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11.发明公开누에 수번데기로부터 아데노신 유도체 화합물을 정제하는방법 및 아데노신 유도체 화합물을 포함하는 발기부전치료용 조성물 有权用于净化从丝光衍生的腺苷衍生物的方法和用于治疗包含腺苷衍生物的血管生成素的组合物
公开(公告)号：KR1020070037041A
公开(公告)日：2007-04-04
申请号：KR1020050092244
申请日：2005-09-30
Applicant: 대한민국(농촌진흥청장)
IPC: A61K31/7076 , A61P15/10
CPC classification number: A61K31/7076 , A61K35/64 , A61K2121/00
Abstract: 본 발명은 누에 수번데기로부터 아데노신 유도체 화합물을 추출, 정제하는 방법 및 추출된 아데노신 유도체 화합물을 포함하는 발기부전 치료용 조성물에 관한 것이다. 구체적으로, 본 발명은 누에 수번데기를 유기용매로 분획하여 농축추출한 후 다시 음이온교환 젤여과 크로마토그래피, 선택적으로 탈염과정 및 선택적으로 역상 HPLC를 수행함으로써 누에 수번데기로부터 아데노신 유도체 화합물을 추출정제하는 방법 및 이를 포함하는 발기부전 치료용 조성물에 관한 것이다.
누에 수번데기, 아데노신 유도체 화합물, 발기부전-
公开(公告)号：KR1020040029899A
公开(公告)日：2004-04-08
申请号：KR1020020060347
申请日：2002-10-02
Applicant: 대한민국(농촌진흥청장)
IPC: A61K35/64
CPC classification number: A61K35/63
Abstract: PURPOSE: Provided is a composition containing a bee larva or its extract, which has anticancer effect and thrombolytic effect, and is used in preventing and treating various kinds of cancers, and thrombus-related diseases, such as coronary thrombosis and cerebrovascular diseases. CONSTITUTION: A composition contains a bee larva, or an extract thereof. The extract comprises a water soluble, alcoholic or organic solvent extract. The composition is used in preventing and treating breast cancer, bladder cancer, skin cancer, stomach cancer, liver cancer, leukemia, and lymphoma.
Abstract translation: 目的：提供含有蜜蜂幼虫或其提取物的组合物，其具有抗癌作用和溶栓作用，用于预防和治疗各种癌症，血栓相关疾病如冠状动脉血栓形成和脑血管疾病。 构成：组合物含有蜜蜂幼虫或其提取物。 提取物包含水溶性，醇或有机溶剂提取物。 该组合物用于预防和治疗乳腺癌，膀胱癌，皮肤癌，胃癌，肝癌，白血病和淋巴瘤。
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公开(公告)号：KR1020030010247A
公开(公告)日：2003-02-05
申请号：KR1020010045133
申请日：2001-07-26
Applicant: 대한민국(농촌진흥청장)
Abstract: PURPOSE: A composition containing new serine protease having thrombolysis obtained by extraction and purification of Scarabaeidae as an insect is provided which is excellent in fibrinolytic activity and can be used as a therapeutic agent for treatment of diseases related with thrombus. CONSTITUTION: Scarabaeidae as an insect is soaked in a mixed solution of tris-hydrochloric buffer solutions and sodium chloride solutions, centrifuged and purified after extraction to produce serine protease. The serine protease has an amino acid sequence represented by an amino acid sequence represented by SEQ ID NO:1 or 2 in Sequence Listing at the amino terminus, a molecular weight of 27,000 daltons and optimum activity in the range of 10 to 15deg.C and pH 5.0 to 10.0.
Abstract translation: 目的：提供含有通过提取和纯化作为昆虫的赤藓科的溶血解决剂的新的丝氨酸蛋白酶的组合物，其具有优异的纤维蛋白溶解活性，可用作治疗与血栓相关的疾病的治疗剂。 构成：作为昆虫的沙棘科浸泡在三盐酸缓冲液和氯化钠溶液的混合溶液中，经提取后离心分离纯化，生成丝氨酸蛋白酶。 丝氨酸蛋白酶具有由氨基末端的序列表中的SEQ ID NO：1或2表示的氨基酸序列表示的氨基酸序列，分子量为27,000道尔顿，最佳活性为10〜15℃， pH 5.0至10.0。
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公开(公告)号：KR100324617B1
公开(公告)日：2002-02-27
申请号：KR1019990032108
申请日：1999-08-05
Applicant: 대한민국(농촌진흥청장) , 홍영식품 주식회사
IPC: A23G9/04
CPC classification number: A23G9/42
Abstract: 본발명은뽕잎을주재로한 아이스크림류의제조방법에관한것이다. 좀더 구체적으로는, 0.05~0.5%의탄산수소나트륨수용액에서약 5초동안데쳐서건조한후, 100~300메쉬로분쇄한미세뽕잎분말과, 질소가스로혐기처리한후, 100~300메쉬로분쇄한미세뽕잎분말을탈지분유, 생크림, 설탕, 물엿, 야자경화유, 과당, 유화안정제등과혼합하는공정을포함하는아이스크림류의제조방법에관한것이다. 본발명의뽕잎을주재로한 아이스크림의조성물로제품화한아이스크림류는맛, 색, 조직감등에있어서고기호성을선호하는현대인들에게적합할뿐만아니라저칼로리다이어트식및 당뇨, 혈압, 혈관등 성인병예방에좋아아이스크림소비층을좀 더폭넓게함은물론주 소비대상인여성과어린이의건강에기여할수 있다.
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公开(公告)号：KR1020140082081A
公开(公告)日：2014-07-02
申请号：KR1020120151374
申请日：2012-12-21
Applicant: 대한민국(농촌진흥청장) , 주식회사 글로벌헬스케어
Inventor： 류강선 , 이희삼 , 강필돈 , 김기영 , 김미자 , 권중무 , 천성남 , 김범수 , 조익성 , 이상환 , 이진영 , 임순희 , 최종길 , 김태완 , 박선국 , 김민선 , 임서정
Abstract: The present invention relates to a pharmaceutical composition including a silkworm extract as an active ingredient for regulating blood glucose, a natural medial product, and a health functional food. The pharmaceutical composition of the present invention includes an active ingredient including an extract extracted from silkworms at day 3 of the fifth stadium, wherein the extract is extracted using ethanol as a solvent. The pharmaceutical composition, the natural medical product including the same for regulating blood glucose, and the health functional food of the present invention have accurate preparation method and capacity to secure a high blood glucose regulatory function so that remedial effects which can be induced therefrom are more excellent than from existing silkworm powder. Moreover, the pharmaceutical composition is not limited to existing silkworm farming products but is able to be developed to a high value product so that incomes in silkworm farms can be increased.
Abstract translation: 本发明涉及包含蚕提取物作为调节血糖的活性成分的药物组合物，天然中间产品和保健功能食品。 本发明的药物组合物包括在第五体育场的第3天从蚕提取的提取物的活性成分，其中使用乙醇作为溶剂提取提取物。 本发明的药物组合物，包含其用于调节血糖的天然医药产品和健康功能食品具有准确的制备方法和确保高血糖调节功能的能力，从而可以诱导其补救效果更多 优于现有蚕粉。 此外，药物组合物不限于现有的蚕农产品，而是能够开发成高价值产品，从而可以增加蚕农的收入。
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Patent Agency Ranking
公开(公告)号：KR1020140062564A
公开(公告)日：2014-05-26
申请号：KR1020120127680
申请日：2012-11-12
Applicant: 대한민국(농촌진흥청장)
CPC classification number: A61K8/987 , A61K8/02 , A61K2800/80 , A61Q19/02
Abstract: The present invention relates to a cosmetic composition including hemolymph derived from silkworms. The cosmetic composition of the present invention comprises hemolymph derived from silkworms, and more specifically, comprises hemolymph from silkworms obtained by putting a crude extract containing silkworm tissues remained after removing silk glands from the silkworms, treating with heat, and refining a supernatant solution obtained by continuous centrifugation. According to the present invention, the cosmetic composition comprising hemolymph derived from silkworms which is harmless to human body and has excellent anti-oxidant activity, anti-microbial activity, whitening effects, etc. is provided.
Abstract translation: 本发明涉及包含从蚕衍生的血淋巴的化妆品组合物。 本发明的化妆品组合物包括来自蚕的血淋巴，更具体地，包括通过将从蚕中除去丝腺后残留的蚕组织的粗提取物，通过加热处理而得到的来自蚕的血淋巴，并且精制上清液 连续离心。 根据本发明，提供了包含对人体无害的具有优异的抗氧化活性，抗微生物活性，美白效果等的来源于蚕的血淋巴的化妆品组合物。
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公开(公告)号：KR101340502B1
公开(公告)日：2013-12-11
申请号：KR1020110144102
申请日：2011-12-28
Applicant: 대한민국(농촌진흥청장) , 오마샤리프화장품 주식회사
Abstract: 본 발명은 누에생실샘 미세분말을 포함하는 트윈 케이크 및 팩트용 화장품에 관한 것이다.
본 발명의 트윈 케이크 및 팩트용 화장품은, 트윈 케이크 및 팩트용 화장품의 전체중량 대비 3~10중량%의 누에생실샘 미세분말을 포함하고, 나머지를 마이카, 실리카, 티타늄디옥사이드, 징크옥사이드, 워터홀딩파우더, 색소, 결합체, 자외선흡수제, 방부제, 향료, 탤크를 포함하는 것이 특징이다.
본 발명에 의해, 유해한 용매를 사용하지 않아 피부 세포에 독성이 없으면서 화학적 반응에 의해 갈변하는 위험성도 없는 누에 생실샘의 미세분말을 포함하여 기초화장 후 고르게 펴 바를수 있고, 동시에 우수한 피부 보습력 및 탄력성을 갖는 트윈 케이크 및 팩트용 화장품이 제공된다.-
公开(公告)号：KR1020130075841A
公开(公告)日：2013-07-08
申请号：KR1020110144102
申请日：2011-12-28
Applicant: 대한민국(농촌진흥청장) , 오마샤리프화장품 주식회사
Abstract: PURPOSE: Fine powder of the raw silk SAM in the fistula in which there is no risk which the cosmetics for twincake and fact with the chemical reaction with browning while there is no toxicity in the skin cell including the silk-worm raw silk SAM fine powder. CONSTITUTION: A cosmetics for the twincake and fact comprises: silk-worm raw silk SAM fine powder of the total weight comparison 3-10 weight% of the cosmetics for twincake and fact; the rest the mica, silica, titanium dioxide, zinc oxide, water hole powder, pigment, combination, ultraviolet-absorbing agent, preservative, perfume, talc is included. The silk-worm raw silk SAM fine powder and silica are comprised 1:1-1:5 weight ratio. The silk-worm raw silk SAM fine powder originates in 5 nought 7 mature larva.
Abstract translation: 目的：瘘管中无丝绸SAM的细粉，其中不含化妆品的化妆品与化妆品褐变同时在皮肤细胞中无毒性，包括蚕丝生丝SAM细粉 。 构成：一种化妆品为双胞胎和事实包括：蚕丝原丝SAM细粉总重量比重为3-10重量％的化妆品为twincake和事实; 其余包括云母，二氧化硅，二氧化钛，氧化锌，水孔粉末，颜料，组合，紫外线吸收剂，防腐剂，香料，滑石粉。 蚕丝原丝SAM细粉和二氧化硅的重量比为1：1-1：5。 丝虫原丝SAM细粉起源于5只成熟的幼虫。
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公开(公告)号：KR1020130033826A
公开(公告)日：2013-04-04
申请号：KR1020110097751
申请日：2011-09-27
Applicant: 대한민국(농촌진흥청장)
IPC: A61K31/047 , A61K38/01 , A61C5/00 , A61P1/02
Abstract: PURPOSE: An antibacterial dental membrane is provided to ensure alkaline phosphatase activity in osteoblast, and to improve bond generation in a lesion. CONSTITUTION: A dental membrane contains 0.01-10 wt% of 4-hexylresorcinol, and 90-99.99 wt% of silk proteins. The silk protein is silk fibroin. A method for manufacturing the dental membrane comprises: a step of dissolving the silk fibroin in an ethanol solution containing a salt, and removing the salt and ethanol to prepare a silk fibroin solution; a step of dissolving 4-hexylresorcinol in ethanol and preparing 4-hexylresorcinol ethanol solution; a step of mixing the silk fibroin solution and the 4-hexylresorcinol ethanol solution, and comprising a dental membrane composition; and a step of pouring the dental membrane composition into a container and drying. [Reference numerals] (AA) Control group without applying a membrane; (BB) Experimental group with applying the membrane of the present invention composed of 3% hexylresorcinol and remaining amount of silk fibroin(an arrow indicates a remaining dental membrane);
Abstract translation: 目的：提供抗菌牙膜，以确保成骨细胞中的碱性磷酸酶活性，并改善病变中的结合产生。 构成：牙膜含有0.01-10重量％的4-己基间苯二酚和90-99.99重量％的丝蛋白。 丝蛋白是丝素蛋白。 一种牙科膜的制造方法，其特征在于，包括将丝素蛋白溶解在含有盐的乙醇溶液中，除去盐和乙醇以制备丝素蛋白溶液的步骤; 将4-己基间苯二酚溶解在乙醇中并制备4-己基间苯二酚乙醇溶液的步骤; 将丝素蛋白溶液与4-己基间苯二酚乙醇溶液混合并包含牙膜组合物的步骤; 以及将牙膜组合物倒入容器中并干燥的步骤。 （标号）（AA）不涂膜的对照组; （BB）使用由3％己基间苯二酚构成的本发明的膜和剩余量的丝素蛋白（箭头表示剩余的牙膜）的实验组。
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公开(公告)号：KR1020130031194A
公开(公告)日：2013-03-28
申请号：KR1020120068600
申请日：2012-06-26
Applicant: 대한민국(농촌진흥청장) , 차의과학대학교 산학협력단
IPC: C07K14/435 , C07K1/12
Abstract: PURPOSE: A method for preparing a silkworm grand-derived hydrolysate is provided to obtain a hydrolysate with excellent cell proliferation effect without a harmful solvent. CONSTITUTION: A method for preparing a silkworm grand-derived hydrolysate comprises: a step of preparing a silkworm; a step of freeze-drying the silkworm and isolating a silk gland; a step of dissolving the silk gland with water and preparing a first lysate; a step of centrifuging the first lysate and collecting supernatant; a step of adding alkali to the supernatant and performing hydrolysate to prepare a second lysate; a step of adding acid to the second lysate and neutralizing to prepare a neutralized solution; a step of desalting the neutralized solution and preparing a hydrolysate; and a step of freeze-drying the hydrolysate. [Reference numerals] (AA) Silkworm; (BB) Freeze-drying and isolating; (CC) Silk gland; (DD) Pulverizing; (EE) Powder; (FF) Dissolving in water; (GG) Centrifuging and isolating supernatant; (HH) Adding alkali; (II) Hydrolyzing; (JJ) Neutralizing; (KK) Desalting; (LL) Freeze-drying; (MM) Hydrolysate
Abstract translation: 目的：提供一种制备蚕大分子水解物的方法，以获得没有有害溶剂的具有优异细胞增殖作用的水解产物。 构成：一种蚕源水解产物的制备方法，包括：制备蚕的步骤; 冷冻干燥蚕丝并分离丝腺的步骤; 将丝腺溶解在水中并制备第一裂解液的步骤; 离心第一裂解物并收集上清液的步骤; 向上清液中加入碱，并进行水解产物制备第二裂解液的步骤; 将酸添加到第二裂解物中并中和以制备中和溶液的步骤; 将中和溶液脱盐并制备水解产物的步骤; 和冷冻干燥水解物的步骤。 （附图标记）（AA）蚕; （BB）冷冻干燥和隔离; （CC）丝腺; （DD）粉碎; （EE）粉末; （FF）溶于水; （GG）离心分离上清液; （HH）加碱; （二）水解; （JJ）中和; （KK）脱盐; （LL）冷冻干燥; （MM）水解产物
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