公开(公告)号：JP2002000267A

公开(公告)日：2002-01-08

申请号：JP2001120859

申请日：2001-04-19

Applicant: ABBOTT LAB

Inventor： MEHTA SMRITI U ,  JOHNSON-PAEPKE JILL ,  GEORGE SHEELA M ,  DESAI SURESH M ,  MIMMS LARRY T ,  DEVARE SUSHIL G ,  TYNER JOAN D ,  GIBADLO MARY S

IPC: C12N5/10 ,  C07K16/10 ,  C12N5/20 ,  C12N15/02 ,  C12P21/08 ,  C12R1/91 ,  G01N33/53 ,  G01N33/576 ,  G01N33/577

Abstract: PROBLEM TO BE SOLVED: To provide an antibody specifically bonding generally to hepatitis C virus(HCV), more particularly, a panel of a new hybridoma cell strain secreting a monoclonal antibody against HCV protein 33C and the use of the monoclonal antibody. SOLUTION: The present invention relates to a monoclonal antibody specifically bonding to HCV protein 33C and free from bonding potency to HCV protein C-100 and a core and to a hybridoma producing the monoclonal antibody and selected from the group consisting of A.T.C.C. deposit No. HB10594, HB10589, HB10607 and HB10600. It also relates to a method for the use of the monoclonal antibody e.g. for the detection of hepatitis C virus HCV 33C protein in a specimen and an assay kit containing the antibody.

公开(公告)号：JP2002012600A

公开(公告)日：2002-01-15

申请号：JP2001120871

申请日：2001-04-19

Applicant: ABBOTT LAB

Inventor： MEHTA SMRITI U ,  JOHNSON-PAEPKE JILL ,  GEORGE SHEELA M ,  DESAI SURESH M ,  MIMMS LARRY T ,  DEVARE SUSHIL G ,  TYNER JOAN D ,  GIBADLO MARY S

IPC: C12N5/10 ,  C07K16/10 ,  C12N5/20 ,  C12N15/02 ,  C12P21/08 ,  C12R1/91 ,  G01N33/53 ,  G01N33/576 ,  G01N33/577

Abstract: PROBLEM TO BE SOLVED: To provide a highly specific and novel monoclonal antibody available for detecting a hepatitis C virus protein. SOLUTION: A monoclonal antibody not binding to hepatitis C virus C-100 protein and hepatitis C virus 33C protein and specifically binding to hepatitis C virus core protein, a hybridoma yielding the monoclonal antibody, a method for using the monoclonal antibody and an assay kit containing the antibody are provided.

公开(公告)号：EP0556320A4

公开(公告)日：1994-11-23

申请号：EP92900907

申请日：1991-11-07

Applicant: ABBOTT LAB

Inventor： MEHTA SMRITI U ,  JOHNSON-PAEPKE JILL ,  GEORGE SHEELA M ,  DESAI SURESH M ,  MIMMS LARRY T ,  DEVARE SUSHIL G ,  TYNER JOAN D ,  GIBADLO MARY S

IPC: C12N5/10 ,  C07K16/10 ,  C12N5/20 ,  C12N15/02 ,  C12P21/08 ,  C12R1/91 ,  G01N33/53 ,  G01N33/576 ,  G01N33/577 ,  C07K15/00 ,  C12N5/00 ,  C12P21/02 ,  C12Q1/70

CPC classification number: C07K16/109

Abstract: Monoclonal antibodies which specifically bind to either Hepatitis C Virus C-100 protein, Hepatitis C Virus 33C protein and Hepatits C Virus CORE protein, and hybridomas which produce these monoclonal antibodies. Also provided are methods for using these monoclonal antibodies and assay kits containing these antibodies.

公开(公告)号：EP0745128A4

公开(公告)日：2000-01-12

申请号：EP94917325

申请日：1994-05-09

Applicant: ABBOTT LAB ,  UNIV GLASGOW

Inventor： CARMAN WILLIAM ,  DECKER RICHARD H ,  WALLACE LESLEY ,  MIMMS LARRY T ,  SOLOMON LARRY R

IPC: G01N33/576 ,  A61K39/00 ,  A61K39/29 ,  A61P31/12 ,  C07K14/02 ,  C07K16/10 ,  C12N5/10 ,  C12N7/00 ,  C12N15/09 ,  C12N15/51 ,  C12P21/02 ,  C12P21/08 ,  C12Q1/68 ,  C12Q1/70 ,  G01N33/577 ,  C07K7/10 ,  C07K13/00 ,  C07K15/06 ,  C12N1/21 ,  C12P21/00

CPC classification number: C07K14/005 ,  A61K39/00 ,  C07K2319/40 ,  C07K2319/61 ,  C12N2730/10122 ,  Y10S435/975 ,  Y10S436/82

公开(公告)号：EP0656116A4

公开(公告)日：1997-04-02

申请号：EP93919871

申请日：1993-08-03

Applicant: ABBOTT LAB

Inventor： LENNARTZ LIESELOTTE ,  MICHEL GERD ,  METHTA SMRITI U ,  TASKAR SUHAS ,  CLEMENS JOHN M ,  MIMMS LARRY T ,  CHAU KURT H ,  VALLARI DAVID S

IPC: A61K39/395 ,  C12N15/09 ,  C12Q1/70 ,  G01N33/576 ,  A61K38/21

CPC classification number: G01N33/5767 ,  G01N2800/52

公开(公告)号：EP0634017A4

公开(公告)日：1997-04-02

申请号：EP92910597

申请日：1992-03-31

Applicant: ABBOTT LAB

Inventor： TASKAR SUHAS ,  CLEMENS JOHN M ,  MIMMS LARRY T ,  CHAU KURT H ,  VALLARI DAVID S

IPC: G01N33/53 ,  C12N15/09 ,  C12Q1/68 ,  C12Q1/70 ,  G01N33/543 ,  G01N33/569 ,  G01N33/576 ,  G01N33/563 ,  G01N33/537

CPC classification number: G01N33/54393 ,  G01N33/5767

Abstract: An assay for determining the presence of HCV IgM in a test sample. A test sample is contacted with at least one HCV antigen, incubated to form antigen/antibody complexes, and then contacted with an indicator reagent in order to produce a detectable signal. The amount of HCV IgM present in the test sample is proportional to the signal generated. The assay also can include the step of contacting the complexes with an enhancer compound prior to the use of an indicator reagent. Also provided is a test kit useful for performing the assay of the invention.

公开(公告)号：EP0569537A4

公开(公告)日：1994-10-05

申请号：EP92906219

申请日：1992-01-30

Applicant: ABBOTT LAB

Inventor： GIBADLO MARY S ,  TYNER JOAN D ,  MIMMS LARRY T ,  VALLARI DAVID S

IPC: C12N5/10 ,  A61K39/00 ,  C07K14/18 ,  C07K16/10 ,  C12N15/02 ,  C12P21/08 ,  C12R1/91 ,  G01N33/53 ,  G01N33/576 ,  G01N33/577

CPC classification number: C07K14/005 ,  A61K39/00 ,  C07K16/109 ,  C12N2770/24222

公开(公告)号：DE69433285T2

公开(公告)日：2004-06-24

申请号：DE69433285

申请日：1994-05-09

Applicant: ABBOTT LAB ,  UNIV GLASGOW

Inventor： CARMAN WILLIAM ,  DECKER RICHARD H ,  WALLACE LESLEY ,  MIMMS LARRY T ,  SOLOMON LARRY R

IPC: G01N33/576 ,  A61K39/00 ,  A61K39/29 ,  A61P31/12 ,  C07K14/02 ,  C07K16/10 ,  C12N5/10 ,  C12N7/00 ,  C12N15/09 ,  C12N15/51 ,  C12P21/02 ,  C12P21/08 ,  C12Q1/68 ,  C12Q1/70 ,  G01N33/577 ,  C12N1/21 ,  C12P21/00 ,  C07K14/08

Abstract: Mutant Hepatitis B Virus (HBV) nucleic acid sequences useful for a variety of diagnostic and therapeutic applications, kits for using the HBV nucleic acid sequences, HBV immunogenic particles, and a method for producing antibodies to HBV. Also provided are methods for producing antibodies, polyclonal or monoclonal, from the HBV nucleic acid sequences.

公开(公告)号：AT178096T

公开(公告)日：1999-04-15

申请号：AT92900907

申请日：1991-11-07

Applicant: ABBOTT LAB

Inventor： MEHTA SMRITI U ,  JOHNSON-PAEPKE JILL ,  GEORGE SHEELA M ,  DESAI SURESH M ,  MIMMS LARRY T ,  DEVARE SUSHIL G ,  TYNER JOAN D ,  GIBADLO MARY S

IPC: C12N5/10 ,  C07K16/10 ,  C12N5/20 ,  C12N15/02 ,  C12P21/08 ,  C12R1/91 ,  G01N33/53 ,  G01N33/576 ,  G01N33/577

Abstract: Monoclonal antibodies which specifically bind to either Hepatitis C Virus C-100 protein, Hepatitis C Virus 33C protein and Hepatits C Virus CORE protein, and hybridomas which produce these monoclonal antibodies. Also provided are methods for using these monoclonal antibodies and assay kits containing these antibodies.

公开(公告)号：CA2162132A1

公开(公告)日：1994-11-24

申请号：CA2162132

申请日：1994-05-09

Applicant: ABBOTT LAB ,  UNIV GLASGOW

Inventor： CARMAN WILLIAM ,  DECKER RICHARD H ,  WALLACE LESLEY ,  MIMMS LARRY T ,  SOLOMON LARRY R

IPC: G01N33/576 ,  A61K39/00 ,  A61K39/29 ,  A61P31/12 ,  C07K14/02 ,  C07K16/10 ,  C12N5/10 ,  C12N7/00 ,  C12N15/09 ,  C12N15/51 ,  C12P21/02 ,  C12P21/08 ,  C12Q1/68 ,  C12Q1/70 ,  G01N33/577 ,  C07H21/00 ,  C07K19/00 ,  C12N7/04 ,  C07K16/08

Abstract: Mutant Hepatitis B Virus (HBV) nucleic acid sequences useful for a variety o f diagnostic and therapeutic applications, kits for usin g the HBV nucleic acid sequences, HBV immunogenic particles, and a method for producing antibodies to HBV. Also provided are methods for producing antibodies, polyclonal or monoclonal, from the HBV nucleic aci d sequences.