公开(公告)号：WO2013097052A1

公开(公告)日：2013-07-04

申请号：PCT/CN2011/002224

申请日：2011-12-30

Applicant: ABBOTT LABORATORIES ,  ABBOTT LABORATORIES TRADING (SHANGHAI) COMPANY, LTD. ,  WANG, Le ,  PRATT, John, K. ,  MCDANIEL, Keith, F.

Inventor： WANG, Le ,  PRATT, John, K. ,  MCDANIEL, Keith, F.

IPC: C07D471/04 ,  C07D487/04 ,  A61K31/437 ,  A61K31/495 ,  A61P35/00 ,  A61P11/06 ,  A61P17/00 ,  A61P1/16 ,  A61P13/12 ,  A61P1/02 ,  A61P17/06 ,  A61P1/18 ,  A61P37/06 ,  A61P3/10

CPC classification number: A61K31/541 ,  A61K31/437 ,  A61K31/5025 ,  A61K31/5377 ,  A61K45/06 ,  C07D471/04 ,  C07D487/04

Abstract: Provided are compounds of formula (I), wherein A 1 , A 2 , A 3 , A 4 , X 1 , X 2 , Y 1 , L 1 , G 1 , R x , and R y have any of the values defined therefor in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Also provided are pharmaceutical compositions comprising one or more compounds of formula (I).

Abstract translation: 提供式（I）的化合物，其中A1，A2，A3，A4，X1，X2，Y1，L1，G1，Rx和Ry具有说明书中定义的任何值及其药学上可接受的盐， 可用作治疗疾病和病症（包括炎性疾病，癌症和AIDS）的药物。 还提供了包含一种或多种式（I）化合物的药物组合物。

公开(公告)号：WO2004041818A1

公开(公告)日：2004-05-21

申请号：PCT/US2003/034707

申请日：2003-10-31

Applicant: ABBOTT LABORATORIES

Inventor： PRATT, John, K. ,  BETEBENNER, David, A. ,  DONNER, Pamela, L. ,  GREEN, Brian, E. ,  KEMPF, Dale, J. ,  MCDANIEL, Keith, F. ,  MARING, Clarence, J. ,  STOLL, Vincent, S. ,  ZHANG, Rong

IPC: C07D471/04

CPC classification number: C07D213/69 ,  C07D215/22 ,  C07D401/04 ,  C07D417/04 ,  C07D417/14 ,  C07D471/04 ,  C07D495/04 ,  C07D513/04

Abstract: The present invention provides an HCV polymerase inhibiting compound having the formula (I) and a composition comprising a therapeutically effective amount of said compound. The present invention also provides a method for inhibiting hepatitis C virus (HCV) polymerase, a method for inhibiting HCV viral replication, and a method for treating or preventing HCV infection. Processes for making said compounds, and synthetic intermediates employed in said processes, are also provided.

Abstract translation: 本发明提供具有式（I）的HCV聚合酶抑制化合物和包含治疗有效量的所述化合物的组合物。 本发明还提供抑制丙型肝炎病毒（HCV）聚合酶的方法，抑制HCV病毒复制的方法，以及治疗或预防HCV感染的方法。 还提供了用于制备所述化合物的方法和在所述方法中使用的合成中间体。

公开(公告)号：WO2007081517A2

公开(公告)日：2007-07-19

申请号：PCT/US2006/048685

申请日：2006-12-20

Applicant: ABBOTT LABORATORIES ,  BETEBENNER, David, A. ,  DEGOEY, David, A. ,  MARING, Clarence, J. ,  KRUEGER, Allan, C. ,  IWASAKI, Nobuhiko ,  ROCKWAY, Todd, W. ,  COOPER, Curt, S. ,  ANDERSON, David, D. ,  DONNER, Pamela, L. ,  GREEN, Brian, E. ,  KEMPF, Dale, J. ,  LIU, Dachun ,  MCDANIEL, Keith, F. ,  MADIGAN, Darold, L. ,  MOTTER, Christopher, E. ,  PRATT, John, K. ,  SHANLEY, Jason, P. ,  TUFANO, Michael, D. ,  WAGNER, Rolf ,  ZHANG, Rong ,  MOLLA, Akhteruzzaman ,  MO, Hongmei ,  PILOT-MATIAS, Tami, J. ,  MASSE, Sherie, VL. ,  CARRICK, Robert, J. ,  HE, Weping ,  LU, Liangjun ,  GRAMPOVNIK, David, J.

Inventor： BETEBENNER, David, A. ,  DEGOEY, David, A. ,  MARING, Clarence, J. ,  KRUEGER, Allan, C. ,  IWASAKI, Nobuhiko ,  ROCKWAY, Todd, W. ,  COOPER, Curt, S. ,  ANDERSON, David, D. ,  DONNER, Pamela, L. ,  GREEN, Brian, E. ,  KEMPF, Dale, J. ,  LIU, Dachun ,  MCDANIEL, Keith, F. ,  MADIGAN, Darold, L. ,  MOTTER, Christopher, E. ,  PRATT, John, K. ,  SHANLEY, Jason, P. ,  TUFANO, Michael, D. ,  WAGNER, Rolf ,  ZHANG, Rong ,  MOLLA, Akhteruzzaman ,  MO, Hongmei ,  PILOT-MATIAS, Tami, J. ,  MASSE, Sherie, VL. ,  CARRICK, Robert, J. ,  HE, Weping ,  LU, Liangjun ,  GRAMPOVNIK, David, J.

IPC: C07D495/04 ,  C07D471/04 ,  C07D513/04

CPC classification number: C07D487/04 ,  C07D471/04 ,  C07D475/06 ,  C07D495/04 ,  C07D513/04

Abstract: Compounds effective in inhibiting replication of Hepatitis C virus ("HCV") or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.

公开(公告)号：WO1996022991A1

公开(公告)日：1996-08-01

申请号：PCT/US1996000178

申请日：1996-01-11

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  MEYER, Michael, D. ,  ALTENBACH, Robert, J. ,  BASHA, Fatima, Z. ,  CARROLL, William, A. ,  DRIZIN, Irene ,  KERWIN, James, F., Jr. ,  LEBOLD, Suzanne, A. ,  LEE, Edmund, L. ,  PRATT, John, K. ,  SIPPY, Kevin, B. ,  TIETJE, Karin, R. ,  YAMAMOTO, Diane, M.

IPC: C07D487/02

CPC classification number: C07D401/06 ,  C07D403/06 ,  C07D471/04 ,  C07D473/04 ,  C07D475/02 ,  C07D487/04 ,  C07D491/04 ,  C07D495/04

Abstract: The present invention relates to a compound of formula (I) and the pharmaceutically acceptable salts thereof wherein W is a bicyclic heterocyclic ring system. The compounds are alpha -1 adrenergic antagonists and are useful in the treatment of BPH; also disclosed are alpha -1 antagonist compositions and a method for antagonizing alpha -1 receptors and treating BPH.

Abstract translation: 本发明涉及式（I）化合物及其药学上可接受的盐，其中W是双环杂环体系。 这些化合物是α-1肾上腺素能拮抗剂，可用于治疗BPH; 还公开了α-1拮抗剂组合物和拮抗α-1受体并治疗BPH的方法。

公开(公告)号：WO2012083170A1

公开(公告)日：2012-06-21

申请号：PCT/US2011/065501

申请日：2011-12-16

Applicant: ABBOTT LABORATORIES ,  KRUEGER, Allan, C. ,  KATI, Warren, M. ,  CARROLL, William, A. ,  PRATT, John, K. ,  HUTCHINSON, Douglas, K.

Inventor： KRUEGER, Allan, C. ,  KATI, Warren, M. ,  CARROLL, William, A. ,  PRATT, John, K. ,  HUTCHINSON, Douglas, K.

IPC: C07D207/16 ,  C07D403/04 ,  A61K31/4025 ,  A61K31/4184 ,  A61K31/4439 ,  A61P31/12

CPC classification number: C07D207/16 ,  A61K31/4025 ,  A61K31/4184 ,  A61K31/4439 ,  C07D403/04

Abstract: Compounds effective in inhibiting replication of Hepatitis C virus ("HCV") are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.

公开(公告)号：WO2010111436A2

公开(公告)日：2010-09-30

申请号：PCT/US2010/028560

申请日：2010-03-25

Applicant: ABBOTT LABORATORIES ,  BETEBENNER, David, A. ,  PRATT, John, K. ,  DEGOEY, David, A. ,  DONNER, Pamela, L. ,  FLENTGE, Charles, A. ,  HUTCHINSON, Douglas, K. ,  KATI, Warren, M. ,  KRUEGER, Allan, C. ,  LONGENECKER, Kenton, L. ,  MARING, Clarence, J. ,  RANDOLPH, John, T. ,  ROCKWAY, Todd, W. ,  TUFANO, Michael, D. ,  WAGNER, Rolf

Inventor： BETEBENNER, David, A. ,  PRATT, John, K. ,  DEGOEY, David, A. ,  DONNER, Pamela, L. ,  FLENTGE, Charles, A. ,  HUTCHINSON, Douglas, K. ,  KATI, Warren, M. ,  KRUEGER, Allan, C. ,  LONGENECKER, Kenton, L. ,  MARING, Clarence, J. ,  RANDOLPH, John, T. ,  ROCKWAY, Todd, W. ,  TUFANO, Michael, D. ,  WAGNER, Rolf

IPC: C07C15/58 ,  A61K31/4166

CPC classification number: C07D409/10 ,  A61K31/18 ,  A61K31/27 ,  A61K31/402 ,  A61K31/4166 ,  A61K31/421 ,  A61K31/425 ,  A61K31/4418 ,  A61K31/503 ,  A61K31/513 ,  A61K45/06 ,  C07C311/08 ,  C07D207/27 ,  C07D213/64 ,  C07D233/32 ,  C07D233/72 ,  C07D239/10 ,  C07D239/54 ,  C07D263/22 ,  C07D263/24 ,  C07D275/02 ,  C07D403/10 ,  C07D405/10 ,  Y02P20/55

Abstract: This invention relates to: (a) compounds and salts thereof that, inter alia, inhibit HCV; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions.

Abstract translation: 本发明涉及：（a）尤其抑制HCV的化合物及其盐; （b）用于制备这样的化合物和盐的中间体; （c）包含这些化合物和盐的组合物; （d）制备这样的中间体，化合物，盐和组合物的方法; （e）使用这些化合物，盐和组合物的方法; 和（f）包含此类化合物，盐和组合物的试剂盒。

公开(公告)号：WO2009039134A1

公开(公告)日：2009-03-26

申请号：PCT/US2008/076592

申请日：2008-09-17

Applicant: ABBOTT LABORATORIES ,  FLENTGE, Charles, A. ,  HUTCHINSON, Douglas, K. ,  BETEBENNER, David, A. ,  DEGOEY, David, A. ,  DONNER, Pamela, L. ,  KATI, Warren, M. ,  KRUEGER, Allan, C. ,  LIU, Dachun ,  LIU, Yaya ,  LONGENECKER, Kenton, L. ,  MARING, Clarence, J. ,  MOTTER, Christopher, E. ,  PRATT, John, K. ,  RANDOLPH, John, T. ,  ROCKWAY, Todd, W. ,  STEWART, Kent, D. ,  WAGNER, Rolf ,  BARNES, David, M. ,  CHEN, Shuang ,  FRANCZYK, Thaddeus, S., II ,  GAO, Yi ,  HAIGHT, Anthony, R. ,  HENGEVELD, John, E. ,  KOTECKI, Brian, J. ,  LOU, Xiaochun ,  ZHANG, Geoff, G., Z.

Inventor： FLENTGE, Charles, A. ,  HUTCHINSON, Douglas, K. ,  BETEBENNER, David, A. ,  DEGOEY, David, A. ,  DONNER, Pamela, L. ,  KATI, Warren, M. ,  KRUEGER, Allan, C. ,  LIU, Dachun ,  LIU, Yaya ,  LONGENECKER, Kenton, L. ,  MARING, Clarence, J. ,  MOTTER, Christopher, E. ,  PRATT, John, K. ,  RANDOLPH, John, T. ,  ROCKWAY, Todd, W. ,  STEWART, Kent, D. ,  WAGNER, Rolf ,  BARNES, David, M. ,  CHEN, Shuang ,  FRANCZYK, Thaddeus, S., II ,  GAO, Yi ,  HAIGHT, Anthony, R. ,  HENGEVELD, John, E. ,  KOTECKI, Brian, J. ,  LOU, Xiaochun ,  ZHANG, Geoff, G., Z.

IPC: C07D239/22 ,  C07D239/54 ,  C07D401/10 ,  C07D403/10 ,  C07D405/10 ,  C07D409/10 ,  C07D413/10 ,  C07D417/10 ,  A61K31/513 ,  A61P31/12

CPC classification number: C07D239/54 ,  A61K31/513 ,  A61K45/06 ,  C07D239/22 ,  C07D401/10 ,  C07D403/10 ,  C07D405/10 ,  C07D409/10 ,  C07D413/10 ,  C07D417/10 ,  A61K2300/00

Abstract: This invention relates to: (a) compounds and salts thereof that, inter alia, inhibit HCV; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions.

Abstract translation: 本发明涉及：（a）特别是抑制HCV的化合物及其盐; （b）可用于制备这些化合物和盐的中间体; （c）包含这些化合物和盐的组合物; （d）制备这种中间体，化合物，盐和组合物的方法; （e）使用这些化合物，盐和组合物的方法; 和（f）包含这些化合物，盐和组合物的试剂盒。

公开(公告)号：WO2007076034A2

公开(公告)日：2007-07-05

申请号：PCT/US2006/049079

申请日：2006-12-20

Applicant: ABBOTT LABORATORIES ,  BETEBENNER, David, A. ,  DEGOEY, David, A. ,  MARING, Clarence, J. ,  KRUEGER, Allan, C. ,  IWASAKI, Nobuhiko ,  ROCKWAY, Todd, W. ,  COOPER, Curt, S. ,  ANDERSON, David, D. ,  DONNER, Pamela, L. ,  GREEN, Brian, E. ,  KEMPF, Dale, J. ,  LIU, Dachun ,  MCDANIEL, Keith, F. ,  MADIGAN, Darold, L. ,  MOTTER, Christopher, E. ,  PRATT, John, K. ,  SHANLEY, Jason, P. ,  TUFANO, Michael, D. ,  WAGNER, Rolf ,  ZHANG, Rong ,  MOLLA, Akhteruzzaman ,  MO, Hongmei ,  PILOT-MATIAS, Tami, J. ,  MASSE, Sherie, VL. ,  CARRICK, Robert, J. ,  HE, Weping ,  LU, Liangjun ,  GRAMPOVNIK, David, J.

Inventor： BETEBENNER, David, A. ,  DEGOEY, David, A. ,  MARING, Clarence, J. ,  KRUEGER, Allan, C. ,  IWASAKI, Nobuhiko ,  ROCKWAY, Todd, W. ,  COOPER, Curt, S. ,  ANDERSON, David, D. ,  DONNER, Pamela, L. ,  GREEN, Brian, E. ,  KEMPF, Dale, J. ,  LIU, Dachun ,  MCDANIEL, Keith, F. ,  MADIGAN, Darold, L. ,  MOTTER, Christopher, E. ,  PRATT, John, K. ,  SHANLEY, Jason, P. ,  TUFANO, Michael, D. ,  WAGNER, Rolf ,  ZHANG, Rong ,  MOLLA, Akhteruzzaman ,  MO, Hongmei ,  PILOT-MATIAS, Tami, J. ,  MASSE, Sherie, VL. ,  CARRICK, Robert, J. ,  HE, Weping ,  LU, Liangjun ,  GRAMPOVNIK, David, J.

IPC: C07D471/04

CPC classification number: C07D471/04 ,  C07D495/04 ,  C07D513/04

Abstract: Compounds effective in inhibiting replication of Hepatitis C virus ("HCV") or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.

Abstract translation: 公开了有效抑制丙型肝炎病毒（“HCV”）或其它病毒复制的化合物。 本发明还涉及包含此类化合物的组合物，此类化合物与其他抗病毒剂或治疗剂的共同配制或共同施用，用于合成此类化合物的方法和中间体，以及使用此类化合物治疗 HCV或其他病毒感染。

公开(公告)号：WO2002070507A2

公开(公告)日：2002-09-12

申请号：PCT/US2002/004541

申请日：2002-01-16

Applicant: ABBOTT LABORATORIES

Inventor： KYM, Philip, R. ,  LANE, Benjamin, C. ,  PRATT, John, K. ,  VON GELDERN, Tom ,  WINN, Martin ,  PATEL, Jyoti, R. ,  ARENDSEN, David, L. ,  AKRITOPOULOU-ZANZE, Irini ,  ASHWORTH, Kimba, L. ,  HARTANDI, Kresna ,  BRENNEMAN, Jehrod

IPC: C07D311/80

CPC classification number: C07D407/04 ,  C07D311/80 ,  C07D409/04

Abstract: Compounds of formula (I) are useful for treating type (II) diabetes, obesity, hyperglycemia, inadequate glucose clearance, hyperinsulinemia, hypertriglyceridemia, and high-circulating glucocorticoid levels, preparations of the compounds, compositions containing the compounds, and methods of treatment using the compounds.

Abstract translation: 式（I）化合物可用于治疗II型糖尿病，肥胖症，高血糖症，葡萄糖清除不足，高胰岛素血症，高甘油三酯血症和高循环糖皮质激素水平，所述化合物的制剂，含有 化合物和使用这些化合物的治疗方法。

公开(公告)号：EP1560827A1

公开(公告)日：2005-08-10

申请号：EP03768559.1

申请日：2003-10-31

Applicant: Abbott Laboratories

Inventor： PRATT, John, K. ,  BETEBENNER, David, A. ,  DONNER, Pamela, L. ,  GREEN, Brian, E. ,  KEMPF, Dale, J. ,  MCDANIEL, Keith, F. ,  MARING, Clarence, J. ,  STOLL, Vincent, S. ,  ZHANG, Rong

IPC: C07D471/04 ,  C07D513/04 ,  C07D519/00 ,  C07D495/04 ,  C07D417/04 ,  C07D513/14 ,  C07D417/14 ,  A61K31/554 ,  A61P31/00 ,  C07D215/22 ,  C07D401/04 ,  C07D213/69

CPC classification number: C07D213/69 ,  C07D215/22 ,  C07D401/04 ,  C07D417/04 ,  C07D417/14 ,  C07D471/04 ,  C07D495/04 ,  C07D513/04

Abstract: The present invention provides an HCV polymerase inhibiting compound having the formula (I) and a composition comprising a therapeutically effective amount of said compound. The present invention also provides a method for inhibiting hepatitis C virus (HCV) polymerase, a method for inhibiting HCV viral replication, and a method for treating or preventing HCV infection. Processes for making said compounds, and synthetic intermediates employed in said processes, are also provided.