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    ANTICUERPOS BIESPECIFICOS IGG4 MODIFICADOS DE SECUENCIA SIMETRICA.
    172.
    发明专利
    ANTICUERPOS BIESPECIFICOS IGG4 MODIFICADOS DE SECUENCIA SIMETRICA. 未知

    公开(公告)号：MX2014010018A

    公开(公告)日：2014-09-12

    申请号：MX2014010018

    申请日：2013-02-22

    Applicant: UCB PHARMA SA

    Inventor： HUMPHREYS DAVID PAUL ,  PETERS SHIRLEY JANE

    IPC: C07K16/00

    Abstract: La presente invención se refiere a un anticuerpo biespecífico simétrico de la clase IgG4 que comprende dos cadenas pesadas que cada una comprende un dominio variable, dominio CH1 y una región de bisagra, en donde en cada cadena pesada: la cisteína en el dominio CH1 que forma un enlace disulfuro entre cadenas con una cisteína en una cadena ligera es sustituida con otro aminoácido; y opcionalmente uno o más de los aminoácidos situados en la región de bisagra superior es sustituido con cisteína, en donde la secuencia de la región constante de la cada cadena pesada es similar o idéntica y la región variable en cada cadena pesada es diferente, formulaciones que comprenden el mismo, el uso de cada uno de los anteriores en tratamiento y procesos para preparar los anticuerpos y formulaciones.

    Cd154 binding protein, its preparation and the preparation of a medicament comprising such for treating an inflammatory or autoimmune response or fibrosis
    174.
    发明专利
    Cd154 binding protein, its preparation and the preparation of a medicament comprising such for treating an inflammatory or autoimmune response or fibrosis 未知

    公开(公告)号：IL201070A

    公开(公告)日：2014-07-31

    申请号：IL20107009

    申请日：2009-09-21

    Applicant: BIOGEN IDEC INC ,  UCB PHARMA SA

    IPC: A61K20060101 ,  C07K20060101

    Abstract: This invention provides binding proteins, including antibodies, antibody derivates and antibody fragments, that specifically bind a CD154 (CD40L) protein. This invention also provides a chimeric, humanized or fully human antibody, antibody derivate or antibody fragment that specifically binds to an epitope to which a humanized Fab fragment comprising a variable heavy chain sequence according to SEQ ID NO: 1 and comprising a variable light chain sequence according to SEQ ID NO: 2 specifically binds. CD154 binding proteins of this invention may elicit reduced effector function relative to a second anti-CD154 antibody. CD154 binding proteins of this invention are useful in diagnostic and therapeutic methods, such as in the treatment and prevention of diseases including those that involve undesirable immune responses that are mediated by CD154-CD40 interactions.

    AUTO-INJECTOR CASSETTE DEVICE FOR ADMINISTERING MEDICATION
    178.
    发明专利
    AUTO-INJECTOR CASSETTE DEVICE FOR ADMINISTERING MEDICATION 未知

    公开(公告)号：CA148850S

    公开(公告)日：2014-05-09

    申请号：CA148850

    申请日：2012-12-05

    Applicant: UCB PHARMA SA

    Abstract: The design is the visual features of the AUTO-INJECTOR CASSETTE DEVICE FOR ADMINISTERING MEDICATION shown in solid lines in the drawings, whether those features are of shape, configuration, ornament, or pattern, or are a combination of any of those features. Shading is used in the drawings to better illustrate the design. The portions shown in stippled lines form no part of the design.Drawings of the design are included.Figure 1 is a perspective view of the auto-injector cassette device for administering medication;Figure 2 is a front elevational view thereof;Figure 3 is a side elevational view thereof;Figure 4 is a top plan view thereof;Figure 5 is a bottom plan view thereof; andFigure 6 is a perspective view thereof.

    AUTO-INJECTOR CASSETTE DEVICE FOR ADMINISTERING MEDICATION
    179.
    发明专利
    AUTO-INJECTOR CASSETTE DEVICE FOR ADMINISTERING MEDICATION 未知

    公开(公告)号：CA148848S

    公开(公告)日：2014-05-09

    申请号：CA148848

    申请日：2012-12-05

    Applicant: UCB PHARMA SA

    Abstract: The design is the visual features of the AUTO-INJECTOR CASSETTE DEVICE FOR ADMINISTERING MEDICATION shown in solid lines in the drawings, whether those features are of shape, configuration, ornament, or pattern, or are a combination of any of those features. Shading is used in the drawings to better illustrate the design. The portions shown in stippled lines form no part of the design.Drawings of the design are included.Figure 1 is a perspective view of the auto-injector cassette device for administering medication;Figure 2 is a front elevational view thereof;Figure 3 is a side elevational view thereof;Figure 4 is a top plan view thereof; andFigure 5 is a bottom plan view thereof.

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