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    Iodinin as an anti-hypertensive agent
    1.
    发明授权
    Iodinin as an anti-hypertensive agent 失效
    IODININ作为抗高血压药物

    公开(公告)号：US3764679A

    公开(公告)日：1973-10-09

    申请号：US3764679D

    申请日：1972-03-20

    Applicant: ABBOTT LAB

    Inventor： JONES P ,  SOMANI P

    IPC: A61K31/495 ,  A61K27/00

    CPC classification number: A61K31/495

    Abstract: A method of reducing blood pressure in hypertensive patients by administering a therapeutically effective amount of iodinin to said patients.

    Abstract translation: 一种通过向所述患者施用治疗有效量的碘汀来降低高血压患者血压的方法。

    "> 4
    2.
    发明授权
    4"-deoxy-4"-oxoerythromycin b derivatives 失效
    4“-DEOXY-4” - 紫罗兰霉素B衍生物

    公开(公告)号：US3842069A

    公开(公告)日：1974-10-15

    申请号：US37238773

    申请日：1973-06-21

    Applicant: ABBOTT LAB

    Inventor： JONES P ,  MARTIN J ,  TADANIER J ,  MCALPINE J ,  PAUVLIK J

    IPC: C07H17/08 ,  C07C129/18

    CPC classification number: C07H17/08

    Abstract: 1. A 4"-DEOXY-4"-OXOERYTHROMYCIN COMPOUND SELECTED FROM THE GROUP CONSISTING OF

    2,10-DI(O=),4,5,7,9,11,13,-HEXA(H3C-),4-((4,6-DI(H3C-),

    4-(H3C-O-),5-(O=),6-(H3C-)-TETRAHYDROPYR-2-YL)-O-),6-

    ((3-(R1-O-),4-((H3C)2-N-),6-(H3C-)-TETRAHYDROPYR-2-YL)-

    O-),7-(HO-),12-(R-O-),14-(H5C2-)-OXACYCLOTETRADECANE

    WHERE R IS -CHR2SR3 WHERE R'' IS HYDROGEN OR LOWERALKYL, R3 IS LOWERALKYL AND R1 IS HYDROGEN OR LOWERALKANOYL AND;

    2-(O=),3,5,7,9,11,13-HEXA(H3C-),4-((4,6-DI(H3C-),

    4-(H3C-O-),5-(O=),6-(H3C-)-TETRAHYDROPYR-2-YL)-O-),6-

    ((3-(R1-O-),4-((H3C)2-N-),6-(H3C-)-TETRAHYDROPYR-2-YL)-

    O-),7,10-(-O-),10,12-(-O-CH(-R2)-O-),12-(H5C2-)-

    OXACYCLOTETRADECANE

    WHERE R1 AND R2 ARE AS BEFORE DEFINED.

    5-alkylpipecolic acids as anti-hypertensive agents
    3.
    发明授权
    5-alkylpipecolic acids as anti-hypertensive agents 失效
    5-ALKYLPIPECOLIC ACIDS作为抗高血压药物

    公开(公告)号：US3840663A

    公开(公告)日：1974-10-08

    申请号：US23752772

    申请日：1972-03-23

    Applicant: ABBOTT LAB

    Inventor： JONES P ,  SOMANI P

    IPC: A61K31/445 ,  A61K27/00

    CPC classification number: A61K31/445

    Abstract: WHEREIN R IS C1-C8 ALKYL OR A SALT THEREOF TO SAID PATIENT.

    2-(HOOC-),5-R1-PIPERIDINE

    1. A METHOD OF LOWERING BLOOD PRESSURE IN HYPERTENSIVE PATIENT COMPRISING ADMINISTERING A THERAPEUTICALLY EFFECTIVE AMOUNT OF A COMPOUND SELECTED FROM THE GROUP CONSISTING OF THE TRANS ISOMER AND A MIXTURE OF THE TRANS AND CIS ISOMERS REPRESENTED BY THE FORMULA

    Erythromycin derivatives
    4.
    发明授权
    Erythromycin derivatives 失效
    红霉素衍生物

    公开(公告)号：US3736313A

    公开(公告)日：1973-05-29

    申请号：US3736313D

    申请日：1971-02-26

    Applicant: ABBOTT LAB

    Inventor： JONES P ,  PERUN T

    IPC: C07H17/08 ,  C07C129/18

    CPC classification number: C07H17/08

    Abstract: THE 2'',4"-DI-O-ALKANOYL AND THE 2'',4",11-TRI-O-ALKANOYL DERIVATIVES OR ERYTHROMYCIN ARE PREPARED BY ESTERFICATION OF ERYTHROMYCIN WITH AN APPROPRIATE ACID ANHYDRIDE. THESE RESULTING ESTER DERIVATIVES ARE INITIALLY DE-ESTERFIED IN THE 2''-POSITION TO PROPARE THE 4"-O-ALKANOYL OR THE 4",11-DI-O-ALKANOYL ERYTHORMYCIN, AND THEN, IF DESIRED, THESE DE-ESTERFICATION PRODUCTS ARE REACTED WITH ANOTHER ACID ANHYDRIDE TO PREPARE A DISSIMILARLY DI-SUBSTITUTED OR TRI-SUBSTITUTED ESTER. THROUGH REPETITIVE ESTERFICATION AND DE-ESTERFICATION, COMBINATIONS OF THE MONO SUBSTITUTED AND THE SIMILARLY OR DISSIMILARLY MULTIPLE SUBSTITUTED ERYTHROMYCIN ESTERS ARE PREPARED. THESE COMPOUNDS HAVE ANTIBIOTIC ACTIVITY.

    ERYTHROMYCIN DERIVATIVES
    9.
    发明专利
    ERYTHROMYCIN DERIVATIVES 未知

    公开(公告)号：GB1270771A

    公开(公告)日：1972-04-12

    申请号：GB1804970

    申请日：1970-04-15

    Applicant: ABBOTT LAB

    Inventor： PERUN T ,  JONES P

    IPC: C07H17/08

    Abstract: 1,270,771. Erythromycin derivatives. ABBOTT LABORATORIES. 15 April, 1970 [1 May, 1969], No. 18049/70. Heading C2A. Erythromycin derivatives having antibiotic activity of the general formula in which R 1 is H or OH and R 2 is H or an O-C 1-4 alkanoyl provided that when R 2 is H R 3 is also H and R 4 is an O-C 1-4 alkanoyl and when R 2 is O-alkanoyl, R 3 and R 4 are independently selected from H and O-C 1-4 alkanoyl groups, and salts thereof with acids may be prepared from erythromycin as shown in the accompanying flow chart wherein reaction type (1) indicates the reaction of erythromycin or an ester derivative thereof to introduce an ester group only into the unsubltituted 2 position without effecting the 11 or 4 11 positions; (2) indicates the reaction of erythromycin to introduce an ester group into the 2 1 and 4 11 positions without affecting the unsubstituted 11 position; (3) indicates the reaction of erythromycin or an ester derivative thereof to introduce an ester group into the unsubstituted 11 position; and also into the 2 1 or 4 11 positions if they also are unsubstituted; and (4) indicates the hydrolysis of a 2 1 or a 4 11 ester. Examples of erythromycin derivatives prepared include 11-acetyl erythromycins A and B, and 11-formyl erythromycins A and B. Antibiotic compositions for oral administration in the form of tablets or capsules comprise the above erythromycin derivatives and a carrier or filler.

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