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公开(公告)号：KR1020110009638A
公开(公告)日：2011-01-28
申请号：KR1020100070745
申请日：2010-07-22
Applicant: 대한민국(농림축산식품부 농림축산검역본부장)
CPC classification number: A23K10/18 , A23K20/195 , C12N1/20 , C12R1/225
Abstract: PURPOSE: A feed additive composition including novel lactobacillus species lactobacillus mixed bacterial strain is provided to offer the excellent antibacterial activity and starch resolution function for various pathogenic bacteria. CONSTITUTION: A feed additive composition contains a lactobacillus mixed bacterial strain formed with lactobacillus johnsonii G22-2, lactobacillus reuteri G8-5, and lactobacillus salivarius G1-1. The lactobacillus mixed bacterial strain has the antimicrobial activity against pathogenic bacteria, the starch degradation capability, the acid resistance, the bile tolerance, and the intestine adhesion capability.
Abstract translation: 目的：提供包含新型乳酸杆菌种乳杆菌混合菌株的饲料添加剂组合物，为各种病原菌提供优异的抗菌活性和淀粉分解功能。 构成：饲料添加剂组合物含有由约翰逊乳杆菌G22-2，乳酸杆菌G8-5和唾液乳杆菌G1-1形成的乳杆菌混合菌株。 乳杆菌混合菌株对病原菌具有抗菌活性，淀粉降解能力，耐酸性，胆汁耐受性和肠粘连能力。
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公开(公告)号：KR1020110009516A
公开(公告)日：2011-01-28
申请号：KR1020090066955
申请日：2009-07-22
Applicant: 대한민국(농림축산식품부 농림축산검역본부장)
Abstract: PURPOSE: A feed additive composition containing Lactobacillus salivarius G1-1 is provided to ensure antibacterial activity to various pathogenic bacteria and to be used as a probiotic composition. CONSTITUTION: A Lactobacillus salivarius G1-1 is deposited in KACC91449P. The Lactobacillus salivarius G1-1 has 16s rDNA of sequence number 1 and is isolated from porcine small intestine by pure culture. A feed additive composition contains the Lactobacillus salivarius G1-1 as an active ingredient. The feed additive suppresses in vivo proliferation of pathogenic bacteria.
Abstract translation: 目的：提供含有唾液乳杆菌G1-1的饲料添加剂组合物，以确保对各种病原菌的抗菌活性，并用作益生菌组合物。 构成：唾液乳杆菌G1-1保藏在KACC91449P中。 唾液乳杆菌G1-1具有序列1的16s rDNA，通过纯培养从猪小肠中分离。 饲料添加剂组合物含有唾液乳杆菌G1-1作为活性成分。 饲料添加剂抑制致病菌的体内增殖。
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公开(公告)号：KR100951055B1
公开(公告)日：2010-04-06
申请号：KR1020070093644
申请日：2007-09-14
Applicant: 대한민국(농림축산식품부 농림축산검역본부장)
IPC: A61K36/344 , A61P37/02
Abstract: 본 발명은 동물의 면역능을 증강시키는 더덕 추출물 및 그 제조방법과 용도에 관한 것이다. 보다 상세하게는 더덕줄기 및 잎을 음지에서 건조시켜 마쇄하여 열탕용 봉지에 넣고 증류수 중에 가열하여 1차 추출한 후, 추출물은 별도로 분리하고 잔류물에 재차 증류수를 넣고 열탕하여 2차 추출하여 추출물을 얻는 단계와, 1차 및 2차 추출물을 혼합하여 추출물에 2배량의 에탄올을 가하여 4∼6℃ 냉장실에서 24시간 정치시켜 침전된 다당체를 원심분리하는 단계와, 분리된 다당체를 순수 에탄올로 원심 세척한 후 35∼38℃ 항온실에서 건조하여 증류수로 1mg/ml 농도로 용해시켜 세균여과지로 여과하여 원액을 얻는 단계로 구성된다.
본 발명의 더덕추출물은 동물의 주요 면역세포인 호중구의 각종 활성과 싸이토카인 생성을 증강시키고 병원성세균의 공격접종에 대한 비특이적인 방어능을 증진시키는 효과가 있으므로 동물용 의약품으로써 면역증강제. 백신보좌제 첨가물 그리고 보조치료제 등으로 광범위하게 활용될 수 있을 것이다.-
公开(公告)号：KR100918098B1
公开(公告)日：2009-09-24
申请号：KR1020070077854
申请日：2007-08-02
Applicant: 대한민국(농림축산식품부 농림축산검역본부장)
IPC: A61K39/02 , A61P37/02 , A61K39/085
Abstract: 본 발명은 스트렙토마이세스 알부스 용균 추출물을 포함하는 백신 보좌제에 관한 것으로, 보다 자세히는 스트렙토마이세스 알부스(Streptomyces albus) 용균 추출물을 이용하여 동물의 면역 능력을 향상시키는 백신 보좌제에 관한 것으로, 동물의 주요 면역세포인 호중구 및 림프구 등의 활성을 증가시켜 병원성 세균의 공격에 대하여 면역 기능을 증진시키는 스트렙토마이세스 알부스(Streptomyces Albus) 용균 추출물을 포함하는 백신 보좌제를 제공하는 것을 목적으로 한다.
본 발명은 이와 같은 스트렙토마이세스 알부스로부터 추출한 용균 추출물을 이용하여 질병 방어에 주요한 역할을 담당하고 있는 각종 면역세포들의 기능을 증강시켜 질병 감염에 대한 특이 및 비특이적 저항성을 높여서, 질병으로부터 동물을 보호할 수 있는 효과를 제공한다.
스트렙토마이세스 알부스, 용균 추출물, 면역-
公开(公告)号：KR1020080106789A
公开(公告)日：2008-12-09
申请号：KR1020070054645
申请日：2007-06-04
Applicant: 대한민국(농림축산식품부 농림축산검역본부장)
IPC: A61K36/236 , A61P37/02
Abstract: A Glycyrrhiza hot water extract, a method for preparing the extract, and an immune enhance containing the extract are provided to improve the immune increasing activity of animals. A Glycyrrhiza hot water extract is prepared by adding 1,000 mL of distilled water per 100 g of the dried Glycyrrhiza to soak Glycyrrhiza for 20-30 min and boiling it down for 150 min to obtain an extract; adding 800 mL of distilled water per 100 g of the dried Glycyrrhiza to the Glycyrrhiza remaining after the extraction and boiling it down for 150 min to obtain an extract; adding 700 mL of distilled water per 100 g of the dried Glycyrrhiza to the Glycyrrhiza remaining after the extraction and boiling it down for 150 min to obtain an extract; collecting the obtained extract and concentrating it; and dry-freezing the concentrated one.
Abstract translation: 提供甘草热水提取物，制备提取物的方法和含有提取物的免疫增强物，以提高动物的免疫增加活性。 通过向100g甘草中加入1000mL蒸馏水，将Glycyrrhiza浸泡20-30分钟，煮沸150分钟，得到甘草热水提取物，得到提取物; 向100g甘草中加入800毫升蒸馏水，然后将其蒸馏除去150分钟，得到提取物; 向100g甘草中加入700毫升蒸馏水至提取后剩余的甘草，煮沸150分钟，得到提取物; 收集所得提取物并浓缩; 并干燥浓缩浓缩的。
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Patent Agency Ranking
公开(公告)号：KR100741359B1
公开(公告)日：2007-07-27
申请号：KR1020070027479
申请日：2007-03-21
Applicant: 대한민국(농림축산식품부 농림축산검역본부장)
IPC: A61K39/44 , A61K39/395 , A61P37/02
Abstract: A preparation method of an inactivated vaccine of swine erysipelas containing an antigen treated with an inactivated swine complement against the antigen is provided to increase immunogenicity of the vaccine while safety of the vaccine is secured. The inactivated vaccine of swine erysipelas treated with an inactivated swine complement against antigen is prepared by adding the inactivated swine complement against antigen into the swine erysipelas antigen in a weight ratio of 1:10, and reacting the mixture at 37 deg.C for 1 hour, or by adding gel containing an immunostimulating agent as an adjuvant into the swine Erysipelas antigen in a weight ratio of 1:10.
Abstract translation: 提供了一种含有用灭活的抗猪补体抗原处理的抗原的猪丹毒灭活疫苗的制备方法，以提高疫苗的免疫原性，同时确保疫苗的安全性。 用灭活的抗猪补体处理灭活的猪丹毒的灭活疫苗通过将重量比为1:10的灭活的抗猪抗原猪补体抗原加入到猪丹毒抗原中，并将混合物在37℃下反应1小时 或者将含有免疫刺激剂的凝胶作为佐剂以1:10的重量比加入到猪丹毒抗原中。
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公开(公告)号：KR1020050108110A
公开(公告)日：2005-11-16
申请号：KR1020040033171
申请日：2004-05-11
Applicant: 대한민국(농림축산식품부 농림축산검역본부장)
IPC: C12N1/20
Abstract: 본 발명은 바실러스 에스피 87 (KACC 91098) 및 이의 용도에 관한 것으로서, 상기 균주는 내산성, 내담즙성 및 생체 안전성이 인정되고, 병원성 세균 억제활성을 가지며, 장내에서 독립된 균총(Niche)으로서 미생물의 길항 작용을 통한 병원성 균총의 증식을 감소시켜 질병을 예방하는 효과가 있다.
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公开(公告)号：KR1020090117448A
公开(公告)日：2009-11-12
申请号：KR1020080043496
申请日：2008-05-09
Applicant: 대한민국(농림축산식품부 농림축산검역본부장)
CPC classification number: A23K10/30 , A23K20/195
Abstract: PURPOSE: An antioxidant for supplementing feed using Forsythiae fructus extract and a preparation method for the Forsythiae Fructus extract are provided to show improved daily gain, feed intake, and feed efficiency compared to a control group. CONSTITUTION: An antioxidant for supplementing feed contains Forsythiae fructus extract. A method for preparing Forsythiae fructus extract comprises the following steps of: washing 100g Forsythiae fructus with water to remove dust; placing the washed Forsythiae fructus in a white bag; adding 1,000ml distilled water into the white bag to soak for 20-30 minutes; boiling down the soaked Forsythiae fructus for 150 minutes and obtaining an extract; adding another 800ml distilled water and boiling down for 150 minutes to obtain the extract; adding another 700ml distilled water and boiling down for 150 minutes to obtain the extract; collecting the extracts and concentrating until the volume becomes 100ml; and freeze-drying the concentrate.
Abstract translation: 目的：提供使用连翘果提取物补充饲料的抗氧化剂和连翘果提取物的制备方法，以显示与对照组相比改善的日增重，进食量和饲料效率。 构成：补充饲料的抗氧化剂含有连翘果提取物。 连翘果提取物的制备方法为：用水洗涤连翘100份，除去灰尘; 将洗涤的连翘属植物置于白色袋中; 在白色袋中加入1000ml蒸馏水浸泡20-30分钟; 煮熟连翘150分钟，得到提取物; 加入800ml蒸馏水，煮沸150分钟，得到提取物; 再加入700ml蒸馏水，煮沸150分钟，得到提取物; 收集提取物并浓缩直到体积变成100ml; 并冷冻干燥浓缩物。
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公开(公告)号：KR1020090093292A
公开(公告)日：2009-09-02
申请号：KR1020080018738
申请日：2008-02-29
Applicant: 대한민국(농림축산식품부 농림축산검역본부장)
CPC classification number: A61K36/06
Abstract: A bacteriolysis extract of Saccharomyces chevalieri is provided to increase the activation of neutrophil and enhance non-specific defense activity against the pathogenic bacteria. An immune enhancer, vaccine adjuvant, adjuvant treating agent or feed additive comprises bacteriolysis extract of Saccharomyces chevalieri as an active ingredient. A method for manufacturing a bacteriolysis extract of Saccharomyces chevalieri comprises: a step of culturing Saccharomyces chevalieri in media at 26°C for 72 hours; a step of centrifuging media and suspending in PBS; a step of adding dissolution agent and treating at room temperature for 2-3 days; a step of confirming the dissolution status with a microscope; a step of adjusting pH concentration to 6.5-7.2; and a step of drying and maintaining in a refrigerator.
Abstract translation: 提供雪花酵母的溶菌提取物以增加嗜中性粒细胞的活化并增强针对致病菌的非特异性防御活性。 免疫增强剂，疫苗佐剂，佐剂处理剂或饲料添加剂包括作为活性成分的雪花酵母的溶菌提取物。 酿酒酵母的溶菌提取物的制备方法包括：在培养基中在26℃下培养雪花酵母（Saccharomyces chevalieri）72小时的步骤; 离心培养基并悬浮于PBS中的步骤; 加入溶解剂并在室温下处理2-3天的步骤; 用显微镜确认溶出状态的步骤; 将pH浓度调节至6.5-7.2的步骤; 以及在冰箱中干燥和保持的步骤。
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公开(公告)号：KR1020090091884A
公开(公告)日：2009-08-31
申请号：KR1020080017089
申请日：2008-02-26
Applicant: 대한민국(농림축산식품부 농림축산검역본부장)
CPC classification number: A61K36/06
Abstract: An immune enhancer and vaccine adjuvant additive for animal, which contains Zygosaccharomyces bailii lysates and an auxiliary therapeutic agent are provided to enhance the activation of neutrophil and non-specific protection effect to attack inoculation. An immune enhancer, vaccine adjuvant additive, auxiliary therapeutic agent and feed additive comprises a Zygosaccharomyces bailii lysates. A method for manufacturing the Zygosaccharomyces bailii lysate comprises: a step of culturing the Zygosaccharomyces bailii in the media at 26‹C for 72 hours; a step of centrifuging the cultured media and suspending in phosphate buffered saline (PBS); a step of adding dissolution agent and stirring at room temperature for two to three days; a step of adjusting pH concentration to 6.5-7.2; and a step of drying and maintaining in a thermostatic chamber.
Abstract translation: 提供含有接合酵母发酵酵母裂解物和辅助治疗剂的动物免疫增强剂和疫苗佐剂添加剂，以增强中性粒细胞的活化和非特异性保护作用来攻击接种。 免疫增强剂，疫苗佐剂添加剂，辅助治疗剂和饲料添加剂包括接合酵母（Zygosaccharomyces bailii lysates）。 一种制造接合酵母发酵酵母裂解物的方法，包括：在培养基中培养接合酵母属酵母在26℃72小时的步骤; 将培养基离心并悬浮于磷酸盐缓冲盐水（PBS）中的步骤; 在室温下加入溶解剂并搅拌2〜3天的步骤; 将pH浓度调节至6.5-7.2的步骤; 以及在恒温室中干燥和保持的步骤。
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