Abstract:
A method of forming a fibrin hydrogel composition including providing one or more unitary masses of a fibrin hydrogel, dividing at least one of the unitary masses of the fibrin hydrogel into a multiplicity of smaller pieces of the fibrin hydrogel, and recombining at least a portion of the smaller pieces into a cohesive mass. Dividing at least one of the unitary masses of fibrin hydrogel into a multiplicity of smaller pieces may include shearing or cutting the unitary masses to form an aqueous dispersion of the fibrin hydrogel in an aqueous medium. The aqueous dispersion of fibrin hydrogel may be applied to a substrate on a roller or an endless belt, and is optionally overlaid by a scrim. The cohesive mass of fibrin hydrogel, which may be formed by removing at least a portion of the aqueous medium from the aqueous dispersion of the smaller pieces of the fibrin hydrogel, finds uses in wound dressing articles.
Abstract:
The disclosed conformable coating provides a highly durable and resilient film useful for protecting and repairing surfaces such as skin and mucous membranes. The coating comprises 0.1% to 65% wt. of a polymerized cyanoacrylate monomer and at least 35% wt. of an elastomer phase. The conformable coating composition comprises a polymerizable cyanoacrylate monomer, an elastomer, and a volatile liquid. The cyanoacrylate monomer is 0.1 to 65% wt. of the nonvolatile portion, the elastomer in an elastomer phase is at least 35% wt. of the nonvolatile portion, and the volatile liquid is at least 40% wt. of the total composition.
Abstract:
A foamable dental composition that includes a film- forming component and a non-aqueous carrier comprising a co-solvent selected from the group consisting of diethylene glycol monoethyl ether, dipropylene glycol, 200 to 45,000 molecular weight poly(ethylene glycol), methoxides of 200 to 45,000 molecular weight poly(ethylene glycol), hexamethyldisiloxane, and a combination thereof, wherein the film-forming component is dissolved in the carrier; wherein the film-forming component forms a retentive polymeric coating on a dental surface; and a method of forming a retentive polymeric coating on the dental surface are disclosed.
Abstract:
Antimicrobial compositions containing an antimicrobial agent, such as an octenidine salt, a solubilizer, such as a glycol, and a cidatrope, such as a C 8 – C 26 alcohol, an ether, an amide, an ester, and combinations thereof, where the compositions are substantially free of water and C 2 – C 5 alcohols and methods of making such antimicrobial compositions.
Abstract:
An applicator (100) including a hollow body (110), the hollow body including a distal portion (112), a proximal portion (114), an exterior surface (118), an interior surface (116), and an activation region (120), where the hollow body includes at least two longitudinal grooves (122) on at least one of the exterior surface and the interior surface in the activation region of the applicator, and where the hollow body has a first radial groove (124) in the activation region that is on at least one of the exterior surface or the interior surface. The applicator includes a frangible ampoule (160) inside the hollow body, the frangible ampoule configured to contain a solution. The applicator may include a head (140) having an absorbent component (150) capable of absorbing the contents of the frangible ampoule when the ampoule is fractured and can aid in application of the ampoule contents to the desired surface.
Abstract:
A wound dressing system comprising a drape and a hydrogel sealant. The drape comprises a film and an adhesive on a first major surface of the film. The hydrogel comprises at least 30% by weight water, a crosslinked hydrophilic absorbent polymer; and a swelling agent. The hydrogel can create a seal between the drape and a surface (e.g., a patient's skin), making the disclosed systems suitable for negative pressure wound therapy (NPWT) applications.
Abstract:
A siloxane-functional isobutylene copolymer and use thereof is described. The copolymer is of the formula: wherein a is at least 20, and at least one of b and c are at least one, X is oxygen or nitrogen; R1 is a covalent bond or a divalent (hetero)hydrocarbyl group; Sil is a polydialkylsiloxane; and x is 1 or 2.
Abstract:
The disclosed conformable coating provides a highly durable and resilient film useful for protecting and repairing surfaces such as skin and mucous membranes. A conformable coating composition comprises an elastomer, a volatile liquid, wherein the volatile liquid is at least 40% wt. of the total composition and the composition has a viscosity less than 1,000 cps. Disclosed is a conformable film that comprises an elastomer on a substrate, wherein the coating weight is from 1 to 30 mg/in 2 , and wherein the film has less than 75% failure at 100% elongation.
Abstract:
The disclosure provides processes and systems for sterilizing an object using a sterilant gas. In some embodiments, the sterilant gas is produced by the thermal decomposition of a salt. Compositions to generate sterilant gasses are also disclosed.