-
11.发明公开
公开(公告)号：KR1020120119562A
公开(公告)日：2012-10-31
申请号：KR1020110037574
申请日：2011-04-22
Applicant: 한림대학교 산학협력단
CPC classification number: A61K47/64 , A23L33/17 , A23V2200/322 , A61K47/22
Abstract: PURPOSE: A composition for preventing and treating brain disorder including imipramine and fused protein which is covalently bonded with protein transport domains and a method for increasing the introduction of the fused protein are provided to reduce cytotoxin induced by hydrogen peroxide. CONSTITUTION: A method for increasing the introduction of the fused protein is processed by adding imipramine and fused protein which is covalently bonded with protein transport domains. The imipramine is primarily processed in the nerve cells or brain cells than the fusion protein. The protein transport domain is Tat, PEP-1, oligolysine, oligo arginine or oligo (the lysine, and the arginine). The therapeutic protein is active oxygen species excision enzyme. The therapeutic protein is catalase, superoxide dismutase or glutathione peroxidase. A composition for preventing and treating neural diseases or brain disorder includes the fused protein and imipramine of the enzyme having the removing activity of active oxygen species. The enzyme having the removing activity of active oxygen species is catalase, superoxide dismutase or glutathione peroxidase.
Abstract translation: 目的：提供用于预防和治疗脑疾病的组合物，包括与蛋白质转运结构域共价结合的丙咪嗪和融合蛋白，以及增加引入融合蛋白的方法，以减少由过氧化氢诱导的细胞毒素。 构成：通过加入与蛋白质转运结构域共价结合的丙咪嗪和融合蛋白来加工融合蛋白的引入的方法。 丙米嗪主要在神经细胞或脑细胞中处理，而不是融合蛋白。 蛋白质转运结构域是Tat，PEP-1，寡聚赖氨酸，寡聚精氨酸或寡聚（赖氨酸和精氨酸）。 治疗性蛋白质是活性氧离子切除酶。 治疗性蛋白质是过氧化氢酶，超氧化物歧化酶或谷胱甘肽过氧化物酶。 用于预防和治疗神经疾病或脑疾病的组合物包括具有活性氧物质去除活性的酶的融合蛋白和丙米嗪。 具有活性氧脱除活性的酶是过氧化氢酶，超氧化物歧化酶或谷胱甘肽过氧化物酶。
-
公开(公告)号：KR101101296B1
公开(公告)日：2012-01-04
申请号：KR1020090107300
申请日：2009-11-09
Applicant: 한림대학교 산학협력단
IPC: B01D15/00 , G01N30/02 , A61K36/484 , A61P17/18
Abstract: 본 발명은 감초로부터 항산화능이 뛰어난 여러 물질을 동시에 분리하는 방법에 관한 것으로, 보다 구체적으로 고속향류크로마토그래피를 이용하여 감초로부터 항산화능이 뛰어난 디하이드로그리아스페린 C, 디하이드로그리아스페린 D 및 아이소안구스톤 A를 동시에 분리하는 방법에 관한 것이다. 본 발명은 감초로부터 동시에 항산화능을 가진 여러 화합물을 높은 순도와 수율로 분리할 수 있으므로, 항산화물질이 이용되는 의료산업, 식품산업 및 화장품산업을 포함한 다양한 산업에 응용될 수 있다.
감초, 항산화 물질, 고속향류크로마토그래피-
公开(公告)号：KR1020120000246A
公开(公告)日：2012-01-02
申请号：KR1020100060503
申请日：2010-06-25
Applicant: 한림대학교 산학협력단
Abstract: PURPOSE: An anti-cancer composition containing Caryophyllaceae plant extract and a food composition containing the same are provided to induce rat-2 fibroblast and B103 apoptosis. CONSTITUTION: An anti-cancer composition contains Melandrium firmum extract as an active ingredient, extracted using water and alcohol of 1-5 carbon atoms at 50-100°C for 30 minutes to 12 hours. The extract is isolated from Melandrium firmum root using 10-95%(v/v) methanol. Melandrium firmum includes Melandrium Apricum, Melandrium Capitarum, or Melandrium Seoulensis. A health food contains the anti-cancer composition and supplementary food and further contains a proper carrier, excipient, and diluent.
Abstract translation: 目的：提供含有Caryophyllaceae植物提取物和含有它们的食品组合物的抗癌组合物，以诱导大鼠-2成纤维细胞和B103细胞凋亡。 构成：抗癌组合物含有Melonrium坚果提取物作为活性成分，使用1-5个碳原子的水和醇在50-100℃下萃取30分钟至12小时。 使用10-95％（v / v）甲醇从Melandrium坚果根分离提取物。 枸杞子包括枸杞，Melonrium Capitarum或Melonrium Seoulensis。 保健食品含有抗癌成分和补充食品，并含有适当的载体，赋形剂和稀释剂。
-
公开(公告)号：KR1020120000240A
公开(公告)日：2012-01-02
申请号：KR1020100060491
申请日：2010-06-25
Applicant: 한림대학교 산학협력단
IPC: A61K36/232 , A61K36/23 , A61P35/00
Abstract: PURPOSE: An anti-cancer composition using Angelica polymorpha root extract is provided to induce B103(neuroblastoma) apoptosis and to ensure anti-cancer effect. CONSTITUTION: An anti-cancer composition contains Angelica polymorpha extract as an active ingredient, which is extracted using water and alcohols of 1-5 carbon atoms. The Angelica polymorpha extract is prepared from Angelica decursiva flowers using 10-95%(v/v) methanol. A method for preparing the anti-cancer composition comprises: a step of preparing dried Angelica polymorpha plants; and a step of extracting the plants at 50-100°C for 1-10 hours to prepare water soluble liquid.
Abstract translation: 目的：提供使用当归多形性根提取物的抗癌成分，诱导B103（神经母细胞瘤）细胞凋亡并确保抗癌作用。 构成：抗癌组合物含有当归多形汉提取物作为活性成分，使用1-5个碳原子的水和醇提取。 使用10-95％（v / v）甲醇，从当归果皮花中制备当归多形汉逊酵素提取物。 制备抗癌组合物的方法包括：制备干燥的当归多形植物植物的步骤; 以及在50-100℃下提取植物1-10小时以制备水溶性液体的步骤。
-
公开(公告)号：KR101063524B1
公开(公告)日：2011-09-07
申请号：KR1020100011694
申请日：2010-02-08
Applicant: 한림대학교 산학협력단
IPC: A61K36/899 , A61P3/10 , A61P3/00
Abstract: 본 발명은 당뇨합병증으로 인해 초래되는 신장섬유증에 직접적으로 관련된 인간 신장 혈관간세포(Human Renal Mesangial Cell, HRMC)를 고혈당에 노출시키고 여기에 검정옥수수 추출물과 3일간 배양함으로써, 결합조직 성장인자(Connetive Tissue Growth Factor, CTGF)의 활성을 억제하고, 제 4(Ⅳ)형 콜라겐(Collagen) 생성을 감소시키며, 막형 기질단백질 분해효소(Membrane Type-1 Matrix Metalloproteinase, MT-1 MMP)의 발현을 증가시켜 만성 고혈당으로 인한 신장 섬유증을 개선시키는 검정옥수수 추출물을 함유하는 당뇨병성 신장섬유증 억제용 조성물 대한 것이다.
-
Patent Agency Ranking
公开(公告)号：KR1020110094175A
公开(公告)日：2011-08-22
申请号：KR1020110077935
申请日：2011-08-04
Applicant: 한림대학교 산학협력단
Abstract: PURPOSE: A pharmaceutical composition containing Siberian chrysanthemum or compound isolated from the plant is provided to ensure excellent anticancer effect. CONSTITUTION: A food composition for improving liver function and promoting fatigue recovery contains Siberian chrysanthemum extract as an active ingredient. A composition for preventing or treating cancer contains acetylene compounds of chemical formula 1 or pharmaceutically acceptable salt thereof as an active ingredient.
Abstract translation: 目的：提供含有西伯利亚菊花或植物分离的化合物的药物组合物，以确保优异的抗癌作用。 构成：用于改善肝功能和促进疲劳恢复的食物组合物含有西伯利亚菊花提取物作为活性成分。 用于预防或治疗癌症的组合物含有化学式1的乙炔化合物或其药学上可接受的盐作为活性成分。
-
公开(公告)号：KR1020110087435A
公开(公告)日：2011-08-03
申请号：KR1020100006852
申请日：2010-01-26
Applicant: 한림대학교 산학협력단
CPC classification number: A61K36/56 , A23V2200/328 , A61K2236/331 , A61K2236/333 , Y10S514/866
Abstract: PURPOSE: A composition containing Campsis grandiflora extract for preventing or treating diabetes complication is provided to suppress aldose reductase and sorbitol generation without side effects. CONSTITUTION: A composition for preventing or treating diabetes complication contains Campsis grandiflora extract as an active ingredient. The Campsis grandiflora extract is isolated from stems of Campsis grandiflora using water, alcohol of 1-5 carbon atoms, or mixture thereof at 4°C-120°C for 10 minutes to 12 hours. A food composition for treating or preventing diabetes complication contains the Campsis grandiflora stem extract as an active ingredient. The composition contains 0.001-99.9 weight% of the Campsis grandiflora extract.
Abstract translation: 目的：提供含有Campsis grandiflora提取物，用于预防或治疗糖尿病并发症的组合物，以抑制醛糖还原酶和山梨糖醇的产生而不产生副作用。 构成：用于预防或治疗糖尿病并发症的组合物含有Campsis grandiflora提取物作为活性成分。 使用水，1〜5个碳原子的醇或其混合物，在4℃〜120℃下分离野菊花提取物10分钟〜12小时。 用于治疗或预防糖尿病并发症的食物组合物含有Campsis grandiflora茎提取物作为活性成分。 该组合物含有0.001-99.9重量％的Campsis grandiflora提取物。
-
18.发明公开나문재(Ｓｕａｅｄａ ａｓｐａｒａｇｏｉｄｅｓ) 추출물을 포함하는 치매 예방 또는 치료 및 인지능 개선용 약학적 조성물 또는 기능성 식품 조성물 失效用于预防或治疗感染的药物或功能食品组合物，并提高包含阿拉伯胶原的提取物的认知能力
公开(公告)号：KR1020110042631A
公开(公告)日：2011-04-27
申请号：KR1020090099386
申请日：2009-10-19
Applicant: 한림대학교 산학협력단
IPC: A61K36/185 , A61P25/28 , A23L1/30
Abstract: PURPOSE: A pharmaceutical composition containing Suaeda asparagoides extract is provided to suppress acetylcholine esterase activation and to prevent and treat Alzheimer's disease. CONSTITUTION: A pharmaceutical composition or functional food composition for preventing or treating dementia contains 0.1-99 weight% of Suaeda asparagoides extract. The Suaeda asparagoides extract is isolated using water or low alcohol of 1-4 carbon atoms. The composition further contains pharmaceutically acceptable carrier, diluent, or excipient.
Abstract translation: 目的：提供含有芦荟天冬氨酸提取物的药物组合物，以抑制乙酰胆碱酯酶活化并预防和治疗阿尔茨海默氏病。 构成：用于预防或治疗痴呆的药物组合物或功能性食品组合物含有0.1-99重量％的芦荟天冬氨酸提取物。 使用1-4个碳原子的水或低级醇来分离芦荟天竺葵提取物。 组合物还含有药学上可接受的载体，稀释剂或赋形剂。
-
19.发明公开
公开(公告)号：KR1020110040371A
公开(公告)日：2011-04-20
申请号：KR1020090097602
申请日：2009-10-14
Applicant: 한림대학교 산학협력단
CPC classification number: Y02A50/411
Abstract: PURPOSE: A Vaccinium uliginosum L. extract which enhances intracellular introducing ability of SOD fusion protein is provided to enhance intracellular activity and to treat various diseases. CONSTITUTION: A Vaccinium uliginosum L. extract enhances cell permeability of cell permeable superoxide dismutase fusion protein. The Vaccinium uliginosum L. extract is an anthocyanin fraction. A protein transport domain is an HIV-1 Tat(49-57), Tat(51-57), Tat(50-56), Tat(50-57), Tat(50-55), oligo arginine having 5-12 arginine residues, oligolysine having 5-12 lysine residues, or 5-12 arginine. A pharmaceutical composition which is useful for SOD-dependent diseases contains a cell permeable SOD fusion protein and pharmaceutically acceptable carrier containing Vaccinium uliginosum L. extract.
Abstract translation: 目的：提供增强SOD融合蛋白的细胞内引入能力的牛痘提取物，以增强细胞内活性和治疗各种疾病。 构成：牛痘提取物增强细胞渗透性超氧化物歧化酶融合蛋白的细胞渗透性。 牛痘提取物是花青素组分。 蛋白质转运结构域是HIV-1 Tat（49-57），Tat（51-57），Tat（50-56），Tat（50-57），Tat（50-55），具有5-12个 精氨酸残基，具有5-12赖氨酸残基的寡聚赖氨酸或5-12精氨酸。 可用于SOD依赖性疾病的药物组合物含有细胞可渗透SOD融合蛋白和含有牛痘提取物的药学上可接受的载体。
-
公开(公告)号：KR1020110038386A
公开(公告)日：2011-04-14
申请号：KR1020090095656
申请日：2009-10-08
Applicant: 한림대학교 산학협력단
CPC classification number: A61K36/71 , A61K2236/331 , A61K2236/333
Abstract: PURPOSE: A composition containing crude extract of Pulsatilla koreana is provided to effectively relieve or treat pain without side effects. CONSTITUTION: An analgesic composition contains crude extract of Pulsatilla koreana as an active ingredient. A composition for preventing or treating pain contains 0.1-99 weight% of Pulsatilla koreana extract. The extract is isolated using water or low alcohol of 1-4 carbon atoms. A food and pharmaceutical composition for preventing or relieving pain contains 0.01-15 weight% of the analgesic composition.
Abstract translation: 目的：提供含有白头翁的粗提物的组合物，有效缓解或治疗无副作用的疼痛。 构成：镇痛药组合物含有白胡萝卜的粗提物作为活性成分。 用于预防或治疗疼痛的组合物含有0.1-99重量％的白头翁提取物。 使用1-4个碳原子的水或低级醇分离提取物。 用于预防或缓解疼痛的食品和药物组合物含有镇痛组合物的0.01-15重量％。
-
-
-
-
-
-
-
-
-
Search Results
137
records
(took 0.097 seconds)
