公开(公告)号：AU517636B2

公开(公告)日：1981-08-13

申请号：AU3781878

申请日：1978-07-06

Applicant: ABBOTT LAB

Inventor： ROTEMAN R

IPC: C07D405/12 ,  A61K31/505 ,  A61P9/12 ,  C07D405/14 ,  A61K31/50 ,  A61K31/49 ,  A61K31/34

Abstract: An improved anti-hypertensive agent, the hydrochloride salt of 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-tetrahydrofuroyl)piperazine dihydrate.

公开(公告)号：SE7808316L

公开(公告)日：1979-02-05

申请号：SE7808316

申请日：1978-08-01

Applicant: ABBOTT LAB

Inventor： ROTEMAN R

IPC: A61K31/505 ,  A61K9/20 ,  A61K31/495 ,  A61P9/12 ,  C07D215/00 ,  C07D403/04 ,  C07D405/12 ,  C07D405/14

公开(公告)号：SE437157B

公开(公告)日：1985-02-11

申请号：SE7808316

申请日：1978-08-01

Applicant: ABBOTT LAB

Inventor： ROTEMAN R

IPC: A61K31/505 ,  A61K9/20 ,  A61K31/495 ,  A61P9/12 ,  C07D215/00 ,  C07D403/04 ,  C07D405/12 ,  C07D405/14

Abstract: Improved anti-hypertension agent, hydrochloride salt of 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-tetrahydrofuryl)-piperazine dihydrate.

公开(公告)号：SE8400042L

公开(公告)日：1984-01-04

申请号：SE8400042

申请日：1984-01-04

Applicant: ABBOTT LAB

Inventor： ROTEMAN R

IPC: A61K31/505 ,  A61K9/20 ,  A61K31/495 ,  A61P9/12 ,  C07D215/00 ,  C07D403/04 ,  C07D405/12 ,  C07D405/14

公开(公告)号：PH14449A

公开(公告)日：1981-07-23

申请号：PH21799

申请日：1978-11-13

Applicant: ABBOTT LAB

Inventor： RAMSAY ANNE BARLOW ,  HSIEH CHIA LUNG ,  LUEBKE D ,  LEATHEM W ,  GUZEK D ,  ROTEMAN R

IPC: A61K9/08 ,  A61K31/715 ,  C13K1/06 ,  A61K31/70

Abstract: High calorie solutions of low molecular weight glucose polymer mixtures useful for intravenous administration, preferably via a peripheral vein, are disclosed. Methods of preparing the solutions and their preferred rate of infusion at less than 5 mg./min./kg. of patient body weight are also disclosed. The solutions can be isotonic to human blood at 20-50% W/V as the glucose polymer mixtures have an average degree of polymerization ranging from 4 to 10. At the preferred rate of infusion high utilization of the glucose polymers infused occurs in human patients, including diabetics. The utilization can be further enhanced by concomitant injections of insulin. The solutions can be administered concomitantly with amino acids, lipid emulsions, vitamins and electrolytes.

公开(公告)号：SE7808316A

公开(公告)日：1979-02-05

申请号：SE7808316

申请日：1978-08-01

Applicant: ABBOTT LAB

Inventor： ROTEMAN R

IPC: A61K31/505 ,  A61K9/20 ,  A61K31/495 ,  A61P9/12 ,  C07D215/00 ,  C07D403/04 ,  C07D405/12 ,  C07D405/14

CPC classification number: A61K31/505

公开(公告)号：SE455373B

公开(公告)日：1988-07-11

申请号：SE8400042

申请日：1984-01-04

Applicant: ABBOTT LAB

Inventor： ROTEMAN R

IPC: A61K31/505 ,  A61K9/20 ,  A61K31/495 ,  A61P9/12 ,  C07D215/00 ,  C07D403/04 ,  C07D405/12 ,  C07D405/14

公开(公告)号：SE8400042D0

公开(公告)日：1984-01-04

申请号：SE8400042

申请日：1984-01-04

Applicant: ABBOTT LAB

Inventor： ROTEMAN R

IPC: A61K31/505 ,  A61K9/20 ,  A61K31/495 ,  A61P9/12 ,  C07D215/00 ,  C07D403/04 ,  C07D405/12 ,  C07D405/14

公开(公告)号：SE407798B

公开(公告)日：1979-04-23

申请号：SE7404455

申请日：1974-04-02

Applicant: ABBOTT LAB

Inventor： JONES P H ,  OURS C W ,  ROTEMAN R

IPC: C07D295/14 ,  C07C237/08 ,  C07C237/20 ,  C07D207/16 ,  C07D207/46 ,  C07D209/20 ,  C07D233/64 ,  C07D295/15 ,  C07C103/50

Abstract: An improved process for synthesizing amino acid amides of dopamine comprising reacting an active ester of an appropriate N-carbobenzyloxy amino acid directly with a dopamine salt. The amino acid amides of dopamine are useful as renal vasodilators and antihypertensive agents.

公开(公告)号：PH10698A

公开(公告)日：1977-08-18

申请号：PH15685

申请日：1974-04-02

Applicant: ABBOTT LAB

Inventor： JONES P ,  OURS C ,  ROTEMAN R

IPC: C07D295/14 ,  C07C237/08 ,  C07C237/20 ,  C07D207/16 ,  C07D207/46 ,  C07D209/20 ,  C07D233/64 ,  C07D295/15 ,  C07C103/38

Abstract: An improved process for synthesizing amino acid amides of dopamine comprising reacting an active ester of an appropriate N-carbobenzyloxy amino acid directly with a dopamine salt. The amino acid amides of dopamine are useful as renal vasodilators and antihypertensive agents.