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公开(公告)号：KR100451671B1
公开(公告)日：2004-10-08
申请号：KR1020020028890
申请日：2002-05-24
Applicant: 한국화학연구원
IPC: C09K11/78
Abstract: PURPOSE: A red fluorescent substance for VUV(Vacuum UltraViolet), its preparation method and a plasma display panel or light emitting lamp containing the fluorescent substance are provided, to obtain a fluorescent substance having a high absorption peak at a range of VUV and an excellent emission luminance. CONSTITUTION: The red fluorescent substance is represented by (Y1-a-b-cGdaEubMc)2O3, wherein M is a rare earth metal selected from the group consisting of Dy, Sm, Nd, Tm, Pr and Sc; and 0
Abstract translation: 目的：提供用于VUV（真空UltraViolet）的红色荧光物质，其制备方法和含有该荧光物质的等离子体显示板或发光灯，以获得在VUV范围内具有高吸收峰的荧光物质， 发光亮度。 构成：红色荧光物质由（Y1-a-b-cGdaEubMc）2O3表示，其中M是选自Dy，Sm，Nd，Tm，Pr和Sc的稀土金属; 并且0 <= a <1,0.005≤b≤0.2，并且0.00001≤c≤0.1。 该方法包括以下步骤：将钇化合物，钆化合物，选自Dy，Sm，Nd，Tm，Pr和Sc的稀土金属的金属化合物，柠檬酸和乙二醇在溶剂中溶解成 准备前体溶液; 通过用气溶胶发生器喷雾所述溶液在300-1500℃下干燥和加热所述前体溶液以制备荧光物质粉末; 在800〜1500℃下加热荧光体粉末1〜5小时。
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公开(公告)号：KR100426346B1
公开(公告)日：2004-04-08
申请号：KR1020000072016
申请日：2000-11-30
Applicant: 한국화학연구원
Abstract: PURPOSE: A pharmaceutical compositions for hypercholesterolemia treatment using of self microemulsifying drug delivery system is provided, thereby improving the solubility and bioavailability of a drug hardly dissolved. CONSTITUTION: The pharmaceutical composition useful for hyperlipidemia treatment using a self microemulsifying drug delivery system(SMEDDS) comprises 1 to 20 wt.% of statin, 5 to 60 wt.% of surfactant, 10 to 60 wt.% of solubilizing agent and 10 to 60 wt.% of co-surfactant, wherein the statin is lovastatin or simvastatin; the surfactant is selected from caster oils, substituted caster oils, twins, spans and bridge; the solubilizing agent is selected from fatty acid ester consisting of propyleneglycol monocaprylate, polyglycolide of oleic acid and linoleic acid, propyleneglycol monolaurate and polyglyceryl dioleate, vegetable oils consisting of coconut oil, olive oil, corn oil, caster oil, macadamia nut oil, apricot oil and unsaturated fatty acid, purified oil, and hydrophobic solubilizing agent; and the co-surfactant is selected from polyethyleneglycol, propylene glycol, dimethylisosorbid and diethyleneglycolmonoethylether.
Abstract translation: 目的：提供一种使用自微乳化药物递送系统治疗高胆固醇血症的药物组合物，由此提高几乎不溶解的药物的溶解度和生物利用度。 组成：用于使用自微乳化药物递送系统（SMEDDS）进行高脂血症治疗的药物组合物包含1至20重量％的他汀，5至60重量％的表面活性剂，10至60重量％的增溶剂和10至 60重量％的辅助表面活性剂，其中他汀为洛伐他汀或辛伐他汀; 表面活性剂选自蓖麻油，取代的蓖麻油，双胞胎，跨度和桥; 增溶剂选自由丙二醇单辛酸酯，油酸和亚油酸的聚乙交酯，丙二醇单月桂酸酯和聚甘油二油酸酯组成的脂肪酸酯，由椰子油，橄榄油，玉米油，蓖麻油，澳大利亚坚果油，杏仁油 和不饱和脂肪酸，精制油和疏水增溶剂; 辅助表面活性剂选自聚乙二醇，丙二醇，二甲基异山梨醇和二甘醇单乙基醚。
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公开(公告)号：KR100411204B1
公开(公告)日：2003-12-18
申请号：KR1020010010385
申请日：2001-02-28
Applicant: 주식회사 아모레퍼시픽그룹 , 한국화학연구원 , 선진뷰티사이언스(주)
Abstract: PURPOSE: A process of preparing double silica-titania composite powders by allowing silica to support titanium dioxide and then coating the surface of the silica with titanium oxide is provided. Whereby, the composite powders are excellent in irregular reflection and low in hiding power and can be used in a make-up product, ultraviolet screening products, etc.. CONSTITUTION: Silica is allowed to support a large amount of titanium dioxide by the reaction of silica, titanium alkoxide and an aqueous alcohol solution to produce a silica-titania composite carried with titanium dioxide, which is reacted with titanium chloride and the aqueous alcohol solution to produce silica-titania composite powder, which are surface-modified with silicon oil or a fatty acid soap to produce the double silica-titania composite powder.
Abstract translation: 目的：提供一种通过使二氧化硅负载二氧化钛，然后用二氧化钛涂覆二氧化硅表面来制备二氧化硅 - 二氧化钛复合粉末的方法。 由此，该复合粉末具有优异的不规则反射和低遮盖力，并且可以用于化妆品，紫外线屏蔽产品等等。构成：二氧化硅可以通过反应支撑大量的二氧化钛 二氧化硅，钛醇盐和醇水溶液反应以生产二氧化钛 - 二氧化钛复合物，所述二氧化钛 - 二氧化钛复合物与二氧化钛反应，其与氯化钛和醇水溶液反应以生产二氧化硅 - 二氧化钛复合物粉末，其用硅油或 脂肪酸皂以生产双重二氧化硅 - 二氧化钛复合粉末。
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公开(公告)号：KR1020020013988A
公开(公告)日：2002-02-25
申请号：KR1020000046447
申请日：2000-08-10
IPC: C07D413/14
CPC classification number: C07D413/06 , C07D205/08 , C07D265/06 , C07D265/14 , C07D487/04 , C07F9/65611 , Y02P20/55
Abstract: PURPOSE: Provided is an intermediate, azetidinone compound which is useful in manufacturing beta-methylcarbapenem antibiotics. And its manufacturing method is provided. CONSTITUTION: The intermediate of carbapenem, azetidinone compound, is represented by the formula(1), wherein R is hydrogen or hydroxy protective group, R1 and R2 are individually C1-C15 alkyl, benzyl, represent 5-6 membered cyclic compound to which R1 and R2 are linked, or hetero cyclic group including at least one oxygen or sulfur atom; R3 is lower alkyl group or lower alkylester group; and R4 is benzene, halogen, lower alkyloxy group, or nitro group substituted benzene ring.
Abstract translation: 目的：提供可用于制备β-甲基碳青霉烯类抗生素的中间体氮杂环丁酮化合物。 并提供其制造方法。 构成：碳青霉烯类氮杂环丁酮化合物的中间体由式（1）表示，其中R是氢或羟基保护基，R1和R2分别是C1-C15烷基，苄基，代表5-6元环状化合物，其中R1 或R 2连接，或包含至少一个氧原子或硫原子的杂环基; R3是低级烷基或低级烷基酯基; R4为苯，卤素，低级烷氧基或硝基取代苯环。
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公开(公告)号：KR1020010038923A
公开(公告)日：2001-05-15
申请号：KR1019990047103
申请日：1999-10-28
IPC: C07D213/89
Abstract: PURPOSE: A method for producing alkyl cis-4-amino-3- methoxy-1-piperidine carboxylate hydrochloride is provided, thereby the titled compound having high purity can be easily produced because the further purification steps are not required and the production is performed under the mild conditions. CONSTITUTION: The method for producing alkyl cis-4-amino-3- methoxy-1-piperidine carboxylate hydrochloride represented by formula (I) comprises the steps of: reacting alkyl trans-4-bromo-3- hydroxypiperidine-1-carboxylate of formula (III) with benzoyl isocyanate in organic solvents to produce alkyl trans-4-bromo-3- benzoylaminocarbonyloxy-1-piperidine carboxylate of formula (IV); adding base such as kalium tert-butoxide into the compound of formula (IV) to produce alkyl cis-1-benzoyl-2-oxo- hexahydro-oxazolo(5,4,c) pyridine-5-carboxylate of formula (V); reacting the compound of formula (V) with lithium hydroxide·H2O to produce alkyl cis-2-oxo-hexahydro-oxazolo(5,4-c) pyridine-5-carboxylate of formula (VI); reacting the compound of formula (VI) with triethylamine, di-tert-butoxy dicarbonate, and dimethylaminopyridine to produce cis-1-tert- butoxycarbonyl-5- ethoxycarbonyl-2-oxo- hexahydro- oxazolo(5,4-c) pyridine of formula (VII); reacting the compound of formula (VII) with cesium carbonate to produce alkyl cis-4-tert- butoxycarbonyl amino-3-hydroxy-1-piperidine carboxylate of formula (VIII); adding sodium hydroxide, dimethyl sulfate, and benzyltriethyl ammonium chloride into the compound of formula (VIII) to produce alkyl cis-4-tert-butoxycarbonylamino- 3-methoxy-1-piperidine carboxylate of formula (IX); and adding hydrogen chloride dissolved organic solvent into the compound of formula (IX) to produce alkyl cis-4-amino-3- methoxy-1-piperidine carboxylate hydrochloride of formula (I).
Abstract translation: 目的：制备顺式-4-氨基-3-甲氧基-1-哌啶羧酸烷基酯盐酸盐的方法，由于不需要进一步的纯化步骤，因此可以容易地制备具有高纯度的标题化合物，并且在 温和的条件。 构成：由式（I）表示的顺式-4-氨基-3-甲氧基-1-哌啶羧酸盐酸烷基酯盐酸盐的制备方法包括以下步骤：使反式-4-溴-3-羟基哌啶-1-羧酸烷基酯 （III）与有机溶剂中的苯甲酰异氰酸酯反应以制备式（IV）的反式-4-溴-3-苯甲酰氨基羰基氧基-1-哌啶羧酸烷基酯; 将碱如叔丁醇钾加入到式（IV）化合物中以制备式（V）的顺式-1-苯甲酰基-2-氧代六氢恶唑并（5,4，c）吡啶-5-羧酸烷基酯; 使式（Ⅴ）化合物与氢氧化锂·H 2 O反应生成式（Ⅵ）的烷基顺式-2-氧代 - 六氢 - 恶唑并（5,4-c）吡啶-5-羧酸酯; 使式（VI）化合物与三乙胺，二叔丁氧基二碳酸酯和二甲基氨基吡啶反应，得到顺式-1-叔丁氧基羰基-5-乙氧基羰基-2-氧代六氢 - 恶唑并（5,4-c）吡啶 式（Ⅶ）; 使式（Ⅶ）化合物与碳酸铯反应制得式（Ⅷ）的顺式-4-叔丁氧基羰基氨基-3-羟基-1-哌啶羧酸烷基酯; 向式（Ⅷ）化合物中加入氢氧化钠，硫酸二甲酯和苄基三乙基氯化铵，得到式（Ⅸ）的顺式-4-叔丁氧基羰基氨基-3-甲氧基-1-哌啶羧酸烷基酯; 并向式（IX）化合物中加入氯化氢溶解的有机溶剂，得到式（I）的烷基顺式-4-氨基-3-甲氧基-1-哌啶羧酸盐酸盐。
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Patent Agency Ranking
公开(公告)号：KR1019990040552A
公开(公告)日：1999-06-05
申请号：KR1019970060989
申请日：1997-11-19
Applicant: 한국화학연구원
IPC: C07D471/04
Abstract: 본 발명은 그람 양성균은 물론 녹농균을 제외한 그람 음성균에 대하여 우수한 항균 작용을 나타내는, 하기 화학식 1a 또는 화학식 1b로 표시되는 카르바페넴 유도체 화합물, 이의 제조 방법 및 이를 포함하는 약제학적 조성물을 제공한다.
식 중, R은 수소, 카르복실 음이온, 카르복실 보호기, 또는 제약학상 허용가능한 무기 또는 유기염이고, R
1 은 수소 또는 히드록시 보호기이며, R
2 는 C
1 내지 C
5 의 시클릭 또는 비시클릭 저급 알킬기 또는 방향족 알킬기이거나, 또는 질소, 황 및 산소로 이루어지는 군으로부터 선택된 1개 이상의 헤테로 원자를 함유하는 모노 또는 비시클릭, 포화 또는 불포화 고리인, 임의 치환된 헤테로시클릭 라디칼이고, R
3 은 수소, C
1 내지 C
5 의 시클릭 또는 비시클릭 저급 알킬기, 카르바모일기 또는 아세틸기이다.-
公开(公告)号：KR100496051B1
公开(公告)日：2005-06-16
申请号：KR1020020062483
申请日：2002-10-14
Applicant: 한국화학연구원
IPC: C09K11/77
Abstract: 본 발명은 하기 화학식 1로 표시된, 유로피움으로 활성화된 이트륨 가돌리늄 보레이트계 적색 형광체 및 그의 제조방법에 관한 것으로서, 본 발명에 따른 이트륨 가돌리늄 보레이트계 형광체는 전구체 용액 제조시 형광체 모체로서 이트륨(Y), 가돌리늄(Gd) 및 붕소(B)를 사용하고 상기 모체를 도핑하기 위한 활성제로서 유로피움(Eu)을 사용하며, 특히 전구체 용액의 수소이온 농도를 특정 범위로 제어함에 따라, 발광 특성이 우수하고 입자 형태 및 분포가 크게 향상되며, 박형화 및 경량화가 용이하여 평판디스플레이 형광체로서 유용하게 사용될 수 있다:
(Y
1-xy Gd
x )BO
3 :Eu
y
상기 식에서,
0〈x〈1이고, 0-
公开(公告)号：KR1020040033407A
公开(公告)日：2004-04-28
申请号：KR1020020062483
申请日：2002-10-14
Applicant: 한국화학연구원
IPC: C09K11/77
CPC classification number: C09K11/7797 , C01P2004/03 , C04B35/6261 , C04B35/6267 , C04B2235/3224 , H01J31/123 , Y02B20/181
Abstract: PURPOSE: An yttrium gadolinium borate-based fluorescent substance activated with europium and its preparation method are provided, to improve a luminous characteristic and the shape and distribution of particles by control the pH of a precursor solution. CONSTITUTION: The yttrium gadolinium borate-based fluorescent substance is represented by (Y(1-x-y)Gdx)BO3:Euy, wherein 0
Abstract translation: 目的：提供用铕活化的钇钆硼酸盐荧光物质及其制备方法，通过控制前体溶液的pH来提高颗粒的发光特性和形状和分布。 构成：由（Y（1-x-y）Gd x）BO 3：Eu y表示的硼酸钇基荧光物质，其中0
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公开(公告)号：KR1020030083839A
公开(公告)日：2003-11-01
申请号：KR1020020022024
申请日：2002-04-22
Applicant: 한국화학연구원
CPC classification number: C09K11/7787 , C01P2004/03 , C01P2004/60 , C01P2004/64 , C04B35/6267 , C04B2235/3224 , Y02B20/181
Abstract: PURPOSE: A method for preparing a nanosized red fluorescent substance and a nanosized red fluorescent substance prepared by the method are provided, to improve the luminous efficiency and the distribution of particle size. CONSTITUTION: The method comprises the steps of dissolving one selected from an yttrium compound, a gadolinium compound or their mixture, an europium compound, an organic acid and polyol for forming a polymer, and a flux to a solvent to prepare a fluorescent substance precursor solution; injecting the precursor solution into a spray device to form aerosol with a diameter of 0.1-100 micrometers; drying and thermally decomposing the aerosol to prepare a fluorescent substance powder, and heating the obtained powder. The nanosized red fluorescent substance is represented by (Y1-xGdx)2O3:Euy, wherein 0
Abstract translation: 目的：提供一种制备纳米尺度红色荧光物质的方法和通过该方法制备的纳米尺寸红色荧光物质，以提高发光效率和粒径分布。 方法：该方法包括将选自钇化合物，钆化合物或其混合物，铕化合物，有机酸和用于形成聚合物的多元醇中的一种溶解到溶剂中以制备荧光物质前体溶液的步骤 ; 将前体溶液注入喷雾装置以形成直径为0.1-100微米的气溶胶; 干燥并热分解气溶胶以制备荧光物质粉末，并加热所得粉末。 纳米尺度的红色荧光物质由（Y1-xGdx）2O3：Euy表示，其中0 <= x <= 1且0.001 <= y <0.5。 优选地，助熔剂是选自Na 2 CO 3，KCl，NaCl，LiCl，Li 2 CO 3，K 2 CO 3和KBr中的任一种。
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公开(公告)号：KR100377448B1
公开(公告)日：2003-03-26
申请号：KR1020000046447
申请日：2000-08-10
IPC: C07D413/14
CPC classification number: C07D413/06 , C07D205/08 , C07D265/06 , C07D265/14 , C07D487/04 , C07F9/65611 , Y02P20/55
Abstract: There is disclosed an azetidinone compound of the formula (I):wherein R is hydrogen, or a hydroxy protecting group, R1 and R2 are each independently alkyl of 1-15 carbon atoms, benzyl or cyclized together with the carbon atom to which they are attached to form a 5 or 6-membered cyclic hydrocarbon or a heterocyclic radical having one or two hetero ring atoms, said hetero ring atoms being selected from the group consisting of O and S; R3 is lower alkyl or -COO(lower alkyl) R4 is phenyl, or phenyl substituted with halogen, lower alkoxy or nitro which is useful as a synthetic intermediate to the 1'beta-methylcarbapenem-type antibacterial agent.
Abstract translation: 公开了式（I）的氮杂环丁酮化合物：其中R是氢或羟基保护基，R 1和R 2各自独立地是1-15个碳原子的烷基，苄基或与它们所连接的碳原子一起环化 连接形成5或6元环烃或具有一个或两个杂环原子的杂环基，所述杂环原子选自O和S; R3是低级烷基或-COO（低级烷基），R4是苯基或被卤素，低级烷氧基或硝基取代的苯基，它可用作1'β-甲基碳代青霉烯类抗菌剂的合成中间体。
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