公开(公告)号：WO1996039922A1

公开(公告)日：1996-12-19

申请号：PCT/US1996004502

申请日：1996-04-02

Applicant: OPTIX LP

Inventor： OPTIX LP ,  BLOCK, Myron, J. ,  SODICKSON, Lester

IPC: A61B05/00

CPC classification number: A61B5/14532 ,  A61B5/0059 ,  A61B5/14546 ,  A61B5/14558 ,  G01N21/359 ,  G01N21/4795 ,  G01N21/49 ,  G01N2021/3137

Abstract: An improved method and apparatus for use in optical testing of concentration in samples has been developed. The apparatus restricts the solid angle of illumination and the solid angle of detection to eliminate a high proportion of the scattered radiation while allowing the ballistic radiation and the snake-like radiation to be transmitted. In samples which contain multiple scattering centers, this allows less correction for variations in effective pathlength and allows easier calibration of the apparatus. The use of polarized radiation as a means of minimizing scattered radiation in the sample is also disclosed. In a second embodiment the detector collects only polarized radiation while excluding depolarized (multiple scattered) radiation. The radiation preferrably is chosen to be in the 700-1500 nm wavelength range. The sample preferrably is a portion of a mammalian body, the analyte to be analyzed is selected from the group consisting of glucose, glucose identifying substances, mixtures thereof or from the group consisting of hemoglobin, deoxyhemoglobin and mixtures thereof. The concentration measurement can be used to derive oxygen saturation of the blood.

Abstract translation: 已经开发了用于样品中浓度的光学测试的改进的方法和装置。 该装置限制了立体照明角度和立体检测角度，以消除散射辐射的高比例，同时允许弹道辐射和蛇状辐射传播。 在包含多个散射中心的样品中，这样可有效地校正光束长度的变化，并允许更容易校准仪器。 还公开了使用偏振辐射作为使样品中的散射辐射最小化的手段。 在第二实施例中，检测器仅收集偏振辐射，同时排除去极化（多散射）辐射。 辐射优选地选择在700-1500nm波长范围内。 样品优选地是哺乳动物体的一部分，待分析的分析物选自葡萄糖，葡萄糖鉴定物质，其混合物或由血红蛋白，脱氧血红蛋白及其混合物组成的组。 浓度测量可用于导出血液的氧饱和度。

公开(公告)号：CA2180128C

公开(公告)日：2004-06-29

申请号：CA2180128

申请日：1995-01-09

Applicant: OPTIX LP

Inventor： SODICKSON LESTER ,  BLOCK MYRON J

IPC: A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  G01N21/31 ,  G01N21/35 ,  G01N21/47 ,  G01N21/61 ,  G01N33/487

Abstract: A new non-invasive non-spectrophotometric method for measuring the blood concentration of ana- lytes such as glucose has been developed. A plurality of broad spectrum filters (30A-30D) transmit distin- guishably coded by choppers (20A-20D) beams of radiation in overlapping portions of the spectrum to the sample. Radiation reflected or transmitted by the sample is detected and decoded. LED's may be used instead of the broad spectrum radiation generating device and the filters. Further, a scanning interfer- ometer cam be used as the illuminating and coding device. In a preferred mode, congruent illumination is utilized. The coded signals are analyzed by anal- ogy to colorimetry and visual processing and can be converted into concentration measurements.

公开(公告)号：AU5382696A

公开(公告)日：1996-12-30

申请号：AU5382696

申请日：1996-04-02

Applicant: OPTIX LP

Inventor： BLOCK MYRON J ,  SODICKSON LESTER

IPC: G01N21/35 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  A61B5/1495 ,  A61B10/00 ,  G01N21/31 ,  G01N21/47 ,  G01N21/49 ,  G01N33/487

Abstract: An improved method and apparatus for use in optical testing of concentration in samples has been developed. The apparatus restricts the solid angle of illumination and the solid angle of detection to eliminate a high proportion of the scattered radiation while allowing the ballistic radiation and the snake-like radiation to be transmitted. In samples which contain multiple scattering centers, this allows less correction for variations in effective pathlength and allows easier calibration of the apparatus. The use of polarized radiation as a means of minimizing scattered radiation in the sample is also disclosed.

公开(公告)号：CA2223408A1

公开(公告)日：1996-12-19

申请号：CA2223408

申请日：1996-04-02

Applicant: OPTIX LP

Inventor： SODICKSON LESTER ,  BLOCK MYRON J

IPC: G01N21/35 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  A61B5/1495 ,  A61B10/00 ,  G01N21/31 ,  G01N21/47 ,  G01N21/49 ,  G01N33/487 ,  A61B6/00

Abstract: An improved method and apparatus for use in optical testing of concentration in samples has been developed. The apparatus restricts the solid angle of illumination and the solid angle of detection to eliminate a high proportion of the scattered radiation while allowing the ballistic radiation and the snake-like radiation to be transmitted. In samples which contain multiple scattering centers, this allows less correction for variations in effective pathlength and allows easier calibration of the apparatus. The use of polarized radiation as a means of minimizing scattered radiation in the sample is also disclosed. In a second embodiment the detector collects only polarized radiation while excluding depolarized (multiple scattered) radiation. The radiation preferrably is chosen to be in the 700-1500 nm wavelength range. The sample preferrably is a portion of a mammalian body, the analyte to be analyzed is selected from the group consisting of glucose, glucose identifying substances, mixtures thereof or from the group consisting of hemoglobin, deoxyhemoglobin and mixtures thereof. The concentration measurement can be used to derive oxygen saturation of the blood.

公开(公告)号：AU2003238843A1

公开(公告)日：2004-02-09

申请号：AU2003238843

申请日：2003-05-30

Applicant: OPTIX LP

Inventor： GUTHERMANN HOWARD E

IPC: A61B5/00 ,  G01N21/35 ,  G01N21/49 ,  G01N33/48

公开(公告)号：AU744758B2

公开(公告)日：2002-03-07

申请号：AU3968499

申请日：1999-04-28

Applicant: OPTIX LP

Inventor： BLOCK MYRON J

IPC: A61B5/145 ,  A61B5/00 ,  A61B5/1455

Abstract: The invention provides non-invasive methods and apparati for measurement of the concentration of a selected constituent of a subject's blood. The invention cools a segment of the subject's tympanic membrane and employs the thermal radiation that the subject's inner ear emits and is transmitted through this cold segment to directly obtain absorption information related to the concentration of various constituents of blood flowing through the membrane. In particular the invention utilizes optical devices inserted into the external ear cavity to direct a portion of the transmitted radiation onto an infrared detection and analysis device. The signal from the detection device is analyzed to obtain the concentration of the constituent of interest. The invention can employ both traditional spectrophotometric techniques and also non-spectrophotometric techniques to derive the concentration of a particular constituent.

公开(公告)号：ES2145843T3

公开(公告)日：2000-07-16

申请号：ES94929335

申请日：1994-09-26

Applicant: OPTIX LP

Inventor： BLOCK MYRON J ,  SODICKSON LESTER

IPC: G01N33/49 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  G01N21/27 ,  G01N21/31 ,  G01N21/35 ,  G01N21/47 ,  G01N21/64 ,  G01N33/487 ,  G01J3/50

公开(公告)号：AU3968499A

公开(公告)日：1999-11-23

申请号：AU3968499

申请日：1999-04-28

Applicant: OPTIX LP

Inventor： BLOCK MYRON J

IPC: A61B5/145 ,  A61B5/00 ,  A61B5/1455

Abstract: The invention provides non-invasive methods and apparati for measurement of the concentration of a selected constituent of a subject's blood. The invention cools a segment of the subject's tympanic membrane and employs the thermal radiation that the subject's inner ear emits and is transmitted through this cold segment to directly obtain absorption information related to the concentration of various constituents of blood flowing through the membrane. In particular the invention utilizes optical devices inserted into the external ear cavity to direct a portion of the transmitted radiation onto an infrared detection and analysis device. The signal from the detection device is analyzed to obtain the concentration of the constituent of interest. The invention can employ both traditional spectrophotometric techniques and also non-spectrophotometric techniques to derive the concentration of a particular constituent.

公开(公告)号：CA2331697A1

公开(公告)日：1999-11-11

申请号：CA2331697

申请日：1999-04-28

Applicant: OPTIX LP

Inventor： BLOCK MYRON J

IPC: A61B5/145 ,  A61B5/00 ,  A61B5/1455

Abstract: The invention provides non-invasive methods and apparati for measurement of the concentration of a selected constituent of a subject's blood. The invention cools a segment of the subject's tympanic membrane (10) and employs the thermal radiation that the subject's inner ear emits and is transmitted through this cold segment to directly obtain absorption information related to the concentration of various constituents of blood flowing through the membrane. In particular, the invention utilizes optical devices (16, 18, 22) inserted into the external ear cavity to direct a portion of the transmitted radiation onto an infrared detection and analysis device (24, 36). The signal from the detection device (24) is analyzed to obtain the concentration of the constituent of interest. The invention can employ both traditional spectrophotometric techniques and also non-spectrophotometric techniques to derive the concentration of a particular constituent.

公开(公告)号：CA2180128A1

公开(公告)日：1995-07-20

申请号：CA2180128

申请日：1995-01-09

Applicant: OPTIX LP

Inventor： BLOCK MYRON J ,  SODICKSON LESTER

IPC: A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  G01N21/31 ,  G01N21/35 ,  G01N21/47 ,  G01N21/61 ,  G01N33/487

Abstract: A new non-invasive non-spectrophotometric method for measuring the blood concentration of analytes such as glucose has been developed. A plurality of broad spectrum filters (30A-30D) transmit distinguishably coded by choppers (20A-20D) beams of radiation in overlapping portions of the spectrum to the sample. Radiation reflected or transmitted by the sample is detected and decoded. LED's may be used instead of the broad spectrum radiation generating device and the filters. Further, a scanning interferometer cam be used as the illuminating and coding device. In a preferred mode, congruent illumination is utilized. The coded signals are analyzed by analogy to colorimetry and visual processing and can be converted into concentration measurements.