Abstract:
PURPOSE: A sustained release microparticle containing pramipexole and ethyl cellulose and an orally fast disintegrating tablet containing the same are provided to maintain effective blood concentration and to improve drug compliance. CONSTITUTION: A sustained release microparticle of pramipexole contains 1 part by weight of pramipexole or a salt thereof and 13-33 parts by weight of ethyl cellulose. The salt is pramipexole hydrochloride. The viscosity of ethyl cellulose is 6-22 cp. An orally fast disintegrating tablet contains the sustained release granules, sugar alcohol, and a disintegrant. The orally fast disintegrating tablet contains 50-55 parts by weight of sugar alcohol based on 100 parts by weight of the sustained release granules. The orally fast disintegrating tablet additionally contains an excipient. [Reference numerals] (AA) Elution rate; (BB) Time(hour); (CC) Embodiment 3-1; (DD) Embodiment 3-2; (EE) Embodiment 3-3; (FF) Embodiment 3-4
Abstract:
The present invention relates to a eutectic composition comprising celecoxib and poloxamer. The eutectic composition comprising celecoxib and poloxamer according to one embodiment of the present invention includes celecoxib or pharmaceutically acceptable salt and block copolymer of poly (polyoxyethylene) and poly (Polyoxypropylene) and is manufactured by thermal melting.
Abstract:
The present invention relates to an eutectic mixture having celecoxib with remarkably enhanced solubility and bioavailability through an eutetic reaction by adding poloxamer of chemical formula 2 to celecoxib of chemical formula 1 which is an insoluble drug. The weight ratio of poloxamer with respect to celecoxib is 3:7-6:4. More preferably, the eutectic mixture according to the present invention contains 1.5 parts by weight of poloxamer with respect to 1 part by weight of celecoxib. [Reference numerals] (AA) Temperature ;(BB) % celecoxib
Abstract:
PURPOSE: An apparatus and a method for balanced power amplification are provided to offer a 90-degree hybrid splitter and a 90-degree hybrid combiner using at least one quarter-wave transmission line, thereby improving the efficiency of wireless power transmission. CONSTITUTION: An amplifier (600) comprises a 90-degree hybrid splitter (620), a first power amplifier (PA) (630), a second PA (640), and a 90-degree hybrid combiner (650). The 90-degree hybrid splitter divides an input signal into a first PA input signal and a second PA input signal which have 90-degree phase difference. The first PA amplifies the first PA input signal to generate a first PA output signal. The second PA amplifies the second PA input signal to generate a second PA output signal. The 90-degree hybrid combiner combines the first and second output signals having 90-degree phase difference of to generate an output signal. [Reference numerals] (AA) First PA input signal; (BB) First PA output signal; (CC) Output signal; (DD) Input signal; (EE) Second PA input signal; (FF) Second PA output signal
Abstract:
PURPOSE: A sustained release fine particle containing pramipexole and a composition containing the same are provided to ensure a release-controlling effect by additional coating of ethyl cellulose. CONSTITUTION: A composition is a release-controlled formulation which is prepared by coating a sustained release fine particle containing pramipexole or a salt thereof with a coating solution containing ethyl cellulose. The sustained release fine particle contains pramipezole or a salt thereof and hydroxypropyl methylcellulose. [Reference numerals] (AA) Elution rate(%); (BB) Time(h); (CC) Bead weight ratio of before coating : after coating = 1 : 1.5; (DD) Bead weight ratio of before coating : after coating = 1 : 1.3;
Abstract:
PURPOSE: A method for preparing levocabastine-containing nanosuspension using hydroxypropyl methylcellulose is provided to enhance drug solubility by redispersion of a solid dispersant in an aqueous phase. CONSTITUTION: A method for preparing levocabastine-containing nanosuspension using hydroypropyl methylceullose comprises: a step of dissolving levocabastine and hydroxypropyl methylcellulose in a solvent and preparing a solid dispersant; and a step of dispersing the solid dispersant. The levocabastine is levocabastine hydrochloride. [Reference numerals] (AA) Particle size(nm); (BB) Example 1; (CC) Example 2; (DD) Example 3; (EE) Comparative example 1; (FF) Comparative example 2; (GG) Comparative example 3;