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1.发明申请
公开(公告)号：WO2010008150A2
公开(公告)日：2010-01-21
申请号：PCT/KR2009/003648
申请日：2009-07-03
IPC: A61K36/78
CPC classification number: A61K36/539 , A61K36/78 , A61K2300/00
Abstract: 본 발명은 삼백초와 황금의 혼합 추출물을 유효성분으로 함유하는 골다공증 예방 또는 치료용 조성물에 관한 것으로, 본 발명에 의한 삼백초와 황금의 혼합 추출물은 파골 세포의 분화를 억제하는 효과, 골밀도 및 골함유량 증가 효과 및 뼈의 미세구조가 치밀해지는 효과를 동시에 볼 수 있는 복합효과를 나타내며, 각각의 생약 추출물을 단독으로 사용했을 경우보다 상기 효과가 상승작용으로 인하여 탁월하게 향상되므로 골다공증 예방 또는 치료에 유용한 의약품 및 건강식품으로 널리 이용될 수 있다.
Abstract translation:
本发明涉及一种用于预防骨质疏松症，或含有的300秒和金作为活性成分的混合提取物的治疗的组合物，根据本发明的混合300秒的提取物和金抑制破骨细胞的分化 是到骨含量的作用，骨矿物质密度和微观结构增加效果和骨代表一个成为同时紧效果，组合效果可以看出，由于效果显着提高，由于当单独使用时，各个草药提取物比的协同效应 可广泛用作预防或治疗骨质疏松症的药物和保健食品。
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2.发明授权
公开(公告)号：KR101209889B1
公开(公告)日：2012-12-10
申请号：KR1020100045593
申请日：2010-05-14
IPC: A61K36/232 , A61K31/37 , A61P3/04 , A61P3/00
Abstract: 본발명은당귀의주성분인데쿠르신으로부터합성된유도체인데쿠시놀벤조에이트(Decursinol benzoate)를이용한비만예방용또는비만치료용조성물에관한것으로써, 보다상세하게는상기데쿠시놀벤조네이트는 AMPK(5' adenosine monophosphate-activated protein kinase)활성능을가짐으로써지방산합성을억제하는것을특징으로갖거나, PPAR-GAMMA(Peroxisome proliferator-activated receptor gamma)의발현및 전사활성을억제하는것을특징으로가질수 있다.
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公开(公告)号：KR1020100009151A
公开(公告)日：2010-01-27
申请号：KR1020080069892
申请日：2008-07-18
IPC: A61K36/78 , A61K36/539 , A61P19/10
CPC classification number: A61K36/539 , A61K36/78 , A61K2300/00
Abstract: PURPOSE: A composition containing mixture extract of Saururus chinensis and Scutellaria baicalensis is provided to suppress osteoclast differentiation, enhance bone density and bone content, and prevent or treat osteoporosis. CONSTITUTION: A pharmaceutical composition for preventing or treating osteoporosis contains mixture extract of Saururus chinensis and Scutellaria baicalensis as an active ingredient. The weight ratio of the Saururus chinensis and Scutellaria baicalensis is 1:10-10:1. A food composition for preventing and relieving osteoporosis contains mixture extract of Saururus chinensis and Scutellaria baicalensis as an active ingredient. A method for producing the mixture extract comprises: a step of washing Saururus chinensis and Scutellaria baicalensis with water and drying; a step of extracting the Saururus chinensis and Scutellaria baicalensis with solvent; a step of cooling the extract at room temperature and filtering; a step of decompress-concentrating and freeze-drying; and a step of mixing the extract of Saururus chinensis and Scutellaria baicalensis.
Abstract translation: 目的：提供含有Saururus chinensis和黄芩的混合物提取物的组合物，以抑制破骨细胞分化，增强骨密度和骨含量，并预防或治疗骨质疏松症。 构成：用于预防或治疗骨质疏松症的药物组合物含有中华黄牛和黄芩的混合物提取物作为活性成分。 中华黄牛和黄芩的重量比为1:10-10:1。 用于预防和缓解骨质疏松症的食物组合物含有中华黄芪和黄芩的混合物提取物作为活性成分。 制备混合物提取物的方法包括：用水洗涤中华黄芩和黄芩的步骤; 用溶剂萃取中华黄龙和黄芩的一步; 在室温下冷却提取物并过滤的步骤; 减压浓缩和冷冻干燥步骤; 并将中国黄芪和黄芩提取物混合在一起。
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公开(公告)号：KR1020090064823A
公开(公告)日：2009-06-22
申请号：KR1020070132164
申请日：2007-12-17
IPC: A61K36/185 , A61P9/08 , A61P9/12
Abstract: A composition for relaxing blood vessel which contains an Ulmus macrocarpa extract prevent and treat various cardiovascular diseases by inducing the relaxation of vascular smooth muscle. A pharmaceutical composition for relaxing blood vessel contains an Ulmus macrocarpa extract as an active ingredient. The composition is effective in preventing and treating hypertension, coronary artery disease, cerebrovascular disease, peripheral vascular disease, main artery disease, kidney dysfunction, cardiac insufficiency or vision disorder An organic solvent for extracting the Ulmus macrocarpa is selected from ethanol, ethanol solution, methanol, methanol solution, butanol, dichloromethane, ethyl acetate, hexane and their mixture. A health food having the effect of blood vessel relaxation contains Ulmus macrocarpa extract.
Abstract translation: 用于放松血管的组合物含有榆木提取物通过诱导血管平滑肌的松弛来预防和治疗各种心血管疾病。 用于放松血管的药物组合物含有榆木大pa提取物作为活性成分。 该组合物有效预防和治疗高血压，冠状动脉疾病，脑血管疾病，外周血管疾病，主动脉疾病，肾功能不全，心功能不全或视力障碍。用于提取榆树的有机溶剂选自乙醇，乙醇溶液，甲醇 ，甲醇溶液，丁醇，二氯甲烷，乙酸乙酯，己烷及其混合物。 具有血管松弛作用的保健食品包含榆树提取物。
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公开(公告)号：KR1020080064238A
公开(公告)日：2008-07-09
申请号：KR1020070000902
申请日：2007-01-04
CPC classification number: A61K36/78 , A23L2/38 , A23L33/105 , A23V2002/00 , A61K31/065 , A61K31/36 , A23V2200/326 , A23V2250/21
Abstract: A composition comprising a root extract of Saururus chinensis or a compound isolated from the extract is provided to show excellent blood pressure lowering effect through vascular relaxation, thereby being usefully used as a pharmaceutical composition or a health food composition for preventing and treating various cardiovascular diseases caused by hypertension and complications of the hypertension. A pharmaceutical composition for vascular relaxation comprises a compound selected from the group consisting of machilin D, saucerneol D and a mixture thereof or a root extract of Saururus chinensis comprising the same compound as an effective ingredient, wherein the extract is prepared by using an organic solvent selected from the group consisting of ethanol, an aqueous solution of the ethanol, methanol, an aqueous solution of the methanol, butanol. dichloromethane, ethylacetate, hexane and a mixture thereof.
Abstract translation: 提供了包含中华鲟的根提取物或从提取物中分离的化合物的组合物，以通过血管松弛显示优异的降血压效果，从而有效地用作预防和治疗引起的各种心血管疾病的药物组合物或保健食品组合物 通过高血压和并发症的高血压。 用于血管松弛的药物组合物包含选自机体D，香草醇D及其混合物的化合物或包含与有效成分相同的化合物的中华黄瓜的根提取物，其中所述提取物通过使用有机溶剂 选自乙醇，乙醇水溶液，甲醇，甲醇水溶液，丁醇组成的组。 二氯甲烷，乙酸乙酯，己烷及其混合物。
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Patent Agency Ranking6.发明授权삼백초 추출물 또는 이로부터 분리된 활성 화합물을포함하는 골다공증 예방 또는 치료용 조성물 有权用于预防或治疗包含SAURURUS CHINENSIS或活性化合物提取物的OSTEOPOSOSIS的组合物，其分离
公开(公告)号：KR100833654B1
公开(公告)日：2008-05-29
申请号：KR1020070013661
申请日：2007-02-09
IPC: A61K36/78 , A61P19/10 , A61K31/341
CPC classification number: A61K36/78
Abstract: A composition comprising the extract of Saururus chinensis or active compounds isolated therefrom is provided to inhibit growth of osteoclast, so that the composition is useful for preventing or treating osteoporosis. A composition for preventing or treating osteoporosis comprises 0.01-30 wt.% of the extract of Saururus chinensis, which is prepared by extracting Saururus chinensis with C1-4 alcohol and its solution, dichloromethane, ethylacetate or a mixture thereof, or active compounds isolated from the Saururus chinensis extract including (-)-saucerneol represented by the formula(1) and sauristolactam represented by the formula(2), and is a pharmaceutical or health food composition having a formulation of beverage.
Abstract translation: 提供了包含中华黄牛提取物或从其分离的活性化合物的组合物以抑制破骨细胞的生长，使得该组合物可用于预防或治疗骨质疏松症。 用于预防或治疗骨质疏松症的组合物包括通过用C 1-4醇提取中华黄芪和其溶液，二氯甲烷，乙酸乙酯或其混合物或从其中分离的活性化合物制备的中华黄瓜提取物的0.01-30重量％ 含有由式（1）表示的（ - ） - 三氯蔗糖和由式（2）表示的沙拉耳内酰胺，是具有饮料配方的药物或保健食品组合物。
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7.发明授权ＢＡＣＥ-1의 활성을 저해하는 파고지 종자 추출물 또는이로부터 분리된 활성물질을 포함하는 퇴행성 뇌질환의예방 또는 치료용 조성물 有权用于预防或治疗包含来自一种PSORALEA CORYLIFOLIA的一种提取物的神经变性疾病的组合物抑制BACE-1或其活性成分的活性
公开(公告)号：KR100833652B1
公开(公告)日：2008-05-29
申请号：KR1020060136696
申请日：2006-12-28
IPC: C07D407/04
Abstract: A composition comprising the extract of Psoralea corylifolia seed or effective compounds contained therein is provided to inhibit the activity of BACE-1(beta-site APP(amyloid precursor protein)-cleaving enzyme 1) mediating the formation of beta-amyloid as a main causing material of dementia, so that the composition is useful for preventing or treating neurodegenerative disease. A composition for preventing or treating neurodegenerative disease comprises the extract of Psoralea corylifolia seed, which is prepared by extracting Psoralea corylifolia seeds with C1-4 alcohol or its solution, dichloromethane, ethylacetate or a mixture thereof, or a compound selected from 7-hydroxy-3-(4-methyl-4-(4-methylpentene-3-yl)-4H-chromen-6-yl)-4H-chromen-4-one represented by the formula(1), bakuchiol, bavachromene, isobavachromene, bavachalcone, isobavachalcone, bavachinin, 7,8-dihydro-8-(4-hydrophenyl)-2,2-dimethyl-2H,6H-[1,2-b:5,4-b']dipyran-6-one isolated from the extract of Psoralea corylifolia seed.
Abstract translation: 提供包含补骨脂素提取物或其中含有的有效化合物的组合物以抑制BACE-1（β-位点APP（淀粉样蛋白前体蛋白）切割酶1）的活性，其介导β-淀粉样蛋白的形成作为主要原因 因此该组合物可用于预防或治疗神经退行性疾病。 用于预防或治疗神经退行性疾病的组合物包括通过用C 1-4醇或其溶液，二氯甲烷，乙酸乙酯或其混合物或选自7-羟基-2-甲基苯酚的化合物提取茄科植物提取物的方法制备的补骨脂素提取物， 由式（1）表示的3-（4-甲基-4-（4-甲基戊烯-3-基）-4H-色烯-6-基）-4H-色烯-4-酮，苯甲酸，巴伐溴苯，异葎草酮，巴伐昔酮 ，异哈查酮，巴伐他丁，7,8-二氢-8-（4-氢苯基）-2,2-二甲基-2H，6H- [1,2-b：5,4-b']二吡喃-6-酮 茯苓提取物。
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公开(公告)号：KR1020090078939A
公开(公告)日：2009-07-21
申请号：KR1020080004805
申请日：2008-01-16
IPC: A61K31/192 , A61K31/045 , A61K31/343 , A61P25/28
Abstract: A composition for preventing and treating neutodegenerative disease, which contains a polyphenol compound as an active ingredient is provided to have the effects of beta-amyloid coagulation inhibition, caspase-3 activity suppression and acetylcholinesterase activation suppression. A composition for preventing and treating neurodegenerative diseases comprises salvianolic acid, bakuchiol, epsilon-viniferin, rhapontigenin, piceatannol, luteolin, myricetin, or their mixture as an active ingredient. The neurodegenerative diseases are Alzheimer's disease, Pick's disease, Creutzfeldt-jakob, Parkinson's disease, Lou Gehrig's Disease, or Huntington's disease. The composition suppresses BACE-1[beta-site APP(amyloid precursor protein)-cleaving enzyme 1], caspase or acetylcholine esterase. The composition further comprises medicinal herb. The medicinal herb is Salviae Miltiorrhizae Radix, Psoraleae Semen, Vitidis Fructus, Rhei Rhizoma, Digitalis Folium, Schizonepeta Herba, Taraxaci Herba, Humuli Herba, Lonicerae Folium or their mixture.
Abstract translation: 提供含有多酚化合物作为活性成分的用于预防和治疗神经变性疾病的组合物，以具有β-淀粉样蛋白凝结抑制，半胱天冬酶-3活性抑制和乙酰胆碱酯酶活化抑制的作用。 用于预防和治疗神经变性疾病的组合物包括salvianolic acid，bakuchiol，ε-viniferin，rhapontigenin，piceatannol，木犀草素，杨梅宁或其混合物作为活性成分。 神经变性疾病是阿尔茨海默氏病，皮克病，克雅氏综合征，帕金森氏病，卢格里希氏病或亨廷顿舞蹈病。 该组合物抑制BACE-1β-位点APP（淀粉样蛋白前体蛋白）切割酶1]，半胱天冬酶或乙酰胆碱酯酶。 该组合物还包含药草。 药用草药是丹参，枸杞子，枸杞子，枸杞子，洋地黄属，荆芥草，竹aci草，虎嘴草，金银花或其混合物。
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公开(公告)号：KR100878331B1
公开(公告)日：2009-01-14
申请号：KR1020070082438
申请日：2007-08-16
IPC: A61K31/343 , A61K36/87 , A61P3/04
Abstract: An anti-obesity pharmaceutical composition, and the anti-obesity food are provided to inhibit the differentiation of preadipocyte into adipocyte and to suppress the synthesis of cholesterol. An anti-obesity pharmaceutical composition comprises the extract of grape tree bark, or at least one component selected from the vitisin A represented by the formula 1, the vitisin B represented by the formula 2, the epsilon-viniferin represented by the formula 3 and the ampelopsin represented by the formula 4 which are separated from the extract of grape tree bark.
Abstract translation: 提供抗肥胖药物组合物和抗肥胖食品，以抑制前脂肪细胞分化成脂肪细胞并抑制胆固醇的合成。 抗肥胖药物组合物包含葡萄树皮提取物或选自由式1表示的维生素A，由式2表示的维生素B，由式3表示的ε-荧光素和 由葡萄树皮提取物分离的由式4表示的黄曲霉素。
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公开(公告)号：KR1020070066104A
公开(公告)日：2007-06-27
申请号：KR1020050126879
申请日：2005-12-21
Applicant: 한국화학연구원
IPC: A61K36/708 , A61K31/05 , A61P9/12
CPC classification number: A61K31/065 , A23L2/52 , A23L29/035 , A23V2200/326 , A23V2200/3262 , A61K31/122 , A61K31/343 , A61K36/708 , Y10S514/912
Abstract: 본 발명은 대황(Rhei Rhizoma) 추출물, 피세아타놀(piceatannol), 입실론비니페린(ε-viniferin), 피시온(physcion) 또는 에모딘(emodin)을 유효성분으로 함유하는 혈압 강하용 조성물에 관한 것으로서, 본 발명에 따른 조성물은 혈관 평활근 이완작용을 통해 우수한 혈압 강하효과를 나타내므로, 고혈압 및 고혈압의 합병증으로 인한 각종 심혈관계 질환의 예방 및 치료를 위한 약학 조성물 뿐만 아니라 식품 조성물로도 유용하게 사용될 수 있다.
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