公开(公告)号：KR1020020079654A

公开(公告)日：2002-10-19

申请号：KR1020020052421

申请日：2002-09-02

Applicant: 동화약품주식회사 ,  한국화학연구원

Inventor： 이철해 ,  김봉진 ,  정원장 ,  김재학 ,  정희정 ,  김은정 ,  송신섭 ,  정용호 ,  곽현정 ,  이진수 ,  편도규

IPC: C07D265/22

Abstract: PURPOSE: Provided are azetidinone compound of the formula(I) as an intermediate useful for the manufacture of carbapenem antibiotics and a process for the preparation thereof. CONSTITUTION: The azetidine compound is represented by the formula(I). It is useful as an intermediate for the manufacture of beta-methylcarbapenem antibiotics and manufactured by reacting 4-acetoxy-azetidine compound of the formula(II) and alpha-halo propionic acid amide compound of the formula(III).

Abstract translation: 目的：提供式（I）的氮杂环丁酮化合物作为制备碳青霉烯类抗生素的中间体及其制备方法。 构成：氮杂环丁烷化合物由式（I）表示。 通过使式（II）的4-乙酰氧基 - 氮杂环丁烷化合物与式（III）的α-卤代丙酸酰胺化合物反应制备β-甲基碳青霉烯类抗生素的中间体是有用的。

公开(公告)号：KR100385364B1

公开(公告)日：2003-05-27

申请号：KR1020020052421

申请日：2002-09-02

Applicant: 동화약품주식회사 ,  한국화학연구원

Inventor： 이철해 ,  김봉진 ,  정원장 ,  김재학 ,  정희정 ,  김은정 ,  송신섭 ,  정용호 ,  곽현정 ,  이진수 ,  편도규

IPC: C07D265/22

Abstract: PURPOSE: Provided are azetidinone compound of the formula(I) as an intermediate useful for the manufacture of carbapenem antibiotics and a process for the preparation thereof. CONSTITUTION: The azetidine compound is represented by the formula(I). It is useful as an intermediate for the manufacture of beta-methylcarbapenem antibiotics and manufactured by reacting 4-acetoxy-azetidine compound of the formula(II) and alpha-halo propionic acid amide compound of the formula(III).

Abstract translation: 目的：提供式（I）的氮杂环丁酮化合物作为可用于制备碳青霉烯类抗生素的中间体及其制备方法。 构成：氮杂环丁烷化合物由式（I）表示。 它可用作制备β-甲基碳青霉烯类抗生素的中间体，并通过使式（II）的4-乙酰氧基 - 氮杂环丁烷化合物与式（III）的α-卤代丙酰胺化合物反应制备。

公开(公告)号：KR100377448B1

公开(公告)日：2003-03-26

申请号：KR1020000046447

申请日：2000-08-10

Applicant: 동화약품주식회사 ,  한국화학연구원

Inventor： 이철해 ,  김봉진 ,  정원장 ,  김재학 ,  정희정 ,  김은정 ,  송신섭 ,  정용호 ,  곽현정 ,  이진수 ,  편도규

IPC: C07D413/14

CPC classification number: C07D413/06 ,  C07D205/08 ,  C07D265/06 ,  C07D265/14 ,  C07D487/04 ,  C07F9/65611 ,  Y02P20/55

Abstract: There is disclosed an azetidinone compound of the formula (I):wherein R is hydrogen, or a hydroxy protecting group, R1 and R2 are each independently alkyl of 1-15 carbon atoms, benzyl or cyclized together with the carbon atom to which they are attached to form a 5 or 6-membered cyclic hydrocarbon or a heterocyclic radical having one or two hetero ring atoms, said hetero ring atoms being selected from the group consisting of O and S; R3 is lower alkyl or -COO(lower alkyl) R4 is phenyl, or phenyl substituted with halogen, lower alkoxy or nitro which is useful as a synthetic intermediate to the 1'beta-methylcarbapenem-type antibacterial agent.

Abstract translation: 公开了式（I）的氮杂环丁酮化合物：其中R是氢或羟基保护基，R 1和R 2各自独立地是1-15个碳原子的烷基，苄基或与它们所连接的碳原子一起环化 连接形成5或6元环烃或具有一个或两个杂环原子的杂环基，所述杂环原子选自O和S; R3是低级烷基或-COO（低级烷基），R4是苯基或被卤素，低级烷氧基或硝基取代的苯基，它可用作1'β-甲基碳代青霉烯类抗菌剂的合成中间体。

公开(公告)号：KR100323652B1

公开(公告)日：2002-03-29

申请号：KR1019990047103

申请日：1999-10-28

Applicant: 동화약품주식회사 ,  한국화학연구원

Inventor： 이철해 ,  김봉진 ,  정용호 ,  편도규 ,  송지섭 ,  정희정 ,  곽현정 ,  김은정

IPC: C07D213/89

Abstract: 본발명은알킬트란스-4-브로모-3-하이드록시-1-피페리딘카르복실레이트를출발물질로하여알킬트란스-4-브로모-3-벤조일아미노카르보닐옥시-1-피페리딘카르복실레이트, 알킬시스-1-벤조일-2-옥소-헥사하이드로-옥사졸로[5,4-c] 피리딘-5-카르복실레이트, 알킬시스-2-옥소-헥사하이드로-옥사졸로[5,4-c] 피리딘-5-카르복실레이트, 시스-1--부톡시카르보닐-5-에톡시카르보닐-2-옥소-헥사하이드로옥사졸로[5,4-c] 피리딘, 알킬시스-4--부톡시카르보닐아미노-3-하이드록시-1-피페리딘카르복실레이트및 알킬시스-4--부톡시카르보닐아미노-3-메톡시-1-피페리딘카르복실레이트의중간물질을거쳐시사프라이드의중간체인알킬시스-4-아미노-3-메톡시-1-피페리딘카르복실레이트염산염을제조하는방법에관한것이다. 본발명은종래기술과는달리모든반응이온화한조건에서진행되고각 단계마다특별히정제과정을필요로하지않으며위험한나트륨하이드라이드나수소가스를사용하지않아종래기술의단점을모두극복함으로써산업화가용이한장점을가지고있으며또한알킬시스-4-아미노-3-메톡시-1-피페리딘카르복실레이트를취급이불편하고순도(80% 이하)가떨어지는종래기술의액상형태와는달리공업적으로다루기쉬운고순도(98% 이상)의분말형태로얻을수 있는장점이있다.

公开(公告)号：KR1020020013988A

公开(公告)日：2002-02-25

申请号：KR1020000046447

申请日：2000-08-10

Applicant: 동화약품주식회사 ,  한국화학연구원

Inventor： 이철해 ,  김봉진 ,  정원장 ,  김재학 ,  정희정 ,  김은정 ,  송신섭 ,  정용호 ,  곽현정 ,  이진수 ,  편도규

IPC: C07D413/14

CPC classification number: C07D413/06 ,  C07D205/08 ,  C07D265/06 ,  C07D265/14 ,  C07D487/04 ,  C07F9/65611 ,  Y02P20/55

Abstract: PURPOSE: Provided is an intermediate, azetidinone compound which is useful in manufacturing beta-methylcarbapenem antibiotics. And its manufacturing method is provided. CONSTITUTION: The intermediate of carbapenem, azetidinone compound, is represented by the formula(1), wherein R is hydrogen or hydroxy protective group, R1 and R2 are individually C1-C15 alkyl, benzyl, represent 5-6 membered cyclic compound to which R1 and R2 are linked, or hetero cyclic group including at least one oxygen or sulfur atom; R3 is lower alkyl group or lower alkylester group; and R4 is benzene, halogen, lower alkyloxy group, or nitro group substituted benzene ring.

Abstract translation: 目的：提供可用于制备β-甲基碳青霉烯类抗生素的中间体氮杂环丁酮化合物。 并提供其制造方法。 构成：碳青霉烯类氮杂环丁酮化合物的中间体由式（1）表示，其中R是氢或羟基保护基，R1和R2分别是C1-C15烷基，苄基，代表5-6元环状化合物，其中R1 或R 2连接，或包含至少一个氧原子或硫原子的杂环基; R3是低级烷基或低级烷基酯基; R4为苯，卤素，低级烷氧基或硝基取代苯环。

公开(公告)号：KR1020010038923A

公开(公告)日：2001-05-15

申请号：KR1019990047103

申请日：1999-10-28

Applicant: 동화약품주식회사 ,  한국화학연구원

Inventor： 이철해 ,  김봉진 ,  정용호 ,  편도규 ,  송지섭 ,  정희정 ,  곽현정 ,  김은정

IPC: C07D213/89

Abstract: PURPOSE: A method for producing alkyl cis-4-amino-3- methoxy-1-piperidine carboxylate hydrochloride is provided, thereby the titled compound having high purity can be easily produced because the further purification steps are not required and the production is performed under the mild conditions. CONSTITUTION: The method for producing alkyl cis-4-amino-3- methoxy-1-piperidine carboxylate hydrochloride represented by formula (I) comprises the steps of: reacting alkyl trans-4-bromo-3- hydroxypiperidine-1-carboxylate of formula (III) with benzoyl isocyanate in organic solvents to produce alkyl trans-4-bromo-3- benzoylaminocarbonyloxy-1-piperidine carboxylate of formula (IV); adding base such as kalium tert-butoxide into the compound of formula (IV) to produce alkyl cis-1-benzoyl-2-oxo- hexahydro-oxazolo(5,4,c) pyridine-5-carboxylate of formula (V); reacting the compound of formula (V) with lithium hydroxide·H2O to produce alkyl cis-2-oxo-hexahydro-oxazolo(5,4-c) pyridine-5-carboxylate of formula (VI); reacting the compound of formula (VI) with triethylamine, di-tert-butoxy dicarbonate, and dimethylaminopyridine to produce cis-1-tert- butoxycarbonyl-5- ethoxycarbonyl-2-oxo- hexahydro- oxazolo(5,4-c) pyridine of formula (VII); reacting the compound of formula (VII) with cesium carbonate to produce alkyl cis-4-tert- butoxycarbonyl amino-3-hydroxy-1-piperidine carboxylate of formula (VIII); adding sodium hydroxide, dimethyl sulfate, and benzyltriethyl ammonium chloride into the compound of formula (VIII) to produce alkyl cis-4-tert-butoxycarbonylamino- 3-methoxy-1-piperidine carboxylate of formula (IX); and adding hydrogen chloride dissolved organic solvent into the compound of formula (IX) to produce alkyl cis-4-amino-3- methoxy-1-piperidine carboxylate hydrochloride of formula (I).

Abstract translation: 目的：制备顺式-4-氨基-3-甲氧基-1-哌啶羧酸烷基酯盐酸盐的方法，由于不需要进一步的纯化步骤，因此可以容易地制备具有高纯度的标题化合物，并且在 温和的条件。 构成：由式（I）表示的顺式-4-氨基-3-甲氧基-1-哌啶羧酸盐酸烷基酯盐酸盐的制备方法包括以下步骤：使反式-4-溴-3-羟基哌啶-1-羧酸烷基酯 （III）与有机溶剂中的苯甲酰异氰酸酯反应以制备式（IV）的反式-4-溴-3-苯甲酰氨基羰基氧基-1-哌啶羧酸烷基酯; 将碱如叔丁醇钾加入到式（IV）化合物中以制备式（V）的顺式-1-苯甲酰基-2-氧代六氢恶唑并（5,4，c）吡啶-5-羧酸烷基酯; 使式（Ⅴ）化合物与氢氧化锂·H 2 O反应生成式（Ⅵ）的烷基顺式-2-氧代 - 六氢 - 恶唑并（5,4-c）吡啶-5-羧酸酯; 使式（VI）化合物与三乙胺，二叔丁氧基二碳酸酯和二甲基氨基吡啶反应，得到顺式-1-叔丁氧基羰基-5-乙氧基羰基-2-氧代六氢 - 恶唑并（5,4-c）吡啶 式（Ⅶ）; 使式（Ⅶ）化合物与碳酸铯反应制得式（Ⅷ）的顺式-4-叔丁氧基羰基氨基-3-羟基-1-哌啶羧酸烷基酯; 向式（Ⅷ）化合物中加入氢氧化钠，硫酸二甲酯和苄基三乙基氯化铵，得到式（Ⅸ）的顺式-4-叔丁氧基羰基氨基-3-甲氧基-1-哌啶羧酸烷基酯; 并向式（IX）化合物中加入氯化氢溶解的有机溶剂，得到式（I）的烷基顺式-4-氨基-3-甲氧基-1-哌啶羧酸盐酸盐。

公开(公告)号：KR100441901B1

公开(公告)日：2004-07-27

申请号：KR1020010039222

申请日：2001-07-02

Applicant: 한국화학연구원 ,  일동홀딩스(주)

Inventor： 이철해 ,  김봉진 ,  강재훈 ,  편도규 ,  김재학 ,  정희정 ,  전미애 ,  정원장 ,  권지웅 ,  박용엽 ,  김기원

IPC: C07D501/57

Abstract: PURPOSE: Provided is an improved process for the preparation of cephalosporin derivatives from (cis)-3-acetoxypropen-cephalosporinic acid in higher yield. CONSTITUTION: The improved process for the preparation of cephalosporin derivative of the formula(1) comprises the steps of: radical reaction of a compound of the formula(5) with benzenthiol and azobisisobutyronitrile as a radical initiator in an organic solvent to convert it into a trans form; continuous reaction of the reaction product with a compound of the formula(10) to obtain a compound of the formula(3); and reaction of the compound of the formula(3) with an acylated compound of the formula(8) and a silylated compound of the formula(9).

Abstract translation: 目的：提供一种由（顺式）-3-乙酰氧基丙烯酸头孢菌素酸以较高产率制备头孢菌素衍生物的改进方法。 构成：制备式（1）头孢菌素衍生物的改进方法包括以下步骤：将式（5）化合物与苯硫醇和偶氮二异丁腈作为自由基引发剂在有机溶剂中进行自由基反应，将其转化为 转变; 使反应产物与式（10）化合物连续反应，得到式（3）化合物; 和式（3）化合物与式（8）酰化化合物和式（9）甲硅烷基化化合物的反应。

公开(公告)号：KR1020030002925A

公开(公告)日：2003-01-09

申请号：KR1020010039222

申请日：2001-07-02

Applicant: 한국화학연구원 ,  일동홀딩스(주)

Inventor： 이철해 ,  김봉진 ,  강재훈 ,  편도규 ,  김재학 ,  정희정 ,  전미애 ,  정원장 ,  권지웅 ,  박용엽 ,  김기원

IPC: C07D501/57

Abstract: PURPOSE: Provided is an improved process for the preparation of cephalosporin derivatives from (cis)-3-acetoxypropen-cephalosporinic acid in higher yield. CONSTITUTION: The improved process for the preparation of cephalosporin derivative of the formula(1) comprises the steps of: radical reaction of a compound of the formula(5) with benzenthiol and azobisisobutyronitrile as a radical initiator in an organic solvent to convert it into a trans form; continuous reaction of the reaction product with a compound of the formula(10) to obtain a compound of the formula(3); and reaction of the compound of the formula(3) with an acylated compound of the formula(8) and a silylated compound of the formula(9).

Abstract translation: 目的：提供从（顺式）-3-乙酰氧基丙基 - 头孢菌酸制备头孢菌素衍生物的较高产率的改进方法。 构成：制备式（1）的头孢菌素衍生物的改进方法包括以下步骤：将式（5）化合物与苯并二酚和偶氮二异丁腈作为自由基引发剂在有机溶剂中进行自由基反应，将其转化为 转变; 反应产物与式（10）化合物的连续反应，得到式（3）化合物; 和式（3）的化合物与式（8）的酰化化合物和式（9）的甲硅烷基化合物的反应。

公开(公告)号：KR1020030023968A

公开(公告)日：2003-03-26

申请号：KR1020010056740

申请日：2001-09-14

Applicant: 한국화학연구원

Inventor： 김봉진 ,  이철해 ,  김재학 ,  정희정 ,  편도규 ,  전미애 ,  권지웅 ,  김현주

IPC: C07D477/14

CPC classification number: Y02P20/55

Abstract: PURPOSE: Provided are carbapenem derivatives represented by formula(1) and a preparation method thereof. The carbapenem derivatives have antibacterial activity against the resistant strains such as methicillin resistant Staphylococcus aureus(MRSA) and resistant strain against Ofloxacin. CONSTITUTION: The method of preparation comprises: reacting a compound of formula(2) with a compound of formula(3) to make an ester derivatives of carbapenem represented by formula(4); and de-protecting carboxy group and hydroxy group. In formula(1), X is S or O atom; Y is hydrogen or halogen atom on a certain location in phenyl group, or C1-2 alkoxy group; M is hydrogen atom or a pair ion forming a pharmaceutically allowable salt. In formula(2,3 and 4), R1 is hydrogen atom or hydroxy protecting group; R2 is carboxy protecting group; X is S or O atom; Y is hydrogen or halogen atom on a certain location in phenyl group.

Abstract translation: 目的：提供式（1）表示的碳青霉烯衍生物及其制备方法。 碳青霉烯衍生物对抗性菌株如耐甲氧西林金黄色葡萄球菌（MRSA）和耐氧沙星的抗性菌株具有抗菌活性。 构成：制备方法包括：使式（2）化合物与式（3）化合物反应，制得由式（4）表示的碳青霉烯的酯衍生物; 并脱保护羧基和羟基。 在式（1）中，X是S或O原子; Y是苯基或C1-2烷氧基中某一位置上的氢或卤素原子; M是氢原子或形成药学上允许的盐的成对离子。 在式（2,3和4）中，R 1是氢原子或羟基保护基; R2是羧基保护基; X是S或O原子; Y是苯基中某一位置的氢或卤素原子。

公开(公告)号：KR1020020006889A

公开(公告)日：2002-01-26

申请号：KR1020000040396

申请日：2000-07-14

Applicant: 한국화학연구원

Inventor： 이철해 ,  김재학 ,  정희정 ,  편도규 ,  곽현정 ,  송신섭 ,  김은정 ,  김봉진 ,  정원장

IPC: C07D205/08

Abstract: PURPOSE: Provided are 2-arylethenyl carbapenem derivative of the formula(1) and its pharmaceutically acceptable salt which have therapeutic effect in methicillin resistant staphylococcus aureus(MRSA) infection. And its manufacturing method and an antibacterial composition containing it as an active ingredient are also provided. CONSTITUTION: 2-arylethenyl carbapenem derivative is represented by the formula(1), wherein R is halogen, nitro, hydroxy or cyano substituted phenyl or fused aryl group; or halogen or C1-3 alkyl group substituted monocyclic, bicyclic or tricyclic 5 or 6 membered hetero aryl group containing at least one of O, S or N atom; and M is hydrogen or zwitterion forming pharmaceutically acceptable salts.

Abstract translation: 目的：提供式（1）的2-亚乙烯基碳青霉烯衍生物及其药用盐，其在耐甲氧西林金黄色葡萄球菌（MRSA）感染中具有治疗作用。 还提供其制造方法和含有它作为活性成分的抗菌组合物。 构成：2-亚乙烯基碳代青霉烯衍生物由式（1）表示，其中R是卤素，硝基，羟基或氰基取代的苯基或稠合芳基; 或含有O，S或N原子中的至少一个的卤素或C 1-3烷基取代的单环，双环或三环5或6元杂芳基; M是氢或两性离子形成药学上可接受的盐。