公开(公告)号：PH10842A

公开(公告)日：1977-09-09

申请号：PH16398

申请日：1974-10-11

Applicant: ABBOTT LAB

Inventor： JONES P ,  SOMANI P ,  KYNOL J ,  OURS C

IPC: A61K31/195 ,  A01N37/44 ,  A61K31/198 ,  A61K31/22 ,  A61P9/08 ,  C07C237/08 ,  C07C103/00

Abstract: Covers the esters of gamma -glutamyl amide of dopamine selected from the group consisting of -CH2-CH2-NHO ¦ PARALLEL C-CH2-CH2-CH-C-OR PARALLEL ¦ ONH2 where R is a C1-C20 alkyl radical, and a pharmaceutically acceptable acid addition salt thereof. Also covers the use of said esters of gamma -glutamyl amide of dopamine to increase renal blood flow by administering said amide to warm-blooded mammals by clinically acceptable routes of administration such as oral, parenteral, rectal, etc.

公开(公告)号：PH10698A

公开(公告)日：1977-08-18

申请号：PH15685

申请日：1974-04-02

Applicant: ABBOTT LAB

Inventor： JONES P ,  OURS C ,  ROTEMAN R

IPC: C07D295/14 ,  C07C237/08 ,  C07C237/20 ,  C07D207/16 ,  C07D207/46 ,  C07D209/20 ,  C07D233/64 ,  C07D295/15 ,  C07C103/38

Abstract: An improved process for synthesizing amino acid amides of dopamine comprising reacting an active ester of an appropriate N-carbobenzyloxy amino acid directly with a dopamine salt. The amino acid amides of dopamine are useful as renal vasodilators and antihypertensive agents.