公开(公告)号：JP2004279432A

公开(公告)日：2004-10-07

申请号：JP2004197669

申请日：2004-07-05

Applicant: Abbott Lab ,  アボット・ラボラトリーズAbbott Laboratories

Inventor： CLARK FREDERIC L ,  CLEMENS JOHN M ,  HANCE ROBERT B ,  HENDRICK KENDALL B ,  TAYI APPARAO ,  KANEWSKE WILLIAM J III ,  LAGOCKI PETER A ,  MARTIN RICHARD R ,  MCDOWELL DOUGLAS D ,  MERRIAM RICHARD A ,  MOORE LARRY W ,  OLEKSAK CARL M ,  PENNINGTON CHARLES D ,  RAYMOURE WILLIAM J ,  RUMBAUGH WILLIAM D ,  SCHMIDT LINDA S ,  SCHRIER PAUL R ,  SMITH B JANE ,  SPRONK ADRIAN M ,  WALKER EDNA S ,  VAUGHT JAMES A ,  VICKSTROM RICHARD L ,  WALKER DONNY RAY ,  WATKINS WILLIAM E III ,  WINTER GARY E ,  WOHLFORD ROBERT A ,  CLIFT GILBERT ,  CLOONAN KEVIN M ,  MITCHELL JAMES E ,  STANTON ALYN K ,  YOST DAVID A ,  HILLS DAVID B

IPC: G01N33/483 ,  B01F11/00 ,  B01L3/00 ,  B29C45/00 ,  G01F23/22 ,  G01F23/26 ,  G01N1/00 ,  G01N21/25 ,  G01N21/64 ,  G01N21/76 ,  G01N21/78 ,  G01N33/53 ,  G01N33/542 ,  G01N33/543 ,  G01N33/553 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10 ,  H01J49/04

CPC classification number: G01N35/0092 ,  B01F11/0022 ,  B01L3/5025 ,  B29C45/00 ,  G01N21/6445 ,  G01N21/6452 ,  G01N21/76 ,  G01N33/5302 ,  G01N33/542 ,  G01N33/54313 ,  G01N35/0099 ,  G01N35/025 ,  G01N35/1004 ,  G01N35/1065 ,  G01N2001/007 ,  G01N2021/6482 ,  G01N2035/00148 ,  G01N2035/00356 ,  G01N2035/0405 ,  G01N2035/0441 ,  G01N2035/0443 ,  G01N2035/0444 ,  G01N2035/0446 ,  G01N2035/1025 ,  G01N2035/1076 ,  G01N2035/1086 ,  H01J49/04

Abstract: PROBLEM TO BE SOLVED: To provide an automated continuous and random access analytical system, having an apparatus and methodology capable of simultaneously performing a plurality of assays of liquid samples using different assay methodologies, and providing continuous and random access while performing a plurality of different assays on the same or different samples during the same time period, and a method of operating an automated continuous and random access analytical system capable of simultaneously effecting the plurality of assays on a plurality of liquid samples. SOLUTION: The method comprises scheduling various assays of the plurality of liquid samples, creating a unit dose disposable and separately transferring a first liquid sample and reagents to a reaction vessel without initiation of an assay reaction sequence, and physically transferring the unit dose disposable to a processing workstation, whereby a mixture of the unit dose disposable reagents and the sample is achieved during incubation. COPYRIGHT: (C)2005,JPO&NCIPI

公开(公告)号：JP2004157140A

公开(公告)日：2004-06-03

申请号：JP2004051180

申请日：2004-02-26

Applicant: Abbott Lab ,  アボット・ラボラトリーズAbbott Laboratories

Inventor： CLARK FREDERIC L ,  CLEMENS JOHN M ,  HANCE ROBERT B ,  HENDRICK KENDALL B ,  TAYI APPARAO ,  KANEWSKE WILLIAM J III ,  LAGOCKI PETER A ,  MARTIN RICHARD R ,  MCDOWELL DOUGLAS D ,  MERRIAM RICHARD A ,  MOORE LARRY W ,  OLEKSAK CARL M ,  PENNINGTON CHARLES D ,  RAYMOURE WILLIAM J ,  RUMBAUGH WILLIAM D ,  SCHMIDT LINDA S ,  SCHRIER PAUL R ,  SMITH B JANE ,  SPRONK ADRIAN M ,  WALKER EDNA S ,  VAUGHT JAMES A ,  VICKSTROM RICHARD L ,  WALKER DONNY RAY ,  WATKINS WILLIAM E III ,  WINTER GARY E ,  WOHLFORD ROBERT A ,  CLIFT GILBERT ,  CLOONAN KEVIN M ,  MITCHELL JAMES E ,  STANTON ALYN K ,  YOST DAVID A ,  HILLS DAVID B

IPC: G01N33/483 ,  B01F11/00 ,  B01L3/00 ,  B29C45/00 ,  G01F23/22 ,  G01F23/26 ,  G01N1/00 ,  G01N21/25 ,  G01N21/64 ,  G01N21/76 ,  G01N21/78 ,  G01N33/53 ,  G01N33/542 ,  G01N33/543 ,  G01N33/553 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10 ,  H01J49/04

CPC classification number: G01N35/0092 ,  B01F11/0022 ,  B01L3/5025 ,  B29C45/00 ,  G01N21/6445 ,  G01N21/6452 ,  G01N21/76 ,  G01N33/5302 ,  G01N33/542 ,  G01N33/54313 ,  G01N35/0099 ,  G01N35/025 ,  G01N35/1004 ,  G01N35/1065 ,  G01N2001/007 ,  G01N2021/6482 ,  G01N2035/00148 ,  G01N2035/00356 ,  G01N2035/0405 ,  G01N2035/0441 ,  G01N2035/0443 ,  G01N2035/0444 ,  G01N2035/0446 ,  G01N2035/1025 ,  G01N2035/1076 ,  G01N2035/1086 ,  H01J49/04

Abstract: PROBLEM TO BE SOLVED: To provide an automated continuous and random access analytical system having an apparatus and a method capable of simultaneously performing multiple assays of liquid samples using different assay methodologies, and providing continuous and random access while performing a plurality of different assays on the same or different samples during the same time period, and to provide a method of operating an automated continuous and random access analytical system capable of simultaneously performing multiple assays of a plurality of liquid samples. SOLUTION: The method comprises scheduling various assays of the plurality of liquid samples, creating a unit dose disposable and separately transferring a first liquid sample and reagents to a reaction vessel without initiation of an assay reaction sequence, and physically transferring the unit dose disposable to a processing workstation, whereby a mixture of the unit dose disposable reagents and a sample is achieved during incubation. COPYRIGHT: (C)2004,JPO

公开(公告)号：JP2003177138A

公开(公告)日：2003-06-27

申请号：JP2002273038

申请日：2002-09-19

Applicant: ABBOTT LAB

Inventor： CLARK FREDERIC L ,  CLEMENS JOHN M ,  HANCE ROBERT B ,  HENDRICK KENDALL B ,  TAYI APPARAO ,  KANEWSKE WILLIAM J III ,  LAGOCKI PETER A ,  MARTIN RICHARD R ,  MCDOWELL DOUGLAS D ,  MERRIAM RICHARD A ,  MOORE LARRY W ,  OLEKSAK CARL M ,  PENNINGTON CHARLES D ,  RAYMOURE WILLIAM J ,  RUMBAUGH WILLIAM D ,  SCHMIDT LINDA S ,  SCHRIER PAUL R ,  SMITH B JANE ,  SPRONK ADRIAN M ,  WALKER EDNA S ,  VAUGHT JAMES A ,  VICKSTROM RICHARD L ,  WALKER DONNY RAY ,  WATKINS WILLIAM E III ,  WINTER GARY E ,  WOHLFORD ROBERT A ,  CLIFT GILBERT ,  CLOONAN KEVIN M ,  MITCHELL JAMES E ,  STANTON ALYN K ,  YOST DAVID A ,  HILLS DAVID B

IPC: G01N33/483 ,  B01F11/00 ,  B01L3/00 ,  B29C45/00 ,  G01F23/22 ,  G01F23/26 ,  G01N1/00 ,  G01N21/25 ,  G01N21/64 ,  G01N21/76 ,  G01N21/78 ,  G01N33/53 ,  G01N33/542 ,  G01N33/543 ,  G01N33/553 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10 ,  H01J49/04

Abstract: PROBLEM TO BE SOLVED: To provide an automatic continuous and random access analytical system having an apparatus and a method capable of simultaneously performing a plurality of assays of liquid samples by using different assay methods, capable of performing continuous and random access and performing a plurality of different assays to the same sample or to different samples during the same time, and a method for operating the automatic random access system capable of executing simultaneously a plurality of assays to a plurality of liquid samples. SOLUTION: In this method, various verifications of the plurality of liquid samples are scheduled, and then a unit dose disposable is generated without starting an assay reaction sequence, and a first liquid sample and a reagent are transferred separately to a reaction vessel. Thereafter, the unit dose disposable is transferred physically to a treatment work station, and thereby the unit dose disposable is mixed with the sample at the incubation time. COPYRIGHT: (C)2003,JPO

公开(公告)号：JP2002323500A

公开(公告)日：2002-11-08

申请号：JP2002050857

申请日：2002-02-27

Applicant: ABBOTT LAB

Inventor： CLARK FREDERIC L ,  CLIFT GILBERT ,  HENDRICK KENDALL B ,  KANEWSKE WILLIAM J III ,  LAGOCKI PETER A ,  MARTIN RICHARD R ,  MITCHELL JAMES E ,  MOORE LARRY W ,  PENNINGTON CHARLES D ,  WALKER EDNA S ,  SMITH B JANE ,  TAYI APPARAO ,  VAUGHT JAMES A ,  YOST DAVID A ,  MERRIAM RICHARD A ,  WALKER DONNY RAY ,  MCDOWELL DOUGLAS D ,  RUMBAUGH WILLIAM A ,  CLEMENS JOHN M

IPC: B01L3/00 ,  B01L3/08 ,  B01L9/06 ,  B29C45/00 ,  B67D99/00 ,  C12M1/34 ,  G01F23/284 ,  G01N1/00 ,  G01N1/14 ,  G01N1/28 ,  G01N21/03 ,  G01N21/25 ,  G01N33/53 ,  G01N33/537 ,  G01N33/538 ,  G01N33/542 ,  G01N33/543 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10 ,  G05D23/19 ,  H01J49/04 ,  H05B1/02

Abstract: PROBLEM TO BE SOLVED: To provide both an automatic and continuous-random access analysis system and a method for operating the same which comprise a device and a method, capable of simultaneously executing a plurality of tests on liquid samples through the use of different test methods, provides random access, and for simultaneously executing the plurality of different tests on the same or different samples during the same period. SOLUTION: In this method, the various tests on the plurality of liquid samples are scheduled, and a disposable unit amount is created; without starting a test reaction sequence, a first liquid sample 26 and a reagent 30 are individually transferred to a reaction vessel 34; then the disposable unit amount 34 is physically transferred to a treatment work station 46. As a result of this, a mixture 34 of the unit amount reagent and the sample is obtained during culturing.

公开(公告)号：WO9508774A3

公开(公告)日：1995-06-01

申请号：PCT/US9410850

申请日：1994-09-22

Applicant: ABBOTT LAB

Inventor： CLARK FREDERICK L ,  CLEMENS JOHN M ,  HANCE ROBERT B ,  HENDRICK KENDALL B ,  TAYI APPARAO ,  KANEWSKE WILLIAM J III ,  LAGOCKI PETER A ,  MARTIN RICHARD R

IPC: G01N33/483 ,  B01F11/00 ,  B01L3/00 ,  B29C45/00 ,  G01F23/22 ,  G01F23/26 ,  G01N1/00 ,  G01N21/25 ,  G01N21/64 ,  G01N21/76 ,  G01N21/78 ,  G01N33/53 ,  G01N33/542 ,  G01N33/543 ,  G01N33/553 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10 ,  H01J49/04

CPC classification number: G01N35/0092 ,  B01F11/0022 ,  B01L3/5025 ,  B29C45/00 ,  G01N21/6445 ,  G01N21/6452 ,  G01N21/76 ,  G01N33/5302 ,  G01N33/542 ,  G01N33/54313 ,  G01N35/0099 ,  G01N35/025 ,  G01N35/1004 ,  G01N35/1065 ,  G01N2001/007 ,  G01N2021/6482 ,  G01N2035/00148 ,  G01N2035/00356 ,  G01N2035/0405 ,  G01N2035/0441 ,  G01N2035/0443 ,  G01N2035/0444 ,  G01N2035/0446 ,  G01N2035/1025 ,  G01N2035/1076 ,  G01N2035/1086 ,  H01J49/04

Abstract: An automated, continuous and random access analytical system, having apparatus and methodology capable of simultaneously performing multiple assays of liquid samples using different assay methodologies, and providing continuous and random access while performing a plurality of different assays on the same or different samples during the same time period, is disclosed. A method is also disclosed of operating an automated continuous and random access analytical system capable of simultaneously effecting multiple assays of a plurality of liquid samples wherein scheduling of various assays of the plurality of liquid samples is followed by creating a unit dose disposable and separately transferring a first liquid sample and reagents to a reaction vessel without initiation of an assay reaction sequence, followed by physical transfer of the unit dose disposable to a processing workstation, whereby a mixture of the unit dose disposable reagents and sample are achieved during incubation. The system is capable of performing more than one scheduled assay in any order, and assays where more than such scheduled assays are presented. The automated, continuous and random access analytical system is also capable of analyzing the incubated reaction mixtures independently and individually by at least two assay procedures.

公开(公告)号：WO2005062040A3

公开(公告)日：2006-03-30

申请号：PCT/US2004038298

申请日：2004-11-17

Applicant: ABBOTT LAB ,  CLEMENS JOHN M ,  SHAIN ERIC B ,  JENG TZYY-WEN ,  SCHNEIDER GEORGE J

Inventor： CLEMENS JOHN M ,  SHAIN ERIC B ,  JENG TZYY-WEN ,  SCHNEIDER GEORGE J

IPC: C12Q1/68 ,  G06F19/00

CPC classification number: G06F19/22 ,  C12Q1/68 ,  C12Q1/6851 ,  C12Q1/686 ,  C12Q2561/113 ,  C12Q2545/101 ,  C12Q2537/165

Abstract: A method and system for determining the quantity of an analyte initially present in a chemical and or biological reaction as well as a computer implemented method and system to automate portions of the analysis comprising mathematical or graphical analysis of an amplification reaction.

Abstract translation: 用于确定最初存在于化学和/或生物反应中的分析物的量的方法和系统以及计算机实现的方法和系统，以使包括扩增反应的数学或图形分析的部分分析自动化。

公开(公告)号：EP0755519A4

公开(公告)日：1995-04-07

申请号：EP93908481

申请日：1993-03-24

Applicant: ABBOTT LAB

Inventor： CLARK FREDERIC L ,  CLIFT GILBERT ,  HENDRICK KENDALL B ,  KANEWSKE WILLIAM J III ,  LAGOCKI PETER A ,  MARTIN RICHARD R ,  MITCHELL JAMES E ,  MOORE LARRY W ,  PENNINGTON CHARLES D ,  WALKER EDNA S ,  SMITH JANE B ,  TAYI APPARAO ,  VAUGHT JAMES A ,  YOST DAVID A ,  MERRIAM RICHARD A ,  WALKER DONNY RAY ,  MCDOWELL DOUGLAS D ,  RUMBAUGH WILLIAM A ,  CLEMENS JOHN M

IPC: B01L3/00 ,  B01L3/08 ,  B01L9/06 ,  B29C45/00 ,  B67D99/00 ,  C12M1/34 ,  G01F23/284 ,  G01N1/00 ,  G01N1/14 ,  G01N1/28 ,  G01N21/03 ,  G01N21/25 ,  G01N33/53 ,  G01N33/537 ,  G01N33/538 ,  G01N33/542 ,  G01N33/543 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10 ,  G05D23/19 ,  H01J49/04 ,  H05B1/02

CPC classification number: G01N35/0095 ,  B01L3/08 ,  B01L3/5025 ,  B01L3/5085 ,  B01L3/50853 ,  B01L9/06 ,  B01L2200/142 ,  B01L2300/042 ,  B01L2300/043 ,  B29C45/00 ,  B29K2995/0032 ,  B29L2023/22 ,  G01N21/03 ,  G01N21/253 ,  G01N33/5302 ,  G01N33/537 ,  G01N33/538 ,  G01N33/542 ,  G01N33/54313 ,  G01N35/0092 ,  G01N35/0099 ,  G01N35/025 ,  G01N35/1004 ,  G01N35/1065 ,  G01N2001/007 ,  G01N2035/00168 ,  G01N2035/00277 ,  G01N2035/00287 ,  G01N2035/00356 ,  G01N2035/00386 ,  G01N2035/00455 ,  G01N2035/00475 ,  G01N2035/00495 ,  G01N2035/00524 ,  G01N2035/00752 ,  G01N2035/0093 ,  G01N2035/0405 ,  G01N2035/0436 ,  G01N2035/0441 ,  G01N2035/0443 ,  G01N2035/0444 ,  G01N2035/0448 ,  G01N2035/0453 ,  G01N2035/0465 ,  G01N2035/1025 ,  G01N2035/1076 ,  G01N2035/1086 ,  H01J49/04

Abstract: An automated, continuous and random access analytical system, havin apparatus and methodology capable of simultaneously performing multiple assays of liquid samples using different assay methodologies, and providing continuous and random access while performing a plurality of different assays on the same or different samples during the same time period, is disclosed. A method is also disclosed of operating an automated continuous and random access analytical system capable of simultaneously effecting multiple assays of a plurality of liquid samples wherein scheduling of various assays of the plurality of liquid samples is followed by creating a unit dose disposable and separately transferring a first liquid sample (26), reagents (30) to a reaction vessel (34) without initiation of an assay reaction sequence, followed by physical transfer of the unit dose disposable (34) to a process work station (46), whereby a mixture of the unit dose disposable reagents and sample (34) are achieved during incubation. The system is capable of performing more than one scheduled assay in any order, and assays where more than such scheduled assays are presented. The automated, continuous and random access analytical system is also capable of analyzing the incubated reaction mixtures independently and individually by at least two assay procedures.

公开(公告)号：EP0656116A4

公开(公告)日：1997-04-02

申请号：EP93919871

申请日：1993-08-03

Applicant: ABBOTT LAB

Inventor： LENNARTZ LIESELOTTE ,  MICHEL GERD ,  METHTA SMRITI U ,  TASKAR SUHAS ,  CLEMENS JOHN M ,  MIMMS LARRY T ,  CHAU KURT H ,  VALLARI DAVID S

IPC: A61K39/395 ,  C12N15/09 ,  C12Q1/70 ,  G01N33/576 ,  A61K38/21

CPC classification number: G01N33/5767 ,  G01N2800/52

公开(公告)号：EP0634017A4

公开(公告)日：1997-04-02

申请号：EP92910597

申请日：1992-03-31

Applicant: ABBOTT LAB

Inventor： TASKAR SUHAS ,  CLEMENS JOHN M ,  MIMMS LARRY T ,  CHAU KURT H ,  VALLARI DAVID S

IPC: G01N33/53 ,  C12N15/09 ,  C12Q1/68 ,  C12Q1/70 ,  G01N33/543 ,  G01N33/569 ,  G01N33/576 ,  G01N33/563 ,  G01N33/537

CPC classification number: G01N33/54393 ,  G01N33/5767

Abstract: An assay for determining the presence of HCV IgM in a test sample. A test sample is contacted with at least one HCV antigen, incubated to form antigen/antibody complexes, and then contacted with an indicator reagent in order to produce a detectable signal. The amount of HCV IgM present in the test sample is proportional to the signal generated. The assay also can include the step of contacting the complexes with an enhancer compound prior to the use of an indicator reagent. Also provided is a test kit useful for performing the assay of the invention.

公开(公告)号：ES2261529T3

公开(公告)日：2006-11-16

申请号：ES02001046

申请日：1994-09-22

Applicant: ABBOTT LAB

Inventor： CLARK FREDERICK L ,  CLEMENS JOHN M ,  HANCE ROBERT B ,  HENDRICK KENDALL B ,  TAYI APPARAO ,  KANEWSKE WILLIAM J III

IPC: G01N33/483 ,  B01F11/00 ,  B01L3/00 ,  B29C45/00 ,  G01F23/22 ,  G01F23/26 ,  G01N1/00 ,  G01N21/25 ,  G01N21/64 ,  G01N21/76 ,  G01N21/78 ,  G01N33/53 ,  G01N33/542 ,  G01N33/543 ,  G01N33/553 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10 ,  H01J49/04 ,  G01F23/284

Abstract: Un sistema automático de detección de nivel de líquido (800) para detectar la presencia de líquido en un recipiente (819), incluyendo el sistema de detección de nivel de líquido (800): una sonda conductora eléctrica orientada verticalmente (806, 807) colocada encima del recipiente (819); una fuente de señal (824) conectada eléctricamente a la sonda (806, 807), energizando la fuente de señal (824) la sonda (806, 807) con una señal eléctrica y haciendo que la sonda (806, 807) transmita la señal eléctrica; una antena receptora (813, 810, 812) colocada debajo del recipiente (819) para recibir la señal eléctrica transmitida; medios (811, 841, 845) para analizar la señal eléctrica recibida con respecto a indicaciones de que la sonda (806, 807) ha contactado líquido en el recipiente (819); medios (808, 809) para transferir la señal eléctrica recibida de la antena receptora (813, 810, 812) a los medios analizadores (811, 841, 845); y medios para indicar que se ha detectado líquido, caracterizado porque el sistema de detección de nivel (800) incluye además medios para introducir y sacar verticalmente la sonda (806, 807) del recipiente (819); incluyendo los medios (811, 841, 845) para analizar la señal eléctrica recibida medios (841, 845) para detectar cambios en la amplitud de la señal recibida y medios (811) para medir la tasa del cambio de la amplitud de la señal recibida.