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公开(公告)号：KR100977407B1
公开(公告)日：2010-08-24
申请号：KR1020080017089
申请日：2008-02-26
Applicant: 대한민국(농림축산식품부 농림축산검역본부장)
Abstract: 본 발명은 동물용 면역증강제, 백신보좌제 첨가물 및 보조치료제에 관한 것으로, 보다 상세하게는 동물의 주요 탐식세포인 호중구의 각종 활성을 증강시키고 병원성세균의 공격접종에 대한 비특이적인 방어능을 증진시키는 자이고사카로마이세스 바일리(
Zygosaccharomyces
bailii ) 용균추출물을 함유하는 동물용 면역증강제, 백신보좌제 첨가물, 보조치료제 및 사료첨가제에 관한 것이다.
자이고사카로마이세스 바일리(Zygosaccharomyces bailii), 용균추출물, 호중구, 유주능, 과산화물, 포도상구균, 파스튜렐라균-
公开(公告)号：KR1020090093293A
公开(公告)日：2009-09-02
申请号：KR1020080018739
申请日：2008-02-29
Applicant: 대한민국(농림축산식품부 농림축산검역본부장)
CPC classification number: A61K36/06
Abstract: A bacteriolysis extract of Saccharomyces dairenensis is provided to enhance non-specific immunity to pathogenic bacteria and activation of neutrophil and use for improving vaccine efficiency and immune enhancer. An immune enhancer, vaccine adjuvant, adjuvant treating agent or feed additive comprises the bacteriolysis extract of Saccharomyces dairenensis as an active ingredient. A method for producing the bacteriolysis extract of Saccharomyces dairenensis comprises: a step of culturing the Saccharomyces dairenensis in culture media at 26°C for 72 hours; a step of suspending the culture material in PBS buffer after centrifuging; a step of adding and treating dissolution buffer for two or three days; and a step of adjusting pH concentration to 6.5-7.2 and storing in a refrigerator.
Abstract translation: 提供了Saccharomyces dairenensis的溶菌提取物，以增强对病原菌的非特异性免疫和嗜中性粒细胞的活化，并用于提高疫苗效率和免疫增强剂。 免疫增强剂，疫苗佐剂，佐剂处理剂或饲料添加剂包括作为活性成分的Saccharomyces dairenensis的溶菌提取物。 一种酿酒酵母溶菌提取物的制备方法，包括：将培养基中的酵母在26℃下培养72小时的步骤; 离心后将培养物悬浮于PBS缓冲液中的步骤; 添加和处理溶解缓冲液两三天的步骤; 以及将pH浓度调节至6.5-7.2并储存在冰箱中的步骤。
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公开(公告)号：KR1020080114231A
公开(公告)日：2008-12-31
申请号：KR1020070063592
申请日：2007-06-27
Applicant: 대한민국(농림축산식품부 농림축산검역본부장)
IPC: A61K36/758 , A61P37/02
CPC classification number: A61K36/758 , A23V2200/324 , A61K9/0019 , A61K9/14 , A61K2236/331 , A61K2236/39 , A61K2236/51 , Y10S514/885
Abstract: A method for manufacturing an immune enhancing composition using Zanthoxylli Fructus crust Fizeau polysaccharide extracts as an active ingredient is provided to have a superior immunostimulating activity, to enhance an immunogenicity of animal and to be used as an immunoadjuvant for animal, a vaccine throne and an adjuvant treating agent. A method for manufacturing an immune enhancing composition using Zanthoxylli Fructus crust Fizeau polysaccharide extracts as an active ingredient comprises steps of: obtaining crude extracts by heating Zanthoxylli Fructus crust; concentrating the extracts; and obtaining the polysaccharide fraction by filtering the condensed products.
Abstract translation: 本发明提供使用花椒壳多糖提取物作为活性成分的免疫增强组合物的制造方法，具有优异的免疫刺激活性，增强动物的免疫原性，并用作动物免疫佐剂，疫苗王位和佐剂 处理剂。 使用花椒壳多糖提取物作为活性成分制造免疫增强组合物的方法包括以下步骤：通过加热花椒油酯来获得粗提物; 浓缩提取物; 并通过过滤冷凝产物获得多糖级分。
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公开(公告)号：KR1020080093486A
公开(公告)日：2008-10-22
申请号：KR1020070037225
申请日：2007-04-17
Applicant: 대한민국(농림축산식품부 농림축산검역본부장)
IPC: A61K36/752 , A61P37/00
CPC classification number: A61K36/752 , A23V2200/324 , A61K2236/331 , Y10S514/885
Abstract: An extract of Citrus unshiu Markovich is provided to enhance various activities of granulocyte and macrophage and induce strong defence capability on attach inoculation of pathogenic bacteria, thereby being used as an animal medicine such as an animal immuno-enhancing agent and a vaccine adjuvant and a feed additive for treating and preventing animal diseases efficiently. A method for purifying an extract of Citrus unshiu Markovich comprises the steps of: (a) extracting the Citrus unshiu Markovich with hot water at a temperature of 80-120 deg.C for 2-3 hours to obtain a crude extract; (b) concentrating the crude extract; and (c) filtering the concentrate to obtain a polysaccharide fraction by filtering paper and microorganism filtering. A composition for increasing immunity comprises the extract of Citrus unshiu Markovich as an active ingredient. The composition further comprises a pharmaceutically acceptable carrier or an excipient.
Abstract translation: 提供柑橘提取物马可夫提取物，以增强粒细胞和巨噬细胞的各种活性，并在附着接种病原菌时诱发强大的防御能力，从而被用作动物药物如动物免疫增强剂和疫苗佐剂和饲料 用于有效治疗和预防动物疾病的添加剂。 一种纯化马铃薯柑橘提取物的方法，包括以下步骤：（a）用80-120℃的热水提取马铃薯柑橘2-3小时，得到粗提物; （b）浓缩粗提物; 和（c）过滤浓缩物以通过滤纸和微生物过滤获得多糖级分。 用于增加免疫力的组合物包含作为活性成分的马铃薯柑橘提取物。 组合物还包含药学上可接受的载体或赋形剂。
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公开(公告)号：KR1020080092008A
公开(公告)日：2008-10-15
申请号：KR1020070035258
申请日：2007-04-10
Applicant: 대한민국(농림축산식품부 농림축산검역본부장)
Abstract: An extract of Lithospermum erythrorhizon is provided to enhance various activities of neutrophil or macrophages and induce strong protectivity on attack inoculation of pathogenic bacteria, thereby being utilized as an immune enhancing agent, a vaccine adjuvant, an adjuvant therapeutic agent and a feed additive for an animal. An extract of Lithospermum erythrorhizon increases the activity of immunocyte such as neutrophil or macrophages. A method for preparing the extract of Lithospermum erythrorhizon comprises the steps of: (a) boiling dried Lithospermum erythrorhizon with distilled water to obtain the extract of Lithospermum erythrorhizon; (b) filtering the extract; and (c) hydrolyzing a filtrate.
Abstract translation: 提供紫草提取物以增强嗜中性粒细胞或巨噬细胞的各种活性，并在致病细菌的侵袭接种中诱发强的保护作用，从而用作免疫增强剂，疫苗佐剂，佐剂治疗剂和动物饲料添加剂 。 紫苏提取物增加免疫细胞如嗜中性粒细胞或巨噬细胞的活性。 制备红豆杉提取物的方法包括以下步骤：（a）用蒸馏水煮沸干燥的紫草红，得到红豆杉提取物; （b）过滤提取物; 和（c）水解滤液。
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Patent Agency Ranking16.发明公开동물의 면역능을 증강시키는 벌나무가지 추출물 및 이를함유하는 면역증강제 无效用于改善动物免疫的ACER TEGMENTOSUM MAXIM RAMULUS的提取物和用于改善含有其的免疫的试剂
公开(公告)号：KR1020090021610A
公开(公告)日：2009-03-04
申请号：KR1020070086250
申请日：2007-08-27
Applicant: 대한민국(농림축산식품부 농림축산검역본부장)
Abstract: Provided is an immunity improver using acer tegmentosum maximowocz extract which improves a function of a nonspecific defense against pathogen and increases activity of animal immunocytes such as neutrophil and macrophages. An immunity improver using acer tegmentosum maximowocz extract comprises acer tegmentosum maximowocz extract as an active ingredient. A method for preparing the acer tegmentosum maximowocz extract includes a step of extracting the extract from the dried acer tegmentosum maximowocz at a temperature of 90~100°C by hot distilled-water.
Abstract translation: 本发明提供了一种免疫改良剂，其使用宏碁提取物，其改善对病原体的非特异性防御的功能，并增加动物免疫细胞如嗜中性粒细胞和巨噬细胞的活性。 使用槭树提取物的抗微生物改良剂作为活性成分。 本发明提供了一种用于制备尖角果胶提取物的方法，其特征在于，在90〜100℃的温度下，通过热蒸馏水从干燥的青蒿中提取提取物。
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公开(公告)号：KR1020090013599A
公开(公告)日：2009-02-05
申请号：KR1020070077854
申请日：2007-08-02
Applicant: 대한민국(농림축산식품부 농림축산검역본부장)
IPC: A61K39/02 , A61P37/02 , A61K39/085
CPC classification number: A61K39/05 , C12R1/47 , Y10S435/887 , Y10S514/885
Abstract: An immunostimulant containing the lystic extract of Streptomyces albus is provided to reinforce the functions of various immune cells having the major role in the disease defense, thereby increasing the specific and nonspecific resistance to the disease infection of animals. The immunostimulant contains the lystic extract of Streptomyces albus which is prepared by cultivating Streptomyces albus in yeast malt extract agar broth at 26 deg. C for 72 hours, centrifuging the cultured fluid at 3000Xg for 30 minutes and collecting it, rinsing the collected pellet with phosphate buffered saline(PBS) of pH 7.2 and suspending the rinsed pellet in PBS, adding 5% of TNT solution containing 50mM of Tris-HCl, 0.15M of NaCl and 4% Triton x-114 as solubilizing agent into the Streptomyces albus suspension, stirring the mixture at room temperature for 2-3 days to solubilize the Streptomyces albus, and regulating pH of the solution to 6.5-7.2, and drying the solution in the thermostatic chamber.
Abstract translation: 提供含有链霉菌（Streptomyces albus）的提取物的免疫刺激剂，以增强在疾病防御中具有主要作用的各种免疫细胞的功能，从而增加对动物疾病感染的特异性和非特异性抗性。 免疫刺激剂含有通过在26度的酵母麦芽提取物琼脂培养基中培养链霉菌（Streptomyces albus）而制备的链霉菌链霉菌的提取物。 培养72小时，将培养液以3000Xg离心30分钟并收集，用pH7.2的磷酸盐缓冲盐水（PBS）冲洗收集的沉淀物，并将漂洗的沉淀悬浮于PBS中，加入5％含有50mM Tris -HCl，0.15M NaCl和4％Triton x-114作为增溶剂加入到Streptomyces albus悬浮液中，在室温下搅拌混合物2-3天以溶解链霉菌，并将溶液的pH调节至6.5-7.2 ，并干燥恒温室中的溶液。
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公开(公告)号：KR1020080092007A
公开(公告)日：2008-10-15
申请号：KR1020070035257
申请日：2007-04-10
Applicant: 대한민국(농림축산식품부 농림축산검역본부장)
IPC: A61K36/804 , A61P17/00
CPC classification number: Y02A50/471
Abstract: An extract of Rehmannia glutinosa is provided to increase various activities of neutrophil or macrophages and induce strong protectivity on attack inoculation of pathogenic bacteria, thereby being used as an immune enhancing agent, a vaccine adjuvant, an adjuvant therapeutic agent and a feed additive for an animal. An extract of Rehmannia glutinosa enhances immunity of an animal by increasing the activity of immunocyte such as neutrophil or macrophages. A method for preparing the extract of Rehmannia glutinosa comprises the steps of: (a) boiling dried Rehmannia glutinosa with distilled water to obtain the extract of Rehmannia glutinosa; (b) filtering the extract; and (c) hydrolyzing a filtrate.
Abstract translation: 提供地黄提取物以增加嗜中性粒细胞或巨噬细胞的各种活性，并在致病细菌的侵袭接种中诱发强的保护作用，从而用作免疫增强剂，疫苗佐剂，佐剂治疗剂和用于动物的饲料添加剂 。 地黄提取物通过增加免疫细胞如嗜中性粒细胞或巨噬细胞的活性来增强动物的免疫力。 一种制备地黄提取物的方法，包括以下步骤：（a）用蒸馏水煮沸干燥的地黄，得到地黄提取物; （b）过滤提取物; 和（c）水解滤液。
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公开(公告)号：KR100850365B1
公开(公告)日：2008-08-05
申请号：KR1020070015656
申请日：2007-02-15
Applicant: 대한민국(농림축산식품부 농림축산검역본부장)
CPC classification number: A61K36/54 , A61K2236/331 , Y10S514/885
Abstract: A method for extracting Cinnamoni ramulus is provided to improve extraction yield of useful ingredients from Cinnamoni ramulus, so that the extract of Cinnamoni ramulus enhances immunity of animals, efficacy of vaccine and therapeutic effects of drugs. A method for extracting Cinnamoni ramulus comprises the steps of: mixing dried Cinnamoni ramulus with distilled water in a weight ratio of 1:4; heating the mixture to concentrate the solution; filtering the concentrated extract of Cinnamoni ramulus with filter paper; and filtering the firstly filtered solution with 0.45mum filter paper.
Abstract translation: 提供肉桂提取物提取方法，以提高肉桂樟脑中有用成分的提取率，从而提高肉桂的提取物，增强动物的免疫力，疫苗的疗效和药物的治疗效果。 一种提取肉桂樟脑的方法，包括以下步骤：将干果肉与蒸馏水混合，重量比为1：4; 加热混合物浓缩溶液; 用滤纸过滤浓缩的肉桂提取物; 并用0.45mum滤纸过滤第一次过滤的溶液。
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公开(公告)号：KR100834007B1
公开(公告)日：2008-06-02
申请号：KR1020060098780
申请日：2006-10-11
Applicant: 대한민국(농림축산식품부 농림축산검역본부장)
CPC classification number: Y02A50/473
Abstract: 본 발명은 세균 또는 이스트로부터 얻어진 세포벽 용균 조성물 및 이를 제조하는 방법에 관한 것으로, 더욱 상세하게는 그람음성균, 그람양성균 및 이스트를 생화학적 및 화학적으로 처리하여 얻어진 세균 또는 이스트의 세포벽 성분을 포함하며, 백신항원, 이종항원운반체, 면역증강제, 백신보좌제 및 복합사료 첨가제로서 사용될 수 있는 세균 및 이스트의 세포벽 용균 조성물 및 이를 제조하는 방법에 관한 것이다.
본 발명에 따르면, 미생물 특이항원 및 면역증강물질이 풍부한 세균 및 이스트의 세포벽을 TNT (Tris-NaCl-Triton X-114)법, DMSO법 등과 같은 다양한 생화학적 및 화학적 방법으로 처리하여 다양한 형태의 투명세포외막, 세포벽 및 용균물질을 얻을 수 있으며, 본 발명의 방법으로 얻어진 투명세포외막은 백신항원 및 이종항원 운반체(delivery system)로 유용하게 사용될 수 있고, 상기 세포벽은 면역증강제 및 백신보좌제로서 유용하게 사용될 수 있으며, 또한 상기 용균물질은 복합사료 첨가제로서 유용하게 사용될 수 있다.
그람음성균, 그람양성균, 이스트, 투명세포외막, 세포벽, 용균물질
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