公开(公告)号：AU2003233315A8

公开(公告)日：2003-11-10

申请号：AU2003233315

申请日：2003-04-25

Applicant: ABBOTT LAB ,  KAROBIO AB

Inventor： ENGSTROM OWE ,  AHOLA HARRI ,  OHMAN LARS ,  JAKOB CLARISSA G ,  MUCHMORE STEVEN ,  KAUPPI BJORN ,  FARNEGARDH MATHIAS ,  HARLAN JOHN E ,  YANG JIE ,  CARLQUIST MATS

IPC: A61K20060101 ,  C07K14/72 ,  G01N33/48 ,  G06F19/00

公开(公告)号：CA2427312A1

公开(公告)日：2002-05-02

申请号：CA2427312

申请日：2001-10-26

Applicant: ABBOTT LAB

Inventor： HUTH JEFFREY R ,  NG IOK C ,  HARLAN JOHN E ,  KEMPF DALE J ,  STOLL VINCENT S ,  BETZ STEPHEN F ,  HARRIS KEVIN S ,  STEWART KENT D ,  STEFFY KEVIN R

IPC: G01N33/566 ,  C07K14/16 ,  C07K16/10 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12P21/02 ,  C40B30/04 ,  G01N33/15 ,  G01N33/50 ,  G01N33/569 ,  G01N33/58 ,  G01N33/68 ,  C12N15/11

Abstract: The subject invention encompasses novel proteins related to the human immunodeficiency virus (HIV-1) gp41 protein and to methods of use thereof. F or example, the proteins may be utilized in the screening of anti-HIV compounds .

公开(公告)号：SG188142A1

公开(公告)日：2013-03-28

申请号：SG2013010228

申请日：2009-05-08

Applicant: ABBOTT GMBH & CO KG ,  ABBOTT LAB

Inventor： GU JIJIE ,  HSIEH CHUNG-MING ,  WU ZHEN ,  DIGIAMMARINO ENRICO L ,  LUO FENG ,  FOX GERARD B ,  HARLAN JOHN E ,  SCHMIDT MARTIN ,  LOEBBERT RALF ,  MUELLER REINHOLD ,  EBERT ULRICH ,  NIMMRICH VOLKER

Abstract: The present application relates to isolated proteins, particularly monoclonal antibodies, in particular CDR-grafted, humanized antibodies which bind to RAGE protein. Specifically, these antibodies have the ability to inhibit the binding of RAGE to its various ligands. The antibodies or portions thereof of described in the present application are useful for treating a disease or disorder characterized by or induced by pathophysiological ligands of RAGE, for example missfolded proteins like amyloid and advanced glycation-end-products.No suitable figure

公开(公告)号：AU2009245354A1

公开(公告)日：2009-11-12

申请号：AU2009245354

申请日：2009-05-08

Applicant: ABBOTT GMBH & CO KG ,  ABBOTT LAB

Inventor： GU JIJIE ,  HSIEH CHUNG-MING ,  NIMMRICH VOLKER ,  LOEBBERT RALF ,  DIGIAMMARINO ENRICO L ,  EBERT ULRICH ,  MUELLER REINHOLD ,  SCHMIDT MARTIN ,  LUO FENG ,  FOX GERARD B ,  HARLAN JOHN E ,  WU ZHEN

IPC: C12N5/00 ,  C12N7/00 ,  C12N15/12

Abstract: The present application relates to isolated proteins, particularly monoclonal antibodies, in particular CDR-grafted, humanized antibodies which bind to RAGE protein. Specifically, these antibodies have the ability to inhibit the binding of RAGE to its various ligands. The antibodies or portions thereof of described in the present application are useful for treating a disease or disorder characterized by or induced by pathophysiological ligands of RAGE, for example misfolded proteins like amyloid ß and advanced glycation-end-products.

公开(公告)号：CA2637472A1

公开(公告)日：2007-06-07

申请号：CA2637472

申请日：2006-11-30

Applicant: ABBOTT GMBH & CO KG ,  ABBOTT LAB

Inventor： EDALJI ROHINTON P ,  HARLAN JOHN E ,  HOLZMAN THOMAS F ,  YU LIPING ,  PERADA-LOPEZ ANA ,  LABKVOSKY BORIS ,  OLEJNICZAK EDWARD T

IPC: C07K14/47 ,  A61P25/00 ,  C07K16/18 ,  G01N33/53

Abstract: The subject invention relates to the cloning, expression and isolation of recombinant forms of beta-amyloid protein containing a N-terminal methionine (or one or more amino acids) as well as to methods of using this recombinant protein in the production of therapeutic antibodies, in the identification of therapeutic small molecules, and in the performance of diagnostic assays.