公开(公告)号：SG174782A1

公开(公告)日：2011-10-28

申请号：SG2011064268

申请日：2007-09-07

Applicant: ABBOTT LAB

Inventor： WU CHENGBIN ,  DIXON RICHARD W ,  BELK JONATHAN P ,  YING HUA ,  ARGIRIADI MARIA A ,  CUFF CAROLYN A ,  HINTON PAUL R ,  KUMAR SHANKAR ,  MELIM TERRY L ,  CHEN YAN

Abstract: The present invention encompasses IL-13 binding proteins. Specifically, the invention relates to antibodies that are chimeric, SDR grafted and humanized antibodies. Preferred antibodies have high affinity for hIL-13 and neutralize hIL-13 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-13 and for inhibiting hIL-13 activity, e.g., in a human subject suffering from a disorder in which hTL-13 activity is detrimental.

公开(公告)号：CA2662701A1

公开(公告)日：2008-10-23

申请号：CA2662701

申请日：2007-09-07

Applicant: ABBOTT LAB

Inventor： KUMAR SHANKAR ,  HINTON PAUL R ,  WU CHENGBIN ,  CUFF CAROLYN A ,  MELIM TERRY L ,  DIXON RICHARD W ,  BELK JONATHAN P ,  CHEN YAN ,  ARGIRIADI MARIA A ,  YING HUA

IPC: C07K16/24 ,  C07K16/46 ,  C12N15/13 ,  C12P21/08

Abstract: The present invention encompasses IL- 13 binding proteins. Specifically, the invention relates to antibodies that are chimeric, CDR grafted and human ized antibodies. Preferred antibodies have high affinity for hIL-13 and neut ralize hIL-13 activity in vitro and in vivo. An antibody of the invention ca n be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provide d. The antibodies, or antibody portions, of the invention are useful for det ecting hIL-13 and for inhibiting hlL-13 activity, e.g., in a human subject s uffering from a disorder in which hTL-13 activity is detrimental.

公开(公告)号：SK286397B6

公开(公告)日：2008-09-05

申请号：SK6332000

申请日：1998-10-29

Applicant: ABBOTT LAB

Inventor： PHAN LY TAM ,  OR YAT SUN ,  CHU DANIEL T ,  PLATTNER JACOB J ,  CHEN YAN ,  CLARK RICHARD F

IPC: C07H17/00 ,  A61K31/00 ,  A61K31/7042 ,  A61K31/7048 ,  A61P31/04 ,  C07H17/08

Abstract: 2-Halo-6-O-substituted ketolide derivatives of general formula (I) and a pharmaceutically acceptable salt thereof, having antibacterial activity, method for their preparation and their use for manufacturing a medicament for treating bacteria infections. Thereinafter there are disclosed pharmaceutical compositions containing a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier.

公开(公告)号：PT1181300E

公开(公告)日：2004-02-27

申请号：PT00936424

申请日：2000-05-31

Applicant: ABBOTT LAB

Inventor： PHAN LY T ,  OR YAT SUN ,  MA ZHENKUN ,  CHEN YAN

IPC: A61K31/7056 ,  A61P31/04 ,  C07H17/08 ,  A61K31/7048

公开(公告)号：DE60005334D1

公开(公告)日：2003-10-23

申请号：DE60005334

申请日：2000-05-31

Applicant: ABBOTT LAB

Inventor： PHAN LY T ,  OR YAT SUN ,  MA ZHENKUN ,  CHEN YAN

IPC: A61K31/7056 ,  A61P31/04 ,  C07H17/08 ,  A61K31/7048

公开(公告)号：MXPA01012661A

公开(公告)日：2002-07-22

申请号：MXPA01012661

申请日：2000-05-31

Applicant: ABBOTT LAB

Inventor： CHEN YAN

IPC: A61K31/7056 ,  A61P31/04 ,  C07H17/08

Abstract: La invencion se refiere a un nuevo compuesto de 6-O-carbamato quetolida o una sal farmaceuticamente aceptable, ester, solvato o promedicamento del mismo, a una composicion que comprende el compuesto y un vehiculo adecuado, un metodo para preparar el compuesto, y un metodo de tratamiento y prevencion de infecciones en un mamifero.

公开(公告)号：HK1031383A1

公开(公告)日：2001-06-15

申请号：HK01100816

申请日：2001-02-05

Applicant: ABBOTT LAB

Inventor： PHAN LY TAM ,  OR YAT SUN ,  CHU DANIEL T ,  PLATTNER JACOB J ,  CLARK RICHARD F ,  CHEN YAN

IPC: A61K31/7042 ,  A61K31/7048 ,  A61P31/04 ,  C07H17/08 ,  C07H ,  A61K

Abstract: Novel 2-halo-6-O-substituted ketolide derivatives and pharmaceutically acceptable salts and esters thereof having antibacterial activity having formula (I) or (II), compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier, a method for treating bacterial infections by administering to a mammal a pharmaceutical composition containing a therapeutically-effective amount of a compound of the invention, and processes for their preparation.

公开(公告)号：TR200001142T2

公开(公告)日：2000-09-21

申请号：TR200001142

申请日：1998-10-29

Applicant: ABBOTT LAB

Inventor： PHAN LY TAM ,  OR YAT SUN ,  CHU DANIEL T ,  PLATINER JACOB J ,  CHEN YAN ,  CLARK RICHARD F

IPC: A61K31/7042 ,  A61K31/7048 ,  A61P31/04 ,  C07H17/08 ,  A61K31/70

Abstract: Novel 2-halo-6-O-substituted ketolide derivatives and pharmaceutically acceptable salts and esters thereof having antibacterial activity having formula (I) or (II), compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier, a method for treating bacterial infections by administering to a mammal a pharmaceutical composition containing a therapeutically-effective amount of a compound of the invention, and processes for their preparation.

公开(公告)号：SK6332000A3

公开(公告)日：2000-09-12

申请号：SK6332000

申请日：1998-10-29

Applicant: ABBOTT LAB

Inventor： PHAN LY TAM ,  OR YAT SUN ,  CHU DANIEL T ,  PLATTNER JACOB J ,  CHEN YAN ,  CLARK RICHARD F

IPC: A61K31/7042 ,  A61K31/7048 ,  A61P31/04 ,  C07H17/08 ,  A61K31/70

Abstract: Novel 2-halo-6-O-substituted ketolide derivatives and pharmaceutically acceptable salts and esters thereof having antibacterial activity having formula (I) or (II), compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier, a method for treating bacterial infections by administering to a mammal a pharmaceutical composition containing a therapeutically-effective amount of a compound of the invention, and processes for their preparation.

公开(公告)号：BRPI0716438A2

公开(公告)日：2014-03-04

申请号：BRPI0716438

申请日：2007-09-07

Applicant: ABBOTT LAB

Inventor： WU CHENGBIN ,  DIXON RICHARD W ,  BELK JONATHAN P ,  YING HUA ,  ARGIRIADI MARIA A ,  CUFF CAROLYN A ,  HINTON PAUL R ,  KUMAR SHANKAR ,  MELIN TERRY L ,  CHEN YAN

IPC: C12P21/08 ,  C07H21/00

Abstract: The present invention encompasses IL-13 binding proteins. Specifically, the invention relates to antibodies that are chimeric, CDR grafted and humanized antibodies. Preferred antibodies have high affinity for hIL-13 and neutralize hIL-13 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-13 and for inhibiting hIL-13 activity, e.g., in a human subject suffering from a disorder in which hIL-13 activity is detrimental.