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1.发明授权포도나무 수피로부터 분리된 ＢＡＣＥ-1 저해 효과를 갖는활성물질을 포함하는 퇴행성 뇌질환의 예방 또는 치료용조성물 有权用于预防或治疗包含活性成分的神经病变组合物，其从VITIS VINIFERA的标准分离，其对BACE-1具有抑制作用
公开(公告)号：KR100860540B1
公开(公告)日：2008-09-26
申请号：KR1020070095884
申请日：2007-09-20
Applicant: 한국화학연구원
IPC: A61K31/343 , A61K31/05 , A61P25/28
Abstract: 본 발명은 비티신(vitisin) B, 입실론-비니페린 (ε-viniferin), 암펠롭신 (ampelopsin) A 및 이들의 혼합물로 이루어진 군으로부터 선택된 화합물 또는 이를 포함하는 포도나무 (
Vitis vinifera ) 수피 (樹皮) 추출물을 유효성분으로 포함하는 조성물에 관한 것으로, 본 발명의 조성물은 각종 치매의 원인 물질로 널리 알려진 베타-아밀로이드 (beta-amyloid)의 형성을 매개하는 BACE-1 (beta-site APP-cleaving enzyme 1)을 효과적으로 저해하므로 알쯔하이머병, 파킨슨병, 루게릭병, 헌팅턴병 및 니만-픽병과 같은 다양한 퇴행성 뇌질환의 예방 및 치료에 유용하게 사용될 수 있다.-
2.发明授权ＢＡＣＥ-1의 활성을 저해하는 파고지 종자 추출물 또는이로부터 분리된 활성물질을 포함하는 퇴행성 뇌질환의예방 또는 치료용 조성물 有权用于预防或治疗包含来自一种PSORALEA CORYLIFOLIA的一种提取物的神经变性疾病的组合物抑制BACE-1或其活性成分的活性
公开(公告)号：KR100833652B1
公开(公告)日：2008-05-29
申请号：KR1020060136696
申请日：2006-12-28
IPC: C07D407/04
Abstract: A composition comprising the extract of Psoralea corylifolia seed or effective compounds contained therein is provided to inhibit the activity of BACE-1(beta-site APP(amyloid precursor protein)-cleaving enzyme 1) mediating the formation of beta-amyloid as a main causing material of dementia, so that the composition is useful for preventing or treating neurodegenerative disease. A composition for preventing or treating neurodegenerative disease comprises the extract of Psoralea corylifolia seed, which is prepared by extracting Psoralea corylifolia seeds with C1-4 alcohol or its solution, dichloromethane, ethylacetate or a mixture thereof, or a compound selected from 7-hydroxy-3-(4-methyl-4-(4-methylpentene-3-yl)-4H-chromen-6-yl)-4H-chromen-4-one represented by the formula(1), bakuchiol, bavachromene, isobavachromene, bavachalcone, isobavachalcone, bavachinin, 7,8-dihydro-8-(4-hydrophenyl)-2,2-dimethyl-2H,6H-[1,2-b:5,4-b']dipyran-6-one isolated from the extract of Psoralea corylifolia seed.
Abstract translation: 提供包含补骨脂素提取物或其中含有的有效化合物的组合物以抑制BACE-1（β-位点APP（淀粉样蛋白前体蛋白）切割酶1）的活性，其介导β-淀粉样蛋白的形成作为主要原因 因此该组合物可用于预防或治疗神经退行性疾病。 用于预防或治疗神经退行性疾病的组合物包括通过用C 1-4醇或其溶液，二氯甲烷，乙酸乙酯或其混合物或选自7-羟基-2-甲基苯酚的化合物提取茄科植物提取物的方法制备的补骨脂素提取物， 由式（1）表示的3-（4-甲基-4-（4-甲基戊烯-3-基）-4H-色烯-6-基）-4H-色烯-4-酮，苯甲酸，巴伐溴苯，异葎草酮，巴伐昔酮 ，异哈查酮，巴伐他丁，7,8-二氢-8-（4-氢苯基）-2,2-二甲基-2H，6H- [1,2-b：5,4-b']二吡喃-6-酮 茯苓提取物。
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3.发明授权ＢＡＣＥ-1 저해 효과를 갖는 포도나무 수피 추출물 또는이로부터 분리된 활성물질을 포함하는 퇴행성 뇌질환의예방 또는 치료용 조성물 有权用于预防或治疗包含来自具有对BACE-1或其活性成分的抑制作用的VITIS VINIFERA的提取物的提取物的神经损伤性疾病的组合物
公开(公告)号：KR100791862B1
公开(公告)日：2008-01-07
申请号：KR1020060090116
申请日：2006-09-18
Applicant: 한국화학연구원
IPC: C07C49/607 , C07C49/617 , C07C69/616
Abstract: A compound having a BACE-1 inhibitory effect and an extract obtained from bark of grapevine and containing the same compound are provided to obtain a pharmaceutical composition or health-aid food for preventing or treating neurodegenerative diseases. A compound having a BACE-1 inhibitory effect is represented by the following formula 1. The compound represented by formula 1 is obtained through an extraction process using an organic solvent selected from the group consisting of C1-C4 alcohols or aqueous solution thereof, dichloromethane, ethyl acetate and a mixture thereof. Particularly, the compound represented by formula 1 is obtained by extracting bark of grapevine with the organic solvent, and by further extracting the extract with an organic solvent selected from the group consisting of butanol, dichloromethane and ethyl acetate.
Abstract translation: 提供具有BACE-1抑制作用的化合物和由葡萄树皮提取并含有相同化合物的提取物，以获得用于预防或治疗神经变性疾病的药物组合物或保健食品。 具有BACE-1抑制效果的化合物由下式1表示。式1所示的化合物是通过使用选自C1-C4醇或其水溶液，二氯甲烷， 乙酸乙酯及其混合物。 特别地，由式1表示的化合物是通过用有机溶剂提取葡萄树皮，并通过用选自丁醇，二氯甲烷和乙酸乙酯的有机溶剂进一步提取提取物而获得的。
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公开(公告)号：KR100732886B1
公开(公告)日：2007-06-27
申请号：KR1020050106005
申请日：2005-11-07
Applicant: 한국화학연구원
IPC: A61K31/7048 , A61K36/65 , A61P9/12
Abstract: 본 발명은 목단피(Moutan Cortex Radicis) 추출물, 옥시패오니플로린(oxypaeoniflorin), 패오니플로린(paeoniflorin), 메틸패오니플로린(methylpaeoniflorin) 또는 패오니다닌(paeonidanin)을 유효성분으로 함유하는 혈압강하용 조성물에 관한 것이다. 본 발명에 따른 조성물은 혈관 평활근 이완작용을 통해 우수한 혈압강하효과를 나타내므로 고혈압 및 고혈압의 합병증으로 인한 각종 심혈관계질환의 예방 및 치료를 위한 약학 조성물뿐만 아니라 식품첨가물로도 유용하게 사용될 수 있다.
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公开(公告)号：KR100704303B1
公开(公告)日：2007-04-09
申请号：KR1020070002744
申请日：2007-01-10
Applicant: 한국화학연구원
Abstract: 본 발명은 삼백초(
Saururus
chinensis ) 추출물, 또는 이로부터 분리된 (-)-소서네올[(-)-saucerneol], 소서네올 C(saucerneol C), 마나산틴 A(manassantin A) 또는 마나산틴 B를 유효성분으로 함유하는 건강증진용 식품에 관한 것이다. 본 발명에 따른 식품은 비정상적인 B 세포 및 T 세포의 증식을 효과적으로 억제하여 우수한 면역억제효과를 나타내므로 장기이식거부반응, 자가면역질환, 알러지, 아토피 등과 같은 면역과민반응으로 야기되는 질환의 예방을 위한 건강증진용 식품으로서 유용하게 사용될 수 있다.Abstract translation: 本发明涉及
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Patent Agency Ranking
公开(公告)号：KR1020070068689A
公开(公告)日：2007-07-02
申请号：KR1020050130601
申请日：2005-12-27
Abstract: A composition for immunosuppression comprising the extract of Saururus chinensis or active compounds isolated therefrom is provided to inhibit abnormal proliferation of B cell and T cell, so that the composition is useful for prevention and treatment of diseases caused by hypersensitive immune responses. The composition for immunosuppression comprises the extract of Saururus chinensis or an active compound isolated from the Saururus chinensis extract selected from (-)-saucerneol, saucerneol C, manassantin A, manassantin B and a mixture thereof as effective ingredient, wherein the Saururus chinensis extract is prepared by using an organic solvent selected from methanol, methanol solution, ethanol, ethanol solution, butanol, dichloromethane, ethylacetate and a mixture thereof. The composition is a pharmaceutical or health food composition. The pharmaceutical composition prevents or treats diseases caused by hypersensitive immune responses including organ transplant rejection, autoimmune disease including lupous erythematosus and rheumatoid arthritis, and allergy disease including rhinitis, asthma and atopic dermatitis, and the health food composition is formulated as drink.
Abstract translation: 提供了包含中华黄牛提取物或从其分离的活性化合物的免疫抑制组合物以抑制B细胞和T细胞的异常增殖，使得该组合物可用于预防和治疗由过敏免疫应答引起的疾病。 用于免疫抑制的组合物包含中华黄牛提取物或从中选出的（ - ） - 沙美拉诺，沙门氏菌素C，马那敏蛋白A，他曼那丁B及其混合物中选择的中华黄瓜提取物作为有效成分分离的活性化合物，其中中华黄瓜提取物为 通过使用选自甲醇，甲醇溶液，乙醇，乙醇溶液，丁醇，二氯甲烷，乙酸乙酯及其混合物的有机溶剂制备。 该组合物是药物或保健食品组合物。 药物组合物预防或治疗由过敏免疫应答引起的疾病，包括器官移植排斥反应，自身免疫性疾病，包括红斑狼疮和类风湿性关节炎，以及过敏疾病，包括鼻炎，哮喘和特应性皮炎，健康食品组合物配制成饮料。
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7.发明公开포도나무 수피로부터 분리된 ＢＡＣＥ-1 저해 효과를 갖는활성물질을 포함하는 퇴행성 뇌질환의 예방 또는 치료용조성물 有权用于预防或治疗包含活性成分的神经病变组合物，其从VITIS VINIFERA的标准分离，其对BACE-1具有抑制作用
公开(公告)号：KR1020080025655A
公开(公告)日：2008-03-21
申请号：KR1020070095884
申请日：2007-09-20
Applicant: 한국화학연구원
IPC: A61K31/343 , A61K31/05 , A61P25/28
Abstract: A composition comprising an extract of stembark of Vitis vinifera is provided to inhibit BACE-1(beta-site APP-cleaving enzyme 1) mediating formation of beta-amyloid, known to be a causing material of various dementia such as Alzheimer's disease, thereby being usefully used for preventing and treating neurodegenerative diseases such as senile dementia. A pharmaceutical composition for preventing or treating neurodegenerative diseases comprises a compound selected from the group consisting of vitisin A, epsilon-viniferin, ampelopsin A and a mixture thereof as an effective ingredient, wherein the compound is obtained by extracting stembark of Vitis vinifera with an organic solvent selected from the group consisting of C1-4 alcohol and an aqueous solution thereof, dichloromethane, ethyl acetate and a mixture thereof.
Abstract translation: 提供了包含葡萄树葡萄树的提取物的组合物以抑制介导β-淀粉样蛋白形成的BACE-1（β-位点APP切割酶1），已知其是引起各种痴呆的物质，例如阿尔茨海默病，因此是 有用地用于预防和治疗老年性痴呆等神经变性疾病。 用于预防或治疗神经退行性疾病的药物组合物包括选自维生素A，ε-荧光素，安非他酮A及其混合物作为有效成分的化合物，其中所述化合物通过用有机物提取葡萄葡萄树 溶剂，其选自C1-4醇及其水溶液，二氯甲烷，乙酸乙酯及其混合物。
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公开(公告)号：KR100749675B1
公开(公告)日：2007-08-17
申请号：KR1020050130601
申请日：2005-12-27
Abstract: 본 발명은 삼백초(
Saururus chinensis ) 추출물, 또는 이로부터 분리된 (-)-소서네올[(-)-saucerneol], 소서네올 C(saucerneol C), 마나산틴 A(manassantin A) 또는 마나산틴 B를 유효성분으로 함유하는 면역억제용 조성물에 관한 것이다. 본 발명에 따른 조성물은 비정상적인 B 세포 및 T 세포의 증식을 효과적으로 억제하여 우수한 면역억제효과를 나타내므로 장기이식거부반응, 자가면역질환, 알러지, 아토피 등과 같은 면역과민반응으로 야기되는 질환의 예방 및 치료를 위한 약학 조성물뿐만 아니라 식품첨가물로도 유용하게 사용될 수 있다.-
公开(公告)号：KR1020070050998A
公开(公告)日：2007-05-17
申请号：KR1020050106005
申请日：2005-11-07
Applicant: 한국화학연구원
IPC: A61K31/7048 , A61K36/65 , A61P9/12
CPC classification number: A61K31/7048 , A23L2/52 , A23L29/035 , A23V2200/326 , A23V2200/3262 , A61K36/65 , A61K2236/55 , Y10S514/824 , Y10S514/912
Abstract: 본 발명은 목단피(Moutan Cortex Radicis) 추출물, 옥시패오니플로린(oxypaeoniflorin), 패오니플로린(paeoniflorin), 메틸패오니플로린(methylpaeoniflorin) 또는 패오니다닌(paeonidanin)을 유효성분으로 함유하는 혈압강하용 조성물에 관한 것이다. 본 발명에 따른 조성물은 혈관 평활근 이완작용을 통해 우수한 혈압강하효과를 나타내므로 고혈압 및 고혈압의 합병증으로 인한 각종 심혈관계질환의 예방 및 치료를 위한 약학 조성물뿐만 아니라 식품첨가물로도 유용하게 사용될 수 있다.
Abstract translation: 本发明mokdanpi（牡丹皮皮质Radicis）提取物，氧基大号污泥林（oxypaeoniflorin），L污泥林（芍药苷），甲基1-污泥林（methylpaeoniflorin）或L污泥行进（paeonidanin），用于降低血压，其包含作为活性成分的组合物 Lt。 根据本发明的组合物可以表现出优异的血压通过血管平滑肌松弛作用降低效果使用以及药物组合物，用于预防和治疗由于高血压和高血压并发症各种心血管疾病是作为食品添加剂也是有用的。
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公开(公告)号：KR1020090078939A
公开(公告)日：2009-07-21
申请号：KR1020080004805
申请日：2008-01-16
IPC: A61K31/192 , A61K31/045 , A61K31/343 , A61P25/28
Abstract: A composition for preventing and treating neutodegenerative disease, which contains a polyphenol compound as an active ingredient is provided to have the effects of beta-amyloid coagulation inhibition, caspase-3 activity suppression and acetylcholinesterase activation suppression. A composition for preventing and treating neurodegenerative diseases comprises salvianolic acid, bakuchiol, epsilon-viniferin, rhapontigenin, piceatannol, luteolin, myricetin, or their mixture as an active ingredient. The neurodegenerative diseases are Alzheimer's disease, Pick's disease, Creutzfeldt-jakob, Parkinson's disease, Lou Gehrig's Disease, or Huntington's disease. The composition suppresses BACE-1[beta-site APP(amyloid precursor protein)-cleaving enzyme 1], caspase or acetylcholine esterase. The composition further comprises medicinal herb. The medicinal herb is Salviae Miltiorrhizae Radix, Psoraleae Semen, Vitidis Fructus, Rhei Rhizoma, Digitalis Folium, Schizonepeta Herba, Taraxaci Herba, Humuli Herba, Lonicerae Folium or their mixture.
Abstract translation: 提供含有多酚化合物作为活性成分的用于预防和治疗神经变性疾病的组合物，以具有β-淀粉样蛋白凝结抑制，半胱天冬酶-3活性抑制和乙酰胆碱酯酶活化抑制的作用。 用于预防和治疗神经变性疾病的组合物包括salvianolic acid，bakuchiol，ε-viniferin，rhapontigenin，piceatannol，木犀草素，杨梅宁或其混合物作为活性成分。 神经变性疾病是阿尔茨海默氏病，皮克病，克雅氏综合征，帕金森氏病，卢格里希氏病或亨廷顿舞蹈病。 该组合物抑制BACE-1β-位点APP（淀粉样蛋白前体蛋白）切割酶1]，半胱天冬酶或乙酰胆碱酯酶。 该组合物还包含药草。 药用草药是丹参，枸杞子，枸杞子，枸杞子，洋地黄属，荆芥草，竹aci草，虎嘴草，金银花或其混合物。
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