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公开(公告)号：KR1020120019232A
公开(公告)日：2012-03-06
申请号：KR1020100082520
申请日：2010-08-25
Applicant: 서울대학교산학협력단
CPC classification number: C12Q1/6886 , C12Q2600/118 , C12Q2600/156
Abstract: PURPOSE: A biomarker for leukemia in children and a method for predicting the risk of leukemia in children are provided to check the genetic character of an individual and to diagnose risk. CONSTITUTION: A marker for diagnosing leukemia in children contains: a polynucleotide containing 8-200 serial base sequences with an SNP of rs703817, rs17433222, or rs3794845; or a complement thereof. A kit for diagnosing leukemia in children contains the marker. A method for diagnosing leukemia in children comprises: a step of preparing nucleic acid samples from a test sample; a step of determining the base sequence of an SNP of rs703817, rs17433222, or rs3794845 in the nucleic acid sample; and a step of determining the risk of leukemia in case that rs703817, rs17433222, and rs3794845 is GG, GG, and CC, respectively.
Abstract translation: 目的：提供儿童白血病生物标志物和预测儿童白血病风险的方法，以检查个体的遗传特性并诊断风险。 构成：用于诊断儿童白血病的标记物包含：含有SNP rs703817，rs17433222或rs3794845的8-200个序列碱基序列的多核苷酸; 或其补体。 用于诊断儿童白血病的试剂盒含有标记物。 用于诊断儿童白血病的方法包括：从测试样品制备核酸样品的步骤; 确定核酸样品中rs703817，rs17433222或rs3794845的SNP的碱基序列的步骤; 在rs703817，rs17433222和rs3794845分别为GG，GG和CC的情况下，确定白血病风险的步骤。
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Patent Agency Ranking
公开(公告)号：KR101335245B1
公开(公告)日：2013-12-05
申请号：KR1020100108347
申请日：2010-11-02
Applicant: 서울대학교산학협력단
Inventor： 박수경
CPC classification number: C12Q1/6886 , C12Q2600/156
Abstract: 본 발명은 이소플라본 대사와 관련한 유전자, 특히, NF-κB, ERK, AKT 신호전달경로상의 유전자로부터 유래된 단일염기다형(Single-Nucleotide Polymorphism; SNP)을 포함하는 폴리뉴클레오티드 또는 그의 상보적 폴리뉴클레오티드를 제공하며, 보다 구체적으로는 서열번호 1 내지 서열번호 13으로 구성되는 군으로부터 1종 이상 선택되는 폴리뉴클레오티드로서, 27번째 염기(다형성부위)를 포함하는 10 내지 50개의 연속 DNA 서열로 구성되는 위암 감수성 진단용 폴리뉴클레오티드 또는 그의 상보적 폴리뉴클레오티드를 제공한다.
상기 폴리뉴클레오티드 또는 그의 상보적 폴리뉴클레오티드는 위암의 임상적 진단의 표지 인자로서 사용될 수 있다.-
公开(公告)号：KR1020130041859A
公开(公告)日：2013-04-25
申请号：KR1020130029843
申请日：2013-03-20
Applicant: 서울대학교산학협력단
Inventor： 박수경
CPC classification number: C12N15/11 , C12Q1/6834 , C12Q1/6886 , C12Q2600/156 , G01N33/57446
Abstract: PURPOSE: An AKT signal transduction-related polynucleotide for diagnosing gastric cancer susceptability is provided to quickly and early classify a patient with high susceptability. CONSTITUTION: An AKT signal transduction polynucleotide for diagnosing gastric cancer susceptability is related to isoflavone metabolism and is selected from sequence numbers 1 and 2. The polypeptide for diagnosing gastric cancer susceptability contains 10-50 continuous DNA sequences containing 27th base(polymorphic site). A probe for diagnosing gastric cancer susceptability contains the polynucleotide or a complementary polynucleotide thereof.
Abstract translation: 目的：提供用于诊断胃癌易感性的AKT信号转导相关多核苷酸，以快速，早期地分类具有高易感性的患者。 构成：用于诊断胃癌易感性的AKT信号转导多核苷酸与异黄酮代谢相关，选自序列号1和2。用于诊断胃癌易感性的多肽包含含有第27碱基（多态位点）的10-50个连续DNA序列。 用于诊断胃癌易感性的探针包含多核苷酸或其互补多核苷酸。
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公开(公告)号：KR1020130032350A
公开(公告)日：2013-04-01
申请号：KR1020130029870
申请日：2013-03-20
Applicant: 서울대학교산학협력단
Inventor： 박수경
CPC classification number: C12N15/11 , C12Q1/6834 , C12Q1/6886 , C12Q2600/156 , G01N33/57446
Abstract: PURPOSE: An ERK signal transduction-related polynucleotide is provided to identify SNP with a relation with gastric cancer susceptibility, and to use the SNP as a clinical marker for diagnosing gastric cancer susceptibility. CONSTITUTION: A polynucleotide or a complementary polynucleotide thereof for diagnosing gastric cancer susceptibility is related to ERK signal transduction pathway, and is selected from the group consisting of sequence numbers 1-4. A kit for diagnosing gastric cancer susceptibility contains the polynucleotide or the complementary polynucleotide thereof. A method for evaluating gastric cancer susceptibility comprises a step of preparing nucleic acid from a sample, and a step of detecting the presence of a gene sequence which indicates gastric cancer development.
Abstract translation: 目的：提供ERK信号转导相关多核苷酸，以鉴别与胃癌易感性有关的SNP，并将SNP用作诊断胃癌易感性的临床标志物。 构成：用于诊断胃癌易感性的多核苷酸或其互补多核苷酸与ERK信号转导途径相关，并且选自序列号1-4。 用于诊断胃癌易感性的试剂盒含有多核苷酸或其互补多核苷酸。 用于评估胃癌易感性的方法包括从样品中制备核酸的步骤和检测指示胃癌发生的基因序列的存在的步骤。
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公开(公告)号：KR101208054B1
公开(公告)日：2012-12-04
申请号：KR1020100082520
申请日：2010-08-25
Applicant: 서울대학교산학협력단
Abstract: 본발명은소아백혈병에대한바이오마커에관한것이다. 보다상세하게는소아백혈병과상관관계를나타내는 SNP를포함하는폴리뉴클레오티드, 키트및 이를이용하여소아백혈병의발병위험도를예측하는방법에관한것이다. 본발명에따른소아백혈병진단용마커를이용한진단및 예측방법을통해, 간단한처리만으로도개인의유전형질을확인하고소아백혈병의발병위험도를진단할수 있다.
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公开(公告)号：KR1020120019222A
公开(公告)日：2012-03-06
申请号：KR1020100082506
申请日：2010-08-25
Applicant: 서울대학교산학협력단
CPC classification number: C12Q1/6886 , C12Q2600/118 , C12Q2600/156
Abstract: PURPOSE: A biomarker for acute lymphocytic leukemia is provided for detecting an individual genetic character and to diagnose the risk of leukemia. CONSTITUTION: A marker for diagnosing acute lymphocytic leukemia contains a polynucleotide or complement thereof having 8-200 serial sequences with an SNP of rs3776932, rs6140264, rs12105972, rs9388856, rs9388857, or rs1360756. A method for diagnosing acute lymphocytic leukemia comprises: a step of preparing a nucleic acid sample from an analyte; a step of determining the base sequence of an SNP of rs3776932, rs6140264, rs12105972, rs9388856, rs9388857, or rs1360756 in the nucleic acid sample; and a step of determining the determined the risk of the sequence.
Abstract translation: 目的：提供急性淋巴细胞白血病的生物标志物，用于检测个体遗传特征并诊断白血病的风险。 构成：用于诊断急性淋巴细胞性白血病的标志物含有具有SNP rs3776932，rs6140264，rs12105972，rs9388856，rs9388857或rs1360756的8-200序列序列的多核苷酸或其互补序列。 诊断急性淋巴细胞白血病的方法包括：从分析物制备核酸样品的步骤; 确定核酸样品中rs3776932，rs6140264，rs12105972，rs9388856，rs9388857或rs1360756的SNP的碱基序列的步骤; 以及确定确定序列风险的步骤。
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