公开(公告)号：KR1020090015766A

公开(公告)日：2009-02-12

申请号：KR1020070080366

申请日：2007-08-09

Applicant: 강원대학교산학협력단

Inventor： 조재열 ,  이용규 ,  이지연 ,  변세은 ,  김주영 ,  김병훈

IPC: A61K31/435 ,  A61P29/00 ,  A61P37/02 ,  A61P35/00

CPC classification number: Y02A50/409 ,  A61K31/435 ,  Y10S514/814 ,  Y10S514/824 ,  Y10S514/825 ,  Y10S514/866 ,  Y10S514/885 ,  Y10S514/886 ,  Y10S514/925

Abstract: A composition comprising 8-(tosylamino)quinoline is provided to inhibit production of nitric oxide, growth of cancer cells and C6 glioma cell, production of PGE2(prostaglandin 2), and activity of IKK(I kappa B alpha kinase) and Src kinase, thereby preventing or treating inflammatory diseases, immune diseases or tumors. The composition for preventing or treating inflammatory diseases, immune diseases or tumors comprises 8-(tosylamino)quinoline or pharmaceutically acceptable salts thereof including an acid addition salt selected from hydrochloric acid, hydrobromic acid, phosphonic acid, sulfuric acid, tartaric acid, acetic acid, citric acid, malic acid, methanesulphonic acid and gluconic acid.

Abstract translation: 提供了包含8-（甲苯磺酰氨基）喹啉的组合物以抑制一氧化氮的产生，癌细胞和C6胶质瘤细胞的生长，PGE2（前列腺素2）的产生以及IKK（IκBα激酶）和Src激酶的活性， 从而预防或治疗炎性疾病，免疫疾病或肿瘤。 用于预防或治疗炎性疾病，免疫疾病或肿瘤的组合物包含8-（甲苯磺酰氨基）喹啉或其药学上可接受的盐，包括选自盐酸，氢溴酸，膦酸，硫酸，酒石酸，乙酸， 柠檬酸，苹果酸，甲磺酸和葡萄糖酸。

公开(公告)号：KR1020090007655A

公开(公告)日：2009-01-20

申请号：KR1020070070926

申请日：2007-07-15

Applicant: 강원대학교산학협력단

Inventor： 조재열 ,  이지연 ,  변세은 ,  이용규 ,  김주영 ,  천승훈 ,  박준석

IPC: A61K31/47 ,  A61K31/4184 ,  A61P37/02

CPC classification number: Y02A50/409 ,  Y02A50/423 ,  A61K31/4745 ,  Y10S424/13 ,  Y10S514/814 ,  Y10S514/824 ,  Y10S514/825 ,  Y10S514/866 ,  Y10S514/886 ,  Y10S514/893 ,  Y10S514/925

Abstract: A composition comprising 5-[4'-(piperidinomethyl)phenyl]-2,3-dihydroimidazo [2,1-a] isoquinoline is provided to inhibit inflammation and regulate immune responses in macrophages, thereby preventing and treating the inflammatory or immune diseases. The composition for prevention and treatment of inflammatory or immune diseases comprises 5-[4'-(piperidinomethyl)phenyl]-2,3-dihydroimidazo [2,1-a] isoquinoline or its pharmaceutically acceptable salt, and inhibits the expression of any one proinflammatory cytokine selected from the group consisting of IL-1(interleukin) beta, IL-6 and TNF-alpha(tumor necrosis factor-alpha).

Abstract translation: 提供包含5- [4' - （哌啶子基甲基）苯基] -2,3-二氢咪唑并[2,1-a]异喹啉的组合物，以抑制炎症和调节巨噬细胞中的免疫应答，从而预防和治疗炎症或免疫疾病。 用于预防和治疗炎症或免疫疾病的组合物包括5- [4' - （哌啶基甲基）苯基] -2,3-二氢咪唑并[2,1-a]异喹啉或其药学上可接受的盐，并且抑制任何一种 选自IL-1（白介素）β，IL-6和TNF-α（肿瘤坏死因子-α）的促炎细胞因子。

公开(公告)号：KR100840558B1

公开(公告)日：2008-06-23

申请号：KR1020070022768

申请日：2007-03-08

Applicant: 강원대학교산학협력단

Inventor： 조동하 ,  조재열 ,  이용규 ,  김주영 ,  변세은 ,  박형재 ,  유창연 ,  이한신 ,  김성무

IPC: A61K36/185 ,  A61P29/00 ,  A61P37/02

Abstract: An extract of Hibiscus cannabinus L., Malvaceae is provided to control the function of macrophage by inhibiting generation of TNF-alpha, mRNA expression of interleukin(IL)-3 and IL-12, and generation of nitric oxide(NO), prostaglandin(PGE2) and reactive oxygen species(PROS), thereby being useful for preventing and treating diseases by immuno-reaction. A pharmaceutical composition for preventing and treating inflammation comprises an extract of Hibiscus cannabinus L. Malvaceae as an effective ingredient, wherein the extract is prepared by extracting the Hibiscus cannabinus L. with at least one solvent selected from the group consisting of water, C1-4 alcohol, glycerol, propylene glycol, 1,3-butyleneglycol, ethylacetate, benzene, hexane, diethyl ether and dichloromethane, filtering the extract and concentrating the filtrate.

Abstract translation: 提供芙蓉大麻提取物，通过抑制TNF-α的产生，白细胞介素（IL）-3和IL-12的mRNA表达以及一氧化氮（NO），前列腺素（NO）的产生来控制巨噬细胞的功能， PGE2）和活性氧（PROS），因此可用于通过免疫反应预防和治疗疾病。 用于预防和治疗炎症的药物组合物包含芙蓉大戟科的提取物作为有效成分，其中所述提取物是通过用至少一种选自水，C 1-4的溶剂萃取木槿大麻制备的 醇，甘油，丙二醇，1,3-丁二醇，乙酸乙酯，苯，己烷，乙醚和二氯甲烷，过滤提取物并浓缩滤液。