公开(公告)号：ZA200110044B

公开(公告)日：2003-03-06

申请号：ZA200110044

申请日：2001-12-06

Applicant: BASF AG

Inventor： BERND MUEHLBAUER ,  GROSS GERHARD ,  STARCK DOROTHEA ,  TREIBER HANS-JOERG

IPC: C07D241/04 ,  A61K31/00 ,  A61K31/472 ,  A61K31/4725 ,  A61K31/495 ,  A61K31/496 ,  A61K31/506 ,  A61K31/517 ,  A61K31/5513 ,  A61K45/00 ,  A61P1/00 ,  A61P13/12 ,  C07D401/12 ,  C07D403/12 ,  A61P ,  A61K

Abstract: The invention relates to the use of dopamine D3 receptor ligands for the production of drugs for treating renal function disorders.

公开(公告)号：ES2174465T3

公开(公告)日：2002-11-01

申请号：ES98938687

申请日：1998-07-03

Applicant: BASF AG

Inventor： STARCK DOROTHEA ,  BLANK STEFAN ,  TREIBER HANS-JORG ,  UNGER LILIANE ,  NEUMANN-SCHULTZ BARBARA ,  LE BRIS THEOPHILE-MARIE

IPC: A61K31/33 ,  A61K31/41 ,  A61K31/4196 ,  A61K31/454 ,  A61K31/506 ,  A61K31/53 ,  A61K31/551 ,  A61P25/00 ,  A61P25/16 ,  A61P25/18 ,  A61P25/22 ,  A61P25/24 ,  A61P43/00 ,  C07D249/08 ,  C07D249/12 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14

Abstract: Triazole compounds of the following formula:where Ar1, A, B and Ar2 have the meanings given in the description, possess a high affinity for the dopamine D3 receptor and can therefore be used for treating diseases which respond to dopamine D3 ligands.

公开(公告)号：ES2172222T3

公开(公告)日：2002-09-16

申请号：ES98951491

申请日：1998-10-05

Applicant: BASF AG

Inventor： LUBISCH WILFRIED ,  DULLWEBER UTA ,  STARCK DOROTHEA ,  STEINER GERD ,  BACH ALFRED ,  EMLING FRANZ

IPC: A61K31/519 ,  A61P1/00 ,  A61P1/14 ,  A61P3/04 ,  A61P5/00 ,  A61P9/12 ,  A61P15/00 ,  A61P25/00 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P43/00 ,  C07D471/00 ,  C07D471/04

Abstract: 3-substituted tetrahydropyridopyrimidinone derivatives of the formula (I) wherein the radicals have the meanings given in the Description, to a method for producing said derivatives and, to their use for producing active ingredients for drugs.

公开(公告)号：CZ290678B6

公开(公告)日：2002-09-11

申请号：CZ2000462

申请日：1998-07-23

Applicant: BASF AG

Inventor： STEINER GERD ,  DULLWEBER UTA ,  STARCK DOROTHEA ,  BACH ALFRED ,  WICKE KARSTEN ,  TESCHENDORF HANS-JUERGEN ,  GARCIA-LADONA XAVIER ,  EMLING FRANZ

IPC: A61K31/435 ,  A61P25/24 ,  C07D495/14 ,  A61K31/4365

Abstract: In the present invention there are disclosed 3,4,5,7-tetrahydropyrrolo[3?, 4?:4,5]thieno[2,3-d]pyrimidine derivatives substituted in position 3 of the general formula I in which the substituents have specific meaning, and their use as a medicament for treating depressions and related disorders with effect as the selective antagonists 5-HTi1A and 5-HTi1B.

公开(公告)号：AU748666B2

公开(公告)日：2002-06-06

申请号：AU9748498

申请日：1998-10-05

Applicant: BASF AG

Inventor： LUBISCH WILFRIED ,  DULLWEBER UTA ,  STARCK DOROTHEA ,  STEINER GERD ,  BACH ALFRED ,  EMLING FRANZ ,  GARCIA-LADONA XAVIER ,  TESCHENDORF HANS-JURGEN ,  WICKE KARSTEN

IPC: A61K31/519 ,  A61P1/00 ,  A61P1/14 ,  A61P3/04 ,  A61P5/00 ,  A61P9/12 ,  A61P15/00 ,  A61P25/00 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P43/00 ,  C07D471/00 ,  C07D471/04

Abstract: 3-substituted tetrahydropyridopyrimidinone derivatives of the formula (I) wherein the radicals have the meanings given in the Description, to a method for producing said derivatives and, to their use for producing active ingredients for drugs.

公开(公告)号：CZ20012484A3

公开(公告)日：2002-05-15

申请号：CZ20012484

申请日：1999-12-22

Applicant: BASF AG

Inventor： STEINER GERD ,  SCHELLHAAS KURT ,  LUBISCH WILFRIED ,  HOLZENKAMP UTA ,  STARCK DOROTHEA ,  SZABO LASZLO ,  EMLING FRANZ ,  GARCIA-LADONA FRANCISCO JAVIER ,  HOFMANN HANS-PETER ,  UNGER LILIANE

IPC: C07D495/04 ,  A61K31/505 ,  A61K31/519 ,  A61P9/10 ,  C07D495/14 ,  A61K31/496 ,  A61K31/4523 ,  A61K31/4427 ,  A61K31/428

Abstract: Use of pyrimidine derivatives of the formula Iwhere the substituents are as defined in the description, and of their physiologically tolerated salts for producing medicaments for the prophylaxis and treatment of cerebral ischemia and strokes.

公开(公告)号：SK9692001A3

公开(公告)日：2002-05-09

申请号：SK9692001

申请日：1999-12-24

Applicant: BASF AG

Inventor： STEINER GERD ,  SCHELLHAAS KURT ,  LUBISCH WILFRIED ,  HOLZENKAMP UTA ,  STARCK DOROTHEA ,  KNOPP MONIKA ,  SZABO LASZLO ,  EMLING FRANZ ,  GARCIA-LADONA FRANCISCO JAVIER ,  HOFMANN HANS-PETER ,  UNGER LILIANE

IPC: C07D495/04 ,  A61K31/505 ,  A61K31/519 ,  A61P9/10 ,  C07D495/14 ,  A61K31/495 ,  A61K31/55

Abstract: Use of pyrimidine derivatives of the formula Iwhere the substituents are as defined in the description, and of their physiologically tolerated salts for producing medicaments for the prophylaxis and treatment of cerebral ischemia and strokes.

公开(公告)号：NZ503604A

公开(公告)日：2002-03-01

申请号：NZ50360498

申请日：1998-10-05

Applicant: BASF AG

Inventor： BACH ALFRED ,  EMLING FRANZ ,  GARCIA-LADONA XAVIER ,  TESCHENDORF HANS-JURGEN ,  WICKE KARSTEN ,  LUBISCH WILFRED ,  DULLWEBER UTA ,  STARCK DOROTHEA ,  STEINER GERD

IPC: A61K31/428 ,  A61P25/24 ,  A61P43/00 ,  C07D275/06 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12 ,  C07D417/14 ,  A61K31/425

Abstract: 2-Substituted 1,2-benzisothiazole derivatives of formula (I) and their enantiomers, diastereomers, tautomers and acid salts are disclosed. R1 and R2 are independently C1-6 alkyl; R3 and R4 are independently H, C1-6 alkyl, OH, C1-6 alkoxy, F, Cl, Br, I, CF3, NR5R6, CO2R7, NO2, CN, pyrrolo, or phenyl-(C1-4 alkyl), which may itself be ring-substituted by F, Cl, Br, I, C1-4 alkyl, C1-4 alkoxy, CF3, OH, NH2, CN or NO2; R5 and R6 are independently H, C1-6 alkyl, benzoyl, CO2-tert.-butyl, (C1-4 alkyl)carbonyl or together form a 5- or 6-membered ring, which may contain a second N atom (e.g. piperazinyl); R7 is H or C1-6 alkyl; A is C1-10 alkylene or C2-10 alkylene containing one or more Z groups; Z is O, S, NR7, cyclopropyl, CHOH, or a double or triple bond; B is 4-piperidine, 4-(1,2,3,6-tetrahydropyridine), 4-piperazine or one of these rings N-bound to A via a methylene group; Ar is phenyl (optionally substituted by C1-6 alkyl, C1-6 alkoxy, OH, F, Cl, Br, I, CF3, NR5R6, CO2R7, CN or phenyl), tetralinyl, indanyl, other condensed aromatic moieties e.g. naphthalinyl (optionally substituted by C1-4 alkyl or C1-4 alkoxy), anthracenyl, or a 5- or 6-membered aromatic heterocycle with 1 or 2 O or N heteroatoms, which can be fused with other aromatic groups.

公开(公告)号：BG105784A

公开(公告)日：2002-02-28

申请号：BG10578401

申请日：2001-08-03

Applicant: BASF AG

Inventor： STARCK DOROTHEA ,  TREIBER HANS-JOERG ,  UNGER LILIANE ,  NEUMANN-SCHULZ BARBARA ,  BLUMBACH KAI ,  SCHOEBEL DIETMAR

IPC: C07D249/14 ,  A61K31/41 ,  A61K31/4196 ,  A61K31/422 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/436 ,  A61K31/4439 ,  A61K31/4725 ,  A61K31/473 ,  A61K31/496 ,  A61K31/497 ,  A61K31/5377 ,  A61K31/55 ,  A61P3/04 ,  A61P9/00 ,  A61P9/10 ,  A61P13/12 ,  A61P15/10 ,  A61P25/00 ,  A61P25/08 ,  A61P25/14 ,  A61P25/16 ,  A61P25/18 ,  A61P25/20 ,  A61P25/22 ,  A61P25/28 ,  A61P25/30 ,  A61P25/32 ,  A61P25/34 ,  A61P25/36 ,  A61P43/00 ,  C07D249/12 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D403/12 ,  C07D403/14 ,  C07D405/06 ,  C07D405/14 ,  C07D409/04 ,  C07D409/14 ,  C07D413/14 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07D491/04 ,  C07D491/052 ,  A61P25/24

Abstract: The invention relates to triazole compounds of formula in which R1, R2, A and B have the meanings given in the description. The compounds provided for in the invention have a high affinity for the dopamine-D3-receptor and are therefore suitable for the treatment of diseases which respond to the influence of dopamine-D3-receptor ligands. 11 claims

公开(公告)号：BG105688A

公开(公告)日：2002-02-28

申请号：BG10568801

申请日：2001-07-10

Applicant: BASF AG

Inventor： STEINER GERD ,  SCHNELLHAAS KURT ,  LUBISCH WILFRIED ,  HOLZENKAMP UTA ,  STARCK DOROTHEA ,  SZABO LASZLO ,  EMLING FRANZ ,  GARCIA-LADONA FRANCISCO J ,  HOFMANN HANS-PETER ,  UNGER LILIANE

IPC: C07D275/06 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/496 ,  A61K31/502 ,  A61K31/517 ,  A61K31/519 ,  A61K31/522 ,  A61K31/55 ,  A61K31/551 ,  A61P9/10 ,  A61P25/28 ,  C07D401/12 ,  C07D417/12 ,  C07D471/04 ,  A61K31/428

Abstract: The invention relates to the utilization of compounds of formula wherein the substituents have the meanings given in the description. The invention also relates to the salts thereof comprising pharmacologically compatible acids for producing medicaments for the prophylaxis and therapy of cerebral ischaemia and strokes. 1 claim