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11.发明授权CELL ADHESION-INHIBITING ANTIINFLAMMATORY AND IMMUNE-SUPPRESSIVE COMPOUNDS 有权ZELLADHÄSION-和抗炎免疫CONNECTIONS
公开(公告)号：EP1140814B1
公开(公告)日：2005-05-25
申请号：EP99966709.0
申请日：1999-12-29
Applicant: ABBOTT LABORATORIES
Inventor： LINK, James , LIU, Gang , PEI, Zhonghua , VON GELDERN, Tom , WINN, Martin , XIN, Zhili , BOYD, Steven, A. , JAE, Hwan-Soo , LYNCH, John, K. , ZHU, Gui-Dong , FREEMAN, Jennifer, C. , GUNAWARDANA, Indrani, W. , STAEGER, Michael, A.
IPC: C07C323/00
CPC classification number: C07D207/27 , C07C323/62 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07D207/09 , C07D207/14 , C07D207/20 , C07D207/22 , C07D207/26 , C07D209/08 , C07D209/18 , C07D211/22 , C07D211/26 , C07D211/42 , C07D211/46 , C07D211/54 , C07D211/60 , C07D211/62 , C07D211/74 , C07D213/74 , C07D213/75 , C07D213/81 , C07D215/36 , C07D217/06 , C07D235/26 , C07D239/42 , C07D241/04 , C07D241/24 , C07D243/08 , C07D265/30 , C07D295/13 , C07D295/185 , C07D295/205 , C07D295/215 , C07D295/26 , C07D295/32 , C07D307/52 , C07D307/68 , C07D317/58 , C07D317/62 , C07D319/18 , C07D319/20 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/04 , C07D413/14 , C07D471/10 , C07D487/08 , C07D491/10
Abstract: The present invention relates to novel cinnamide compounds that are useful for treating inflammatory and immune diseases, to pharmaceutical compositions containing these compounds, and to methods of inhibiting inflammation or suppressing immune response in a mammal.
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12.发明授权CELL ADHESION-INHIBITING ANTIINFLAMMATORY AND IMMUNE-SUPPRESSIVE COMPOUNDS 有权ZELLADHÄSIONINHIBIERENDEENTZÜNDUNGSHEMMENDEUND IMMUNSUPPRIVEIVE VERBINDUNGEN
公开(公告)号：EP1165505B1
公开(公告)日：2004-09-08
申请号：EP00921654.0
申请日：2000-04-03
Applicant: ABBOTT LABORATORIES
Inventor： LINK, James , LIU, Gang , PEI, Zhonghua , VON GELDERN, Thomas, W. , WINN, Martin , XIN, Zhili , WANG, Sheldon , BOYD, Steven, A. , ZHU, Gui-Dong , FREEMAN, Jennifer, C. , GUNAWARDANA, Indrani, W. , STAEGER, Michael, A. , JAE, Hwan-Soo , LYNCH, John, K.
IPC: C07C323/62 , C07D233/61 , C07D207/26 , C07D295/18 , C07D213/74 , C07D211/22 , C07D207/14 , C07D211/46 , C07D211/62 , C07D211/60 , C07D401/04 , C07D217/02 , C07D307/68 , C07D295/26 , C07D317/66 , C07D209/08 , C07D295/205 , C07D401/12 , A61K31/165 , A61K31/33 , A61P29/00
CPC classification number: C07D207/27 , C07C323/62 , C07C2601/02 , C07D205/04 , C07D207/09 , C07D207/14 , C07D207/16 , C07D209/08 , C07D211/20 , C07D211/22 , C07D211/46 , C07D211/60 , C07D211/62 , C07D213/40 , C07D213/74 , C07D213/81 , C07D217/02 , C07D217/06 , C07D231/12 , C07D233/56 , C07D241/04 , C07D249/08 , C07D295/185 , C07D295/26 , C07D307/68 , C07D317/66 , C07D401/04 , C07D401/12
Abstract: The present invention relates to cinnamide compounds of formula (I), in which at least one of R1 to R5 is a "cis-cinnamide" (a) or a "trans-cinnamide" (b) and the other variables are as defined in the claims, that are useful for treating inflammatory and immune diseases, to pharmaceutical compositions containing these compounds and to methods of inhibiting inflammation or suppressing immune response in a mammal.
Abstract translation: 本发明涉及式（I）的肉桂酰胺化合物，其中R 1至R 5中的至少一个为“顺式 - 酰胺”（a）或“反式肉桂酰胺”（b），其它变量如 可用于治疗炎症和免疫疾病的权利要求，含有这些化合物的药物组合物和抑制哺乳动物炎症或抑制免疫应答的方法。
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Patent Agency Ranking13.发明公开
公开(公告)号：EP1140814A2
公开(公告)日：2001-10-10
申请号：EP99966709.0
申请日：1999-12-29
Applicant: ABBOTT LABORATORIES
Inventor： LINK, James , LIU, Gang , PEI, Zhonghua , VON GELDERN, Tom , WINN, Martin , XIN, Zhili , BOYD, Steven, A. , JAE, Hwan-Soo , LYNCH, John, K. , ZHU, Gui-Dong , FREEMAN, Jennifer, C. , GUNAWARDANA, Indrani, W. , STAEGER, Michael, A.
IPC: C07C323/00
CPC classification number: C07D207/27 , C07C323/62 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07D207/09 , C07D207/14 , C07D207/20 , C07D207/22 , C07D207/26 , C07D209/08 , C07D209/18 , C07D211/22 , C07D211/26 , C07D211/42 , C07D211/46 , C07D211/54 , C07D211/60 , C07D211/62 , C07D211/74 , C07D213/74 , C07D213/75 , C07D213/81 , C07D215/36 , C07D217/06 , C07D235/26 , C07D239/42 , C07D241/04 , C07D241/24 , C07D243/08 , C07D265/30 , C07D295/13 , C07D295/185 , C07D295/205 , C07D295/215 , C07D295/26 , C07D295/32 , C07D307/52 , C07D307/68 , C07D317/58 , C07D317/62 , C07D319/18 , C07D319/20 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/04 , C07D413/14 , C07D471/10 , C07D487/08 , C07D491/10
Abstract: The present invention relates to novel cinnamide compounds that are useful for treating inflammatory and immune diseases, to pharmaceutical compositions containing these compounds, and to methods of inhibiting inflammation or suppressing immune response in a mammal.
Abstract translation: 本发明涉及可用于治疗炎症和免疫疾病的新型肉桂酰胺化合物，含有这些化合物的药物组合物，以及抑制哺乳动物炎症或抑制免疫应答的方法。
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14.发明公开NOVEL BENZO-1,3-DIOXOLYL- AND BENZOFURANYL SUBSTITUTED PYRROLIDINE DERIVATIVES AS ENDOTHELIN ANTAGONISTS 失效新苯并-1,3-二唑和取代的苯并呋喃PYRROLIDINEDERIVATE ALS内皮素拮抗剂
公开(公告)号：EP0885215A1
公开(公告)日：1998-12-23
申请号：EP97905816.0
申请日：1997-02-12
Applicant: Abbott Laboratories
Inventor： WINN, Martin , BOYD, Steven, A. , HUTCHINS, Charles, W. , JAE, Hwan-Soo , TASKER, Andrew, S. , VON GELDERN, Thomas, W. , KESTER, Jeffrey, A. , SORENSEN, Bryan, K. , SZCZEPANKIEWICZ, Bruce, G. , HENRY, Kenneth, J., Jr. , LIU, Gang , WITTENBERGER, Steven, J. , KING, Steven, A.
IPC: A61K31 , A61P1 , A61P7 , A61P9 , A61P11 , A61P13 , A61P25 , A61P43 , C07D207 , C07D211 , C07D401 , C07D403 , C07D405 , C07D409 , C07D413 , C07D417 , C07D419 , C07D453 , C07D471 , C07D491 , C07F9
CPC classification number: C07D401/04 , C07D207/16 , C07D405/04 , C07D405/12 , C07D405/14 , Y02P20/55
Abstract: A compound of formula (I), or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof, and a method of antagonizing endothelin.
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公开(公告)号：EP2142552A1
公开(公告)日：2010-01-13
申请号：EP08747140.5
申请日：2008-04-30
Applicant: Abbott Laboratories
Inventor： LIU, Gang , XIN, Zhili , KYM, Philip R. , SOUERS, Andrew J
IPC: C07D487/04 , A61K31/519 , A61P3/04 , A61P3/10
CPC classification number: C07D487/04
Abstract: The present invention relates to compounds of formula (I): wherein R1, R2, and R3, are defined herein. Pharmaceutical compositions and methods for treating DGAT-1 related diseases or conditions are also disclosed.
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16.发明公开
公开(公告)号：EP1165505A1
公开(公告)日：2002-01-02
申请号：EP00921654.0
申请日：2000-04-03
Applicant: ABBOTT LABORATORIES
Inventor： LINK, James , LIU, Gang , PEI, Zhonghua , VON GELDERN, Thomas, W. , WINN, Martin , XIN, Zhili , WANG, Sheldon , BOYD, Steven, A. , ZHU, Gui-Dong , FREEMAN, Jennifer, C. , GUNAWARDANA, Indrani, W. , STAEGER, Michael, A. , JAE, Hwan-Soo , LYNCH, John, K.
IPC: C07C323/62 , C07D233/61 , C07D207/26 , C07D295/18 , C07D213/74 , C07D211/22 , C07D207/14 , C07D211/46 , C07D211/62 , C07D211/60 , C07D401/04 , C07D217/02 , C07D307/68 , C07D295/26 , C07D317/66 , C07D209/08 , C07D295/205 , C07D401/12 , A61K31/165 , A61K31/33 , A61P29/00
CPC classification number: C07D207/27 , C07C323/62 , C07C2601/02 , C07D205/04 , C07D207/09 , C07D207/14 , C07D207/16 , C07D209/08 , C07D211/20 , C07D211/22 , C07D211/46 , C07D211/60 , C07D211/62 , C07D213/40 , C07D213/74 , C07D213/81 , C07D217/02 , C07D217/06 , C07D231/12 , C07D233/56 , C07D241/04 , C07D249/08 , C07D295/185 , C07D295/26 , C07D307/68 , C07D317/66 , C07D401/04 , C07D401/12
Abstract: The present invention relates to cinnamide compounds of formula (I), in which at least one of R1 to R5 is a "cis-cinnamide" (a) or a "trans-cinnamide" (b) and the other variables are as defined in the claims, that are useful for treating inflammatory and immune diseases, to pharmaceutical compositions containing these compounds and to methods of inhibiting inflammation or suppressing immune response in a mammal.
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17.发明公开PYRROLIDINE-3-CARBOXYLIC ACID DERIVATIVES AND THEIR USE AS ENDOTHELIN ANTAGOISTS 失效吡咯烷-3-羧酸衍生物及其作为内皮素拮抗剂的用途
公开(公告)号：EP1003740A2
公开(公告)日：2000-05-31
申请号：EP98937139.8
申请日：1998-07-27
Applicant: Abbott Laboratories
Inventor： WINN, Martin , BOYD, Steven, A. , HUTCHINS, Charles, W. , JAE, Hwan-Soo , TASKER, Andrew, S. , von GELDERN, Thomas, W. , KESTER, Jeffrey, A. , SORENSEN, Bryan, K. , SZCZEPANKIEWICZ, Bruce, G. , HENRY, Kenneth, J. , LIU, Gang , WITTENBERGER, Steven, J. , KING, Steven, A.
IPC: C07D405/00
CPC classification number: C07D207/27 , C07D207/16 , C07D403/04 , C07D405/04 , C07D405/14 , C07D413/14 , C07D417/14
Abstract: A compound of formula (I), or a pharmaceutically acceptable salt thereof, is disclosed, as well as processes for and intermediates in the preparation thereof, and a method of antagonizing endothelin.
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