公开(公告)号：WO1995017502A1

公开(公告)日：1995-06-29

申请号：PCT/US1994014579

申请日：1994-12-16

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  PAUL, Deborah, A. ,  KNIGGE, Mark, F.

IPC: C12N05/20

CPC classification number: C07K16/10 ,  C07K2319/00 ,  Y10S436/82

Abstract: Monoclonal antibodies are described which specifically bind to Hepatitis E Virus (HEV), and more particularly to HEV ORF-3 antigen. Also provided are hybridoma cell lines which secrete these monoclonal antibodies, methods for using these monoclonal antibodies, and assay kits which contain these monoclonal antibodies.

Abstract translation: 描述了特异性结合戊型肝炎病毒（HEV），特别是HEV ORF-3抗原的单克隆抗体。 还提供了分泌这些单克隆抗体的杂交瘤细胞系，使用这些单克隆抗体的方法和含有这些单克隆抗体的测定试剂盒。

公开(公告)号：WO1995017501A1

公开(公告)日：1995-06-29

申请号：PCT/US1994014505

申请日：1994-12-16

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  PAUL, Deborah, A. ,  KNIGGE, Mark, F.

IPC: C12N05/20

CPC classification number: C07K16/10 ,  C07K2319/00

Abstract: Monoclonal antibodies are described which specifically bind to Hepatitis E Virus (HEV), and more particularly to HEV orf-2 antigen. Also provided are hybridoma cell lines which secrete these monoclonal antibodies, methods for using these monoclonal antibodies, and assay kits which contain these monoclonal antibodies.

Abstract translation: 描述了特异性结合戊型肝炎病毒（HEV）的单克隆抗体，更具体地说是结合HEV orf-2抗原。 还提供了分泌这些单克隆抗体的杂交瘤细胞系，使用这些单克隆抗体的方法和含有这些单克隆抗体的测定试剂盒。

公开(公告)号：WO1995014533A1

公开(公告)日：1995-06-01

申请号：PCT/US1994013539

申请日：1994-11-22

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  GORDON, Julian ,  STIMPSON, Donald, I. ,  HSIEH, Wang-Ting

IPC: B01L03/00

CPC classification number: G01N1/4077 ,  B01J3/006 ,  B01L3/502 ,  B01L3/5025 ,  B01L3/50255 ,  B01L3/5635 ,  G01N33/53 ,  G01N2001/007 ,  G01N2001/4088 ,  Y10T436/25375 ,  Y10T436/255

Abstract: A method and apparatus for collecting a cell sample from a liquid specimen utilizes a collection receptacle (10) in which the specimen is deposited, with a filter media (20) being placed in communication with a discharge port (14) in the collection receptacle (10) and a transfer device (40) for drawing specimen from the collection receptacle (10) and through the filter (20) for capturing the cellular component of the specimen on the filter media (20) for defining a cell sample for analysis. The collection receptacle (10), filter media (20) and carrier therefor (18) and the transfer device (40) may be supplied in kit form for use in a clinical environment. A hypobaric vessel may be used and the transfer device (40) and this vessel (40) may also serve as a disposal receptacle for the liquid specimen passed through the filter media (20).

Abstract translation: 用于从液体样本收集细胞样品的方法和装置利用其中沉积样本的收集容器（10），过滤介质（20）被放置成与收集容器中的排出口（14）连通 10）和用于从收集容器（10）抽取样品并通过过滤器（20）的传送装置（40），用于将样品的细胞组分捕获在过滤介质（20）上，用于限定用于分析的细胞样品。 收集容器（10），过滤介质（20）及其载体（18）和转移装置（40）可以以套件形式供应，以用于临床环境。 可以使用低压容器，并且转移装置（40）和该容器（40）也可以用作通过过滤介质（20）的液体试样的处理容器。

公开(公告)号：WO1995012816A1

公开(公告)日：1995-05-11

申请号：PCT/EP1994003550

申请日：1994-10-28

Applicant: ABBOTT LABORATORIES ,  MICHEL, Gerd ,  BRAUN, Hans-Bertram ,  RÖHRIG, Kay ,  THOME-KROMER, Birgit

Inventor： ABBOTT LABORATORIES

IPC: G01N33/576

CPC classification number: G01N33/5767 ,  G01N33/564 ,  G01N2800/24

Abstract: An assay and test kit for the determination of LKM-1 autoantibodies in test samples suspected of containing anti-LKM-1 autoantibodies. The method uses a solid phase which preferably is a microparticle. The method is standardized and can be performed in automated systems, allowing quantitation of the amount of anti-LKM antibody in test samples.

Abstract translation: 用于测定怀疑含有抗LKM-1自身抗体的测试样品中LKM-1自身抗体的测定和测试试剂盒。 该方法使用优选为微粒的固相。 该方法是标准化的，可以在自动化系统中进行，允许定量测试样品中抗LKM抗体的量。

公开(公告)号：WO1995011437A1

公开(公告)日：1995-04-27

申请号：PCT/US1994011016

申请日：1994-09-28

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  ZAUN, Peter ,  BOUMA, Stanley, R. ,  GORDON, Julian ,  KOTLARIK, John, J. ,  SOLOMON, Natalie, A.

IPC: G01N01/00

CPC classification number: B01L7/52 ,  B01L3/502 ,  G01N35/1095 ,  G01N2035/00237 ,  G01N2035/00366 ,  G01N2035/00376 ,  G01N2035/00752 ,  Y10S435/808

Abstract: Methods, devices, apparatus and kits for amplifying and detecting nucleic acid are provided. The apparatus is a one or two-tier thermal cycling device (16) that operates in conjunction with a reaction/detection unit (20). A sample (38) is loaded into a reaction chamber (30) of the device which is then mated with a detection chamber (32) to form the reaction/detection unit. A first heating element (90) of the thermal cycling apparatus applies a desired temperature to the reaction/detection device to amplify target nucleic acid in the sample. The reaction mixture is then transferred to the detection chamber by the second heating element (92) and amplified target nucleic acid is immobilized on a support in the detection chamber. Microprocessor control controls the heat applied by the second element independently of the heat applied by the first element. A detection system associated with the apparatus detects and analyzes the immobilized amplified nucleic acid target. Images are captured and digitized and subjected to statistical analysis to improve the accuracy of the method.

Abstract translation: 提供了用于扩增和检测核酸的方法，装置，装置和试剂盒。 该装置是与反应/检测单元（20）一起操作的一层或两层热循环装置（16）。 将样品（38）装载到装置的反应室（30）中，然后与检测室（32）配合以形成反应/检测单元。 热循环装置的第一加热元件（90）对反应/检测装置施加期望的温度以放大样品中的靶核酸。 然后将反应混合物通过第二加热元件（92）转移到检测室，并将扩增的靶核酸固定在检测室中的载体上。 微处理器控制独立于第一元件施加的热量来控制由第二元件施加的热量。 与该装置相关的检测系统检测并分析固定的扩增的核酸靶。 图像被捕获并数字化并进行统计分析以提高该方法的准确性。

公开(公告)号：WO1995006756A2

公开(公告)日：1995-03-09

申请号：PCT/US1994013895

申请日：1994-08-18

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  BURCZAK, John, D. ,  CARRINO, John, J. ,  SALITURO, John, A. ,  PABICH, Edward, K. ,  KLONOWSKI, Paul, A. ,  MANLOVE, Matthew, T. ,  MARSHALL, Ronald, L.

IPC: C12Q01/68

CPC classification number: C12Q1/689 ,  C12Q1/6895

Abstract: The present invention relates to oligonucleotide probes useful in detecting, e.g. by hybridization or the ligase chain reaction, Chlamydia trachomatis DNA in the presence of other related DNA. The present invention is also directed to methods of detecting Chlamydia trachomatis organisms in a sample using the ligase chain reaction.

Abstract translation: 本发明涉及可用于检测，例如， 通过杂交或连接酶链反应，沙眼衣原体DNA在其他相关DNA存在下进行。 本发明还涉及使用连接酶链反应检测样品中沙眼衣原体生物体的方法。

公开(公告)号：WO1995005808A1

公开(公告)日：1995-03-02

申请号：PCT/US1994009529

申请日：1994-08-24

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  GUPTA, Pramod, K. ,  SEMLA, Susan, J. ,  ALVAREZ, Francisco, J.

IPC: A61K09/20

CPC classification number: A61K9/2013

Abstract: A pharmaceutical tablet containing a therapeutically active compound and between 5 % and about 20 % by weight of an oil, preferably selected from vegetable, mineral, animal and edible oils, as well as a method for preparing such tablets. Such tablets provide for the controlled release of the therapeutically active compound from the tablet and also enhance the stability of some therapeutically active compounds.

Abstract translation: 含有治疗活性化合物和5重量％至约20重量％油的药物片剂，优选选自植物油，矿物油，动物油和食用油，以及制备该片剂的方法。 这样的片剂提供治疗活性化合物从片剂的控制释放并且还增强了一些治疗活性化合物的稳定性。

公开(公告)号：WO1995004564A1

公开(公告)日：1995-02-16

申请号：PCT/US1994003997

申请日：1994-04-12

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  GOLDHARDT, Donald, Jay ,  HIRSCH, William, Henry

IPC: A61M05/32

CPC classification number: A61L29/085 ,  A61J15/00 ,  A61J15/0003 ,  A61J15/0015 ,  A61J15/0034 ,  A61J15/0038 ,  A61J15/0042 ,  A61J15/0069 ,  A61J15/0073 ,  A61L31/10 ,  C08L65/04

Abstract: An enteral feeding device (10) for feeding directly into the gastrointestinal tract is provided with a tube (12) having an outer (13) and an inner surface, and with the inner surface encompassing a feeding lumen (14) and being coated with a substituted and/or unsubstituted poly(p-xylene) polymer (50) to retard the deterioration and clogging of the device. Examples of such devices are nasogastric tubes, gastrostomy tubes and jejunostomy tubes.

Abstract translation: 用于直接进入胃肠道的肠内喂养装置（10）设置有具有外部（13）和内表面的管（12），并且内表面包围进料腔（14）并且涂覆有 取代和/或未取代的聚（对二甲苯）聚合物（50）以延缓装置的劣化和堵塞。 这种装置的实例是鼻胃管，胃造口管和空肠造口管。

公开(公告)号：WO1995004540A1

公开(公告)日：1995-02-16

申请号：PCT/US1994008577

申请日：1994-07-29

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  HAVIV, Fortuna ,  FITZPATRICK, Timothy, D. ,  SWENSON, Rolf, E. ,  NICHOLS, Charles, J. ,  MORT, Nicholas, A.

IPC: A61K37/00

CPC classification number: C07K7/23 ,  A61K38/00

Abstract: Decapeptides substituted on the N-terminal nitrogen atom by acyl groups are potent antagonists of LHRH and are useful for suppressing the levels of sex hormones in mammals.

Abstract translation: 在N-末端氮原子上被酰基取代的十肽是LHRH的有效拮抗剂，可用于抑制哺乳动物中的性激素水平。

公开(公告)号：WO1995002070A1

公开(公告)日：1995-01-19

申请号：PCT/US1994007280

申请日：1994-06-28

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  DAWSON, George, J. ,  GUTIERREZ, Robin, A. ,  PAUL, Deborah, A. ,  KNIGGE, Mark, F.

IPC: C12Q01/70

CPC classification number: C07K14/005 ,  C12N2770/28122 ,  G01N33/5767

Abstract: An assay, reagents and a test kit useful for detecting the presence of anti-HEV antibody which may be present in a test sample. The assay method comprises (a) contacting the test sample with at least one synthetic peptide which specifically binds anti-HEV antibody, for a time and under conditions sufficient to form peptide/antibody complexes; (b) contacting said peptide/antibody complexes with an indicator reagent which comprises a signal generating compound attached to an anti-human antibody, and incubating for a time and under conditions sufficient for peptide/antibody/antibody complexes to form; and (c) detecting a measurable signal to indicate the presence of anti-HEV in the test sample.

Abstract translation: 用于检测可能存在于测试样品中的抗HEV抗体的存在的测定法，试剂和测试试剂盒。 测定方法包括（a）在足以形成肽/抗体复合物的时间和条件下，使测试样品与至少一种特异性结合抗HEV抗体的合成肽接触; （b）使所述肽/抗体复合物与包含与抗人抗体连接的信号产生化合物的指示剂接触，并在足以使肽/抗体/抗体复合物形成的时间和条件下孵育; 和（c）检测可测量的信号以指示测试样品中存在抗HEV。