公开(公告)号：CO5190657A1

公开(公告)日：2002-08-29

申请号：CO00044700

申请日：2000-06-15

Applicant: BASF AG

Inventor： RADEMACHER WILHEM ,  KRAMER KLAUS ,  SCHWEDEN JURGEN

IPC: A01G7/00 ,  A01N35/04 ,  A01N37/42 ,  A61K8/96 ,  A61K8/97 ,  A61K36/00 ,  A61P3/06 ,  A61P3/10 ,  A61P9/00 ,  A61P35/00 ,  A61P39/06 ,  A61P43/00 ,  C07D311/30

Abstract: Procedimiento para elevar el contenido de flavonoides y de constituyentes fenólicos en las plantas, caracterizado porque las plantas son tratadas con acilciclohexadionas de acuerdo con la Fórmula I reguladoras del crecimiento: en la cual R representa en especial hidrógeno, un grupo alquilo de 1 a 6 átomos de carbono, haloalquilo de 1 a 6 átomos de carbono, C2-C10-alquiltioalquilo o fenilo (sustituido o no sustituido), y R´ representa hidrógeno, un grupo alquilo de 1 a 6 átomos de carbono, ciclo alquilo de 3 a 6 átomos de carbono, bencilo (sustituido o no sustituido), feniletilo, fenoxietilo, 2-tienilmetilo, alcoximetilo o alquiltiometilo; o unas sales adecuadas de la fórmula I.

公开(公告)号：BR9707280A

公开(公告)日：1999-07-20

申请号：BR9707280

申请日：1997-02-11

Applicant: BASF AG

Inventor： RADITSCH MARTIN ,  FRIEDRICH THOMAS ,  BOLLSCHWEILER CLAUS ,  SCHMIDT MARTIN ,  HOFFKEN HANS WOLFGANG ,  SCHWEDEN JURGEN ,  RUBSAMEN KLAUS

IPC: C12N15/09 ,  A61K31/00 ,  A61K38/00 ,  A61K38/46 ,  A61P7/00 ,  A61P7/04 ,  C07K14/47 ,  C12N9/74 ,  C12N15/00 ,  C12N15/57 ,  C12R1/91 ,  A61K38/48

Abstract: PCT No. PCT/EP97/00612 Sec. 371 Date Aug. 4, 1998 Sec. 102(e) Date Aug. 4, 1998 PCT Filed Feb. 11, 1997 PCT Pub. No. WO97/29198 PCT Pub. Date Aug. 14, 1997The invention concerns thrombin muteins which have the following differences in their sequences as compared with natural thrombin: (a) the exchange of a Gly after Ala, the Gly being in the sequence environment Tyr-Gly-Phe and having position 558 in natural human thrombin (SEQ ID No. 14); (b) at least one exchange or deletion of the following radicals: (b1) His, located in the sequence environment Ala-His-Cys and having position 363 in natural human thrombin (SEQ ID No. 14); (b2) Asp, located in the sequence environment Arg-Asp-Ile and having position 419 in natural human thrombin (SEQ ID No. 14); (b3) Ser, located in the sequence environment Asp-Ser-Gly and having position 525 in natural human thrombin (SEQ ID No. 14). The invention further concerns the use of these muteins as antidotes.

公开(公告)号：AU775511B2

公开(公告)日：2004-08-05

申请号：AU5220300

申请日：2000-06-07

Applicant: BASF AG

Inventor： RADEMACHER WILHELM ,  KRAMER KLAUS ,  SCHWEDEN JURGEN

IPC: A01G7/00 ,  A01N37/42 ,  A61K8/96 ,  A61K8/97 ,  A61K36/00 ,  A61P3/06 ,  A61P3/10 ,  A61P9/00 ,  A61P35/00 ,  A61P39/06 ,  A61P43/00

Abstract: The invention relates to a method of increasing the flavonoid content of plants by treating the plants with the growth-regulating acylcyclohexadiones according to formula (I).

公开(公告)号：PT730473E

公开(公告)日：2002-02-28

申请号：PT95901432

申请日：1994-11-25

Applicant: BASF AG

Inventor： ECKES PETER ,  SCHWEDEN JURGEN ,  WILFRIED HORNBERGER ,  SUBKOWSKI THOMAS

IPC: A61K38/00 ,  A61K47/48 ,  A61P7/02

Abstract: PCT No. PCT/EP94/03901 Sec. 371 Date May 31, 1996 Sec. 102(e) Date May 31, 1996 PCT Filed Nov. 25, 1994 PCT Pub. No. WO95/15183 PCT Pub. Date Jun. 8, 1995The invention relates to novel hirudin conjugates formed from a hirudin and one or more lipophilic compounds, where the lipophilic compound has an octanol/water partition coefficient of more than 1.8 and is chemically linked to the hirudin, to the preparation thereof and to the use thereof.

公开(公告)号：ES2163487T3

公开(公告)日：2002-02-01

申请号：ES95901432

申请日：1994-11-25

Applicant: BASF AG

Inventor： SCHWEDEN JURGEN ,  ECKES PETER ,  HORNBERGER WILFRIED ,  SUBKOWSKI THOMAS

IPC: A61K38/00 ,  A61K47/48 ,  A61P7/02

Abstract: PCT No. PCT/EP94/03901 Sec. 371 Date May 31, 1996 Sec. 102(e) Date May 31, 1996 PCT Filed Nov. 25, 1994 PCT Pub. No. WO95/15183 PCT Pub. Date Jun. 8, 1995The invention relates to novel hirudin conjugates formed from a hirudin and one or more lipophilic compounds, where the lipophilic compound has an octanol/water partition coefficient of more than 1.8 and is chemically linked to the hirudin, to the preparation thereof and to the use thereof.

公开(公告)号：CZ9802477A3

公开(公告)日：1999-03-17

申请号：CZ247798

申请日：1997-02-11

Applicant: BASF AG

Inventor： RADITSCH MARTIN ,  FRIEDRICH THOMAS ,  BOLLSCHWEILER CLAUS ,  SCHMIDT MARTIN ,  HOFFKEN HANS WOLFGANG ,  SCHWEDEN JURGEN ,  RUBSAMEN KLAUS

IPC: C12N15/09 ,  A61K31/00 ,  A61K38/00 ,  A61K38/46 ,  A61P7/00 ,  A61P7/04 ,  C07K14/47 ,  C12N9/74 ,  C12N15/00 ,  C12N15/57 ,  C12R1/91 ,  A61K38/48

CPC classification number: C12N9/6429 ,  A61K38/00 ,  C12Y304/21005

公开(公告)号：AU679811B2

公开(公告)日：1997-07-10

申请号：AU1067095

申请日：1994-11-25

Applicant: BASF AG

Inventor： SCHWEDEN JURGEN ,  ECKES PETER ,  HORNBERGER WILFRIED ,  SUBKOWSKI THOMAS

IPC: A61K38/00 ,  A61K47/48 ,  A61P7/02

Abstract: PCT No. PCT/EP94/03901 Sec. 371 Date May 31, 1996 Sec. 102(e) Date May 31, 1996 PCT Filed Nov. 25, 1994 PCT Pub. No. WO95/15183 PCT Pub. Date Jun. 8, 1995The invention relates to novel hirudin conjugates formed from a hirudin and one or more lipophilic compounds, where the lipophilic compound has an octanol/water partition coefficient of more than 1.8 and is chemically linked to the hirudin, to the preparation thereof and to the use thereof.

公开(公告)号：NO962261A

公开(公告)日：1996-05-31

申请号：NO962261

申请日：1996-05-31

Applicant: BASF AG

Inventor： SCHWEDEN JURGEN ,  ECKES PETER ,  HORNBERGER WILFRIED ,  SUBKOWSKI THOMAS

IPC: A61K38/00 ,  A61K47/48 ,  A61P7/02

CPC classification number: A61K47/545 ,  A61K38/00 ,  A61K47/54

公开(公告)号：NZ516188A

公开(公告)日：2004-07-30

申请号：NZ51618800

申请日：2000-06-07

Applicant: BASF AG

Inventor： RADEMACHER WILHELM ,  KRAMER KLAUS ,  SCHWEDEN JURGEN

IPC: A01G7/00 ,  A01N37/42 ,  A61K8/96 ,  A61K8/97 ,  A61K36/00 ,  A61P3/06 ,  A61P3/10 ,  A61P9/00 ,  A61P35/00 ,  A61P39/06 ,  A61P43/00

Abstract: A method of increasing and qualitatively modifying the content of flavonoids and phenolic constituents in grapevines, cherries, plums, sloes, blueberries, strawberries, citrus fruit, pawpaw, red cabbage, broccoli, brussel sprouts, kale, carrots, parsley, celery/celeriac, onion, garlic, tea, coffee, cacao, mate, hops, soya, oilseed rape, oats, wheat, rye, Aronia melanocarpa or Gingko biloba, which comprises treating the plants with an acylcyclohexadione of formula I wherein R is hydrogen or C1-C6-alkyl and R' is C1-C6-alkyl or C3-C6-cycloalkyl; and the use the treated plants for the preparation of curative composition, health-promoting compositions or tonics and cosmetics.

公开(公告)号：ES2198317T3

公开(公告)日：2004-02-01

申请号：ES00936870

申请日：2000-06-07

Applicant: BASF AG

Inventor： RADEMACHER WILHELM ,  KRAMER KLAUS ,  SCHWEDEN JURGEN

IPC: A01G7/00 ,  A01N37/42 ,  A61K8/96 ,  A61K8/97 ,  A61K36/00 ,  A61P3/06 ,  A61P3/10 ,  A61P9/00 ,  A61P35/00 ,  A61P39/06 ,  A61P43/00

Abstract: The invention relates to a method of increasing the flavonoid content of plants by treating the plants with the growth-regulating acylcyclohexadiones according to formula (I).