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公开(公告)号：KR1020140085815A
公开(公告)日：2014-07-08
申请号：KR1020120155487
申请日：2012-12-27
Applicant: 한국과학기술원
Abstract: The present invention relates to a selection method of RNA-binding antibodies and to an antibody specifically binding to BC200 RNAs. The selection method of the present invention can be suitably used for manufacturing human antibodies which recognize functional RNA structures, and the antibody specifically binding to BC200 RNA recognizes BC200 RNAs or controls actions thereof, thereby can be suitably applied in related medical fields.
Abstract translation: 本发明涉及RNA结合抗体和特异性结合BC200 RNA的抗体的选择方法。 本发明的选择方法可以适用于制造识别功能性RNA结构的人抗体，特异性结合BC200 RNA的抗体识别BC200 RNA或其控制作用，因此可以适用于相关医疗领域。
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公开(公告)号：KR101777344B1
公开(公告)日：2017-09-18
申请号：KR1020150148989
申请日：2015-10-26
Applicant: 한국과학기술원
IPC: C07K14/195 , C07K14/79 , C12N15/63 , C12P21/00
CPC classification number: C07K14/195 , C07K14/47 , C07K2319/00 , C07K2319/24
Abstract: 본발명은강하고안정한비오틴결합능을갖는모노머형아비딘유사단백질과이를둘 이상 포함하는비오틴에대한다가(multivalent) 결합능을갖는단백질컨쥬게이트, 상기모노머형아비딘유사단백질을암호화하는핵산분자, 및상기모노머형아비딘유사단백질을제조하는방법을제공한다. 본발명은모노머구조로인하여, 종래의테트라머형스트렙타비딘이나테트라머형이지만 1가(monovalent)인스트렙타비딘변형체에서발생하는올리고머화에의한수용체의기능방해문제점에서자유로운이점이있다.
Abstract translation: 本发明是强而稳定的单体型抗生物素蛋白类似具有生物素结合蛋白和具有多价（价）含有两个或更多个的核酸分子编码的单体型抗生物素蛋白样蛋白的生物素结合能力此蛋白缀合物，和所述单体类型 抗生物素蛋白样蛋白质。 本发明是从受体功能干扰问题的由链霉亲本变异体产生的寡聚化问题自由由于单体结构，常规的四链霉meohyeong或四meohyeong虽然一价（一价）。
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公开(公告)号：KR100936276B1
公开(公告)日：2010-01-13
申请号：KR1020070107774
申请日：2007-10-25
Applicant: 한국과학기술원
Abstract: 본 발명은 미세유체제어기술 기반으로 난관의 물리적 특징 및 생물적 특징을 모방한 수정란 및 난자 배양 시스템에 관한 것으로, 구체적으로 난관에서의 압축, 연동운동 및 섬모운동을 모방할 수 있는 장치를 미세유체제어기술과 조합함으로써 수정란 및 난자의 배양 및 발달을 효율적으로 하기 위한 방법을 제공하는 것이다. 본 발명에 의한 미세유체제어기술을 기반으로 한 난관 생체모방 수정란 배양 시스템은 수정란 및 난자의 효율적인 배양 및 발달을 도울 수 있기 때문에 줄기세포 및 발생학 연구의 편의성 및 높은 효율성을 제공하고, 일반 산부인과에서도 효과적으로 불임부부를 위한 인공수정 및 체외수정에 응용될 수 있다.
미세유체제어기술, 수정란 배양, 배양 시스템, 난관, 압축, 연동운동, 섬모운동-
14.发明公开
公开(公告)号：KR1020090041962A
公开(公告)日：2009-04-29
申请号：KR1020070107774
申请日：2007-10-25
Applicant: 한국과학기술원
Abstract: A culture system for fertilized egg or ovum using micro-fluid mechanics is provided to improve culture of fertilized egg and ovum, thereby being used for artificial insemination and external fertilization for infertility couples. A culture system for fertilized egg or ovum comprises: an inlet(1) for fertilized egg or ovum; an ovum movement micro-fluidic channel(10), linked with the inlet, in which ovum can move; a plurality of ovum compression micro-fluidic channels(20) formed by reducing diameter of the ovum movement micro-fluidic channel; and an outlet(60) for fertilized egg or ovum connected to the ovum movement micro-fluidic channel.
Abstract translation: 提供使用微量流体力学的受精卵或卵的培养系统，以改善受精卵和卵子的培养，从而用于不育夫妇的人工授精和外受精。 受精卵或卵子的培养系统包括：受精卵或卵子的入口（1） 与入口连接的卵移动微流体通道（10），卵子可移动; 通过减小卵移动微流体通道的直径形成的多个卵压缩微流体通道（20）; 以及用于受精卵或卵的出口（60），其连接到所述卵移动微流体通道。
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公开(公告)号：KR100891487B1
公开(公告)日：2009-04-01
申请号：KR1020070110988
申请日：2007-11-01
Applicant: 한국과학기술원
Abstract: An enucleation system of oocyte or ovum based on microfluid mechanics and an enucleation method of oocyte or ovum using the same are provided to perform single cells manipulation and to perform automatically and efficiently the enucleation of oocyte or ovum and to ensure high convenience and effectiveness of the stem cell and embryology research. An enucleation system of oocyte or ovum comprises oocyte or ovum culture medium and reagent inlet port(1); a microfluid channel part(7); and an envelope incision microfluidic channel part(10) reducing the diameter of an ovum movement microfluidic channel part; an ovum squeeze microfluidic channel part(16); an enucleated oocyte or the ovum vent(50); and a necleus vent(51) separated from oocyte or ovum.
Abstract translation: 提供基于微流体力学的卵母细胞或卵的摘除系统和使用其的卵母细胞或卵的摘除方法，以执行单细胞操作并自动和有效地执行卵母细胞或卵子的摘除，并确保高效的方便和有效性 干细胞和胚胎学研究。 卵母细胞或卵子的摘除系统包括卵母细胞或卵子培养基和试剂入口（1）; 微流体通道部分（7）; 和包膜切口微流体通道部分（10），其减小卵移动微流体通道部分的直径; 卵子挤压微流体通道部分（16）; 去核卵母细胞或排卵孔（50）; 和从卵母细胞或卵子分离出的心脏通气口（51）。
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Patent Agency Ranking
公开(公告)号：KR101804957B1
公开(公告)日：2018-01-10
申请号：KR1020160102605
申请日：2016-08-11
Applicant: 한국과학기술원
IPC: C12N15/113 , C12N15/63
CPC classification number: C12N15/113 , C12N15/63
Abstract: 본발명은미생물의생물막형성을조절할수 있는 sRNA를발현하는뉴클레오타이드를포함하는미생물의생물막형성조절용조성물, 상기뉴클레오타이드를포함하는재조합벡터, 상기재조합벡터로형질전환된형질전환세포및 상기재조합벡터를미생물에형질전환하는단계를포함하는미생물의생물막형성조절방법에관한것이다.
Abstract translation: 本发明微生物的重组载体，转化有重组载体细胞和重组载体生物膜形成用于调节含有表达的sRNA的核苷酸，可以控制含有核苷酸的微生物的生物膜形成微生物的组合物改变了开关 以及一种控制微生物生物膜形成的方法。
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公开(公告)号：KR101207274B1
公开(公告)日：2012-12-03
申请号：KR1020100107555
申请日：2010-11-01
Applicant: 한국과학기술원
Abstract: 본발명은음향재생장치에관한것이다. 본발명에따른음향재생장치는제1, 제2 및제3 음원신호를받아, 청취영역에서의음압레벨이청취영역이아닌영역에서의음압레벨보다높도록제1, 제2 및제3 음원신호의크기와위상을제어하여, 제1, 제2 및제3 제어음원신호를출력하는제어수단; 제1 제어음원신호를받아음향을재생하는제1 스피커; 제2 제어음원신호를받아음향을재생하는제2 스피커; 및제3 제어음원신호를받아음향을재생하는제3 스피커를포함하고, 상기제1, 제2 및제3 스피커는원형으로배열되며, 상기원형으로배열된상기제1, 제2 및제3 스피커의하방에상기청취영역이위치되어있다.
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公开(公告)号：KR1020130013675A
公开(公告)日：2013-02-06
申请号：KR1020110075419
申请日：2011-07-28
Applicant: 한국과학기술원
IPC: C12N15/11 , A61K48/00 , A61K31/7105 , A61P35/00
Abstract: PURPOSE: An siRNA which suppresses BC200 RNA activation and a pharmaceutical composition containing the same for suppressing tumor metastasis are provided to inhibit cancer cell migration and metastasis and to effectively treat cancer. CONSTITUTION: An siRNA which suppresses BC200 RNA(sequence number 1) activation has a base sequence of 5'-GUAACUUCCCUCAAAGCAA-3'(sequence number 2) or 5'- UUGCUUUGAGGGAAGUUAC-3'(sequence number 3). The siRNA additionally contains a dTdT base sequence at the 3'-end of the siRNA. A vector contains a polynucleotide which enables transcription of shRNA. The vector transcribes shRNA in a cell and the transcribed shRNA is converted into siRNA by cleavage using RNase III. A pharmaceutical composition for suppressing tumor metastasis contains the vector as an active ingredient. The composition additionally contains a pharmaceutically acceptable carrier. [Reference numerals] (AA) Negative control group siRNA
Abstract translation: 目的：提供抑制BC200 RNA活化的siRNA和抑制肿瘤转移的药物组合物，以抑制癌细胞迁移和转移并有效治疗癌症。 构成：抑制BC200 RNA（序列号1）活化的siRNA具有5'-GUAACUUCCCUCAAAGCAA-3'（序列号2）或5'UUGCUUGAGGGAAGUUAC-3'（序列号3）的碱基序列。 siRNA另外在siRNA的3'端含有dTdT碱基序列。 载体含有能够转录shRNA的多核苷酸。 载体在细胞中转录shRNA，转录的shRNA通过使用核糖核酸酶III的切割转化成siRNA。 用于抑制肿瘤转移的药物组合物含有作为活性成分的载体。 该组合物另外含有药学上可接受的载体。 （AA）阴性对照组siRNA
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公开(公告)号：KR1020120045771A
公开(公告)日：2012-05-09
申请号：KR1020100107555
申请日：2010-11-01
Applicant: 한국과학기술원
CPC classification number: G11B20/10481 , H04R5/02
Abstract: PURPOSE: A sound reproducing device is provided to grasp a transfer function considering features of a sound space, thereby enabling a user to obtain a sound signal optimized for generating a listening area. CONSTITUTION: The higher a sound pressure level of a listening area is than other areas except for the listening area, the more first, second, and third control sound signals a control unit outputs by controlling the amplitudes and phases of the first, second, and third sound signals. A first speaker(111) reproduces a sound by receiving the first control sound signal. A second speaker(112) reproduces a sound by receiving the second control sound signal. A third speaker(113) reproduces a sound by receiving the third control sound signal.
Abstract translation: 目的：提供一种考虑声音空间特征的传递函数的声音再现装置，从而使得用户能够获得优化以产生收听区域的声音信号。 构成：监听区域的声压级别除了听觉区域以外的其他区域越高，控制单元通过控制第一，第二和第三控制声音信号的幅度和相位来输出越多的第一，第二和第三控制声音信号， 第三声音信号。 第一扬声器（111）通过接收第一控制声音信号再现声音。 第二扬声器（112）通过接收第二控制声音信号再现声音。 第三扬声器（113）通过接收第三控制声音信号再现声音。
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