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公开(公告)号：WO2011130377A3
公开(公告)日：2011-12-08
申请号：PCT/US2011032269
申请日：2011-04-13
Applicant: ABBOTT LAB , BARGHORN STEFAN , HILLEN HEINZ , STRIEBINGER ANDREAS , GIAISI SIMONE , EBERT ULRICH , BENATUIL LORENZO , ABBOTT GMBH & CO KG
Inventor： BARGHORN STEFAN , HILLEN HEINZ , STRIEBINGER ANDREAS , GIAISI SIMONE , EBERT ULRICH , BENATUIL LORENZO
IPC: C07K16/18
CPC classification number: C07K16/18 , A61K39/3955 , A61K47/6835 , A61K49/00 , C07K14/4711 , C07K2317/21 , C07K2317/24 , C07K2317/30 , C07K2317/31 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/569 , C07K2317/622 , C07K2317/624 , C07K2317/626 , C07K2317/92
Abstract: The present invention relates to amyloid-beta (As) binding proteins. Antibodies of the invention have high affinity to As(20-42) globulomer or any A form that comprises the globulomer epitope. Method of making and method of using the antibodies of the invention are also provided.
Abstract translation: 本发明涉及淀粉状蛋白-β（As）结合蛋白。 本发明的抗体对As（20-42）球聚体或包含球聚体表位的任何A形式具有高亲和力。 还提供了制备方法和使用本发明抗体的方法。
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公开(公告)号：WO2009114093A3
公开(公告)日：2010-01-21
申请号：PCT/US2009001351
申请日：2009-03-03
Applicant: ABBOTT LAB , HSIEH CHUNG-MING , BELK JONATHAN P , PEREZ JENNIFER M , BENATUIL LORENZO
Inventor： HSIEH CHUNG-MING , BELK JONATHAN P , PEREZ JENNIFER M , BENATUIL LORENZO
Abstract: This invention is directed to the transformation of yeast, and mutants thereof, by electroporation, which result in stably transformed yeast host cells that express recombinant products. This invention also is directed to transformed yeast cells and libraries.
Abstract translation: 本发明涉及通过电穿孔转化酵母及其突变体，其导致表达重组产物的稳定转化的酵母宿主细胞。 本发明还涉及转化的酵母细胞和文库。
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公开(公告)号：WO2011163478A3
公开(公告)日：2012-05-03
申请号：PCT/US2011041633
申请日：2011-06-23
Applicant: ABBOTT LAB , GHAYUR TARIQ , LIU JUNJIAN , JAKWAY JAMES J , TALANIAN ROBERT V , BENATUIL LORENZO
Inventor： GHAYUR TARIQ , LIU JUNJIAN , JAKWAY JAMES J , TALANIAN ROBERT V , BENATUIL LORENZO
IPC: A61K39/395 , C07K16/00 , C12P21/02
CPC classification number: C07K16/2875 , C07K16/241 , C07K16/468 , C07K2317/31 , C07K2317/64
Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
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公开(公告)号：WO2011025964A3
公开(公告)日：2011-04-21
申请号：PCT/US2010047006
申请日：2010-08-27
Applicant: ABBOTT LAB , BENATUIL LORENZO , BOGHAERT ERWIN R , GU JIJIE , HARRIS MARIA , HICKSON JONATHAN A , HSIEH CHUNG-MING , KUTSKOVA YULIYA , LI YINGCHUN , LIU ZHIHONG , MORGAN-LAPPE SUSAN
Inventor： BENATUIL LORENZO , BOGHAERT ERWIN R , GU JIJIE , HARRIS MARIA , HICKSON JONATHAN A , HSIEH CHUNG-MING , KUTSKOVA YULIYA , LI YINGCHUN , LIU ZHIHONG , MORGAN-LAPPE SUSAN
IPC: C07K16/28
CPC classification number: C07K16/22 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K7/06 , C07K7/08 , C07K14/47 , C07K16/18 , C07K2317/21 , C07K2317/33 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2317/94
Abstract: Improved DLL4 binding proteins are described, including antibodies, CDR-grafted antibodies, human antibodies, and DLL4 binding fragments thereof, proteins that bind DLL4 with high affinity, and DLL4 binding proteins that neutralize DLL4 activity. The DLL4 binding proteins are useful for treating or preventing cancers and tumors and especially for treating or preventing tumor angiogenesis, and/or other angiogenesis-dependent diseases such as ocular neovascularization, or angiogenesis-independent diseases characterized by aberrant DLL4 expression or activity such as autoimmune disorders including multiple sclerosis.
Abstract translation: 描述了改进的DLL4结合蛋白，包括抗体，CDR-移植抗体，人抗体和DLL4结合片段，以高亲和力结合DLL4的蛋白质，以及中和DLL4活性的DLL4结合蛋白。 DLL4结合蛋白可用于治疗或预防癌症和肿瘤，特别是用于治疗或预防肿瘤血管生成和/或其它血管发生依赖性疾病，例如眼新生血管形成或以异常DLL4表达或活性为特征的血管发生非依赖性疾病，例如自身免疫 包括多发性硬化的疾病。
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公开(公告)号：WO2011163478A4
公开(公告)日：2012-07-05
申请号：PCT/US2011041633
申请日：2011-06-23
Applicant: ABBOTT LAB , GHAYUR TARIQ , LIU JUNJIAN , JAKWAY JAMES J , TALANIAN ROBERT V , BENATUIL LORENZO
Inventor： GHAYUR TARIQ , LIU JUNJIAN , JAKWAY JAMES J , TALANIAN ROBERT V , BENATUIL LORENZO
IPC: A61K39/395 , C07K16/00 , C12P21/02
CPC classification number: C07K16/2875 , C07K16/241 , C07K16/468 , C07K2317/31 , C07K2317/64
Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
Abstract translation: 本发明涉及工程化的多价和多特异性结合蛋白，制备方法，具体涉及用于预防，诊断和/或治疗疾病的用途。
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Patent Agency Ranking
公开(公告)号：EP2257638A4
公开(公告)日：2011-06-29
申请号：EP09719237
申请日：2009-03-03
Applicant: ABBOTT LAB
Inventor： HSIEH CHUNG-MING , BELK JONATHAN P , PEREZ JENNIFER M , BENATUIL LORENZO
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公开(公告)号：SG188944A1
公开(公告)日：2013-05-31
申请号：SG2012094900
申请日：2011-06-23
Applicant: ABBOTT LAB
Inventor： GHAYUR TARIQ , LIU JUNJIAN , JAKWAY JAMES J , TALANIAN ROBERT V , BENATUIL LORENZO
Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
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公开(公告)号：CR20120105A
公开(公告)日：2012-06-22
申请号：CR20120105
申请日：2012-02-28
Applicant: ABBOTT LAB
Inventor： BENATUIL LORENZO , BOGHAERT ERWIN R , GU JIJIE , HARRIS MARIA , HICKSON JONATHAN A , HSIEH CHUNG-MING , KUTSKOVA YULIYA , LI YINGEHUN , LIU ZHIHONG , MORGAN-LAPPE SUSAN
IPC: C07K16/28
Abstract: Proteinas de unión a DLL4 mejoradas, inclusive anticuerpos, anticuerpos de CDR, anticuerpos humanos y fragmentos de unión a DLL4 de los mismos, proteínas que se unen a DLL4 con gran afinidad y proteínas de union a DLL4 que neutralizan la actividad de DLL4 y/o VEGF.
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公开(公告)号：AR080914A1
公开(公告)日：2012-05-16
申请号：ARP110101306
申请日：2011-04-15
Applicant: ABBOTT GMBH & CO KG , ABBOTT LAB
Inventor： BARGHORN STEFAN , HILLEN HEINZ , STRIEBINGER ANDREAS , GIAISI SIMONE , EBERT ULRICH , BENATUIL LORENZO
Abstract: Proteínas que se unen al péptido amiloide-b (Ab). Los anticuerpos de la solicitud presentan una afinidad elevada por el globulomero Ab(20-42) o por cualquier forma de A° que comprenda el epítope del globulomero. Método para elaborar y método para usar los anticuerpos de la solicitud. Reivindicacion 1: Una proteína de union caracterizada porque comprende una primera secuencia de aminoácidos que es al menos 90% idéntica a SEQ ID Ns 2 o SEQ ID Ns 3; y una segunda secuencia de aminoácidos que es al menos 90% idéntica a SEQ ID Ns 1.
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公开(公告)号：CA2771575A1
公开(公告)日：2011-03-03
申请号：CA2771575
申请日：2010-08-27
Applicant: ABBOTT LAB
Inventor： BENATUIL LORENZO , BOGHAERT ERWIN R , GU JIJIE , HARRIS MARIA , HICKSON JONATHAN A , HSIEH CHUNG-MING , KUTSKOVA YULIYA , LI YINGCHUN , LIU ZHIHONG , MORGAN-LAPPE SUSAN
IPC: C07K16/28
Abstract: Improved DLL4 binding proteins are described, including antibodies, CDR-grafted antibodies, human antibodies, and DLL4 binding fragments thereof, proteins that bind DLL4 with high affinity, and DLL4 binding proteins that neutralize DLL4 activity. The DLL4 binding proteins are useful for treating or preventing cancers and tumors and especially for treating or preventing tumor angiogenesis, and/or other angiogenesis-dependent diseases such as ocular neovascularization, or angiogenesis-independent diseases characterized by aberrant DLL4 expression or activity such as autoimmune disorders including multiple sclerosis.
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