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公开(公告)号：PL352777A1
公开(公告)日：2003-09-08
申请号：PL35277700
申请日：2000-04-17
Applicant: BASF AG
Inventor： KLING ANDREAS , LANGE UDO , LAUTERBACH ARNULF , GENESTE HERVE , SUBKOWSKI THOMAS , ZECHEL JOHANN CHRISTIAN , GRAEF CLAUDIA ISABELLA , HORNBERGER WILFRIED
IPC: C12N9/99 , A61K31/27 , A61K31/381 , A61K31/421 , A61K31/426 , A61K31/4406 , A61K31/443 , A61K31/4439 , A61K38/00 , A61K45/00 , A61K45/06 , A61P3/10 , A61P3/14 , A61P7/02 , A61P9/00 , A61P9/04 , A61P9/08 , A61P9/10 , A61P13/12 , A61P17/02 , A61P17/06 , A61P19/02 , A61P19/08 , A61P19/10 , A61P29/00 , A61P31/04 , A61P31/12 , A61P33/00 , A61P35/00 , A61P43/00 , C07C275/42 , C07D207/34 , C07D213/56 , C07D249/14 , C07D263/34 , C07D263/48 , C07D277/20 , C07D277/48 , C07D277/56 , C07D307/68 , C07D333/38 , C07D333/40 , C07D401/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07K5/02 , C07K5/023 , A61K38/04 , A61K31/33
Abstract: The invention relates to new compounds which bind to integrin receptors, as well as to their production, their use as integrin receptor antagonists and for the treatment of diseases, pharmaceutical preparations containing said compounds and pharmaceutical preparations containing at least one other active compound.
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公开(公告)号：SK2002002A3
公开(公告)日：2002-11-06
申请号：SK2002002
申请日：2000-08-01
Applicant: BASF AG
Inventor： KLING ANDREAS , GENESTE HERVE , LANGE UDO , LAUTERBACH ARNULF , GRAEF CLAUDIA ISABELLA , SUBKOWSKI THOMAS , HOLZENKAMP UTA , MACK HELMUT , SADOWSKI JENS , HORNBERGER WILFRIED , LAUX VOLKER
IPC: A61K31/4402 , A61K31/55 , A61K31/5513 , A61P3/14 , A61P5/18 , A61P7/02 , A61P9/00 , A61P9/08 , A61P9/10 , A61P9/12 , A61P9/14 , A61P13/12 , A61P17/02 , A61P17/06 , A61P19/00 , A61P19/08 , A61P19/10 , A61P29/00 , A61P31/04 , A61P31/12 , A61P33/00 , A61P35/00 , A61P35/04 , A61P43/00 , C07D213/74 , C07D223/20 , C07D243/38 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D409/12 , C07D409/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D495/04 , C07D495/14 , C07D213/73 , C07D491/04
Abstract: The invention relates to novel compounds which bind to integrin receptors, and to the preparation thereof and the use thereof as drugs.
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公开(公告)号：SK14102001A3
公开(公告)日：2002-07-02
申请号：SK14102001
申请日：2000-03-29
Applicant: BASF AG
Inventor： ZECHEL JOHANN-CHRISTIAN , KLING ANDREAS , GENESTE HERVE , LANGE UDO , LAUTERBACH ARNULF , GRAEF CLAUDIA ISABELLA , SUBKOWSKI THOMAS , SADOWSKI JENS , HORNBERGER WILFRIED
IPC: A61K31/505 , A61K45/00 , A61K45/06 , A61P3/14 , A61P7/02 , A61P9/10 , A61P9/12 , A61P13/12 , A61P17/02 , A61P17/06 , A61P19/08 , A61P19/10 , C07D239/36 , A61P29/00 , A61P31/04 , A61P31/12 , A61P33/00 , A61P35/00 , C07D239/34 , C07D239/60 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/14 , C07D417/12 , C07D417/14 , C07D239/46 , C07D403/04
Abstract: The invention relates to novel compounds which bind to integrin receptors, to their preparation, to their use as integrin receptor ligands and for treating diseases, to pharmaceutical preparations comprising these compounds, and to pharmaceutical preparations comprising at least one other active compound.
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公开(公告)号：BG105979A
公开(公告)日：2002-06-28
申请号：BG10597901
申请日：2001-10-04
Applicant: BASF AG
Inventor： ZEICHEL JOHANN-CHRISTIA , KLING ANDREAS , GENESTE HERVE , LANGE UDO , LAUTERBACH ARNULF , GRAEF CLAUDIA I , SUBKOWSKI THOMAS , SADOWSKI JEANS , HORNBERGER WILFRIED
IPC: C07D239/36 , A61K31/505 , A61K45/00 , A61K45/06 , A61P3/14 , A61P7/02 , A61P9/10 , A61P9/12 , A61P13/12 , A61P17/02 , A61P17/06 , A61P19/08 , A61P19/10 , A61P29/00 , A61P31/04 , A61P31/12 , A61P33/00 , A61P35/00 , C07D239/34 , C07D239/60 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/14 , C07D417/12 , C07D417/14 , C07D239/46 , C07D403/04
Abstract: The invention relates to novel compounds that bind to integrin receptor ligands. The invention also relates to the production thereof, to their use as integrin receptor ligands and to their use for treating diseases, to pharmaceutical preparations that contain said compounds and to pharmaceutical preparations that contain at least one additional active compound. 33 claims
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185.发明专利
公开(公告)号：AU748841B2
公开(公告)日：2002-06-13
申请号：AU8540698
申请日：1998-06-23
Applicant: BASF AG
Inventor： SUBKOWSKI THOMAS , HORNBERGER WILFRIED
IPC: A61K38/00 , A61K39/395 , A61P7/02 , A61P7/04 , A61P39/02 , C07K16/00 , C07K16/40 , C12N5/10 , C12N15/02 , C12P21/08 , G01N33/573
Abstract: Ancrod-specific monoclonal antibodies, antibody fragments, mixtures or derivatives thereof are used in pharmaceutical preparations and in diagnosis. Cells which express these antibodies, antibody fragments, mixtures or derivatives thereof are also disclosed.
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Patent Agency Ranking
公开(公告)号：TR200103090T2
公开(公告)日：2002-05-21
申请号：TR200103090
申请日：2000-04-17
Applicant: BASF AG
Inventor： ZECHEL JOHANN CHRISTIAN , KLING ANDREAS , GENESTE HERVE , LANGE UDO , LAUTERBACH ARNULF , GRAEF CLAUDIA ISABELLA , SUBKOWSKI THOMAS , HORNBERGER WILFRIED
IPC: C12N9/99 , A61K31/27 , A61K31/381 , A61K31/421 , A61K31/426 , A61K31/4406 , A61K31/443 , A61K31/4439 , A61K38/00 , A61K45/00 , A61K45/06 , A61P3/10 , A61P3/14 , A61P7/02 , A61P9/00 , A61P9/04 , A61P9/08 , A61P9/10 , A61P13/12 , A61P17/02 , A61P17/06 , A61P19/02 , A61P19/08 , A61P19/10 , A61P29/00 , A61P31/04 , A61P31/12 , A61P33/00 , A61P35/00 , A61P43/00 , C07C275/42 , C07D207/34 , C07D213/56 , C07D249/14 , C07D263/34 , C07D263/48 , C07D277/20 , C07D277/48 , C07D277/56 , C07D307/68 , C07D333/38 , C07D333/40 , C07D401/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07K5/02 , C07K5/023
Abstract: The invention relates to new compounds which bind to integrin receptors, as well as to their production, their use as integrin receptor antagonists and for the treatment of diseases, pharmaceutical preparations containing said compounds and pharmaceutical preparations containing at least one other active compound.
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公开(公告)号：BR0013265A
公开(公告)日：2002-05-14
申请号：BR0013265
申请日：2000-08-01
Applicant: BASF AG
Inventor： KLING ANDREAS , GENESTE HERVE , LANGE UDO , LAUTERBACH ARNULF , GRAEF CLAUDIA ISABELLA , SUBKOWSKI THOMAS , HOLZENKAMP UTA , MACK HELMUT , SADOWSKI JENS , HORNBERGER WILFRIED , LAUX VOLKER
IPC: A61K31/4402 , A61K31/55 , A61K31/5513 , A61P3/14 , A61P5/18 , A61P7/02 , A61P9/00 , A61P9/08 , A61P9/10 , A61P9/12 , A61P9/14 , A61P13/12 , A61P17/02 , A61P17/06 , A61P19/00 , A61P19/08 , A61P19/10 , A61P29/00 , A61P31/04 , A61P31/12 , A61P33/00 , A61P35/00 , A61P35/04 , A61P43/00 , C07D213/74 , C07D223/20 , C07D243/38 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D409/12 , C07D409/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D495/04 , C07D495/14 , C07D243/00
Abstract: The invention relates to novel compounds which bind to integrin receptors, and to the preparation thereof and the use thereof as drugs.
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公开(公告)号：SK14092001A3
公开(公告)日：2002-05-09
申请号：SK14092001
申请日：2000-04-05
Applicant: BASF AG
Inventor： BAUCKE DORIT , MACK HELMUT , SEITZ WERNER , HORNBERGER WILFRIED , BACKFISCH GISELA , DELZER JURGEN
IPC: C12N9/99 , A61K38/00 , A61K38/55 , A61K47/48 , A61P7/02 , A61P43/00 , C07B43/00 , C07D401/12 , C07K5/062 , C07K5/065 , A61K31/4427
Abstract: The present invention relates to prodrugs of general formula (I). The meaning of said formula is given in the description. Disclosed are the prodrugs of pharmaceutically active, heterocyclic amidines. In vivo compounds which are competitive inhibitors of trypsin-like serine proteases, especially thrombin, are produced from the amidines. The invention also relates to the production and use of the prodrugs as medicaments.
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公开(公告)号：BR0009739A
公开(公告)日：2002-04-09
申请号：BR0009739
申请日：2000-03-29
Applicant: BASF AG
Inventor： ZECHEL JOHANN-CHRISTIAN , KLING ANDREAS , GENESTE HERVE , LANGE UDO , LAUTERBACH ARNULF , GRAEF CLAUDIA ISABELLA , SUBKOWSKI THOMAS , SADOWSKI JENS , HORNBERGER WILFRIED
IPC: C07D239/36 , A61K31/505 , A61K45/00 , A61K45/06 , A61P3/14 , A61P7/02 , A61P9/10 , A61P9/12 , A61P13/12 , A61P17/02 , A61P17/06 , A61P19/08 , A61P19/10 , A61P29/00 , A61P31/04 , A61P31/12 , A61P33/00 , A61P35/00 , C07D239/34 , C07D239/60 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/14 , C07D417/12 , C07D417/14
Abstract: The invention relates to novel compounds which bind to integrin receptors, to their preparation, to their use as integrin receptor ligands and for treating diseases, to pharmaceutical preparations comprising these compounds, and to pharmaceutical preparations comprising at least one other active compound.
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公开(公告)号：TR200102914T2
公开(公告)日：2002-01-21
申请号：TR200102914
申请日：2000-04-05
Applicant: BASF AG
Inventor： BAUCKE DORIT , MACK HELMUT , SEITZ WERNER , HORNBERGER WILFRIED , BACKFISCH GISELA , DELZER JUERGEN
IPC: C12N9/99 , A61K38/00 , A61K38/55 , A61K47/48 , A61P7/02 , A61P43/00 , C07B43/00 , C07D401/12 , C07K5/062 , C07K5/065
Abstract: The present invention relates to prodrugs of general formula (I). The meaning of said formula is given in the description. Disclosed are the prodrugs of pharmaceutically active, heterocyclic amidines. In vivo compounds which are competitive inhibitors of trypsin-like serine proteases, especially thrombin, are produced from the amidines. The invention also relates to the production and use of the prodrugs as medicaments.
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