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公开(公告)号：WO2008060766A2
公开(公告)日：2008-05-22
申请号：PCT/US2007/080132
申请日：2007-10-02
Applicant: ABBOTT LABORATORIES , COWART, Marlon D , ALTENBACH, Robert J , LIU, Huaqing , DRIZIN, Irene , WISHART, Neil , BABINSKI, David J , GREGG, Robert J , ESBENSHADE, Timothy A , HSIEH, Gin C , BRIONI, Jorge D , HONORE, Marie P , BLACK, Lawrence A , ZHAO, Chen , WAKEFIELD, Brian D
Inventor： ALTENBACH, Robert J , LIU, Huaqing , DRIZIN, Irene , WISHART, Neil , BABINSKI, David J , GREGG, Robert J , ESBENSHADE, Timothy A , HSIEH, Gin C , BRIONI, Jorge D , HONORE, Marie P , BLACK, Lawrence A , ZHAO, Chen , WAKEFIELD, Brian D
CPC classification number: A61K31/506 , A61K31/417 , A61K31/496 , A61K45/06
Abstract: This invention discloses a method of treating pain by administering histamine H 4 receptor ligands and compositions comprising the same.
Abstract translation: 本发明公开了一种通过施用组胺H 4受体配体和包含其的组合物来治疗疼痛的方法。
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12.发明申请BICYCLIC SUBSTITUTED HEXAHYDROBENZ[E]ISOINDOLE ALPHA-1- ADRENERGIC ANTAGONISTS 审中-公开BICYCLIC取代HEXAHYDROBENZ [E] ISOINDOLE ALPHA-1- ADRENERGIC ANTAGONISTS
公开(公告)号：WO1996022991A1
公开(公告)日：1996-08-01
申请号：PCT/US1996000178
申请日：1996-01-11
Applicant: ABBOTT LABORATORIES
Inventor： ABBOTT LABORATORIES , MEYER, Michael, D. , ALTENBACH, Robert, J. , BASHA, Fatima, Z. , CARROLL, William, A. , DRIZIN, Irene , KERWIN, James, F., Jr. , LEBOLD, Suzanne, A. , LEE, Edmund, L. , PRATT, John, K. , SIPPY, Kevin, B. , TIETJE, Karin, R. , YAMAMOTO, Diane, M.
IPC: C07D487/02
CPC classification number: C07D401/06 , C07D403/06 , C07D471/04 , C07D473/04 , C07D475/02 , C07D487/04 , C07D491/04 , C07D495/04
Abstract: The present invention relates to a compound of formula (I) and the pharmaceutically acceptable salts thereof wherein W is a bicyclic heterocyclic ring system. The compounds are alpha -1 adrenergic antagonists and are useful in the treatment of BPH; also disclosed are alpha -1 antagonist compositions and a method for antagonizing alpha -1 receptors and treating BPH.
Abstract translation: 本发明涉及式（I）化合物及其药学上可接受的盐，其中W是双环杂环体系。 这些化合物是α-1肾上腺素能拮抗剂，可用于治疗BPH; 还公开了α-1拮抗剂组合物和拮抗α-1受体并治疗BPH的方法。
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公开(公告)号：EP2350002A1
公开(公告)日：2011-08-03
申请号：EP09737258.5
申请日：2009-10-01
Applicant: Abbott Laboratories
Inventor： BHATIA, Pramila, A. , DOHERTY, George, A. , DRIZIN, Irene , MACK, Helmut , PERNER, Richard, J. , STEWART, Andrew, O. , ZHANG, Qing Wei
IPC: C07D211/76 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D413/06 , C07D413/12 , C07D417/12 , C07D471/04 , C07D207/27 , C07D207/48 , C07D487/10 , A61K31/395 , A61P25/04 , C07D413/14
CPC classification number: C07D487/10 , C07D207/27 , C07D207/48 , C07D209/52 , C07D211/76 , C07D211/96 , C07D241/08 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D409/14 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04
Abstract: The present application relates to calcium channel inhibitors containing compounds of formula (I) wherein Ar
1 , Ar
2 , L
1 , L
2 , n, R
1 , R
4 , X and Y are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.-
14.发明授权FUSED AZABICYCLIC COMPOUNDS THAT INHIBIT VANILLOID RECEPTOR SUBTYPE 1 (VR1) RECEPTOR 有权THE VANILLOIDREZEPTORSUBTYP 1（VR1）简明氮杂双环化合物 - 受体禁止
公开(公告)号：EP1660455B1
公开(公告)日：2008-10-15
申请号：EP04780017.2
申请日：2004-08-04
Applicant: ABBOTT LABORATORIES
Inventor： BAYBURT, Erol, K. , DIDOMENICO, Stanley, Jr. , DRIZIN, Irene , GOMTSYAN, Arthur, R.; , KOENIG, John, R. , PENNER, Richard, J. , SCHMIDT, Robert, G., Jr. , TURNER, Sean, C. , WHITE, Tammie, K. , ZHENG, Guo Zhu
IPC: C07D217/24 , C07D217/02 , C07D237/28 , C07D217/22 , C07D209/08 , C07D231/56 , C07D217/26 , C07D401/12 , C07D405/12 , C07D403/12 , C07D451/02 , A61K31/47 , A61K31/472 , A61K31/496 , A61K31/5377
CPC classification number: C07D249/08 , C07D209/08 , C07D217/02 , C07D217/22 , C07D217/24 , C07D217/26 , C07D231/12 , C07D231/56 , C07D233/56 , C07D237/28 , C07D401/12 , C07D405/12
Abstract: Compounds of Formula (I), are novel VR1 antagonists that are useful in treating pain, inflammatory thermal hyperalgesia, urinary incontinence and bladder overactivity.
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15.发明公开FUSED AZABICYCLIC COMPOUNDS THAT INHIBIT VANILLOID RECEPTOR SUBTYPE 1 (VR1) RECEPTOR 有权THE VANILLOIDREZEPTORSUBTYP 1（VR1）简明氮杂双环化合物 - 受体禁止
公开(公告)号：EP1660455A1
公开(公告)日：2006-05-31
申请号：EP04780017.2
申请日：2004-08-04
Applicant: ABBOTT LABORATORIES , Lee, Chih-Hung
Inventor： BAYBURT, Erol, K. , DIDOMENICO, Stanley, Jr. , DRIZIN, Irene , GOMTSYAN, Arthur, R.; , KOENIG, John, R. , PENNER, Richard, J. , SCHMIDT, Robert, G., Jr. , TURNER, Sean, C. , WHITE, Tammie, K. , ZHENG, Guo Zhu
IPC: C07D217/24 , C07D217/02 , C07D237/28 , C07D217/22 , C07D209/08 , C07D231/56 , C07D217/26 , C07D401/12 , C07D405/12 , C07D403/12 , C07D451/02 , A61K31/47 , A61K31/472 , A61K31/496 , A61K31/5377
CPC classification number: C07D249/08 , C07D209/08 , C07D217/02 , C07D217/22 , C07D217/24 , C07D217/26 , C07D231/12 , C07D231/56 , C07D233/56 , C07D237/28 , C07D401/12 , C07D405/12
Abstract: Compounds of Formula (I), are novel VR1 antagonists that are useful in treating pain, inflammatory thermal hyperalgesia, urinary incontinence and bladder overactivity.
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Patent Agency Ranking
公开(公告)号：EP1124828A1
公开(公告)日：2001-08-22
申请号：EP99960168.5
申请日：1999-10-28
Applicant: ABBOTT LABORATORIES
Inventor： CARROLL, William, A. , AGRIOS, Konstantinos, A. , ALTENBACH, Robert, J. , DRIZIN, Irene , KORT, Michael, E.
IPC: C07D471/04 , C07D471/14 , C07D495/14 , C07D491/04 , C07D491/14 , C07D495/04 , A61K31/44 , A61K31/47 , A61P9/12 , A61P11/06 , A61P13/10 , A61P15/00 , A61P21/00 , A61P25/08 , A61P29/00
CPC classification number: C07D471/04 , C07C45/00 , C07C45/298 , C07C45/41 , C07C45/63 , C07C205/44 , C07D471/14 , C07D491/14 , C07D495/14 , C07C47/565 , C07C47/55
Abstract: The present invention provides novel compounds of formula (I) which may be useful in hyperpolarizing cell membranes, opening potassium channels, relaxing smooth muscle cells, and inhibiting bladder contractions.
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17.发明公开FUSED AZABICYCLIC COMPOUNDS THAT INHIBIT VANILLOID RECEPTOR SUBTYPE 1 (VR1) RECEPTOR 有权CONDENSED AZABICYCLISCHEVERBINDUNGEN作为香草素受体1的抑制剂（VR1）
公开(公告)号：EP1478363A1
公开(公告)日：2004-11-24
申请号：EP03716014.0
申请日：2003-02-11
Applicant: Abbott Laboratories
Inventor： LEE, Chih-Hung , BAYBURT, Erol, K. , DIDOMENICO, Stanley Jr. , DRIZIN, Irene , GOMTSYAN, Arthur, R. , KOENIG, John R. , PERNER, Richard, J. , SCHMIDT, Robert G. , TURNER, Sean C. , WHITE, Tammie, K. , ZHENG, Guo, Zhu
IPC: A61K31/502 , C07D217/02 , C07D237/28 , C07D217/22 , C07D209/08 , C07D231/56 , A61K31/472 , A61K31/416 , A61K31/404
CPC classification number: C07D249/08 , A61K31/404 , A61K31/416 , A61K31/47 , A61K31/472 , A61K31/496 , A61K31/5377 , A61K31/541 , C07D209/08 , C07D217/02 , C07D217/22 , C07D217/24 , C07D217/26 , C07D231/12 , C07D231/56 , C07D233/56 , C07D237/28 , C07D401/12 , C07D405/12
Abstract: Compounds of formula (I), are novel VR1 antagonists that are useful in treating pain, inflammatory thermal hyperalgesia, urinary incontinence and bladder overactivity.
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18.发明公开TRICYCLIC DIHYDROPYRAZOLONE AND TRICYCLIC DIHYDROISOXAZOLONE POTASSIUM CHANNEL OPENERS 有权三环dihydropyrazolones和三环DIHYDROISOAXAZOLONE钾通道开放
公开(公告)号：EP1259510A2
公开(公告)日：2002-11-27
申请号：EP01918338.3
申请日：2001-03-02
Applicant: ABBOTT LABORATORIES
Inventor： DRIZIN, Irene , ALTENBACH, Robert, J. , CARROLL, William, A.
IPC: C07D471/04 , C07D495/14 , C07D491/04 , C07D491/14 , C07D498/14 , C07D498/04 , A61K31/4353 , A61P13/00 , A61P9/00
CPC classification number: C07D471/04 , C07C45/298 , C07C45/41 , C07C45/63 , C07C205/44 , C07D491/14 , C07D495/14 , C07C47/55
Abstract: Compounds of formula (I) are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.
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19.发明授权BICYCLIC SUBSTITUTED HEXAHYDROBENZ(E)ISOINDOLE ALPHA-1- ADRENERGIC ANTAGONISTS 失效双环取代的六氢苯并（E）与α-1肾上腺素能拮抗剂活性的异吲哚
公开(公告)号：EP0805812B1
公开(公告)日：2001-06-13
申请号：EP96903364.6
申请日：1996-01-11
Applicant: Abbott Laboratories
Inventor： MEYER, Michael, D. , ALTENBACH, Robert, J. , BASHA, Fatima, Z. , CARROLL, William, A. , DRIZIN, Irene , KERWIN, James, F., Jr. , LEBOLD, Suzanne, A. , LEE, Edmund, L. , PRATT, John, K. , SIPPY, Kevin, B. , TIETJE, Karin, R. , YAMAMOTO, Diane, M.
IPC: C07D487/02 , A61K31/505 , C07D495/02 , C07D475/02 , C07D487/00
CPC classification number: C07D401/06 , C07D403/06 , C07D471/04 , C07D473/04 , C07D475/02 , C07D487/04 , C07D491/04 , C07D495/04
Abstract: The present invention relates to a compound of formula (I) and the pharmaceutically acceptable salts thereof wherein W is a bicyclic heterocyclic ring system. The compounds are α-1 adrenergic antagonists and are useful in the treatment of BPH; also disclosed are α-1 antagonist compositions and a method for antagonizing α-1 receptors and treating BPH.
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公开(公告)号：EP1040097A1
公开(公告)日：2000-10-04
申请号：EP98963249.2
申请日：1998-12-16
Applicant: Abbott Laboratories
Inventor： CARROLL, William, A. , HOLLADAY, Mark, W. , SULLIVAN, James, P. , DRIZIN, Irene , ZHANG, Henry, Q.
IPC: C07D211/84 , C07D215/36 , C07D495/04 , C07D495/14 , A61K31/44 , A61K31/47 , A61K31/38
CPC classification number: C07D221/04 , C07C45/298 , C07D215/36 , C07D495/04 , C07D495/14 , C07C47/55
Abstract: Compounds having the formula (I) are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.
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