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    Stabilized Trinder reagent
    11.
    发明公开
    Stabilized Trinder reagent 失效
    Stabilisiertes Trinder-Reagens。

    公开(公告)号：EP0415471A2

    公开(公告)日：1991-03-06

    申请号：EP90202128.6

    申请日：1990-08-04

    Applicant: INSTRUMENTATION LABORATORY S.p.A.

    Inventor： Frontini, Dario ,  D'Alterio, Maurizio

    IPC: C12Q1/28

    CPC classification number: C12Q1/28

    Abstract: Spontaneous aspecific coloration in so-called Trinder reagents which can alter subsequent colorimetric determinations is inhibited by adding compounds of the chelating agent class to the solution. The resultant compositions contain a peroxidase enzyme, a phenylpyrazone derivative, a compound of phenolic or aromatic amine structure and a stabilizer. Preferred stablizers are ethylenediaminetetraacetic acid (EDTA) and diethylenetriaminepentaacetic acid (DTPA).

    Abstract translation: 所谓Trinder试剂中的自发的特异性着色可通过向溶液中加入螯合剂类的化合物来抑制随后的比色测定。 所得组合物含有过氧化物酶，苯基腙衍生物，酚或芳族胺结构的化合物和稳定剂。 优选的稳定剂是乙二胺四乙酸（EDTA）和二亚乙基三胺五乙酸（DTPA）。

    Buffer solution systems for standardizing ph analyzers and electrolytes
    12.
    发明公开
    Buffer solution systems for standardizing ph analyzers and electrolytes 无效
    用于标准分析仪和电解质的缓冲溶液系统

    公开(公告)号：EP0341793A3

    公开(公告)日：1990-09-12

    申请号：EP89201165.1

    申请日：1989-05-08

    Applicant: INSTRUMENTATION LABORATORY S.p.A.

    Inventor： Manzoni, Angelo ,  Belluati, Mario

    IPC: G01N27/416

    CPC classification number: G01N33/492 ,  G01N33/84

    Abstract: The invention relates to the formulation of combined-composition electrolyte and pH buffers for use as standardization solutions in analyzers for clinical chemistry which simultaneously use more than one ion-selective electrode plus more than one standard solution.
    Each ion is present in the standard solution in stoichiometric quantity such as to compensate the effect due to the incomplete dissociation of the salt used, and to obtain an activity coefficient and liquid junction potential such as to reduce the error generated by the use of standardization solutions which do not take account of these quantities.
    Buffer solutions are described having a pH within the range of 6-8 and an electrolyte composition (Na⁺, K⁺, Ca⁺ and Cl⁻) which reflect the composition of the biological liquid to be analyzed, namely whole blood, plasma or serum, in equilibrium with different partial pressures of oxygen and CO₂.

    Method, apparatus and solution for calibration of partial pressure value
    13.
    发明公开
    Method, apparatus and solution for calibration of partial pressure value 失效
    Verfahren，Vorrichtung undLösungzur Eichung vonPartialdrücken。

    公开(公告)号：EP0355896A2

    公开(公告)日：1990-02-28

    申请号：EP89202034.8

    申请日：1989-08-03

    Applicant: INSTRUMENTATION LABORATORY S.p.A.

    Inventor： Calabrese, Gary Stephen ,  Calzi, Claudio

    IPC: G01N27/416

    CPC classification number: G01N27/4163

    Abstract: Electrodes for the measurement of pCO2 and/or pO2 are calibrated with an exposed aliquot of a calibration liquid. A constituent such as a ferrioxalate salt in the calibration liquid is converted to the gas in a reproducible concentration by exposure of the aliquot to light. In some instances, the calibration liquid is equilibrated with air prior to exposure. Some mechanisms of light generation of carbon dioxide also consume oxygen, so as to depress the pO2 value by a reproducible amount. The use of two different calibration liquids enables both one-point and two-point calibration of the Clark oxygen electrode and the Severinghaus pCO2 electrode of a blood gas instrument.
    Aqueous acidic ferrioxalate compositions are disclosed for use as calibrants of pCO2 and of pO2 after photodecomposition. Compositions with high iron(III) to oxalate molar ratios (e.g., 5:1 to 100:1 with 0.3 to 15 millimolar oxalate) produce carbon dioxide on exposure without oxygen consumption. Compositions with low iron(III) to oxalate ratios (e.g., 1:1000 to 1:2000) with 0.1 to 5 millimolar iron(III) produce carbon dioxide on exposure with concurrent oxygen consumption. Use of the two types of compositions enables calibration values to be established with varying pCO2 values and with, respectively, high and low pO2 values.

    Abstract translation: 测量pCO2和/或pO2的电极用标准液体的暴露等分试样进行校准。 通过将等分试样暴露于光，将校正液中的草酸盐等成分如可再现的浓度转化为气体。 在某些情况下，在曝光之前用空气平衡校准液。 二氧化碳的光产生的一些机制也消耗氧气，以便将pO2值降低可重复的量。 使用两种不同的校准液体可以对血气仪器的Clark氧电极和Severinghaus pCO2电极进行一点和两点校准。 公开了酸性草酸铁酸酯组合物作为光分解后用作pCO 2和pO2的配位体。 具有高铁（III）至草酸酯摩尔比的组合物（例如，具有0.3至15毫摩尔草酸盐的5:1至100:1）在没有氧消耗的情况下产生二氧化碳。 具有0.1至5毫摩尔铁（III）的低铁（III）至草酸酯比例（例如1：1000至1：2000）的组合物在暴露于同时耗氧的情况下产生二氧化碳。 使用两种类型的组合物可以使用不同的pCO2值和分别为高和低pO2值建立校准值。

    Electrochemical cell for measuring ionic activity in a solution and its method of use
    15.
    发明公开
    Electrochemical cell for measuring ionic activity in a solution and its method of use 失效
    用于测量溶液中的离子活性的电化学电池，以及它们的使用方法。

    公开(公告)号：EP0350116A2

    公开(公告)日：1990-01-10

    申请号：EP89201743.5

    申请日：1989-06-29

    Applicant: INSTRUMENTATION LABORATORY S.p.A.

    Inventor： Calzi, Claudio

    IPC: G01N27/28

    CPC classification number: G01N27/403

    Abstract: An electrochemical cell for measuring the activity of one or more ionic species such as pNa, pK, pCa, pNH₄, pCl etc. consisting of two sensors selective to the actual ionic species, one of which is used as the reference electrode and the other as the measurement electrode.
    The two sensors are chosen preferably identical.
    The electrode used as the reference electrode is brought into contact with a solution of known ionic activity and an ionic strength which is greater, equal to or substantially greater than that of the unknown solution to be measured.
    The measurment electrode is brought into contact with the unknown solution to be measured, while a third electrode is used purely for instrumental reasons and does not participate in the measurement.

    Abstract translation: 用于测量一个或多个离子物质的活性的电化学电池：例如PNA，PK，PCA，pNH4，PCL等两个传感器选择性的实际离子物质，它被用作参比电极，另一个为的所有一个由......组成 测量电极。 两个传感器被选择优选相同。 用作参比电极的电极被带入与已知的离子活性的溶液接触，并在离子强度的所有这是更大的，等于或基本上大于所述未知溶液中，以进行测量。 所述measurment电极被带入与所述未知溶液接触要被测量，而第三电极纯粹是用于仪器的原因，不参与在测量中。

    Heating and temperature-control device for biological sample containers
    16.
    发明公开
    Heating and temperature-control device for biological sample containers 失效
    on ung on。。。。。。。。。。。。。。。。。

    公开(公告)号：EP0345882A1

    公开(公告)日：1989-12-13

    申请号：EP89201409.3

    申请日：1989-06-02

    Applicant: INSTRUMENTATION LABORATORY S.p.A.

    Inventor： Calzi, Claudio ,  Bonfiglio, Paolo

    IPC: G05D23/27 ,  B04B15/02 ,  G01N21/07

    CPC classification number: G05D23/27 ,  G01N21/0332 ,  G01N21/07

    Abstract: A heating and temperature-control device for biological sample containers comprises an assembly of lamps emitting infrared radiation within a wavelength of 1-5.5 micrometers and heating said containers by irradiation, and a sensor for infrared radiation of wavelength 7-14 micrometers which picks up the emission from the containers which derives from their heating. The signal obtained from said sensor is used to control the lamp emission in such a manner as to obtain the required container temperature and then keep it constant.

    Abstract translation: 用于生物样品容器的加热和温度控制装置包括发射波长为1-5.5微米的红外辐射的灯的组件，并通过照射加热所述容器，以及用于红外辐射的传感器，其用于拾取 来自其加热的容器的排放。 从所述传感器获得的信号用于以获得所需容器温度并且然后保持恒定的方式控制灯发射。

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