公开(公告)号：KR1020000052504A

公开(公告)日：2000-08-25

申请号：KR1019990058632

申请日：1999-12-17

Applicant: 로레알

Inventor： 시모네쟝-띠에리 ,  쏜느빌오딜 ,  르그레실비

IPC: A61K9/107 ,  A61K9/51 ,  B82Y5/00

CPC classification number: B82Y5/00 ,  A61K8/06 ,  A61K8/37 ,  A61K2800/21 ,  A61K2800/413 ,  A61Q1/14 ,  Y10S514/844 ,  Y10S514/845 ,  Y10S514/846 ,  Y10S514/912 ,  Y10S514/937 ,  Y10S514/938

Abstract: PURPOSE: Nanoemulsion based on alkylethercitrate is provided to give the stability of storage, the maintenance of good transparency and the incorporation of bulky oil with good cosmetic property. In addition to the nanoemulsion above, their use in cosmetics, skin science, pharmacy and/or ophthalmology are provided. CONSTITUTION: A nanoemulsion is comprised of oil phase dispersed in water phase, has less than 100nm of number average size of oil small sphere, contains anionic surfactants selected from alkylethercitrate, also at least one oil having more than 400 of molecular weight, and has 2 to 10 at their ratios of oil phase for amounts of the surfactant. The nanoemulsion is characterized in that its turbidity is 60 to 600 NTUs. The amount of the surfactant is characterized by being 0.2 to 15wt%, preferably 3 to 6wt% based on total weight of nanoemulsion.

Abstract translation: 目的：提供基于烷基醚酸酯的纳米乳液，以提供储存的稳定性，维持良好的透明度和掺入具有良好化妆品性质的大体积油。 除了上述纳米乳液之外，还提供了它们在化妆品，皮肤科学，药学和/或眼科学中的应用。 构成：纳米乳液由分散在水相中的油相组成，具有小于100nm的小球体数均粒径，含有选自烷基醚的阴离子表面活性剂，还含有至少一种具有400以上分子量的油，并且具有2 以相对于表面活性剂的量的油相比为10。 纳米乳液的特征在于其浊度为60至600NTU。 表面活性剂的用量相对于纳米乳液的总重量为0.2〜15重量％，优选为3〜6重量％。

公开(公告)号：KR1020000048452A

公开(公告)日：2000-07-25

申请号：KR1019990063482

申请日：1999-12-28

Applicant: 로레알

Inventor： 시모네쟝-띠에리 ,  리샤르파스칼 ,  비아뜨리브루노

IPC: A61K9/51 ,  B82Y5/00

CPC classification number: A61K9/5146 ,  A61K8/11 ,  A61K9/5153 ,  A61K9/5161 ,  A61K2800/413 ,  A61Q19/00 ,  B01J13/04 ,  Y10S977/727 ,  Y10S977/797 ,  Y10S977/896 ,  Y10S977/915 ,  Y10S977/926

Abstract: PURPOSE: A nanocapsule comprising poly(alkylene adipate) which effectively protects an active ingredient and makes a manufacturing process of the nanocapsule easy, a method for preparing thereof and a cosmetics or a dermatological composition containing thereof are provided. CONSTITUTION: A nanocapsule comprises: (a) a lipidic core which forms or contains a lipophilic active component; and (b) a water-insoluble, continued polymer envelope, wherein the polymer envelope contains at least one linear or branched polyester of poly(alkylene adipate) including an unit derived from an adipic acid and an unit derived from more than one alkane-diol and/or more than one ether-diol and/or more than one triol. The cosmetics or dermatological composition include the nanocapsule of poly(alkylene adipate) in physiologically acceptable carrier. The nanocapsule is prepared by: (i) dissolving poly(alkylene adipate), lipidic phase which forms or contains lipophilic active component and an optional coating agent in an adequate, water-miscible organic solvent; (ii) preparing an aqueous solution of an adequate surfactant; (iii) adding the organic phase prepared from the step (i) to the aqueous phase prepared from the step (ii) with stirring at a proper speed; and (iv) evaporating all organic phases and possible, a little aqueous phase.

Abstract translation: 目的：提供一种包含聚（亚烷基己二酸酯）的纳米胶囊，其有效保护活性成分并使纳米胶囊的制造过程容易，其制备方法和含有其的化妆品或皮肤病学组合物。 构成：纳米胶囊包含：（a）形成或含有亲脂性活性成分的脂核; 和（b）水不溶性连续的聚合物外壳，其中聚合物外壳包含至少一种包含衍生自己二酸的单元的聚（亚烷基己二酸酯）的直链或支链聚酯和衍生自多于一种烷烃二醇的单元 和/或多于一种醚 - 二醇和/或多于一种三醇。 化妆品或皮肤病学组合物包括在生理上可接受的载体中的聚（亚烷基己二酸酯）的纳米胶囊。 纳米胶囊通过以下方法制备：（i）将聚（亚烷基己二酸酯），形成或含有亲脂性活性成分的脂质相和任选的涂布剂溶解在足够的与水混溶的有机溶剂中; （ii）制备足够表面活性剂的水溶液; （iii）将以步骤（i）制备的有机相以适当速度搅拌加入到由步骤（ii）制备的水相中; 和（iv）蒸发所有有机相和可能的少量水相。

公开(公告)号：KR1020000048107A

公开(公告)日：2000-07-25

申请号：KR1019990057230

申请日：1999-12-13

Applicant: 로레알

Inventor： 시모네쟝-띠에리 ,  쏜느빌오딜 ,  르그레실비

IPC: A61K9/107 ,  A61K9/50 ,  B82Y5/00

CPC classification number: A61Q19/007 ,  A61K8/06 ,  A61K8/062 ,  A61K8/60 ,  A61K8/602 ,  A61K2800/21 ,  A61K2800/413 ,  A61Q1/14 ,  A61Q5/00 ,  A61Q19/00 ,  B82Y5/00 ,  Y10S514/938

Abstract: PURPOSE: A nanoemulsion based on fatty esters of sugar or fatty ethers of sugar is provided, which has stability in preservation; maintains excellent transparency; has good cosmetic property; and contains a lot of oil. An use of the nanoemulsion in the fields of cosmetics, dermatology and/or ophtalmology is also provided. CONSTITUTION: A nanoemulsion based on fatty esters of sugar or fatty ethers of sugar comprises of: a surfactant(C8-C22 fatty esters of sucrose, maltose, glucose and fructose, esters of C14-C22 fatty acid and methylglucose, alkyl polyglucoside and mixture thereof) being solid under 45°C, selected from an esters of fatty acid and sugar, and an ether of fatty alcohol and sugar; one or more oil having over 400 of molecular weight. In the o/w nanoemulsion, weight ratio of oil phase to the surfactant is 2-10, and average size of an oil globule of the nanoemulsion is smaller than 100nm by passing through high-pressure homogenizer more than one times.

Abstract translation: 目的：提供基于糖或糖的脂肪醚的脂肪酯的纳米乳液，其具有保存的稳定性; 保持良好的透明度; 具有良好的化妆品性能; 并含有大量的油。 还提供了在化妆品，皮肤病学和/或眼科学领域中使用纳米乳剂。 构成：基于糖或糖的脂肪醚的脂肪酸的纳米乳液包括：表面活性剂（蔗糖，麦芽糖，葡萄糖和果糖的C8-C22脂肪酯，C14-C22脂肪酸和甲基葡萄糖的酯，烷基聚葡萄糖苷及其混合物 ）在45℃下为固体，选自脂肪酸和糖的酯，以及脂肪醇和糖的醚; 一种或多种具有超过400分子量的油。 在o / w纳米乳液中，油相与表面活性剂的重量比为2-10，通过高压均化器超过一次，纳米乳液的油球的平均尺寸小于100nm。

公开(公告)号：KR101799632B1

公开(公告)日：2017-11-20

申请号：KR1020147036914

申请日：2012-06-04

Applicant: 로레알

Inventor： 조우시안지 ,  부이히시 ,  시모네쟝-띠에리 ,  리춘후아

IPC: A61K8/35 ,  A61K8/55 ,  A61K8/81 ,  A61Q3/02

CPC classification number: A61K8/8164 ,  A61K8/35 ,  A61K8/55 ,  A61K8/8152 ,  A61K2800/81 ,  A61K2800/95 ,  A61Q3/02

Abstract: 본원에서는 (a) 하나이상의에틸렌계불포화중합가능한화합물및 (b) 약 350 ㎚초과의하나이상의흡수파장을갖는 1종이상의광개시제를포함한하나이상의광개시제시스템을포함하는화장품조성물을개시한다. 또한본원에서는 (1) 상기화장품조성물을케라틴성기재에적용함으로써케라틴성기재에하나이상의필름을형성하고 (2) 필름을 UV-LED 방사선에노출시키는것을포함하는케라틴성기재의외관을메이크업 및/또는개선하는방법을개시한다.

Abstract translation: 本申请公开了一种化妆品组合物，其包含（a）一种或多种烯属不饱和可聚合化合物和（b）一种或多种含有一种或多种具有大于约350㎚中的至少一种吸收波长多种光引发剂光引发剂体系。 也存在于角蛋白圣基板的1式的外观，该方法包括通过将所述化妆品组合物施用到角蛋白圣衬底并暴露（2）装载有UV-LED照射使形成于角蛋白圣基板的至少一个薄膜和 等等。

公开(公告)号：KR1020090118889A

公开(公告)日：2009-11-18

申请号：KR1020090089388

申请日：2009-09-22

Applicant: 로레알

Inventor： 꼴랭-쟝곤크리스틴 ,  시모네쟝-띠에리

IPC: C12N15/11 ,  C12N15/63 ,  A61Q19/02

CPC classification number: C12N15/1137 ,  A61K8/606 ,  A61K2800/782 ,  A61Q19/02 ,  C12N2310/14 ,  C12Y114/18001

Abstract: PURPOSE: A novel double strand RNA oligonucleotide is provided to use as whitening agent and/or anti-browning agent in cosmetics. CONSTITUTION: A method for suppressing tyrosinase expression is using double strand RNA oligonucleotide. The double strand RNA oligonucleotide contains sequence of the sequence number 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46 or 47. The zeta potential of the oligonucleotide is 10~-80 mV and the oligonucleotide is bound to cationic particle. The double strand RNA oligonucleotide is used as a whitening agent or anti-browning agent.

Abstract translation: 目的：提供一种新型双链RNA寡核苷酸，用作化妆品中的增白剂和/或抗褐变剂。 构成：抑制酪氨酸酶表达的方法是使用双链RNA寡核苷酸。 双链RNA寡核苷酸包含序列号1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20的序列 ，21，22，23，24，25，26，27，28，29，30，31，32，33，34，35，36，37，38，39，40，41，42，43，44，45 ，46或47.寡核苷酸的ζ电位为10〜-80mV，寡核苷酸与阳离子颗粒结合。 双链RNA寡核苷酸用作增白剂或抗褐变剂。

公开(公告)号：KR1020050059281A

公开(公告)日：2005-06-17

申请号：KR1020057006841

申请日：2003-10-16

Applicant: 로레알

Inventor： 시모네쟝-띠에리

IPC: A61K8/55 ,  B82Y5/00 ,  B82Y40/00

CPC classification number: A61K8/0291 ,  A61K8/06 ,  A61K8/35 ,  A61K8/368 ,  A61K8/4966 ,  A61K8/63 ,  A61K8/90 ,  A61Q1/00 ,  A61Q13/00 ,  A61Q17/04 ,  A61Q19/00 ,  B01F17/0028 ,  B01F17/005 ,  B01F17/0057 ,  B01F17/0064 ,  B01F17/0071

Abstract: The invention relates to a process for dissolving at least one lipophilic compound in at least one aqueous phase, characterized in that it comprises the step of associating the said lipophilic compound with an effective amount of at least one amphilic block copolymer comprising at least one ionic and/or at least one nonionic hydrophilic polymer block, and at least one hydrophobic polymer block.

Abstract translation: 本发明涉及一种在至少一个水相中溶解至少一种亲脂性化合物的方法，其特征在于其包括将所述亲脂性化合物与有效量的至少一种两亲嵌段共聚物缔合的步骤，所述两亲嵌段共聚物包含至少一种离子和/ /或至少一种非离子亲水性聚合物嵌段和至少一种疏水性聚合物嵌段。

公开(公告)号：KR100369258B1

公开(公告)日：2003-01-24

申请号：KR1019990057228

申请日：1999-12-13

Applicant: 로레알

Inventor： 시모네쟝-띠에리 ,  쏜느빌오딜 ,  르그레실비

IPC: A61K9/107 ,  A61K9/10 ,  B82Y5/00

CPC classification number: A61Q19/007 ,  A61K8/06 ,  A61K8/4993 ,  A61K9/0048 ,  A61K9/1075 ,  A61K2800/21 ,  A61K2800/413 ,  A61Q1/14 ,  A61Q5/00 ,  B82Y5/00 ,  Y10S514/844 ,  Y10S514/938 ,  Y10S514/941 ,  Y10S514/942

Abstract: A nanoemulsion comprising a dispersed lipid phase in an aqueous phase with the lipid globules having an average size of less than 100 nm contains: (1) a surfactant (solid at up to 45 degrees C); (2) at least one oil with a molecular weight of more than 400; and (3) at least one ionic amphiphilic lipid . A nanoemulsion comprising a dispersed lipid phase in an aqueous phase with the lipid globules having an average size of less than 100 nm contains: (1) a surfactant (solid at up to 45 degrees C) such as sorbitan fatty esters optionally oxyethylenated; (2) at least one oil with a molecular weight of more than 400; and (3) at least one ionic amphiphilic lipid such as alkaline salts of dicetyl- and dimyristylphosphate, alkaline salts of cholesterol sulfate or phosphate, lipoaminoacids, sodium salts of phosphatidic acid, cationic amphiphilic lipid or alkylsulfonic derivatives at a lipid phase/surfactant weight ratio of 2-10. Independent claims are also included for: (1) a topical composition comprising the above described composition; (2) an ophthalmic support comprising the above described composition; (3) a pharmaceutical composition comprising the above described composition; (4) a cosmetic method for the care and/or hydration of the skin, mucosa and/or scalp by applying the above described composition; and (5) the preparation of the composition by mixing an aqueous phase and a lipid phase at 10-80 degrees C and homogenizing the mixture at 6 x 10 -18 x 10 Pa.

Abstract translation: 包含在含水相中的分散脂质相的纳米乳剂与平均尺寸小于100nm的脂质球包含：（1）表面活性剂（在高达45摄氏度下的固体）; （2）至少一种分子量大于400的油; 和（3）至少一种离子两亲脂质。 包含在水相中的分散的脂质相和平均尺寸小于100nm的脂质球的纳米乳剂包含：（1）表面活性剂（在高达45摄氏度下的固体），例如任选氧乙烯化的脱水山梨糖醇脂肪酸酯; （2）至少一种分子量大于400的油; 和（3）脂质相/表面活性剂重量比的至少一种离子两亲脂质，例如二鲸蜡基和二肉豆蔻基磷酸的碱性盐，胆固醇硫酸盐或磷酸盐的碱性盐，脂氨基酸，磷脂酸的钠盐，阳离子两亲脂质或烷基磺酸衍生物 为2-10。 独立权利要求还包括：（1）包含上述组合物的局部组合物; （2）包含上述组合物的眼科支持物; （3）包含上述组合物的药物组合物; （4）通过应用上述组合物护理和/或水合皮肤，粘膜和/或头皮的美容方法; 和（5）通过在10-80℃混合水相和脂质相并在6×10 7 -18×10 7 M 2下均化混合物来制备组合物。 霸。

公开(公告)号：KR100354357B1

公开(公告)日：2002-09-28

申请号：KR1019990055800

申请日：1999-12-08

Applicant: 로레알

Inventor： 쏜느빌오딜 ,  시모네쟝-띠에리 ,  르그레실비

IPC: A61K9/107 ,  B82Y5/00

CPC classification number: B82Y5/00 ,  A61K8/06 ,  A61K8/37 ,  A61K2800/21 ,  A61K2800/413 ,  A61Q1/14 ,  Y10S514/844 ,  Y10S514/937 ,  Y10S514/938

Abstract: 본발명은지방산또는지방알콜, 카르복실산및 글리세롤의혼합에스테르에서선택된계면활성제, 및분자량이 400 이상인하나이상의오일을함유하며, 계면활성제의양에대한오일상의양의중량비율이 2 내지 10인것을특징으로하는, 오일구(球)의수평균크기가 100 nm 미만인나노에멀젼에관한것이다. 사용되는계면활성제는예를들면, C-C지방산또는지방알콜및 α-히드록시산및/또는숙신산과글리세롤의혼합에스테르, 및이들의혼합물에서선택된다. 수득되는에멀젼은투명하며, 저장에대해안정하다. 이는우수한투명도를유지하고우수한화장특성을가지면서다량의오일을함유할수 있다. 본발명은또한, 본발명에따른나노에멀젼의, 화장품및 피부과학분야에서의용도, 특히피부및/또는점막의보습, 및모발의트리트먼트를위한용도, 및눈의트리트먼트를위한아이로션으로서안과학분야에서의용도에관한것이다.

公开(公告)号：KR100313727B1

公开(公告)日：2002-08-22

申请号：KR1019980034224

申请日：1998-08-24

Applicant: 로레알

Inventor： 시모네쟝-띠에리

IPC: A61K8/92 ,  A61Q17/00

Abstract: 본 발명은, 염증 반응 진행과 관련된 피부 질환의 예방 및/또는 치료를 위한, 특히 피부 자극의 예방 및/또는 치료를 위한, 및/또는 태양 홍반의 예방 및/또는 치료를 위한, 화장품용 조성물 또는 피부과학적 조성물 내에서의, 각각이 모노라멜라(monolamellar) 또는 올리고라멜라(oligolamellar) 액정 코팅 처리된, 오일상 글로불의 수성 분산액의 용도에 관한 것이다.

公开(公告)号：KR1020020060176A

公开(公告)日：2002-07-16

申请号：KR1020027003218

申请日：2001-06-19

Applicant: 로레알

Inventor： 오브룅-손느빌오딜 ,  시모네쟝-띠에리

IPC: A61K8/84 ,  A61K8/06

Abstract: 본 발명은, 생리학적 허용가능 매질 내에 폴리올레핀에서 유도된 하나 이상의 올리고머 또는 중합체를 유화제로서 함유하는 유중수 에멀션에 관한 것이다.
사용되는 올리고머 또는 중합체는 바람직하게는 임의로 에스테르화되거나 아미드화된 숙신 말단부를 갖는 폴리올레핀, 또는 상기 폴리올레핀의 염, 특히 에스테르화 또는 아미드화 숙신 말단부를 갖는 폴리이소부틸렌이다.
수득된 에멀션은 높은 비율의 수성상의 존재 하에서도 안정하다. 또한, 이것은 적용시 신선한 느낌을 제공한다. 이것은 특히 화장용, 피부과적 및 약학적 분야, 특히 피부 및/또는 네일 케어용, 피부의 메이크업 제거 및/또는 클렌싱용, 및/또는 피부 메이크업으로서 사용될 수 있다.