公开(公告)号：US3840663A

公开(公告)日：1974-10-08

申请号：US23752772

申请日：1972-03-23

Applicant: ABBOTT LAB

Inventor： JONES P ,  SOMANI P

IPC: A61K31/445 ,  A61K27/00

CPC classification number: A61K31/445

Abstract: WHEREIN R IS C1-C8 ALKYL OR A SALT THEREOF TO SAID PATIENT.

2-(HOOC-),5-R1-PIPERIDINE

1. A METHOD OF LOWERING BLOOD PRESSURE IN HYPERTENSIVE PATIENT COMPRISING ADMINISTERING A THERAPEUTICALLY EFFECTIVE AMOUNT OF A COMPOUND SELECTED FROM THE GROUP CONSISTING OF THE TRANS ISOMER AND A MIXTURE OF THE TRANS AND CIS ISOMERS REPRESENTED BY THE FORMULA

公开(公告)号：US3764679A

公开(公告)日：1973-10-09

申请号：US3764679D

申请日：1972-03-20

Applicant: ABBOTT LAB

Inventor： JONES P ,  SOMANI P

IPC: A61K31/495 ,  A61K27/00

CPC classification number: A61K31/495

Abstract: A method of reducing blood pressure in hypertensive patients by administering a therapeutically effective amount of iodinin to said patients.

Abstract translation: 一种通过向所述患者施用治疗有效量的碘汀来降低高血压患者血压的方法。

公开(公告)号：ZA7406331B

公开(公告)日：1975-12-31

申请号：ZA7406331

申请日：1974-10-04

Applicant: ABBOTT LAB

Inventor： OURS C ,  SOMANI P ,  JONES P ,  KUNCL J

IPC: A61K31/195 ,  A01N37/44 ,  A61K31/198 ,  A61K31/22 ,  A61P9/08 ,  C07C237/08 ,  A61K ,  C07C

CPC classification number: A01N37/44 ,  Y10S514/929

公开(公告)号：SE7413303L

公开(公告)日：1975-04-24

申请号：SE7413303

申请日：1974-10-22

Applicant: ABBOTT LAB

Inventor： JONES P H ,  KYNCL J ,  OURS C W ,  SOMANI P

IPC: A61K31/195 ,  A01N37/44 ,  A61K31/198 ,  A61K31/22 ,  A61P9/08 ,  C07C237/08 ,  C07C103/50

Abstract: Covers the esters of gamma -glutamyl amide of dopamine selected from the group consisting of -CH2-CH2-NHO ¦ PARALLEL C-CH2-CH2-CH-C-OR PARALLEL ¦ ONH2 where R is a C1-C20 alkyl radical, and a pharmaceutically acceptable acid addition salt thereof. Also covers the use of said esters of gamma -glutamyl amide of dopamine to increase renal blood flow by administering said amide to warm-blooded mammals by clinically acceptable routes of administration such as oral, parenteral, rectal, etc.

公开(公告)号：DK552074A

公开(公告)日：1975-07-07

申请号：DK552074

申请日：1974-10-22

Applicant: ABBOTT LAB

Inventor： JONES P H ,  KYNCL J ,  OURS C W ,  SOMANI P

IPC: A61K31/195 ,  A01N37/44 ,  A61K31/198 ,  A61K31/22 ,  A61P9/08 ,  C07C237/08 ,  C07C103/50

Abstract: Covers the esters of gamma -glutamyl amide of dopamine selected from the group consisting of -CH2-CH2-NHO ¦ PARALLEL C-CH2-CH2-CH-C-OR PARALLEL ¦ ONH2 where R is a C1-C20 alkyl radical, and a pharmaceutically acceptable acid addition salt thereof. Also covers the use of said esters of gamma -glutamyl amide of dopamine to increase renal blood flow by administering said amide to warm-blooded mammals by clinically acceptable routes of administration such as oral, parenteral, rectal, etc.

公开(公告)号：SE7413303A

公开(公告)日：1975-04-24

申请号：SE7413303

申请日：1974-10-22

Applicant: ABBOTT LAB

Inventor： JONES P H ,  KYNCL J ,  OURS C W ,  SOMANI P

IPC: A61K31/195 ,  A01N37/44 ,  A61K31/198 ,  A61K31/22 ,  A61P9/08 ,  C07C237/08 ,  C07C103/50

CPC classification number: A01N37/44 ,  Y10S514/929

公开(公告)号：ZA746331B

公开(公告)日：1975-12-31

申请号：ZA746331

申请日：1974-10-04

Applicant: ABBOTT LAB

Inventor： OURS C ,  SOMANI P ,  JONES P ,  KUNCL J

IPC: A61K31/195 ,  A01N37/44 ,  A61K31/198 ,  A61K31/22 ,  A61P9/08 ,  C07C237/08 ,  A61K ,  C07C

Abstract: Covers the esters of gamma -glutamyl amide of dopamine selected from the group consisting of -CH2-CH2-NHO ¦ PARALLEL C-CH2-CH2-CH-C-OR PARALLEL ¦ ONH2 where R is a C1-C20 alkyl radical, and a pharmaceutically acceptable acid addition salt thereof. Also covers the use of said esters of gamma -glutamyl amide of dopamine to increase renal blood flow by administering said amide to warm-blooded mammals by clinically acceptable routes of administration such as oral, parenteral, rectal, etc.

公开(公告)号：ZA735642B

公开(公告)日：1974-07-31

申请号：ZA735642

申请日：1973-08-17

Applicant: ABBOTT LAB

Inventor： SOMANI P ,  MARTIN D

IPC: A61K20060101 ,  A61K31/00 ,  A61K31/185 ,  A61K31/255 ,  C07C20060101 ,  A61K27/00

Abstract: The present invention is directed to the provision of a therapeutically active composition having diuretic and renal vasodialator properties. The composition contains as its active ingredient a (substituted) aminoalkylsulfate ester. Such an ester is of extremely low toxicity and has a high therapeutic index.

公开(公告)号：SE409702B

公开(公告)日：1979-09-03

申请号：SE7413303

申请日：1974-10-22

Applicant: ABBOTT LAB

Inventor： JONES P H ,  KYNCL J ,  OURS C W ,  SOMANI P

IPC: A61K31/195 ,  A01N37/44 ,  A61K31/198 ,  A61K31/22 ,  A61P9/08 ,  C07C237/08 ,  C07C103/50

Abstract: Covers the esters of gamma -glutamyl amide of dopamine selected from the group consisting of -CH2-CH2-NHO ¦ PARALLEL C-CH2-CH2-CH-C-OR PARALLEL ¦ ONH2 where R is a C1-C20 alkyl radical, and a pharmaceutically acceptable acid addition salt thereof. Also covers the use of said esters of gamma -glutamyl amide of dopamine to increase renal blood flow by administering said amide to warm-blooded mammals by clinically acceptable routes of administration such as oral, parenteral, rectal, etc.

公开(公告)号：PH10842A

公开(公告)日：1977-09-09

申请号：PH16398

申请日：1974-10-11

Applicant: ABBOTT LAB

Inventor： JONES P ,  SOMANI P ,  KYNOL J ,  OURS C

IPC: A61K31/195 ,  A01N37/44 ,  A61K31/198 ,  A61K31/22 ,  A61P9/08 ,  C07C237/08 ,  C07C103/00

Abstract: Covers the esters of gamma -glutamyl amide of dopamine selected from the group consisting of -CH2-CH2-NHO ¦ PARALLEL C-CH2-CH2-CH-C-OR PARALLEL ¦ ONH2 where R is a C1-C20 alkyl radical, and a pharmaceutically acceptable acid addition salt thereof. Also covers the use of said esters of gamma -glutamyl amide of dopamine to increase renal blood flow by administering said amide to warm-blooded mammals by clinically acceptable routes of administration such as oral, parenteral, rectal, etc.