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    바이오플라보노이드 화합물을 포함하는 혈당 강하용 조성물
    11.
    发明公开
    바이오플라보노이드 화합물을 포함하는 혈당 강하용 조성물 无效
    含有生物素化合物的高分子组合物

    公开(公告)号：KR1020010015494A

    公开(公告)日：2001-02-26

    申请号：KR1020000058704

    申请日：2000-10-06

    Applicant: 한국과학기술연구원

    Inventor： 복성해 ,  정태숙 ,  배기환 ,  박용복 ,  최명숙 ,  문석식 ,  권용국 ,  이은숙 ,  현병화 ,  최양규 ,  이철호 ,  안병태 ,  이새봄

    IPC: A23L1/29

    Abstract: PURPOSE: A hypotensive composition containing a bioflavonoid compound is provided to use itself as a therapeutic agent for glycosemia or as a health food. CONSTITUTION: A hypotensive composition comprises an effective amount, preferably, 0.01-50 wt.% of bioflavonoid of formula (1) and a pharmaceutical acceptable carrier thereof. The flavonoids consist in citrus fruits such as orange, lemon, citron, grapefruit and the like. The composition containing the flavonoid compounds is useful to treat glycosemia. To drop the blood sugar level, the flavonoid compound of formula (1) can be added to foods, for example meats, beverages, snacks, chocolates etc. In the formula (1), R1 is OH, rutinosyl or rhaminosyl group; R2 is H, OH or rutinosyl group; R3 is H or OH group; R4 is OH or methoxy group; X is single bond or double bond.

    Abstract translation: 目的：提供含有生物类黄酮化合物的低血压组合物作为糖血症的治疗剂或作为保健食品。 构成：低血压组合物包含有效量，优选0.01-50重量％的式（1）的生物类黄酮及其药学上可接受的载体。 黄酮类化合物包括橙子，柠檬，柚子，葡萄柚等柑橘类水果。 含有类黄酮化合物的组合物可用于治疗糖血症。 为了降低血糖水平，式（1）的类黄酮化合物可以加入到食品中，例如肉类，饮料，小吃，巧克力等。在式（1）中，R 1是OH，芸香酰基或脱氨基糖基; R2是H，OH或芸香糖基; R3是H或OH基; R4是OH或甲氧基; X是单键或双键。

    디오스민을 포함하는 동맥경화증 및 고지혈증의 예방 및치료용 조성물
    12.
    发明公开
    디오스민을 포함하는 동맥경화증 및 고지혈증의 예방 및치료용 조성물 失效
    含有二氢DI UL UL UL UL UL A A A A A A A A A A A A A A A A A A A A A A A A

    公开(公告)号：KR1020010007625A

    公开(公告)日：2001-01-26

    申请号：KR1020000058789

    申请日：2000-10-06

    Applicant: 한국과학기술연구원

    Inventor： 복성해 ,  정태숙 ,  배기환 ,  박용복 ,  최명숙 ,  문석식 ,  권용국 ,  이은숙 ,  현병화 ,  최양규 ,  이철호 ,  안병태 ,  이새봄

    IPC: A61K31/70

    Abstract: PURPOSE: A composition containing diosmin is provided for preventing and treating ateriosclerosis and hyperlipemia, thereby adhesion of macrophage-lipid complex on inner layer of artery is strongly inhibited, the amounts of cholesterol and fat in serum is decreased, and the activity of ACAT and HMG-CoA reductase is inhibited. CONSTITUTION: The amount of cholesterol in serum can be decreased by inhibiting the activities of acyl CoA:cholesterol-o-acyltransferase(ACAT) in liver, cholesterol ester transfer protein(CETP) transferring cholesterol between lipid proteins, 3-hydroxy-3-methylglutaryl coenzyme A(HMG-CoA) relating to biosynthesis of cholesterol in liver. Diosmin(C28H32O15, M.W. 608.55) may be obtained from vegetables and oranges or be synthesized. The composition containing an effective amount of diosmin, that is, 0.1 to 500 mg/kg, preferably 1 to 100 mg/kg a day, is orally or topically administrated into a patient and the dose thereof may be variable by patient's age, weight, sex, health, diet, severity of disease, and so on. The composition containing diosmin may be added into foods and drinks in an amount of 0.01 to 10 wt.%, preferably 0.1 to 5 wt.% of diosmin.

    Abstract translation: 目的：提供含有diosmin的组合物，用于预防和治疗动脉硬化和高脂血症，从而强烈抑制巨噬细胞 - 脂质复合物对动脉内层的粘附，血清中胆固醇和脂肪的含量降低，ACAT和HMG的活性 -CoA还原酶被抑制。 构成：通过抑制肝脏中酰基CoA：胆固醇 - 邻 - 酰基转移酶（ACAT），胆固醇酯转移蛋白（CETP）在脂质蛋白，3-羟基-3-甲基戊二醛之间转运胆固醇的活性，可以降低血清中的胆固醇含量 辅酶A（HMG-CoA）涉及胆固醇在肝脏中的生物合成。 Diosmin（C28H32O15，M.W. 608.55）可以从蔬菜和橙子中获得或被合成。 将包含有效量的二糖苷的组合物，即每天0.1至500mg / kg，优选1至100mg / kg，口服或局部施用于患者，其剂量可以根据患者的年龄，体重， 性别，健康，饮食，疾病严重程度等。 含有diosmin的组合物可以以diosmin的0.01〜10重量％，优选0.1〜5重量％的量添加到食品和饮料中。

    바이오플라보노이드계화합물을포함하는혈청고밀도지단백질증가용조성물
    13.
    发明公开
    바이오플라보노이드계화합물을포함하는혈청고밀도지단백질증가용조성물 失效
    用于增加含有生物素的血清高密度脂蛋白的组合物

    公开(公告)号：KR1020000026393A

    公开(公告)日：2000-05-15

    申请号：KR1019980043909

    申请日：1998-10-20

    Applicant: 한국과학기술연구원

    Inventor： 복성해 ,  현병화 ,  이철호 ,  최양규 ,  정태숙 ,  최명숙 ,  문석식 ,  권용국 ,  이은숙 ,  김성규 ,  문옥성 ,  이새봄 ,  안병태 ,  박용복

    IPC: A61K31/35

    CPC classification number: A61K31/352 ,  A61K31/7034 ,  A61K31/704

    Abstract: PURPOSE: A composition for increasing serum high density lipoprotein containing bioflavonoids is provided which is useful for preventing and treating diseases of cardiac circulatory organs. CONSTITUTION: The medical composition for increasing high density lipoprotein consists of(i) an effective amount of bioflavonoids of the following general formula(I) or a plant extract containing thereof, where each R¬1-R¬9 is independently hydrogen, hydroxy, alkoxy having 1-9 carbon atoms(optionally, which is able to include hydroxy, alkoxy having 1-5 carbon atoms, aryloxy or phenyl group which is substituted by one to three substituents selected from hydroxy, alkoxy, aryloxy, halogen, nitro and amido), cycloalkyloxy having 5-9 carbon atoms which is substituted by one to three substituents selected from hydroxy, alkoxy, aryloxy, halogen, nitro and amido, cycloalkylcarbonyloxy having 5-9 carbon atoms which is substituted by one to three substituents selected from hydroxy, alkoxy, aryloxy, halogen, nitro and amido, acyloxy having 2-10 or 16-18 carbon atoms(optionally, which is able to include hydroxy, alkoxy having 1-5 carbon atoms, aryloxy or phenyl group which is substituted by one to three substituents selected from hydroxy, alkoxy, aryloxy, halogen, nitro and amido), or rutinosyl, and X is either a single bond or a double bond; and (ii) a medically acceptable carrier.

    Abstract translation: 目的：提供一种用于增加血清高密度脂蛋白含有生物类黄酮的组合物，可用于预防和治疗心脏循环系统疾病。 构成：用于增加高密度脂蛋白的医药组合物包括（i）有效量的以下通式（I）的生物类黄酮或含有它们的植物提取物，其中每个R 1 -R 9独立地是氢，羟基， 具有1-9个碳原子的烷氧基（任选地，其可以包括羟基，具有1-5个碳原子的烷氧基，芳氧基或被一至三个选自羟基，烷氧基，芳氧基，卤素，硝基和酰氨基的取代基取代的苯基） ），具有5-9个碳原子的环烷氧基，其被一至三个选自羟基，烷氧基，芳氧基，卤素，硝基和酰氨基的取代基取代，具有5-9个碳原子的环烷基羰基氧基，被一至三个选自羟基， 烷氧基，芳氧基，卤素，硝基和酰氨基，具有2-10或16-18个碳原子的酰氧基（任选地，其可以包括羟基，具有1-5个碳原子的烷氧基，芳氧基或被一个 至三个选自羟基，烷氧基，芳氧基，卤素，硝基和酰氨基的取代基）或芸香糖基，X为单键或双键; 和（ii）医学上可接受的载体。

    탄닌 또는 탄닌 유래 페놀성 화합물을 포함하는동맥경화증, 고지혈증 및 지방간의 예방 및 치료용 식품조성물
    19.
    发明公开
    탄닌 또는 탄닌 유래 페놀성 화합물을 포함하는동맥경화증, 고지혈증 및 지방간의 예방 및 치료용 식품조성물 无效
    食品复合材料用于预防和治疗阿片样物质，高胆固醇和包括鞣制或鞣制酚醛化合物的肝硬化

    公开(公告)号：KR1020010030556A

    公开(公告)日：2001-04-16

    申请号：KR1020000062335

    申请日：2000-10-23

    Applicant: 한국과학기술연구원

    Inventor： 복성해 ,  정태숙 ,  배기환 ,  박용복 ,  최명숙 ,  문석식 ,  권용국 ,  이은숙 ,  현병화 ,  최양규 ,  이철호 ,  안병태 ,  이새봄

    IPC: A23L1/29 ,  A61K36/00 ,  A23L2/00

    Abstract: PURPOSE: Food composites including tannin or tannin-derived phenolics are provided to prevent and treat arteriosclerosis, hyperlipidemia and hepatic steatosis by dosing tannin, gallic acid or/and ellagic acid. CONSTITUTION: Tannin, gallic acid or/and ellagic acid is/are added to a food or a drink to prevent and treat arteriosclerosis. Tannin(C76H52O46) is extracted from acorns, persimmons and walnut shells. Gallic acid(C7H6O5) and ellagic acid(C14H6O8) are the decomposition products of tannin and have anticancer activities. The amount of the tannin-derived phenolics is from 0.01wt.% to 20wt.% according to the weight, age, gender, health status, diet, dosage time and method, excretory rate and disease level of patients.

    Abstract translation: 目的：提供包括单宁或单宁衍生物酚类的食品复合材料，以预防和治疗单宁，没食子酸或鞣花酸的动脉硬化，高脂血症和肝脂肪变性。 构成：将单宁，没食子酸或/和鞣花酸加入到食物或饮料中以预防和治疗动脉硬化。 单宁（C76H52O46）从橡子，柿子和核桃壳中提取。 没食子酸（C7H6O5）和鞣花酸（C14H6O8）是单宁的分解产物，具有抗癌活性。 根据体重，年龄，性别，健康状况，饮食，剂量时间和方法，患者的排泄率和病情水平，单宁衍生物酚类的含量为0.01重量％〜20重量％。

    엘라그산을 포함하는 동맥경화증, 고지혈증 및 지방간의예방 및 치료용 조성물
    20.
    发明公开
    엘라그산을 포함하는 동맥경화증, 고지혈증 및 지방간의예방 및 치료용 조성물 失效
    含有鞣制，酸性或非酸性的组合物，用于预防和治疗肠梗塞，高血压和肝脏疾病

    公开(公告)号：KR1020010015510A

    公开(公告)日：2001-02-26

    申请号：KR1020000062334

    申请日：2000-10-23

    Applicant: 한국과학기술연구원

    Inventor： 복성해 ,  정태숙 ,  배기환 ,  박용복 ,  최명숙 ,  문석식 ,  권용국 ,  이은숙 ,  현병화 ,  최양규 ,  이철호 ,  안병태 ,  이새봄

    IPC: A61K31/366

    Abstract: PURPOSE: A composition containing tannin, gallic acid or ellagic acid is provided for preventing and treating arteriosclerosis, hyperlipemia and liver diseases. CONSTITUTION: When tannin, gallic acid or ellagic acid are administrated into an animal body, they prevent the deposition of macrophage-lipid complex within the inner surface of arterial duct, decrease the concentration of GOT(glutamate-oxaloacetate transaminase), GPT(glutamate-pyruvate transaminase), gammaGTP(gamma-glutamyl transpeptidase), and lipid in serum, and strongly inhibit the damage of liver cells and the progress of fatty liver. The composition contains an effective of ellagic acid displaying an anticancer activity, that is 0.1 mg to 500 mg/weight kg a day. The composition is preferably administrated into an animal body 5 times a day in a dosage of 1 mg to 100 mg/weight kg.

    Abstract translation: 目的：提供含有单宁，没食子酸或鞣花酸的组合物，用于预防和治疗动脉硬化，高脂血症和肝脏疾病。 构成：当将单宁，没食子酸或鞣花酸施用于动物体内时，可防止巨噬细胞 - 脂质复合物在动脉管内表面沉积，降低GOT（谷氨酸 - 草酰乙酸转氨酶）浓度，GPT（谷氨酸 - 丙酮酸转氨酶），γGTP（γ-谷氨酰转肽酶）和血清中的脂质，并且强烈地抑制肝细胞的损伤和脂肪肝的进展。 组合物含有显示抗癌活性的有效的鞣花酸，即每天0.1mg至500mg /重量kg。 组合物优选以1mg至100mg / kg kg的剂量每天施用5次。

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