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公开(公告)号：KR101208054B1
公开(公告)日：2012-12-04
申请号：KR1020100082520
申请日：2010-08-25
Applicant: 서울대학교산학협력단
Abstract: 본발명은소아백혈병에대한바이오마커에관한것이다. 보다상세하게는소아백혈병과상관관계를나타내는 SNP를포함하는폴리뉴클레오티드, 키트및 이를이용하여소아백혈병의발병위험도를예측하는방법에관한것이다. 본발명에따른소아백혈병진단용마커를이용한진단및 예측방법을통해, 간단한처리만으로도개인의유전형질을확인하고소아백혈병의발병위험도를진단할수 있다.
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公开(公告)号：KR1020120019222A
公开(公告)日：2012-03-06
申请号：KR1020100082506
申请日：2010-08-25
Applicant: 서울대학교산학협력단
CPC classification number: C12Q1/6886 , C12Q2600/118 , C12Q2600/156
Abstract: PURPOSE: A biomarker for acute lymphocytic leukemia is provided for detecting an individual genetic character and to diagnose the risk of leukemia. CONSTITUTION: A marker for diagnosing acute lymphocytic leukemia contains a polynucleotide or complement thereof having 8-200 serial sequences with an SNP of rs3776932, rs6140264, rs12105972, rs9388856, rs9388857, or rs1360756. A method for diagnosing acute lymphocytic leukemia comprises: a step of preparing a nucleic acid sample from an analyte; a step of determining the base sequence of an SNP of rs3776932, rs6140264, rs12105972, rs9388856, rs9388857, or rs1360756 in the nucleic acid sample; and a step of determining the determined the risk of the sequence.
Abstract translation: 目的：提供急性淋巴细胞白血病的生物标志物，用于检测个体遗传特征并诊断白血病的风险。 构成：用于诊断急性淋巴细胞性白血病的标志物含有具有SNP rs3776932，rs6140264，rs12105972，rs9388856，rs9388857或rs1360756的8-200序列序列的多核苷酸或其互补序列。 诊断急性淋巴细胞白血病的方法包括：从分析物制备核酸样品的步骤; 确定核酸样品中rs3776932，rs6140264，rs12105972，rs9388856，rs9388857或rs1360756的SNP的碱基序列的步骤; 以及确定确定序列风险的步骤。
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Patent Agency Ranking
公开(公告)号：KR101213173B1
公开(公告)日：2012-12-18
申请号：KR1020100049352
申请日：2010-05-26
Applicant: 서울대학교산학협력단 , 인제대학교 산학협력단
Abstract: 본발명은() 유전자의단일염기다형성(SNP) 부위(GenBank SNP 데이터베이스, rs 2972388) 및() 유전자의단일염기다형성(SNP) 부위(GenBank SNP 데이터베이스, (rs 1801132))가유방암의발병위험도와밀접한관계가있다는발견에근거하여유방암의진단용키트및 유방암의진단방법을제공한다. 본발명은한국인여성에게서빈번히발병하는유방암에대한간편하고신뢰성높은체외진단시스템에유용하게이용될수 있다.
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公开(公告)号：KR1020140098695A
公开(公告)日：2014-08-08
申请号：KR1020140010197
申请日：2014-01-28
Applicant: 서울대학교산학협력단
IPC: G06F19/00
CPC classification number: G06F19/00
Abstract: The present invention relates to a method for female breast cancer risk analysis and future breast cancer probability assessment, which includes the steps of: a) collecting the information needed to predict the risk of breast cancer from women who know their clinical information; and b) using the logistic regression analysis to select risk factors that influence the occurrence of breast cancer of the women, selecting the risk factors by distinguishing the women less than 50 years old and the women 50 years old and above, and obtaining a female breast cancer risk model by modeling the relation between the selected risk factors and the breast cancer of the women.
Abstract translation: 本发明涉及一种女性乳腺癌风险分析和未来乳腺癌概率评估方法，其中包括以下步骤：a）从知道其临床信息的妇女收集预测乳腺癌风险所需的信息; 和b）使用逻辑回归分析来选择影响女性乳腺癌发生的危险因素，通过区分不到50岁的女性和50岁以上的女性选择危险因素，并获得女性乳房 通过对所选择的危险因素与女性乳腺癌之间的关系进行建模，确定癌症风险模型。
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公开(公告)号：KR1020110129783A
公开(公告)日：2011-12-02
申请号：KR1020100049352
申请日：2010-05-26
Applicant: 서울대학교산학협력단 , 인제대학교 산학협력단
CPC classification number: C12Q1/6886 , C12Q2600/156
Abstract: PURPOSE: A breast cancer-associated SNP is provided to be used in an in vitro diagnosis system with simplicity and high reliability. CONSTITUTION: A kit for breast cancer diagnosis contains a primer or probe which specifically binds to 10-100 serial nucleotide sequences, containing SNP site(GenBank SNP database, rs 2972388) having T at 401th nucleotide of sequence number 1. A T allele is TT homozygote. The kit is applied to Asians. A method for detecting a marker for breast cancer comprises a step of detecting the SNP as a CDK7 gene SNP. The detection is performed by a microarray method or gene amplification method.
Abstract translation: 目的：提供乳腺癌相关SNP，用于体外诊断系统，其简单性和可靠性高。 构成：用于乳腺癌诊断的试剂盒含有特异性结合10-100个序列核苷酸序列的引物或探针，其包含序列号1为第401位核苷酸的具有T的SNP位点（GenBank SNP数据库，rs2972388）.AT等位基因为TT纯合子 。 该套件适用于亚洲人。 用于检测乳腺癌标志物的方法包括检测作为CDK7基因SNP的SNP的步骤。 通过微阵列法或基因扩增法进行检测。
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公开(公告)号：KR101208051B1
公开(公告)日：2012-12-04
申请号：KR1020100082506
申请日：2010-08-25
Applicant: 서울대학교산학협력단
Abstract: 본발명은급성림프구성백혈병에대한바이오마커에관한것이다. 보다상세하게는급성림프구성백혈병과상관관계를나타내는 SNP를포함하는폴리뉴클레오티드, 키트및 이를이용하여소아급성림프구성백혈병의발병위험도를예측하는방법에관한것이다. 본발명에따른급성림프구성백혈병진단용마커를이용한진단및 예측방법을통해, 간단한처리만으로도개인의유전형질을확인하고급성림프구성백혈병의발병위험도를진단할수 있다.
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公开(公告)号：KR1020120019232A
公开(公告)日：2012-03-06
申请号：KR1020100082520
申请日：2010-08-25
Applicant: 서울대학교산학협력단
CPC classification number: C12Q1/6886 , C12Q2600/118 , C12Q2600/156
Abstract: PURPOSE: A biomarker for leukemia in children and a method for predicting the risk of leukemia in children are provided to check the genetic character of an individual and to diagnose risk. CONSTITUTION: A marker for diagnosing leukemia in children contains: a polynucleotide containing 8-200 serial base sequences with an SNP of rs703817, rs17433222, or rs3794845; or a complement thereof. A kit for diagnosing leukemia in children contains the marker. A method for diagnosing leukemia in children comprises: a step of preparing nucleic acid samples from a test sample; a step of determining the base sequence of an SNP of rs703817, rs17433222, or rs3794845 in the nucleic acid sample; and a step of determining the risk of leukemia in case that rs703817, rs17433222, and rs3794845 is GG, GG, and CC, respectively.
Abstract translation: 目的：提供儿童白血病生物标志物和预测儿童白血病风险的方法，以检查个体的遗传特性并诊断风险。 构成：用于诊断儿童白血病的标记物包含：含有SNP rs703817，rs17433222或rs3794845的8-200个序列碱基序列的多核苷酸; 或其补体。 用于诊断儿童白血病的试剂盒含有标记物。 用于诊断儿童白血病的方法包括：从测试样品制备核酸样品的步骤; 确定核酸样品中rs703817，rs17433222或rs3794845的SNP的碱基序列的步骤; 在rs703817，rs17433222和rs3794845分别为GG，GG和CC的情况下，确定白血病风险的步骤。
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