Abstract:
PURPOSE: A final glycosylation product inhibitor or health functional food is provided to suppress development of diabetic complication. CONSTITUTION: A final glycosylation product inhibitor which suppresses the development of diabetes complication contains mulberrofuran G isolated from Morus bark, mulberrofuran K, kuwanon G, kuwanon Z, oxyresveratrol, 2',4',5,7-tetrahydroxyflavanone, morusignin L, or dihydromorin as an active ingredient. The diabetic complication includes diabetic splenocyte nephritis, diabetic retinopathy or diabetic splenocyte neuropathic disease. [Reference numerals] (1) Normal group(-20°C); (10) Morusignin-L; (11) Dihydromorin; (2) Control group(37°C); (3) Pyridoxamine(positive control group); (4) Mulberrofuran-G; (5) Mulberrofuran-K; (6) Kuwanon-G; (7) Kuwanon-Z; (8) 2'.4'.5.7-tetrahydroxyflavanone; (9) Oxyresveratrol; (AA) Anti-AGEs antibody; (BB) Anti-CML antibody; (CC) Ponseau S staining
Abstract:
본발명은쥐꼬리망초(L) 알코올또는유기용매추출물을유효성분으로포함하는호흡기질환의예방또는치료용약학적조성물, 및저스티시딘 A (Justicidin A), 저스티시딘 B (Justicidin B), 저스티시딘 C (Justicidin C) 및필라미리신 C (Phyllamyricin C) 중어느하나이상을포함하는쥐꼬리망초(L) 알코올또는유기용매추출물을포함하는호흡기질환의예방또는치료용약학적조성물, 및이들의호흡기질환예방또는개선용식품조성물에관한것이다. 본발명의쥐꼬리망초추출물을포함하는조성물은비장세포의비정상적인과증식을억제하고알레르기염증성사이토카인의분비를억제할수 있으며, 객담배출효과및 기도수축억제효과를나타내므로, 호흡기질환을효과적으로예방, 치료또는개선할수 있다.
Abstract:
본 발명은 감수 (Euphorbia kansui ) 추출물을 유효성분으로 함유하는 골다공증 예방 및 치료용 약학 조성물에 관한 것이다. 또한 본 발명은 감수 (Euphorbia kansui )에서 분리되는 화학식 1로 표시되는 화합물 칸수이닌A(kansuinine A), 화학식 2로 표시되는 화합물 γ-유포르볼(γ-euphorbol)을 유효성분으로 함유하는 골다공증 예방 및 치료용 약학 조성물에 관한 것이다.
Abstract:
본 발명은 생약재 갈근(Puerariae Radix), 백강잠(Bombycis corpus) 또는 독활(Araliae Continentalis Radix)중에서 1 이상 선택되는 생약 추출물을 함유하는 의약 및 건강기능식품에 관한 것이다. 본 발명에 따른 생약재는 독립적으로 또는 혼합조성물로 하여 신장질환 예방 및 치료 또는 신장기능 개선을 위해 유용하게 이용될 수 있다. 갈근, 백강잠, 독활, 신장질환
Abstract:
A composition for preventing and treating osteoporosis comprising terpenoids isolated from Euphorbia kansui or the extracts thereof is provided to inhibit bone absorption of osteoclasts without side effects. The composition for preventing and treating osteoporosis comprises kansuinine A represented by the formula(1) and gamma-euphorbol represented by the formula(2) or the extracts thereof. The kansuinine A represented by the formula(1) and gamma-euphorbol represented by the formula(2) are isolated by extracting and concentrating Euphorbia kansui with methanol, suspending the concentrated extract of Euphorbia kansui in water, and adding nucleic acid into the suspension to separate a nucleic acid layer, adding methylene chloride into a water layer obtained by separating the nucleic acid layer to obtain a methylene chloride fraction, and subjecting the methylene chloride fraction to chromatography.