公开(公告)号：WO2005061450A2

公开(公告)日：2005-07-07

申请号：PCT/US2004/037745

申请日：2004-11-10

Applicant: ABBOTT LABORATORIES ,  FLENTGE, Charles, A. ,  CHEN, Hui-Ju ,  DEGOEY, David, A. ,  FLOSI, William, J. ,  GRAMPOVNIK, David, J. ,  HUANG, Peggy, P. ,  KEMPF, Dale, J. ,  KLEIN, Larry, L. ,  KRUEGER, Allan, C. ,  MADIGAN, Darold, L. ,  RANDOLPH, John, T. ,  SUN, Minghua ,  YEUNG, Ming, C. ,  ZHAO, Chen

Inventor： FLENTGE, Charles, A. ,  CHEN, Hui-Ju ,  DEGOEY, David, A. ,  FLOSI, William, J. ,  GRAMPOVNIK, David, J. ,  HUANG, Peggy, P. ,  KEMPF, Dale, J. ,  KLEIN, Larry, L. ,  KRUEGER, Allan, C. ,  MADIGAN, Darold, L. ,  RANDOLPH, John, T. ,  SUN, Minghua ,  YEUNG, Ming, C. ,  ZHAO, Chen

IPC: C07D

CPC classification number: C07D471/04 ,  A61K31/175 ,  A61K31/18 ,  A61K31/195 ,  A61K31/277 ,  A61K31/4168 ,  A61K31/65 ,  A61K45/06 ,  C07D213/30 ,  C07D213/40 ,  C07D213/78 ,  C07D233/32 ,  C07D233/72 ,  C07D277/28 ,  C07D277/46 ,  C07D277/48 ,  C07D307/20 ,  C07D307/42 ,  C07D401/06 ,  C07D403/06 ,  C07D403/10 ,  C07D405/06 ,  C07D405/10 ,  C07D409/06 ,  C07D417/06 ,  C07D417/14 ,  C07D493/04 ,  A61K2300/00

Abstract: A compound of the formula (I) is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.

Abstract translation: 式（I）的化合物被公开为HIV蛋白酶抑制剂。 还公开了抑制HIV感染的方法和组合物。

公开(公告)号：WO1996005180A1

公开(公告)日：1996-02-22

申请号：PCT/US1995009472

申请日：1995-07-26

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  ZHAO, Chen ,  KEMPF, Dale, J. ,  SHAM, Hing, L. ,  NORBECK, Daniel, W. ,  BETEBENNER, David, A. ,  LIN, Shuqun

IPC: C07D255/02

CPC classification number: C07D405/06 ,  C07C281/02 ,  C07D255/02 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14

Abstract: A retriviral protease inhibiting compound of formula (A) is disclosed.

Abstract translation: 公开了式（A）的抗病毒蛋白酶抑制化合物。

公开(公告)号：WO1994019332A1

公开(公告)日：1994-09-01

申请号：PCT/US1994001457

申请日：1994-02-08

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  NORBECK, Daniel, W. ,  SHAM, Hing, Leung ,  KEMPF, Dale, J. ,  ZHAO, Chen

IPC: C07D263/34

CPC classification number: C07D213/30 ,  C07C281/02 ,  C07C281/06 ,  C07C2601/14 ,  C07D213/38 ,  C07D213/40 ,  C07D261/08 ,  C07D263/32 ,  C07D265/30 ,  C07D275/02 ,  C07D277/24 ,  C07D277/28 ,  C07D307/52 ,  C07D309/04 ,  C07D405/12 ,  C07D413/12 ,  C07D417/12

Abstract: A retroviral protease inhibiting compound of formula (I) is disclosed.

Abstract translation: 公开了式（I）的逆转录病毒蛋白酶抑制化合物。

公开(公告)号：EP0674513A1

公开(公告)日：1995-10-04

申请号：EP94905429.0

申请日：1993-12-16

Applicant: ABBOTT LABORATORIES

Inventor： KEMPF, Dale J. ,  NORBECK, Daniel W. ,  SHAM, Hing Leung ,  ZHAO, Chen ,  SOWIN, Thomas J. ,  RENO, Daniel S. ,  HAIGHT, Anthony R. ,  COOPER, Arthur J.

IPC: C07D ,  C07D275 ,  A61K31 ,  A61K45 ,  A61P31 ,  A61P35 ,  A61P37 ,  A61P43 ,  C07C33 ,  C07C43 ,  C07C45 ,  C07C53 ,  C07C69 ,  C07C211 ,  C07C215 ,  C07C229 ,  C07C233 ,  C07C235 ,  C07C237 ,  C07C239 ,  C07C247 ,  C07C251 ,  C07C271 ,  C07C275 ,  C07C311 ,  C07C317 ,  C07C323 ,  C07C381 ,  C07D213 ,  C07D233 ,  C07D235 ,  C07D239 ,  C07D241 ,  C07D261 ,  C07D263 ,  C07D265 ,  C07D277 ,  C07D295 ,  C07D303 ,  C07D307 ,  C07D333 ,  C07D401 ,  C07D413 ,  C07D417 ,  C07D521 ,  C07F5 ,  C07K5 ,  A61K38

CPC classification number: C07D413/12 ,  A61K31/425 ,  A61K31/427 ,  A61K31/70 ,  A61K38/00 ,  A61K45/06 ,  C07C33/46 ,  C07C43/164 ,  C07C43/1742 ,  C07C43/2055 ,  C07C43/215 ,  C07C43/23 ,  C07C43/30 ,  C07C43/315 ,  C07C45/004 ,  C07C45/29 ,  C07C45/567 ,  C07C45/62 ,  C07C45/673 ,  C07C45/74 ,  C07C53/134 ,  C07C69/34 ,  C07C69/65 ,  C07C69/732 ,  C07C211/27 ,  C07C215/18 ,  C07C215/20 ,  C07C215/28 ,  C07C229/08 ,  C07C229/26 ,  C07C229/34 ,  C07C233/36 ,  C07C233/40 ,  C07C235/10 ,  C07C235/12 ,  C07C235/34 ,  C07C235/78 ,  C07C237/10 ,  C07C237/20 ,  C07C237/22 ,  C07C239/10 ,  C07C239/18 ,  C07C239/20 ,  C07C247/10 ,  C07C251/40 ,  C07C271/20 ,  C07C271/22 ,  C07C271/34 ,  C07C275/16 ,  C07C275/24 ,  C07C311/03 ,  C07C311/13 ,  C07C311/18 ,  C07C317/10 ,  C07C317/28 ,  C07C317/44 ,  C07C323/12 ,  C07C323/25 ,  C07C381/00 ,  C07D213/26 ,  C07D213/30 ,  C07D213/34 ,  C07D213/40 ,  C07D213/54 ,  C07D213/56 ,  C07D213/61 ,  C07D213/75 ,  C07D231/12 ,  C07D233/56 ,  C07D233/64 ,  C07D233/84 ,  C07D235/14 ,  C07D235/16 ,  C07D239/26 ,  C07D241/12 ,  C07D249/08 ,  C07D261/08 ,  C07D263/32 ,  C07D277/24 ,  C07D277/28 ,  C07D277/30 ,  C07D277/34 ,  C07D277/36 ,  C07D277/40 ,  C07D277/42 ,  C07D277/56 ,  C07D295/13 ,  C07D295/205 ,  C07D295/215 ,  C07D303/36 ,  C07D307/42 ,  C07D333/16 ,  C07D401/12 ,  C07D417/12 ,  C07K5/06026 ,  C07K5/06078 ,  A61K31/00 ,  A61K2300/00 ,  C07C49/233 ,  C07C49/255 ,  C07C49/215 ,  C07C49/245 ,  C07C49/235 ,  C07C49/223

Abstract: A retroviral protease inhibiting compound of formula (A) is disclosed for use in combination with other active pharmaceutical agents for treating a human infected by HIV. Intermediates and processes useful in the manufacture of compounds of formula (A) are also disclosed.

公开(公告)号：EP1735332B1

公开(公告)日：2011-10-19

申请号：EP05738987.6

申请日：2005-04-06

Applicant: ABBOTT LABORATORIES

Inventor： ZHAO, Chen ,  SUN, Minghua ,  COWART, Marlon, D. ,  BENNANI, Youssef, L.

IPC: C07J71/00 ,  A61K31/58 ,  A61P25/28 ,  A61P29/00

CPC classification number: C07J71/0042

Abstract: Azacyclosteroid histamine-3 receptor ligands, pharmaceutical compositions comprising such compounds, and methods for using such compounds and compositions are described herein.

公开(公告)号：EP2237779A1

公开(公告)日：2010-10-13

申请号：EP08867156.5

申请日：2008-12-18

Applicant: Abbott Laboratories

Inventor： BLACK, Lawrence A. ,  COWART, Marlon D. ,  GFESSER, Gregory A. ,  WAKEFIELD, Brian D. ,  ALTENBACH, Robert J. ,  LIU, Huaqing ,  ZHAO, Chen ,  HSIEH, Gin C.

IPC: A61K31/423 ,  A61K31/428 ,  C07D413/14 ,  C07D417/14 ,  A61P25/00 ,  A61P3/10

CPC classification number: C07D417/14 ,  C07D413/04 ,  C07D417/04

Abstract: Compounds of formula (I) are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions of compounds of formula (I), methods for using such compounds and compositions, and a process for preparing the compounds.

公开(公告)号：EP1926729A1

公开(公告)日：2008-06-04

申请号：EP06814914.5

申请日：2006-09-19

Applicant: ABBOTT LABORATORIES

Inventor： COWART, Marlon, D. ,  SUN, Minghua ,  ZHAO, Chen ,  ZHENG, Guo Zhu

IPC: C07D417/04 ,  C07D417/08 ,  C07D417/12 ,  C07D277/64 ,  C07D487/04 ,  A61K31/428 ,  A61K51/04 ,  A61P9/10

CPC classification number: C07D277/64 ,  C07D417/04 ,  C07D417/08 ,  C07D417/12 ,  C07D487/04

Abstract: Compounds of formula (I) are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands, methods for using such compounds and compositions, and a process for preparing compounds within the scope of formula (I).

公开(公告)号：EP0724563B1

公开(公告)日：1999-09-01

申请号：EP94929340.1

申请日：1994-09-26

Applicant: ABBOTT LABORATORIES

Inventor： STUK, Timothy, L. ,  KERDESKY, Francis, A., J. ,  LIJEWSKI, Linda, M. ,  NORBECK, Daniel, W. ,  SCARPETTI, David ,  TIEN, Jien-Heh, J. ,  ALLEN, Michael, S. ,  LANGRIDGE, Denton, C. ,  MELCHER, Laura ,  RENO, Daniel, S. ,  SHAM, Hing, Leung ,  ZHAO, Chen ,  HAIGHT, Anthony, R. ,  LEANNA, M., Robert ,  MORTON, Howard, E. ,  ROBBINS, Timothy, A. ,  SOWIN, Thomas, J.

IPC: C07C225/16 ,  C07C213/00 ,  C07C255/42 ,  C07C271/20 ,  C07C269/06 ,  C07C215/28 ,  C07C251/40

CPC classification number: C07D221/14 ,  C07B2200/07 ,  C07C213/00 ,  C07C215/28 ,  C07C225/16 ,  C07C251/40 ,  C07C255/42 ,  C07C269/06 ,  C07C271/20 ,  C07D209/44 ,  C07C215/08

Abstract: Intermediates and processes are disclosed which are useful for the preparation of a substantially pure compound of formula (3), wherein R6 and R7 are each hydrogen or R6 and R7 are independently selected from (i), wherein Ra and Rb are independently selected from hydrogen, loweralkyl and phenyl and Rc, Rd and Re are independently selected from hydrogen, loweralkyl, trifluoromethyl, alkoxy, halo and phenyl; and (ii) wherein the naphthyl ring is unsubstituted or substituted with one, two or three substituents independently selected from loweralkyl, trifluoromethyl, alkoxy and halo; or R6 is as defined above and R7 is R7aOC (O)-wherein R7a is loweralkyl or benzyl; or R6 and R7 taken together with the nitrogen atom to which they are bonded are (a) or (b), wherein Rf, Rg, Rh and Ri are independently selected from hydrogen, loweralkyl, alkoxy, halogen and trifluoromethyl and R8 is hydrogen or -C(O)R' wherein R' is loweralkyl, alkoxy, benzyloxy or phenyl wherein the phenyl ring is unsubstituted or substituted with one, two or three substituents independently selected from loweralkyl, trifluoromethyl, alkoxy and halo; or an acid addition salt thereof.

公开(公告)号：EP0674513B1

公开(公告)日：1996-09-25

申请号：EP94905429.0

申请日：1993-12-16

Applicant: ABBOTT LABORATORIES

Inventor： KEMPF, Dale J. ,  NORBECK, Daniel W. ,  SHAM, Hing Leung ,  ZHAO, Chen ,  SOWIN, Thomas J. ,  RENO, Daniel S. ,  HAIGHT, Anthony R. ,  COOPER, Arthur J.

IPC: A61K31/425 ,  A61K31/42 ,  C07D277/24 ,  C07D275/02 ,  C07D261/08 ,  C07D263/32 ,  C07F5/02 ,  C07D417/12 ,  C07D413/12 ,  C07D277/28 ,  C07D277/42

CPC classification number: C07D413/12 ,  A61K31/425 ,  A61K31/427 ,  A61K31/70 ,  A61K38/00 ,  A61K45/06 ,  C07C33/46 ,  C07C43/164 ,  C07C43/1742 ,  C07C43/2055 ,  C07C43/215 ,  C07C43/23 ,  C07C43/30 ,  C07C43/315 ,  C07C45/004 ,  C07C45/29 ,  C07C45/567 ,  C07C45/62 ,  C07C45/673 ,  C07C45/74 ,  C07C53/134 ,  C07C69/34 ,  C07C69/65 ,  C07C69/732 ,  C07C211/27 ,  C07C215/18 ,  C07C215/20 ,  C07C215/28 ,  C07C229/08 ,  C07C229/26 ,  C07C229/34 ,  C07C233/36 ,  C07C233/40 ,  C07C235/10 ,  C07C235/12 ,  C07C235/34 ,  C07C235/78 ,  C07C237/10 ,  C07C237/20 ,  C07C237/22 ,  C07C239/10 ,  C07C239/18 ,  C07C239/20 ,  C07C247/10 ,  C07C251/40 ,  C07C271/20 ,  C07C271/22 ,  C07C271/34 ,  C07C275/16 ,  C07C275/24 ,  C07C311/03 ,  C07C311/13 ,  C07C311/18 ,  C07C317/10 ,  C07C317/28 ,  C07C317/44 ,  C07C323/12 ,  C07C323/25 ,  C07C381/00 ,  C07D213/26 ,  C07D213/30 ,  C07D213/34 ,  C07D213/40 ,  C07D213/54 ,  C07D213/56 ,  C07D213/61 ,  C07D213/75 ,  C07D231/12 ,  C07D233/56 ,  C07D233/64 ,  C07D233/84 ,  C07D235/14 ,  C07D235/16 ,  C07D239/26 ,  C07D241/12 ,  C07D249/08 ,  C07D261/08 ,  C07D263/32 ,  C07D277/24 ,  C07D277/28 ,  C07D277/30 ,  C07D277/34 ,  C07D277/36 ,  C07D277/40 ,  C07D277/42 ,  C07D277/56 ,  C07D295/13 ,  C07D295/205 ,  C07D295/215 ,  C07D303/36 ,  C07D307/42 ,  C07D333/16 ,  C07D401/12 ,  C07D417/12 ,  C07K5/06026 ,  C07K5/06078 ,  A61K31/00 ,  A61K2300/00 ,  C07C49/233 ,  C07C49/255 ,  C07C49/215 ,  C07C49/245 ,  C07C49/235 ,  C07C49/223

Abstract: A retroviral protease inhibiting compound of formula (A) is disclosed for use in combination with other active pharmaceutical agents for treating a human infected by HIV. Intermediates and processes useful in the manufacture of compounds of formula (A) are also disclosed.

公开(公告)号：EP0724563A1

公开(公告)日：1996-08-07

申请号：EP94929340.0

申请日：1994-09-26

Applicant: ABBOTT LABORATORIES

Inventor： STUK, Timothy, L. ,  KERDESKY, Francis, A., J. ,  LIJEWSKI, Linda, M. ,  NORBECK, Daniel, W. ,  SCARPETTI, David ,  TIEN, Jien-Heh, J. ,  ALLEN, Michael, S. ,  LANGRIDGE, Denton, C. ,  MELCHER, Laura ,  RENO, Daniel, S. ,  SHAM, Hing, Leung ,  ZHAO, Chen ,  HAIGHT, Anthony, R. ,  LEANNA, M., Robert ,  MORTON, Howard, E. ,  ROBBINS, Timothy, A. ,  SOWIN, Thomas, J.

IPC: C07C213 ,  C07C215 ,  C07C225 ,  C07C227 ,  C07C229 ,  C07C231 ,  C07C233 ,  C07C251 ,  C07C255 ,  C07C269 ,  C07C271 ,  C07D209 ,  C07D221

CPC classification number: C07D221/14 ,  C07B2200/07 ,  C07C213/00 ,  C07C215/28 ,  C07C225/16 ,  C07C251/40 ,  C07C255/42 ,  C07C269/06 ,  C07C271/20 ,  C07D209/44 ,  C07C215/08

Abstract: Intermediates and processes are disclosed which are useful for the preparation of a substantially pure compound of formula (3), wherein R6 and R7 are each hydrogen or R6 and R7 are independently selected from (i), wherein Ra and Rb are independently selected from hydrogen, loweralkyl and phenyl and Rc, Rd and Re are independently selected from hydrogen, loweralkyl, trifluoromethyl, alkoxy, halo and phenyl; and (ii) wherein the naphthyl ring is unsubstituted or substituted with one, two or three substituents independently selected from loweralkyl, trifluoromethyl, alkoxy and halo; or R6 is as defined above and R7 is R7aOC (O)-wherein R7a is loweralkyl or benzyl; or R6 and R7 taken together with the nitrogen atom to which they are bonded are (a) or (b), wherein Rf, Rg, Rh and Ri are independently selected from hydrogen, loweralkyl, alkoxy, halogen and trifluoromethyl and R8 is hydrogen or -C(O)R' wherein R' is loweralkyl, alkoxy, benzyloxy or phenyl wherein the phenyl ring is unsubstituted or substituted with one, two or three substituents independently selected from loweralkyl, trifluoromethyl, alkoxy and halo; or an acid addition salt thereof.