with a physiologically tolerated acid, or stereoisomers thereof, wherein R 1 , R 2 , A, B, C and D have the meanings described in the specification.