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公开(公告)号：KR1019970001164B1
公开(公告)日：1997-01-29
申请号：KR1019930010442
申请日：1993-06-09
Applicant: 한국과학기술연구원
IPC: C07D501/46
Abstract: Cephalosporin(I), useful as an antibiotic, manufacturied by reacting iodomethylcephem(II) and amine or heterocyclic amine(III) at 20-25 deg.C in presence of solvent to give intermediate compound, which is reacted with compound(IV) continuously. In formula, Q is N or CH, P is N-methyl-bis (2-hydroxyethyl)amine, racemic-3,4-trans-dihydroxy-1-methylpyrrolidine, (3R,4R)-3,4-dihydroxy-1-methylpyrrolidine,(3R,4R)-3,4-dihydroxy-1-methyl pyrrolidine,meso-3,4-dihydroxy-1-methylpyrro-lidine,(2S,4R)-4-hydroxy-1- methyl-2-pyrrolidine methanol,4-cis-dihydroxy-1-methylpyrrolidine,3,4-trans-dihydroxy-1-methylpiperidine and tropine.
Abstract translation: 头孢菌素（I），可用作抗生素，通过碘代甲基头孢烯（II）和胺或杂环胺（III）在20-25℃在溶剂存在下反应制备，得到中间体化合物，其与化合物（IV）连续反应 。 在式中，Q是N或CH，P是N-甲基 - 双（2-羟乙基）胺，外消旋-3,4-反式 - 二羟基-1-甲基吡咯烷，（3R，4R）-3,4-二羟基-1 - 甲基吡咯烷，（3R，4R）-3,4-二羟基-1-甲基吡咯烷，内消旋-3,4-二羟基-1-甲基吡咯 - 啶，（2S，4R）-4-羟基-1-甲基-2- 吡咯烷甲醇，4-顺式 - 二羟基-1-甲基吡咯烷，3,4-反式 - 二羟基-1-甲基哌啶和托品。
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Patent Agency Ranking
公开(公告)号：KR1019950000710A
公开(公告)日：1995-01-03
申请号：KR1019930010442
申请日：1993-06-09
Applicant: 한국과학기술연구원
IPC: C07D501/46
Abstract: 본 발명에서는 다음 일반식(Ⅰ)으로 표시되는 세팔로스포린 화합물 및 그의 제조방법이 제공된다;
상기식에서 Q는 질소 혹은 CH이고, P는 하나의 질소를 가지는 동시에 한개 또는 두개의 히드록실기를 가지는 비고리형 아민 또는 헤테로시클릭아민으로서 N-메틸-비스(2-히드록시에틸)아민, 라세믹-3,4-트란스-디히드록시-1-메틸피롤리딘, (3S,4S)-3,4-디히드록시-1-메틸피롤리딘, (3R,4R)-3,4-디히드록시-1-메틸피롤리딘, 메조-3,4-디히드록시-1-메틸피롤리딘, (2S,4R)-4-히드록시-1-메틸-2-피롤리딘메탄올, 3,4-시스-디히드록시-1-메틸피페리딘, 3,4-트란스-디히드록시-1-메틸피페리딘, 또는 트로핀이다.
본 발명의 세팔로스포린 화합물은 세프타지딤보다 더 광범위하며 월등한 향균력을 나타낸다.-
公开(公告)号：KR100012631B1
公开(公告)日：1982-08-28
申请号：KR1019810000917
申请日：1981-03-20
Applicant: 한국과학기술연구원
IPC: C07C221/00
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