公开(公告)号：KR1020140047645A

公开(公告)日：2014-04-22

申请号：KR1020140037956

申请日：2014-03-31

Applicant: 한국과학기술연구원

Inventor： 강기성 ,  함정엽 ,  김수남 ,  권학철 ,  정봉철 ,  이우정 ,  박순혜

IPC: A61K36/258 ,  A61K31/704 ,  A61P7/02 ,  A61P29/00 ,  A61P25/00

CPC classification number: A61K36/258 ,  A23L33/105 ,  A23L33/175 ,  A61K31/198 ,  A61K31/704 ,  A61K2236/333

Abstract: The present invention relates to an extract of processed Panax genus plant obtained by maillard browning reaction of Panax genus extract with at least one amino acid selected from the group consisting of valine, arginine, and alanine at 100-130°C for 0.5-12 hours; a method for manufacturing the same; and a composition comprising the extract for anti-cancer, neuroprotection, inhibition of platelet aggregation, antioxidant, anti-inflammatory, renal protection, or anti-fatigue. The present invention also provides an extract of processed Panax genus plant obtained by maillard browning reaction of Panax genus extrac with at least one amino acid selected from the group consisting of leucine and glutamine at 100-130°C for 0.1-12 hours; a method for manufacturing the same; and an anti-cancer composition comprising the extract.

Abstract translation: 本发明涉及通过将亚麻提取物与选自缬氨酸，精氨酸和丙氨酸的至少一种氨基酸在100-130℃下进行0.5-12小时的美拉德褐变反应而获得的加工番荔枝属植物提取物 ; 其制造方法; 以及包含用于抗癌，神经保护，抑制血小板聚集，抗氧化，抗炎，肾脏保护或抗疲劳的提取物的组合物。 本发明还提供了将Panax属提取物的玉米褐变反应与100-130℃下选自亮氨酸和谷氨酰胺的至少一种氨基酸进行0.1-12小时的经加工的Panax属植物提取物; 其制造方法; 以及包含所述提取物的抗癌组合物。

公开(公告)号：KR1020130132264A

公开(公告)日：2013-12-04

申请号：KR1020130036448

申请日：2013-04-03

Applicant: 한국과학기술연구원

Inventor： 함정엽 ,  강기성 ,  정봉철 ,  권학철 ,  박순혜 ,  최필주 ,  김수남 ,  양현옥

IPC: A61K36/258 ,  A61K31/56 ,  A61K9/48 ,  A61K9/20

CPC classification number: A61K36/258 ,  A61K31/704 ,  A61K2236/37 ,  A61K2300/00

Abstract: The present invention provides Panax spp. plant extract which includes 90% or more of Rg3, Rk1, and Rg5 based on the weight of ginsenoside Rb1, Rc, Rb2, Rd, Rg3, Rk1 and Rg5 obtained by making microwave reaction with Panax spp. plant or the extract, a method for preparing the same, a pharmaceutical composition for improving anti-cancer agent side effects selected from immune degradation and anti-cancer agent tolerance, antioxidant, anti-cancer, antiinflammatory, brain function or cognitive skills, blood vessel relaxation, platelet coagulation suppression, dermatitis, or psoriasis and a composition for health supplement. [Reference numerals] (AA) Voltage (mV);(BB) Time (minute)

Abstract translation: 本发明提供了Panax spp。 基于通过与Panax spp进行微波反应获得的人参皂甙Rb1，Rc，Rb2，Rd，Rg3，Rk1和Rg5的重量，含有90％以上的Rg3，Rk1和Rg5的植物提取物。 植物或提取物，其制备方法，用于改善选自免疫降解和抗癌药耐受性，抗氧化剂，抗癌，抗炎，脑功能或认知技能的抗癌剂副作用的药物组合物，血管 松弛，血小板凝血抑制，皮炎或银屑病以及健康补充剂的组合物。 （标号）（AA）电压（mV）;（BB）时间（分钟）

公开(公告)号：KR1020130083427A

公开(公告)日：2013-07-22

申请号：KR1020130080351

申请日：2013-07-09

Applicant: 한국과학기술연구원

Inventor： 김수남 ,  이우정 ,  함정엽 ,  정유정 ,  황예란 ,  전영식 ,  윤구

IPC: A61K31/045 ,  A61K31/122 ,  A61K31/05 ,  A61P3/10

Abstract: PURPOSE: A composition for preventing, treating, or alleviating peroxisome proliferator-activated receptor (PPAR) action regulatory diseases is provided to promote PPAR activation and to prevent, treat, or alleviate the diseases including obesity, metabolic diseases, and cardiovascular diseases. CONSTITUTION: A pharmaceutical composition for preventing or treating PPAR action regulator diseases selected among diabetes, obesity, hyperinsulinemia, hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, artery scleroma, and combination thereof contains a compound of chemical formula 1 or 2, or a pharmaceutically acceptable salt or a solvate thereof. A composition for health functional foods for preventing or treating the diseases contains the compound, the pharmaceutically acceptable salt, or the solvate.

Abstract translation: 目的：提供一种预防，治疗或减轻过氧化物酶体增殖物激活受体（PPAR）作用调节性疾病的组合物，用于促进PPAR活化并预防，治疗或减轻包括肥胖，代谢疾病和心血管疾病在内的疾病。 构成：用于预防或治疗选自糖尿病，肥胖症，高胰岛素血症，高脂血症，高胆固醇血症，高甘油三酯血症，动脉硬化及其组合的PPAR活性调节剂疾病的药物组合物含有化学式1或2的化合物或其药学上可接受的盐或 其溶剂合物。 用于预防或治疗疾病的健康功能性食品的组合物含有化合物，药学上可接受的盐或溶剂合物。

公开(公告)号：KR1020130082048A

公开(公告)日：2013-07-18

申请号：KR1020120031828

申请日：2012-03-28

Applicant: 한국과학기술연구원

Inventor： 강기성 ,  김수남 ,  함정엽 ,  이우정 ,  야마베노리꼬 ,  이지환

IPC: A61K36/258 ,  A61P13/12

CPC classification number: A61K36/258 ,  A61K9/14 ,  A61K9/20 ,  A61K9/48 ,  A61K31/198 ,  A61K31/704

Abstract: PURPOSE: A therapeutic composition is provided to be able to be effectively used in prevention, alleviation or treatment of kidney diseases as the Panax species plant extract or the product of the Maillard type browning reaction with glucose amino acid have an excellent removal ability of active oxygen, and remarkably excellent activation to suppress damage of kidney epithelial cell due to the oxidative stress. CONSTITUTION: A pharmaceutical composition for prevention or treatment of kidney diseases comprises ginsenoside Re, Panax species plant extract including ginsenoside Re, or the product of the Maillard browning reaction obtained by reacting ginsenoside-originated saccharide with amino acid at 100-130deg.C, as an active ingredient. A composition for health functional food for prevention or alleviation of kidney diseases includes ginsenoside Re, Panax species plant extract including ginsenoside Re, or the product of the Maillard browning reaction obtained by reacting ginsenoside-originated saccharide with amino acid at 100-130deg.C, as an active ingredient. The Panax species plant is Korean ginseng, Panax quinquefolius, Panax notoginseng, Japanse seng, Panax trifolium, Himalayan ginseng, Panax vietnamensis, their cultured root, or their combination. [Reference numerals] (AA) Ginsenoside Re; (BB) Ginsenoside Rg_2; (CC) Dehydration reaction; (DD) Ginsenoside Rg_6; (EE) Ginsenoside F_4; (FF) Separated glucose + Glycine; (GG) Maillard browning reaction

Abstract translation: 目的：提供治疗组合物，以能够有效地用于预防，减轻或治疗肾脏疾病，因为人参植物提取物或美拉德型褐变反应与葡萄糖氨基酸的产物具有优异的活性氧去除能力 ，并且显着优异的活化以抑制由于氧化应激引起的肾上皮细胞的损伤。 构成：用于预防或治疗肾脏疾病的药物组合物包括人参皂甙Re，人参皂苷Re的人参植物提取物，或将人参皂甙起源的糖与氨基酸在100-130℃下反应获得的美拉德褐变反应的产物，作为 活性成分。 用于预防或减轻肾脏疾病的健康功能食品的组合物包括人参皂苷Re，人参皂苷Re的人参植物提取物，或通过使人参皂甙起源的糖与氨基酸在100-130℃反应而获得的美拉德褐变反应的产物， 作为活性成分。 人参植物是韩国人参，三七，三七，日本人，三七，喜马拉雅，人参，培养根或其组合。 （AA）人参皂甙Re; （BB）人参皂甙Rg_2; （CC）脱水反应; （DD）人参皂甙Rg_6; （EE）人参皂甙F_4; （FF）分离葡萄糖+甘氨酸; （GG）美拉德褐变反应

公开(公告)号：KR101260047B1

公开(公告)日：2013-05-06

申请号：KR1020130007651

申请日：2013-01-23

Applicant: 한국과학기술연구원

Inventor： 함정엽 ,  강기성 ,  정봉철 ,  권학철 ,  박순혜 ,  최필주 ,  김수남 ,  양현옥

IPC: A61K36/258 ,  A61K9/48 ,  A61K9/20 ,  A61K9/16

CPC classification number: A61K36/258 ,  A61K31/704 ,  A61K2236/37 ,  A61K2300/00

Abstract: PURPOSE: A Panax species plant extract having the increased content of ginsenoside Rg5 and Rk1 by microwave irradiation, a manufacturing method thereof, and a composition containing the processed Panax species plant extract are provided to enhance an effect of Rg5 and Rk1 compared to an extract by simple thermal-processing. CONSTITUTION: A manufacturing method of a Panax species plant extract comprises: a step of irradiating Panax species plants or an extract thereof with microwaves. The Panax species plant or the extract contains more than 90% of Rg3, Rk1, and Rg5 to the weight of ginsenoside Rb1, Rc, Rb2, Rd, Rg3, Rk1 and Rg5. The microwave irradiation is performed at 150-190 deg. C for 30-90 minutes while pressurizing. The microwave irradiation is performed under 2-100 atmospheric pressure. The Panax species plant extract has a ratio of ginsenoside (Rg5+Rk1)/(Rg3) of 2 or greater. [Reference numerals] (AA) Voltage(mv); (BB) Time(minutes)

Abstract translation: 目的：提供通过微波照射提高人参皂甙Rg5和Rk1含量增加的Panax种植物提取物，其制备方法和含有加工的Panax种植物提取物的组合物，以提高Rg5和Rk1与提取物相比的作用 简单的热处理。 构成：人参植物提取物的制造方法包括：将微生物种类植物或其提取物照射到微波的步骤。 人参植物或提取物含有人参皂甙Rb1，Rc，Rb2，Rd，Rg3，Rk1和Rg5重量的Rg3，Rk1和Rg5的90％以上。 微波照射在150-190度进行。 C加压30-90分钟。 微波照射在2-100大气压下进行。 人参植物提取物的人参皂甙（Rg5 + Rk1）/（Rg3）的比值为2以上。 （附图标记）（AA）电压（mv）; （BB）时间（分钟）

公开(公告)号：KR100961688B1

公开(公告)日：2010-06-09

申请号：KR1020080018323

申请日：2008-02-28

Applicant: 한국과학기술연구원

Inventor： 김수남 ,  이석준 ,  김용기

IPC: A61K31/423 ,  A61K31/421 ,  A61K31/422 ,  A61P35/00

Abstract: 본 발명은 다중약물내성 암세포에 유용한 항암제에 관한 것으로서, 구체적으로 상기 3-(2-벤족사졸릴)-7-(디에틸아미노)쿠마린[3-(2-Benzoxazolyl)- 7-(diethylamino)Coumarin]을 유효성분으로 함유하는 기존 항암제에 대해 다중약물내성을 나타내는 암세포에 대한 우수한 사멸효과를 제공하는 조성물에 관한 것이다. 본 발명의 조성물은 항암제에 내성을 나타내는 다중약물내성(Multidrug resistance, MDR) 세포에서 보이는 항암제내성을 극복할 수 있어서 정상암세포는 물론 MDR을 나타내는 세포에서도 항암효과가 있으므로, 약학적으로 유용한 항암제로 사용될 수 있다.
3-(2-벤족사졸릴)-7-(디에틸아미노)쿠마린, 다중약물내성

公开(公告)号：KR1020090041533A

公开(公告)日：2009-04-29

申请号：KR1020070107087

申请日：2007-10-24

Applicant: 한국과학기술연구원

Inventor： 김수남 ,  엄병헌 ,  김철영 ,  이우정 ,  박연숙 ,  강석우

IPC: A61K36/185 ,  A61K8/97 ,  A61P17/18 ,  A61Q19/08

CPC classification number: A61K36/185

Abstract: A composition containing Chamaenerion angustifolium extract with anti-wrinkle and antioxidant activities is provided to show wrinkle and elasticity improvement by the Chamaenerion angustifolium extracts having effects of inhibiting type I collagenase and AP-1. A composition containing Chamaenerion angustifolium extract with anti-wrinkle and antioxidant activities comprises Chamaenerion angustifolium extract obtained by adding water and alcohol or a mixed solvent thereof. The Chamaenerion angustifolium extract inhibits inflammation and improves skin elasticity. The composition has a formulation of external skin application. The composition represents cosmetics or health foods. The Chamaenerion angustifolium extract is an active ingredient in the composition.

Abstract translation: 提供了具有抗皱和抗氧化活性的含有Chamaenerion angustifolium提取物的组合物，以显示具有抑制I型胶原酶和AP-1的作用的Chamaenerion angustifolium提取物的皱纹和弹性改善。 具有抗皱和抗氧化活性的含有尖角鳗提取物的组合物包括通过加入水和醇或其混合溶剂获得的Challenerion angustifolium提取物。 Chamaenerion angustifolium提取物抑制炎症并改善皮肤弹性。 该组合物具有外用皮肤应用的配方。 组合物代表化妆品或保健食品。 Chamaenerion angustifolium提取物是组合物中的活性成分。

公开(公告)号：KR1020090041531A

公开(公告)日：2009-04-29

申请号：KR1020070107085

申请日：2007-10-24

Applicant: 한국과학기술연구원

Inventor： 김수남 ,  엄병헌 ,  김철영 ,  이우정 ,  박연숙 ,  강석우

IPC: A61K36/185 ,  A61K8/97 ,  A61P39/06 ,  A61Q19/08

CPC classification number: A61K36/45 ,  A23L2/02 ,  A23L2/52 ,  A23L33/105 ,  A61K8/97 ,  A61K9/0095 ,  A61K9/1617 ,  A61K9/1623 ,  A61K9/2018 ,  A61K9/2059 ,  A61K2800/522 ,  A61K2800/782 ,  A61Q19/08

Abstract: A composition containing Ortilia secunda extracts is provided to show wrinkle and elasticity improvement by the Ortilia secunda extracts having effects of inhibiting type I collagenase and AP-1 and increasing generation of collagen while suppressing decomposition of the collagen. A composition for wrinkle improvement comprises Ortilia secunda extracts obtained by adding water and C1-C4 low alcohol such as ethanol and methanol or mixed solvents thereof. The Ortilia secunda extracts are active ingredients in the composition for wrinkle improvement. The Ortilia secunda extracts eliminate radicals. The composition has a formulation of external skin application. The composition for wrinkle improvement represents antioxidant.

Abstract translation: 提供含有Ortilia secunda提取物的组合物，以显示具有抑制I型胶原酶和AP-1的作用的Ortilia secunda提取物的皱纹和弹性改善，并增加胶原蛋白的产生，同时抑制胶原蛋白的分解。 用于皱纹改良的组合物包括通过加入水和C1-C4低级醇如乙醇和甲醇或其混合溶剂获得的Ortilia secunda提取物。 Ortilia secunda提取物是用于皱纹改善的组合物中的活性成分。 Ortilia secunda提取物消除自由基。 该组合物具有外用皮肤应用的配方。 用于皱纹改善的组合物表示抗氧化剂。

公开(公告)号：KR100837682B1

公开(公告)日：2008-06-13

申请号：KR1020060021934

申请日：2006-03-08

Applicant: 한국과학기술연구원

Inventor： 노주원 ,  김수남 ,  문길주 ,  이샛별 ,  차광현 ,  엄병헌 ,  이은하 ,  산두인,사타르 ,  사타린,알탄체체그 ,  삼단,자브잔 ,  오이디브삼부,사란게렐 ,  둘람자브,바추렌 ,  야,자먄산 ,  안병성

IPC: A01N65/22

Abstract: 본 발명은 드라코세팔룸 포에티둠 추출물, 고두자 추출물 또는 이의 분획물을 포함하는 항균용 조성물에 관한 것으로, 보다 상세하게는 드라코세팔룸 포에티둠 추출물, 고두자 추출물 및 이의 분획물은 피부표면의 세균 및 진균, 식품의 부패와 식중독을 일으키는 원인균 및 충치균뿐 아니라 항생제 내성균에 대해서도 항균활성을 가지고 있으며, 드라코세팔룸 포에티둠 추출물은 그의 휘발성분에 의해서도 항균활성을 나타내므로 피부표면을 세정 및 정균·살균하고, 식품의 부패를 막고 식중독을 예방하며, 구강 내 질환 및 충치를 예방하는 항균용 조성물뿐만 아니라 공기청정용품의 필터 등에 천연 항균제로서 부작용없이 유용하게 사용할 수 있다.

公开(公告)号：KR1020070092033A

公开(公告)日：2007-09-12

申请号：KR1020060021934

申请日：2006-03-08

Applicant: 한국과학기술연구원

Inventor： 노주원 ,  김수남 ,  문길주 ,  이샛별 ,  차광현 ,  엄병헌 ,  이은하 ,  산두인,사타르 ,  사타린,알탄체체그 ,  삼단,자브잔 ,  오이디브삼부,사란게렐 ,  둘람자브,바추렌 ,  야,자먄산 ,  안병성

IPC: A01N65/22

CPC classification number: A01N65/22 ,  A01N65/20 ,  A61K8/97 ,  A61Q11/00 ,  A61Q19/00 ,  B01D2279/50

Abstract: An extract of Dracocephalum foetidum and an extract of Sophora alopecuroides are provided to be used as an antibacterial composition for washing and sterilizing the skin surface, prevent the decay and the poisoning of the food, and periodontal diseases, and be used as a natural antibacterial agent for a filter of an air purifying product by having antibacterial activity on bacteria and fungi of skin surface, bacteria causing decay of foods and food-poisoning, Streptococcus Mutans and antibiotics resistant bacteria. An antibacterial composition comprises an extract of Dracocephalum foetidum which is a refined oil ingredient of the Dracocephalum foetidum or an extract of Sophora alopecuroides which is prepared by using a solvent such as water, alcohol, hexane, methylene chloride, ethyl acetate and a mixture thereof.

Abstract translation: 提供杜鹃花提取物和苦参提取物作为抗菌组合物，用于对皮肤表面进行洗涤和灭菌，防止食物的腐烂和中毒，以及牙周病，并用作天然抗菌剂 通过对皮肤表面的细菌和真菌具有抗菌活性，引起食物腐烂和食物中毒的细菌，变形链球菌和抗生素抗性细菌，对空气净化产品的过滤器。 一种抗菌组合物，其特征在于，含有作为茯苓的精制油成分的Dracocephalum foetidum的提取物或通过使用溶剂如水，醇，己烷，二氯甲烷，乙酸乙酯及其混合物制备的苦参甙提取物。