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    A LYTIC REAGENT SYSTEM FOR FLOW CYTOMETRIC ANALYSIS OF LEUKOCYTES BASED ON MORPHOLOGY OR IMMUNOPHENOTYPES
    12.
    发明申请
    A LYTIC REAGENT SYSTEM FOR FLOW CYTOMETRIC ANALYSIS OF LEUKOCYTES BASED ON MORPHOLOGY OR IMMUNOPHENOTYPES 审中-公开
    基于形态学或免疫荧光的流式细胞仪分析淋巴细胞的LYTIC试剂系统

    公开(公告)号：WO2011143044A2

    公开(公告)日：2011-11-17

    申请号：PCT/US2011035346

    申请日：2011-05-05

    Applicant: IDEXX LAB INC ,  LIN JUIMING ,  DEKA CHIRANJIT

    Inventor： LIN JUIMING ,  DEKA CHIRANJIT

    IPC: C12Q1/00

    CPC classification number: G01N33/537 ,  G01N33/56972

    Abstract: A lytic reagent composition and methods for differentiation and enumeration of leukocytes are disclosed. The lytic reagent is useful for rapid and automated sample preparation methods in an automated hematology analyzer, and also for manual and slow sample preparation methods required for immunophenotyping cells in a conventional fluorescence flow cytometer. The reagent system includes a nonionic surfactant in a hypotonic solution, an inorganic buffer to maintain the pH in a range of from about 6 to about 10, and optionally a leukocyte stabilizer. The reagent system is used to lyse red blood cells and stabilize the leukocytes so that antibody binding sites on the leukocytes remain unaffected by the process and the blood samples may be labeled with antibodies either before or after the lysis of the red blood cells.

    Abstract translation: 公开了一种裂解试剂组合物和白细胞的分化和计数方法。 溶解试剂可用于自动血液分析仪中的快速和自动化样品制备方法，以及常规荧光流式细胞仪中免疫分型细胞所需的手动和慢速样品制备方法。 试剂系统包括在低渗溶液中的非离子表面活性剂，将pH保持在约6至约10范围内的无机缓冲剂和任选的白细胞稳定剂。 试剂系统用于裂解红细胞并稳定白细胞，使得白细胞上的抗体结合位点不受该过程的影响，血液样品可以在红细胞裂解之前或之后用抗体标记。

    METHODS, DEVICES, KITS AND COMPOSITIONS FOR DETECTING WHIPWORM
    13.
    发明申请
    METHODS, DEVICES, KITS AND COMPOSITIONS FOR DETECTING WHIPWORM 审中-公开
    方法，装置，用于检测WHIPWORM的装置和组合物

    公开(公告)号：WO2009143067A3

    公开(公告)日：2010-01-14

    申请号：PCT/US2009044373

    申请日：2009-05-18

    Applicant: IDEXX LAB INC ,  DIVERGENCE INC ,  ELSEMORE DAVID ALLEN ,  FLYNN LAURIE A ,  CRAWFORD MICHAEL

    Inventor： ELSEMORE DAVID ALLEN ,  FLYNN LAURIE A ,  CRAWFORD MICHAEL

    IPC: C12Q1/70 ,  C07K14/435 ,  C07K16/18 ,  G01N33/53

    CPC classification number: C07K14/43536 ,  C07K16/18 ,  G01N33/5308 ,  G01N2333/43526

    Abstract: Methods, devices, kits and compositions for detecting the presence or absence of whipworm in a fecal sample are disclosed herein. The methods, devices, kits and compositions of the present invention may be used to confirm the presence or absence of whipworm in a fecal sample from a mammal that may also be infected with one or more of hookworm, roundworm, and heartworm. Confirmation of the presence or absence of whipworm in the mammal may be made, for example, for the purpose of selecting an optimal course of treating the mammal and/or for the purpose of determining whether the mammal has been rid of the infection after treatment has been initiated.

    Abstract translation: 本文公开了用于检测粪便样品中鞭虫的存在或不存在的方法，装置，试剂盒和组合物。 本发明的方法，装置，试剂盒和组合物可用于确认来自哺乳动物的粪便样品中是否存在鞭虫，所述哺乳动物也可能被钩虫，蛔虫和心虫中的一种或多种感染。 可以确认哺乳动物中鞭虫的存在或不存在，例如，为了选择治疗哺乳动物的最佳过程和/或为了确定哺乳动物是否已经在治疗后已经除去感染的目的 已经启动

    PIPETTE TIP
    17.
    发明申请
    PIPETTE TIP 审中-公开
    PIPETTE提示

    公开(公告)号：WO2008063544A3

    公开(公告)日：2008-08-21

    申请号：PCT/US2007024035

    申请日：2007-11-16

    Applicant: IDEXX LAB INC ,  PELLETIER DOMINIC ,  PHELPS JEFFREY ,  AGUIAR JASON ,  HAMMOND JEREMY ,  TRAIGLE WILLIAM J ,  SINNETT CHANDLER G

    Inventor： PELLETIER DOMINIC ,  PHELPS JEFFREY ,  AGUIAR JASON ,  HAMMOND JEREMY ,  TRAIGLE WILLIAM J ,  SINNETT CHANDLER G

    IPC: B01L3/02

    CPC classification number: B01L3/0275 ,  B01L3/0262 ,  B01L2200/141 ,  B01L2400/025

    Abstract: A pipette tip includes a main body having an upper end, a lower end and a sidewall extending between the two ends. A bore extends axially through the main body between the upper and lower ends. The lower end has a bottom surface in which is formed a central opening that communicates with the axial bore to allow the passage of fluid therethrough. The bottom surface is formed with at least one groove that may be concentrically disposed or spirally disposed about the central opening. The at least one groove acts to inhibit fluid passing through the central opening from at least partially flowing along the outer surface of the sidewall from the central opening toward the upper end of the main body of the pipette tip.

    Abstract translation: 移液管尖端包括具有上端，下端和在两端之间延伸的侧壁的主体。 孔在上端和下端之间轴向延伸通过主体。 下端具有底表面，其中形成有与轴向孔连通以允许流体通过的中心开口。 底表面形成有至少一个凹槽，其可以围绕中心开口同心地设置或螺旋地设置。 所述至少一个凹槽用于阻止流经中心开口的流体至少部分地沿着侧壁的外表面从中心开口朝向移液管尖端主体的上端流动。

    LATERAL FLOW ASSAY AND DEVICE USING MAGNETIC PARTICLES
    20.
    发明申请
    LATERAL FLOW ASSAY AND DEVICE USING MAGNETIC PARTICLES 审中-公开
    横向流动测定和使用磁性颗粒的装置

    公开(公告)号：WO2007011936A2

    公开(公告)日：2007-01-25

    申请号：PCT/US2006027845

    申请日：2006-07-18

    Applicant: IDEXX LAB INC ,  CARPENTER CHARLES R ,  FARACE GIOSI ,  MACHENRY PAUL SCOTT ,  FOSTER BRIAN JOHN ,  ZIEBA MIROLEE BLUE

    Inventor： CARPENTER CHARLES R ,  FARACE GIOSI ,  MACHENRY PAUL SCOTT ,  FOSTER BRIAN JOHN ,  ZIEBA MIROLEE BLUE

    IPC: G01N33/50

    CPC classification number: G01N33/54333 ,  G01N33/558 ,  H01F1/0054

    Abstract: A complex including magnetic particle bound to a metal colloid. The complex may be part of a reagent for use in a method for determining analytes. The reagent may include a binding partner specific for an analyte. The reagent may further include a first label that is distinguishable from a second label that is used to detect the analyte. The reagent is used in kits and methods for detecting analytes in samples. The methods include immunoassay methods, including method where the first label is used to calibrate the assay.

    Abstract translation: 包含结合到金属胶体上的磁性颗粒的复合物。 该复合物可以是用于测定分析物的方法中的试剂的一部分。 该试剂可以包括对分析物特异的结合配偶体。 该试剂还可以包括与用于检测分析物的第二标签可区分的第一标签。 该试剂用于检测样品中分析物的试剂盒和方法。 这些方法包括免疫分析方法，包括使用第一个标记来校准分析的方法。

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