Abstract:
PURPOSE: A haematin substance has characteristically an LDL(low density lipoprotein)-antioxidation, reduces the concentration of cholesterol in blood, and inhibits the activity of liver microsome ACAT(acyl-CoA: cholesterol acyl-transferase). Thereby, the pharmaceutical composition containing the haematin has an excellent effect for treating or protecting specific diseases such as hyperlipidemia or arteriosclerosis. CONSTITUTION: The haematin used is conventionally derivable from Heartwood of Caesalpinia sappan, or is available industrially. The pharmaceutical composition is used to treat or protect hyperlipidemia or arteriosclerosis by using usual haematin in drug, beverage or food.
Abstract:
본 발명은 신규 지질과산화 저해 활성물질 및 그 제조방법에 관한 것으로 좀더 구체적으로 스트렙토미이세스(Streptomyces sp.)속에 속하는 방선균으로부터 생산되는 신규 지질과산화 저해 활성물질인 하기 주소식(Ⅰ)의 리프스타틴(lipstatin) 및 그 제조방법에 관한 것이다.