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公开(公告)号：US20240255415A1
公开(公告)日：2024-08-01
申请号：US18104198
申请日：2023-01-31
Applicant: Lawrence Livermore National Security, LLC
Inventor： Brian Giera , Adam Jaycox , Brian Au , Alex Caviness , Alexander Blum , Nishant Ojal
IPC: G01N21/01
CPC classification number: G01N21/01 , G01N2021/1734 , G01N2021/1757 , G01N2021/1785 , G01N2201/0675 , G01N2201/11
Abstract: A method is disclosed for selecting an optimal value for an adjustable parameter of a structured light metrology (SLM) system, for scanning an object. The SLM system performs test scans of the object to acquire a plurality of sets of measurements of the object, wherein a different value is used for the parameter for each test scan. For each test scan, a value of a quality metric is calculated, based on the set of measurements of the object associated with the test scan and simulation data representing a simulated scan of the object by the SLM system. A test scan is then identified that has a quality metric value that satisfies a specified optimization criterion; and a value of the adjustable parameter that was used for the identified test scan is selected as the optimal value of the adjustable parameter, for scanning the object.
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公开(公告)号：US20190033284A1
公开(公告)日：2019-01-31
申请号：US16046530
申请日：2018-07-26
Applicant: HAMAMATSU PHOTONICS K.K.
Inventor： Naoya MATSUMOTO , Koyo WATANABE , Hirotoshi TERADA
IPC: G01N33/483 , G01N21/41 , G03H1/00 , G01N21/64 , G02B27/00 , G03H1/08 , G02B5/32 , G01B11/24 , G03H1/22 , G02B21/00 , G01N21/63
CPC classification number: G01N33/4833 , G01B11/24 , G01N21/41 , G01N21/636 , G01N21/6458 , G01N21/6486 , G01N2021/6471 , G01N2201/0675 , G02B5/32 , G02B21/00 , G02B21/16 , G02B27/0068 , G03H1/0005 , G03H1/08 , G03H1/2294 , G03H2001/0072
Abstract: A photostimulation apparatus includes an objective lens arranged to face a biological object, a light source configured to output light to be radiated toward the biological object via the objective lens, a shape acquisition unit configured to acquire information about a shape with a refractive index difference in the biological object, a hologram generation unit configured to generate aberration correction hologram data for correcting aberrations due to the shape with the refractive index difference on the basis of the information acquired by the shape acquisition unit, and a spatial light modulator on which a hologram based on the aberration correction hologram data is presented and which modulates the light output from the light source.
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公开(公告)号：US10078254B2
公开(公告)日：2018-09-18
申请号：US15123760
申请日：2015-04-03
Applicant: Sony Corporation
Inventor： Yoshihito Higashitsutsumi , Shinichiro Gomi , Jun Iwama
IPC: G03B15/06 , G02F1/335 , G01N21/21 , G02B5/30 , H04N5/225 , G01B11/30 , A61B5/00 , G03B15/03 , G02F1/1335 , G03B15/05 , G03B15/14 , A61B5/107 , G02B21/06
CPC classification number: G03B15/06 , A61B5/00 , A61B5/0022 , A61B5/0077 , A61B5/107 , A61B5/442 , G01B11/303 , G01N21/21 , G01N2201/0675 , G02B5/3083 , G02B21/06 , G02F1/133528 , G03B15/03 , G03B15/05 , G03B15/14 , H04N5/225 , H04N5/2256
Abstract: An imaging device includes a camera 31, a light source 32, a polarizer 35 arranged between the camera 31 plus the light source 32 and an object 11, and a spatial light modulator 40A arranged between the polarizer 35 and the object 11 to control a revolution angle of an emitting light polarization plane relative to an incident light polarization plane.
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公开(公告)号：US10054545B2
公开(公告)日：2018-08-21
申请号：US15276397
申请日：2016-09-26
Applicant: NIKON CORPORATION
Inventor： Fumihiro Dake , Hiroki Yazawa
CPC classification number: G01N21/6458 , G01N21/636 , G01N2201/0675 , G01N2201/0697 , G02B21/0076 , G02B21/0084 , G02B21/086 , G02B21/16 , G02B21/367 , G02B27/58 , G02F1/11
Abstract: A super-resolution observation device includes an illumination optical system that focus a first illuminating light at optical frequency ω1 and a second illuminating light at optical frequency ω2 on a region of an observation object plane; a modulation unit that modulates a property of the first illuminating light heading toward the region at a modulation frequency fm; and an extraction unit that extracts a component at the optical frequency ω1 or ω2 from a light generated in the region according to the first illuminating light and the second illuminating light, the component of which the property changes at a frequency higher than the modulation frequency fm.
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175.发明授权公开(公告)号：US10018817B2
公开(公告)日：2018-07-10
申请号：US15061056
申请日：2016-03-04
Inventor： Thomas Bifano , Shannon L. Eichmann , Bennett B. Goldberg , Mazen Kanj , Hari P. Paudel , William Shain
CPC classification number: G02B21/0028 , G01N21/6458 , G01N2201/0675 , G02B21/002 , G02B21/0032 , G02B21/0048 , G02B21/0076 , G02B21/008 , G02B21/02 , G02B21/367 , G02B27/0068
Abstract: Embodiments of the invention provide an imaging system and method using adaptive optics and optimization algorithms for imaging through highly scattering media in oil reservoir applications and lab-based petroleum research. Two-/multi-photon fluorescence microscopy is used in conjunction with adaptive optics for enhanced imaging and detection capabilities in scattering reservoir media. Advanced fluorescence techniques are used to allow for super-penetration imaging to compensate for aberrations both in and out of the field of interest, extending the depth at which pore geometry can be imaged within a rock matrix beyond the current capability of confocal microscopy. The placement of a Deformable Mirror or Spatial Light Modulator for this application, in which scattering and index mismatch are dominant aberrations, is in an optical plane that is conjugate to the pupil plane of the objective lens in the imaging system.
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Patent Agency Ranking
176.发明申请公开(公告)号：US20180177401A1
公开(公告)日：2018-06-28
申请号：US15735550
申请日：2016-06-13
Inventor： Samuel Yang , Karl A. Deisseroth , William E. Allen , Isaac V. Kauvar , Aaron S. Andalman
CPC classification number: A61B5/0071 , A61B5/0048 , A61B5/4064 , G01N21/4788 , G01N21/6428 , G01N21/6458 , G01N2021/6478 , G01N2201/06113 , G01N2201/0635 , G01N2201/0675 , G02B21/06 , G02B21/16 , G06T7/0012 , G06T2207/10056 , G06T2207/10064 , G06T2207/10152 , G06T2207/30016 , H04N7/18
Abstract: A method for measuring the activity of one or more excitable cells, such as neurons, in a target tissue is provided. The present method may include measuring the activity of individual, selected excitable cells by projecting one or more three dimensional (3D) multi-focal laser light patterns into a target tissue containing excitable cells adapted to emit cellular electrical activity—sensitive fluorescence, to generate a multiplexed 2D diffraction pattern of fluorescence emitted by the neurons, and resolving the multiplexed 2D diffraction pattern. Also provided herein is a system configured to perform the present method, the system including a microscope configured to project one or more 3D multi-focal laser light patterns into a target tissue using a spatial light modulator and a mirror galvanometer, and a microlens array and an image detector to record individual and multiplexed 2D diffraction patterns of light emitted from the target tissue.
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177.发明申请公开(公告)号：US20180088347A1
公开(公告)日：2018-03-29
申请号：US15694398
申请日：2017-09-01
Applicant: ASML Netherlands B.V.
Inventor： Gerbrand Van Der Zouw , Martin Jacobus Johan Jak , Martin Ebert
CPC classification number: G02B27/283 , G01J1/08 , G01N21/8806 , G01N21/9501 , G01N2021/8848 , G01N2201/0675 , G02F1/01 , G03F7/70633
Abstract: In an illumination system (12, 13) for a scatterometer, first and second spatial light modulators lie in a common plane and are formed by different portions of a single liquid crystal cell (260). Pre-polarizers (250) apply polarization to first and second radiation prior to the spatial light modulators. A first spatial light modulator (236-S) varies a polarization state of the first radiation in accordance with a first programmable pattern. Second spatial light modulator (236-P) varies a polarization state of the second radiation accordance with a second programmable pattern. A polarizing beam splitter (234) selectively transmits each of the spatially modulated first and second radiation to a common output path, depending on the polarization state of the radiation. In an embodiment, functions of pre-polarizers are performed by the polarizing beam splitter.
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公开(公告)号：US09733177B2
公开(公告)日：2017-08-15
申请号：US14362392
申请日：2012-11-30
Applicant: THE UNIVERSITY OF NOTTINGHAM
Inventor： Stephen Sharples , Roger Light
IPC: G01N21/17 , G01H9/00 , H01L27/146
CPC classification number: G01N21/1702 , G01H9/00 , G01N2201/0612 , G01N2201/0675 , H01L27/14609
Abstract: An optical detector comprises a plurality of pixels, each pixel comprising a photodiode operable to detect light incident on that pixel and to generate a signal indicative of an intensity of that light. The plurality of pixels comprises a plurality of pixel pairs, and for each pixel pair, in a configuration mode, the detector is arranged to compare the signal generated by a first pixel of the pair with the signal generated by a second pixel of the pair. A method of optical detection is also described, as is a system incorporating the described optical detector.
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公开(公告)号：US20170176338A1
公开(公告)日：2017-06-22
申请号：US15384918
申请日：2016-12-20
Applicant: Verily Life Sciences LLC
Inventor： Cheng-Hsun Wu , Victor Marcel Acosta , Ian Peikon , Paul Lebel , Jerrod Joseph Schwartz
CPC classification number: G01N21/6458 , G01J3/0208 , G01J3/021 , G01J3/0224 , G01J3/0229 , G01J3/0237 , G01J3/08 , G01J3/14 , G01J3/18 , G01J3/2823 , G01J3/32 , G01J3/4406 , G01J2003/1213 , G01J2003/2826 , G01N21/6408 , G01N21/6428 , G01N2021/6421 , G01N2021/6441 , G01N2021/6463 , G01N2201/0633 , G01N2201/0675 , G02B5/1828 , G02B21/16 , G02B21/361 , G02B21/367 , G02B26/0808 , G02B26/0833 , G02F1/29 , G02F2201/34 , G02F2203/12 , G06T7/90 , G06T2207/10004 , G06T2207/10056
Abstract: Methods are provided to identify spatially and spectrally multiplexed probes in a biological environment. Such probes are identified by the ordering and color of fluorophores of the probes. The devices and methods provided facilitate determination of the locations and colors of such fluorophores, such that a probe can be identified. In some embodiments, probes are identified by applying light from a target environment to a spatial light modulator that can be used to control the direction and magnitude of chromatic dispersion of the detected light; multiple images of the target, corresponding to multiple different spatial light modulator settings, can be deconvolved and used to determine the colors and locations of fluorophores. In some embodiments, light from a region of the target can be simultaneously imaged spatially and spectrally. Correlations between the spatial and spectral images over time can be used to determine the color of fluorophores in the target.
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公开(公告)号：US20170082546A1
公开(公告)日：2017-03-23
申请号：US15276397
申请日：2016-09-26
Applicant: NIKON CORPORATION
Inventor： Fumihiro DAKE , Hiroki YAZAWA
CPC classification number: G01N21/6458 , G01N21/636 , G01N2201/0675 , G01N2201/0697 , G02B21/0076 , G02B21/0084 , G02B21/086 , G02B21/16 , G02B21/367 , G02B27/58 , G02F1/11
Abstract: A super-resolution observation device includes an illumination optical system that focus a first illuminating light at optical frequency ω1 and a second illuminating light at optical frequency ω2 on a region of an observation object plane; a modulation unit that modulates a property of the first illuminating light heading toward the region at a modulation frequency fm; and an extraction unit that extracts a component at the optical frequency ω1 or ω2 from a light generated in the region according to the first illuminating light and the second illuminating light, the component of which the property changes at a frequency higher than the modulation frequency fm.
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