公开(公告)号：KR100878331B1

公开(公告)日：2009-01-14

申请号：KR1020070082438

申请日：2007-08-16

Applicant: 한국식품연구원 ,  한국화학연구원

Inventor： 권대영 ,  김명선 ,  구민선 ,  김순희 ,  양혜정 ,  김영섭 ,  유시용 ,  유미영

IPC: A61K31/343 ,  A61K36/87 ,  A61P3/04

Abstract: An anti-obesity pharmaceutical composition, and the anti-obesity food are provided to inhibit the differentiation of preadipocyte into adipocyte and to suppress the synthesis of cholesterol. An anti-obesity pharmaceutical composition comprises the extract of grape tree bark, or at least one component selected from the vitisin A represented by the formula 1, the vitisin B represented by the formula 2, the epsilon-viniferin represented by the formula 3 and the ampelopsin represented by the formula 4 which are separated from the extract of grape tree bark.

Abstract translation: 提供抗肥胖药物组合物和抗肥胖食品，以抑制前脂肪细胞分化成脂肪细胞并抑制胆固醇的合成。 抗肥胖药物组合物包含葡萄树皮提取物或选自由式1表示的维生素A，由式2表示的维生素B，由式3表示的ε-荧光素和 由葡萄树皮提取物分离的由式4表示的黄曲霉素。

公开(公告)号：KR1020070066104A

公开(公告)日：2007-06-27

申请号：KR1020050126879

申请日：2005-12-21

Applicant: 한국화학연구원

Inventor： 김영섭 ,  유시용 ,  연규환 ,  이병호 ,  오광석 ,  서호원 ,  유미영 ,  이정원 ,  권대영

IPC: A61K36/708 ,  A61K31/05 ,  A61P9/12

CPC classification number: A61K31/065 ,  A23L2/52 ,  A23L29/035 ,  A23V2200/326 ,  A23V2200/3262 ,  A61K31/122 ,  A61K31/343 ,  A61K36/708 ,  Y10S514/912

Abstract: 본 발명은 대황(Rhei Rhizoma) 추출물, 피세아타놀(piceatannol), 입실론비니페린(ε-viniferin), 피시온(physcion) 또는 에모딘(emodin)을 유효성분으로 함유하는 혈압 강하용 조성물에 관한 것으로서, 본 발명에 따른 조성물은 혈관 평활근 이완작용을 통해 우수한 혈압 강하효과를 나타내므로, 고혈압 및 고혈압의 합병증으로 인한 각종 심혈관계 질환의 예방 및 치료를 위한 약학 조성물 뿐만 아니라 식품 조성물로도 유용하게 사용될 수 있다.

公开(公告)号：KR100732888B1

公开(公告)日：2007-06-27

申请号：KR1020050126879

申请日：2005-12-21

Applicant: 한국화학연구원

Inventor： 김영섭 ,  유시용 ,  연규환 ,  이병호 ,  오광석 ,  서호원 ,  유미영 ,  이정원 ,  권대영

IPC: A61K36/708 ,  A61K31/05 ,  A61P9/12

Abstract: An anti-hypertensive composition comprising the extract of Rhei rhizoma or active compounds isolated therefrom is provided to induce smooth muscle relaxation of the blood vessel, so that the composition is useful for treatment of hypersensitive and hypersensitive complications. The anti-hypertensive composition comprises the extract of Rhei rhizoma or active compounds isolated therefrom including piceatannol represented by the formula(1), epsilon-viniferin represented by the formula(2), physcion represented by the formula(3) or emodin represented by the formula(4) as an effective ingredient. The Rhei rhizoma extract is prepared with an organic solvent of methanol, ethanol, butanol, dichloromethane or ethylacetate; and the active compounds are isolated from the Rhei rhizoma extract by subjecting the Rhei rhizoma extract to reverse phase or silica gel column chromatography.

Abstract translation: 提供包含大黄提取物或从其中分离的活性化合物的抗高血压组合物，以诱导血管的平滑肌松弛，使得该组合物可用于治疗过敏和过敏性并发症。 该抗高血压组合物含有大黄提取物或由其分离的活性化合物，包括由式（1）表示的白皮素醇，由式（2）表示的ε-v草素，由式（3）表示的化合物或由 公式（4）作为有效成分。 大黄提取物用甲醇，乙醇，丁醇，二氯甲烷或乙酸乙酯等有机溶剂制备; 通过将大黄根茎提取物进行反相或硅胶柱色谱从大黄根提取物中分离活性化合物。