公开(公告)号：CR20130151A

公开(公告)日：2013-05-23

申请号：CR20130151

申请日：2013-04-03

Applicant: ABBOTT LAB

Inventor： LACY SUSAN E ,  FUNG EMMA ,  BELK JONATHAN P ,  DIXON RICHARD W ,  ROGUSKA MICHAEL ,  HINTON PAUL R ,  KUMAR SHANKAR

IPC: C07K16/00

Abstract: Proteínas de unión a IL-12 p40, en particular anticuerpos que se unen a la interleuquina-12 humana (hIL-12) y/o IL-23 humana (hIL-23). Específicamente, la invención se relaciona con anticuerpos que son quiméricos, con injertos de CDR y anticuerpos humanizados.

公开(公告)号：MX2010009679A

公开(公告)日：2010-09-22

申请号：MX2010009679

申请日：2009-03-03

Applicant: ABBOTT LAB

Inventor： BELK JONATHAN P ,  HSIEH CHUNG MING ,  PEREZ JENNIFER M ,  BENATUIL LORENZO

IPC: C12Q1/68 ,  C40B40/02 ,  C40B50/06

Abstract: La presente invención se refiere a la transformación de levadura, y mutantes de la misma, mediante electroporación, lo cual da como resultado células huésped de levadura transformadas de manera estable que expresan los productos recombinantes La presente invención también se refiere a células de levadura transformadas y librerías.

公开(公告)号：HK1103746A1

公开(公告)日：2007-12-28

申请号：HK07106305

申请日：2007-06-12

Applicant: ABBOTT LAB

Inventor： REILLY EDWARD B ,  LACY SUSAN E ,  FUNG EMMA ,  BELK JONATHAN P ,  ROGUSKA MICHAEL

IPC: A61K20060101 ,  A61K39/395 ,  C07K20060101 ,  C07K16/28 ,  C12N20060101 ,  C12N5/10 ,  C12N15/13 ,  C12N15/63 ,  C12Q1/70 ,  G01N33/53

公开(公告)号：NZ596992A

公开(公告)日：2013-07-26

申请号：NZ59699206

申请日：2006-06-29

Applicant: ABBOTT LAB

Inventor： LACY SUSAN E ,  FUNG EMMA ,  BELK JONATHAN P ,  DIXON RICHARD W ,  ROGUSKA MICHAEL ,  HINTON PAUL R ,  KUMAR SHANKAR

IPC: A61K39/395 ,  C07K14/715 ,  C07K16/00 ,  C07K16/24 ,  C12N15/13

Abstract: 596992 Disclosed is a binding protein that possesses an antigen binding domain, said binding protein capable of binding a p40 subunit of human IL-12, said antigen binding domain possessing six CDRs: CDR-H1, CDR-H2, CDR-H3, CDR-L1, CDR-L2, and CDR-L3, wherein: CDR-H1 is: KSVMGVS, HIYWDDDKYYNPSLKS, RGIRSAMDY, KASQSVSNDVA, YASNRYT and QQDYNSPWT respectively.

公开(公告)号：CR20130156A

公开(公告)日：2013-05-23

申请号：CR20130156

申请日：2013-04-03

Applicant: ABBOTT LAB

Inventor： LACY SUSAN E ,  FUNG EMMA ,  BELK JONATHAN P ,  DIXON RICHARD W ,  ROGUSKA MICHAEL ,  HINTON PAUL R ,  KUMAR SHANKAR

IPC: C07K16/00

Abstract: Proteínas de unión a IL-12 p40, en particular anticuerpos que se unen a la interleuquina-12 humana (hIL-12) y/o IL-23 humana (hIL-23). Específicamente, la invención se relaciona con anticuerpos que son quiméricos, con injertos de CDR y anticuerpos humanizados. Los anticuerpos preferidos tienen gran afinidad por hIL-12 y/o hIL-23 y neutralizan la actividad de hIL-12 y/o hIL-23 in vitro y in vivo. Un anticuerpo de la invención puede ser un anticuerpo de longitud completa o una porción de unión al antígeno del mismo.

公开(公告)号：SG174782A1

公开(公告)日：2011-10-28

申请号：SG2011064268

申请日：2007-09-07

Applicant: ABBOTT LAB

Inventor： WU CHENGBIN ,  DIXON RICHARD W ,  BELK JONATHAN P ,  YING HUA ,  ARGIRIADI MARIA A ,  CUFF CAROLYN A ,  HINTON PAUL R ,  KUMAR SHANKAR ,  MELIM TERRY L ,  CHEN YAN

Abstract: The present invention encompasses IL-13 binding proteins. Specifically, the invention relates to antibodies that are chimeric, SDR grafted and humanized antibodies. Preferred antibodies have high affinity for hIL-13 and neutralize hIL-13 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-13 and for inhibiting hIL-13 activity, e.g., in a human subject suffering from a disorder in which hTL-13 activity is detrimental.

公开(公告)号：SG163559A1

公开(公告)日：2010-08-30

申请号：SG2010047561

申请日：2006-06-29

Applicant: ABBOTT LAB

Inventor： LACY SUSAN E ,  FUNG EMMA ,  BELK JONATHAN P ,  DIXON RICHARD W ,  ROGUSKA MICHAEL ,  HINTON PAUL R ,  KUMAR SHANKAR

Abstract: The present invention encompasses IL-12p40 binding proteins, particularly antibodies that bind human interleukin-12 (hIL-12) and/or human IL-23 (hIL- 23). Specifically, the invention relates to antibodies that are chimeric, CDR grafted and humanized antibodies. Preferred antibodies have high affinity for hIL-12 and/or hIL-23 and neutralize h IL-12 and/or hIL-23 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-12 and/or hIL- 23 and for inhibiting hIL-12 and/or hIL-23 activity, e.g., in a human subject suffering from a disorder in which hIL-12 and/or hIL-23 activity is detrimental.

公开(公告)号：CA2717128A1

公开(公告)日：2009-09-17

申请号：CA2717128

申请日：2009-03-03

Applicant: ABBOTT LAB

Inventor： HSIEH CHUNG-MING ,  BELK JONATHAN P ,  PEREZ JENNIFER M ,  BENATUIL LORENZO

IPC: C40B50/06 ,  C12N15/87 ,  C40B40/02

Abstract: This invention is directed to the transformation of yeast, and mutants thereof, by electroporation, which result in stably transformed yeast host cells that express recombinant products. This invention also is directed to transformed yeast cells and libraries.

公开(公告)号：CR9599A

公开(公告)日：2009-06-05

申请号：CR9599

申请日：2007-12-18

Applicant: ABBOTT LAB

Inventor： LACY SUSAN E ,  FUNG EMMA ,  BELK JONATHAN P ,  DIXON RICHARD W ,  ROGUSKA MICHAEL ,  HINTON PAUL R ,  KUMAR SHANKAR

IPC: C07K14/715

Abstract: Proteinas de union a IL-12p40, en particular anticuerpos que se unen a la interleuquina-12 humana (hIL-12) y/o IL-23 humana (hIL-23). Especificamente, ia invencion se relaciona con anticuerpos que son quimericos, con injertos de CDR y anticuerpos humanizados.

公开(公告)号：CA2662701A1

公开(公告)日：2008-10-23

申请号：CA2662701

申请日：2007-09-07

Applicant: ABBOTT LAB

Inventor： KUMAR SHANKAR ,  HINTON PAUL R ,  WU CHENGBIN ,  CUFF CAROLYN A ,  MELIM TERRY L ,  DIXON RICHARD W ,  BELK JONATHAN P ,  CHEN YAN ,  ARGIRIADI MARIA A ,  YING HUA

IPC: C07K16/24 ,  C07K16/46 ,  C12N15/13 ,  C12P21/08

Abstract: The present invention encompasses IL- 13 binding proteins. Specifically, the invention relates to antibodies that are chimeric, CDR grafted and human ized antibodies. Preferred antibodies have high affinity for hIL-13 and neut ralize hIL-13 activity in vitro and in vivo. An antibody of the invention ca n be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provide d. The antibodies, or antibody portions, of the invention are useful for det ecting hIL-13 and for inhibiting hlL-13 activity, e.g., in a human subject s uffering from a disorder in which hTL-13 activity is detrimental.