公开(公告)号：DE3687276D1

公开(公告)日：1993-01-21

申请号：DE3687276

申请日：1986-10-03

Applicant: ABBOTT LAB

Inventor： BROWN III ,  DEVEREAUX SHARON M ,  KNIGGE KEVIN M ,  CLEMENS JOHN M ,  HOFLER JOHN G ,  SAFFORD SARAH E

IPC: G01N33/548 ,  G01N31/22 ,  G01N33/52 ,  G01N33/543 ,  G01N33/546 ,  G01N33/569 ,  G01N33/576 ,  G01N33/76

Abstract: A novel material and device useful in solid-phase binding assays to determine the presence or amount of an analyte in a test sample, particularly antigens or antibodies, is disclosed. The material comprises a porous matrix of fibers and a plurality of substantially spherical, solid particles having an average diameter of from about 0.1 to about 5 microns. The particles are retained and immobilized upon the fibers of the matrix. Preferably, the particles have on their surfaces a substance capable of reaction with the analyte in the sample, and the average diameter of the particles is less than the average pore size of the matrix. The device, in a preferred embodiment, comprises a substantially planar layer of the described material.

公开(公告)号：AU613797B2

公开(公告)日：1991-08-08

申请号：AU4170289

申请日：1989-09-21

Applicant: ABBOTT LAB

Inventor： BROWN WILLIAM E III ,  CLEMENS JOHN M ,  DEVEREAUX SHARON M ,  HOFLER JOHN G ,  KNIGGE KEVIN M ,  SAFFORD SARAH E

IPC: G01N33/548 ,  G01N31/22 ,  G01N33/52 ,  G01N33/543 ,  G01N33/546 ,  G01N33/569 ,  G01N33/576 ,  G01N33/76 ,  G01N33/545

Abstract: A novel material and device useful in solid-phase binding assays to determine the presence or amount of an analyte in a test sample, particularly antigens or antibodies, is disclosed. The material comprises a porous matrix of fibers and a plurality of substantially spherical, solid particles having an average diameter of from about 0.1 to about 5 microns. The particles are retained and immobilized upon the fibers of the matrix. Preferably, the particles have on their surfaces a substance capable of reaction with the analyte in the sample, and the average diameter of the particles is less than the average pore size of the matrix. The device, in a preferred embodiment, comprises a substantially planar layer of the described material.

公开(公告)号：ES2001811A6

公开(公告)日：1988-06-16

申请号：ES8602370

申请日：1986-10-02

Applicant: ABBOTT LAB

Inventor： BROWN WILLIAM E ,  CLEMENS JOHN M ,  DEVEREAUX SHARON M ,  HOFLER JOHN G ,  KNIGGE KEVIN M ,  SAFFORD SARAH E

IPC: G01N33/548 ,  G01N31/22 ,  G01N33/52 ,  G01N33/543 ,  G01N33/546 ,  G01N33/569 ,  G01N33/576 ,  G01N33/76 ,  G01N33/545

Abstract: UN NUEVO MATERIAL Y UN NUEVO DISPOSITIVO UTILES EN ENSAYOS DE FIJACION EN FASE SOLIDA PARA DETERMINAR LA PRESENCIA O LA CANTIDAD DE UN ANALITO EN UNA MUESTRA DE ENSAYO, EN PARTICULAR ANTIGENOS O ANTICUERPOS. EL MATERIAL COMPRENDE UNA MATRIZ POROSA DE FIBRAS Y UNA PLURALIDAD DE PARTICULAS SOLIDAS, SUSTANCIALMENTE ESFERICAS, QUE TIENEN UN DIAMETRO MEDIO APROXIMADO DE 0,1 A 5 MICRAS. LAS PARTICULAS SE RETIENEN E INMOVILIZAN SOBRE LAS FIBRAS DE LA MATRIZ. PREFERIBLEMENTE, LAS PARTICULAS TIENEN SOBRE SU SUPERFICIE UNA SUSTANCIA CAPAZ DE REACCIONAR CON EL ANALITO EN LA MUESTRA, Y EL DIAMETRO MEDIO DE LAS PARTICULAS ES MENOR QUE EL TRAMA O DE PORO MEDIO DE LA MATRIZ. EL DISPOSITIVO, EN UNA REALIZACION PREFERIDA, COMPRENDE UNA CAPA SUSTANCIALMENTE PLANA DEL MATERIAL DESCRITO.

公开(公告)号：AU6350286A

公开(公告)日：1987-04-09

申请号：AU6350286

申请日：1986-10-03

Applicant: ABBOTT LAB

Inventor： BROWN WILLIAM E III ,  CLEMENS JOHN M ,  DEVEREAUX SHARON M ,  HOFLER JOHN G ,  KNIGGE KEVIN M ,  SAFFORD SARAH E

IPC: G01N33/548 ,  G01N31/22 ,  G01N33/52 ,  G01N33/543 ,  G01N33/546 ,  G01N33/569 ,  G01N33/576 ,  G01N33/76 ,  G01N33/545

Abstract: A novel material and device useful in solid-phase binding assays to determine the presence or amount of an analyte in a test sample, particularly antigens or antibodies, is disclosed. The material comprises a porous matrix of fibers and a plurality of substantially spherical, solid particles having an average diameter of from about 0.1 to about 5 microns. The particles are retained and immobilized upon the fibers of the matrix. Preferably, the particles have on their surfaces a substance capable of reaction with the analyte in the sample, and the average diameter of the particles is less than the average pore size of the matrix. The device, in a preferred embodiment, comprises a substantially planar layer of the described material.

公开(公告)号：AT116443T

公开(公告)日：1995-01-15

申请号：AT89105114

申请日：1989-03-22

Applicant: ABBOTT LAB

Inventor： BROWN WILLIAM E III ,  SAFFORD SARAH E ,  CLEMENS JOHN M

IPC: G01N33/52 ,  G01N33/543 ,  G01N33/569 ,  G01N33/576 ,  G01N33/76 ,  G01N33/558

Abstract: A novel material and device useful in solid-phase binding assays to determine the presence or amount of an analyte in a test sample, particularly antigens, antibodies, or other ligands or DNA segments. The material and device comprises a reaction site having procedural controls and an analyte binding area capable of being simultaneously contacted by the sample and reagent used in the performance of the assay. The procedural controls and analyte binding areas operate to provide readable results as to the presence or absence of analyte and simultaneously verify the assay procedure and therefore the assay result.

公开(公告)号：DE3686116T2

公开(公告)日：1993-01-28

申请号：DE3686116

申请日：1986-10-03

Applicant: ABBOTT LAB

Inventor： BROWN III WILLIAM E ,  DEVEREAUX SHARON M ,  KNIGGE KEVIN M ,  CLEMENS JOHN M ,  HOFLER JOHN G ,  SAFFORD SARAH E

IPC: G01N33/548 ,  G01N31/22 ,  G01N33/52 ,  G01N33/543 ,  G01N33/546 ,  G01N33/569 ,  G01N33/576 ,  G01N33/76

Abstract: A novel material and device useful in solid-phase binding assays to determine the presence or amount of an analyte in a test sample, particularly antigens or antibodies, is disclosed. The material comprises a porous matrix of fibers and a plurality of substantially spherical, solid particles having an average diameter of from about 0.1 to about 5 microns. The particles are retained and immobilized upon the fibers of the matrix. Preferably, the particles have on their surfaces a substance capable of reaction with the analyte in the sample, and the average diameter of the particles is less than the average pore size of the matrix. The device, in a preferred embodiment, comprises a substantially planar layer of the described material.

公开(公告)号：AT83325T

公开(公告)日：1992-12-15

申请号：AT90109680

申请日：1990-05-22

Applicant: ABBOTT LAB

Inventor： BROWN WILLIAM E III ,  DEVEREAUX SHARON M ,  KNIGGE KEVIN M ,  CLEMENS JOHN M ,  HOFLER JOHN G ,  SAFFORD SARAH E

IPC: G01N33/548 ,  G01N31/22 ,  G01N33/52 ,  G01N33/543 ,  G01N33/546 ,  G01N33/569 ,  G01N33/576 ,  G01N33/76

Abstract: A novel material and device useful in solid-phase binding assays to determine the presence or amount of an analyte in a test sample, particularly antigens or antibodies, is disclosed. The material comprises a porous matrix of fibers and a plurality of substantially spherical, solid particles having an average diameter of from about 0.1 to about 5 microns. The particles are retained and immobilized upon the fibers of the matrix. Preferably, the particles have on their surfaces a substance capable of reaction with the analyte in the sample, and the average diameter of the particles is less than the average pore size of the matrix. The device, in a preferred embodiment, comprises a substantially planar layer of the described material.

公开(公告)号：AU593285B2

公开(公告)日：1990-02-08

申请号：AU6350286

申请日：1986-10-03

Applicant: ABBOTT LAB

Inventor： BROWN WILLIAM E III ,  CLEMENS JOHN M ,  DEVEREAUX SHARON M ,  HOFLER JOHN G ,  KNIGGE KEVIN M ,  SAFFORD SARAH E

IPC: G01N33/548 ,  G01N31/22 ,  G01N33/52 ,  G01N33/543 ,  G01N33/546 ,  G01N33/569 ,  G01N33/576 ,  G01N33/76 ,  G01N33/545

Abstract: A novel material and device useful in solid-phase binding assays to determine the presence or amount of an analyte in a test sample, particularly antigens or antibodies, is disclosed. The material comprises a porous matrix of fibers and a plurality of substantially spherical, solid particles having an average diameter of from about 0.1 to about 5 microns. The particles are retained and immobilized upon the fibers of the matrix. Preferably, the particles have on their surfaces a substance capable of reaction with the analyte in the sample, and the average diameter of the particles is less than the average pore size of the matrix. The device, in a preferred embodiment, comprises a substantially planar layer of the described material.