公开(公告)号：EP1165505A1

公开(公告)日：2002-01-02

申请号：EP00921654.0

申请日：2000-04-03

Applicant: ABBOTT LABORATORIES

Inventor： LINK, James ,  LIU, Gang ,  PEI, Zhonghua ,  VON GELDERN, Thomas, W. ,  WINN, Martin ,  XIN, Zhili ,  WANG, Sheldon ,  BOYD, Steven, A. ,  ZHU, Gui-Dong ,  FREEMAN, Jennifer, C. ,  GUNAWARDANA, Indrani, W. ,  STAEGER, Michael, A. ,  JAE, Hwan-Soo ,  LYNCH, John, K.

IPC: C07C323/62 ,  C07D233/61 ,  C07D207/26 ,  C07D295/18 ,  C07D213/74 ,  C07D211/22 ,  C07D207/14 ,  C07D211/46 ,  C07D211/62 ,  C07D211/60 ,  C07D401/04 ,  C07D217/02 ,  C07D307/68 ,  C07D295/26 ,  C07D317/66 ,  C07D209/08 ,  C07D295/205 ,  C07D401/12 ,  A61K31/165 ,  A61K31/33 ,  A61P29/00

CPC classification number: C07D207/27 ,  C07C323/62 ,  C07C2601/02 ,  C07D205/04 ,  C07D207/09 ,  C07D207/14 ,  C07D207/16 ,  C07D209/08 ,  C07D211/20 ,  C07D211/22 ,  C07D211/46 ,  C07D211/60 ,  C07D211/62 ,  C07D213/40 ,  C07D213/74 ,  C07D213/81 ,  C07D217/02 ,  C07D217/06 ,  C07D231/12 ,  C07D233/56 ,  C07D241/04 ,  C07D249/08 ,  C07D295/185 ,  C07D295/26 ,  C07D307/68 ,  C07D317/66 ,  C07D401/04 ,  C07D401/12

Abstract: The present invention relates to cinnamide compounds of formula (I), in which at least one of R1 to R5 is a "cis-cinnamide" (a) or a "trans-cinnamide" (b) and the other variables are as defined in the claims, that are useful for treating inflammatory and immune diseases, to pharmaceutical compositions containing these compounds and to methods of inhibiting inflammation or suppressing immune response in a mammal.

公开(公告)号：EP1165505B1

公开(公告)日：2004-09-08

申请号：EP00921654.0

申请日：2000-04-03

Applicant: ABBOTT LABORATORIES

Inventor： LINK, James ,  LIU, Gang ,  PEI, Zhonghua ,  VON GELDERN, Thomas, W. ,  WINN, Martin ,  XIN, Zhili ,  WANG, Sheldon ,  BOYD, Steven, A. ,  ZHU, Gui-Dong ,  FREEMAN, Jennifer, C. ,  GUNAWARDANA, Indrani, W. ,  STAEGER, Michael, A. ,  JAE, Hwan-Soo ,  LYNCH, John, K.

IPC: C07C323/62 ,  C07D233/61 ,  C07D207/26 ,  C07D295/18 ,  C07D213/74 ,  C07D211/22 ,  C07D207/14 ,  C07D211/46 ,  C07D211/62 ,  C07D211/60 ,  C07D401/04 ,  C07D217/02 ,  C07D307/68 ,  C07D295/26 ,  C07D317/66 ,  C07D209/08 ,  C07D295/205 ,  C07D401/12 ,  A61K31/165 ,  A61K31/33 ,  A61P29/00

CPC classification number: C07D207/27 ,  C07C323/62 ,  C07C2601/02 ,  C07D205/04 ,  C07D207/09 ,  C07D207/14 ,  C07D207/16 ,  C07D209/08 ,  C07D211/20 ,  C07D211/22 ,  C07D211/46 ,  C07D211/60 ,  C07D211/62 ,  C07D213/40 ,  C07D213/74 ,  C07D213/81 ,  C07D217/02 ,  C07D217/06 ,  C07D231/12 ,  C07D233/56 ,  C07D241/04 ,  C07D249/08 ,  C07D295/185 ,  C07D295/26 ,  C07D307/68 ,  C07D317/66 ,  C07D401/04 ,  C07D401/12

Abstract: The present invention relates to cinnamide compounds of formula (I), in which at least one of R1 to R5 is a "cis-cinnamide" (a) or a "trans-cinnamide" (b) and the other variables are as defined in the claims, that are useful for treating inflammatory and immune diseases, to pharmaceutical compositions containing these compounds and to methods of inhibiting inflammation or suppressing immune response in a mammal.

Abstract translation: 本发明涉及式（I）的肉桂酰胺化合物，其中R 1至R 5中的至少一个为“顺式 - 酰胺”（a）或“反式肉桂酰胺”（b），其它变量如 可用于治疗炎症和免疫疾病的权利要求，含有这些化合物的药物组合物和抑制哺乳动物炎症或抑制免疫应答的方法。

公开(公告)号：EP1358154A2

公开(公告)日：2003-11-05

申请号：EP00972042.6

申请日：2000-10-10

Applicant: Abbott Laboratories

Inventor： MARING, Clarence J. ,  GIRANDA, Vincent L. ,  KEMPF, Dale J. ,  STOLL, Vincent S. ,  SUN, Minghua ,  ZHAO, Chen ,  GU, Yu Gui ,  HANESSIAN, Stephen ,  WANG, Gary T. ,  KRUEGER, Allan C. ,  CHEN, Hui-Ju ,  CHEN, Yuanwei ,  DEGOEY, David A. ,  FLOSI, William J. ,  GRAMPOVNIK, David J. ,  KATI, Warren M. ,  KENNEDY, April L. ,  KLEIN, Larry L. ,  LIN, Zhen ,  MADIGAN, Darold L. ,  MCDANIEL, Keith F. ,  MUCHMORE, Steven W. ,  SHAM, Hing L. ,  STEWART, Kent D. ,  TU, Noah P. ,  WAGENAAR, Frank L. ,  WANG, Sheldon ,  WIEDEMAN, Paul E. ,  XU, Yibo ,  YEUNG, Ming C. ,  BAYRAKDARIAN, Malken ,  LUO, Xuehong

IPC: C07D207/16 ,  C07D403/04 ,  C07D417/04

CPC classification number: C07D207/16 ,  C07D207/26 ,  C07D207/327 ,  C07D207/38 ,  C07D207/46 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D303/16 ,  C07D403/04 ,  C07D405/04 ,  C07D405/06 ,  C07D409/06 ,  C07D413/04 ,  C07D417/04 ,  C07D417/06

Abstract: Enantiomerically enriched compounds having the absolute stereochemistry of the formula (I) or a pharmaceutically acceptable salt, ester or prodrug thereof, which are useful for inhibiting neuraminidases from disease-causing microorganisms, especially, influenza neuraminidase. Also disclosed are compositions and methods for preventing and treating diseases caused by microorganisms having a neuraminidase, processes for preparing the compounds and synthetic intermediates used in these processes.

公开(公告)号：EP1294704A1

公开(公告)日：2003-03-26

申请号：EP01946705.9

申请日：2001-06-22

Applicant: ABBOTT LABORATORIES

Inventor： WANG, Gary, T. ,  WANG, Sheldon ,  GENTLES, Robert

IPC: C07D263/48 ,  C07D277/42 ,  C07D239/42 ,  C07D403/12 ,  C07D401/04 ,  C07D403/04 ,  C07D401/14 ,  A61K31/425 ,  A61K31/505

CPC classification number: C07D239/42 ,  C07D263/48 ,  C07D277/42 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12

Abstract: The present invention relates to novel heterocyclyl-containing diaryl sulfide compounds that are useful for treating inflammatory and immune diseases, to pharmaceutical compositions comprising these compounds, and to methods of inhibiting inflammation or suppressing immune response in a mammal.

公开(公告)号：EP1087938A1

公开(公告)日：2001-04-04

申请号：EP99918495.5

申请日：1999-04-12

Applicant: ABBOTT LABORATORIES

Inventor： MARING, Clarence, J. ,  GU, Yu-Gui ,  CHEN, Yuanwei ,  DEGOEY, David, A. ,  GIRANDA, Vincent, L. ,  GRAMPOVNIK, David, J. ,  KATI, Warren, M. ,  KEMPF, Dale, J. ,  KENNEDY, April ,  LIN, Zhen ,  MADIGAN, Darold, L. ,  MUCHMORE, Steven, W. ,  SHAM, Hing, L. ,  STEWART, Kent, D. ,  STOLL, Vincent, S. ,  SUN, Minghua ,  WANG, Gary, T. ,  WANG, Sheldon ,  YEUNG, Ming, C.

IPC: C07C271/24 ,  C07C233/52 ,  C07C233/47 ,  C07C271/22 ,  C07D233/54 ,  C07D263/32 ,  A61K31/33 ,  A61K31/16 ,  C07C237/24 ,  C07D307/24 ,  C07D405/04

CPC classification number: C07D233/64 ,  C07C233/52 ,  C07C237/24 ,  C07C271/24 ,  C07C2601/08 ,  C07D307/24 ,  C07D317/32 ,  C07D493/08

Abstract: Disclosed are compounds of formula (I), (II) or (III), which are useful for inhibiting neuraminidases from disease-causing microorganisms, especially, influenza neuraminidase. Also disclosed are compositions and methods for preventing and treating diseases caused by microorganisms having a neuraminidase, processes for preparing the compounds and synthetic intermediates used in these processes.

Abstract translation: 公开了式（I），（II）或（III）的化合物，其可用于抑制致病微生物，特别是流感神经氨酸酶的神经氨酸酶。 还公开了用于预防和治疗由具有神经氨酸酶的微生物引起的疾病的组合物和方法，用于制备这些方法中使用的化合物和合成中间体的方法。