公开(公告)号：WO2014015235A3

公开(公告)日：2014-03-06

申请号：PCT/US2013051247

申请日：2013-07-19

Applicant: ACADEMIA SINICA ,  UNIV NAT TAIWAN ,  LIANG CHI MING

Inventor： CHEN CHING-CHOW ,  CHEN JHIH-BIN ,  WEI TZU-TANG ,  LIN JUNG-HSIN ,  FANG JIM-MIN ,  CHERN TING-RONG

IPC: C07C235/26 ,  A61K31/16 ,  A61P35/00

CPC classification number: C07D215/14 ,  A61K31/221 ,  A61K31/401 ,  A61K31/4045 ,  A61K31/44 ,  A61K31/47 ,  A61K31/505 ,  A61K45/06 ,  C07B2200/07 ,  C07C259/06 ,  C07C259/08 ,  C07C2602/28 ,  C07D207/34 ,  C07D209/24 ,  C07D213/56 ,  C07D239/42

Abstract: The present invention provides novel compounds of Formula (I), and pharmaceutically compositions thereof. Compounds of Formula (I) are inhibitors of histone deacetylases (HDACs) and 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase (HMGR). Also provided are methods of using the compounds and pharmaceutical compositions for inhibiting the activity of HDACs and HMGR, treating diseases associated with HDACs or HMGR (e.g., cancer, hypercholesterolemia, an acute or chronic inflammatory disease, autoimmune disease, allergic disease, pathogen infection, neurodegenerative disease, and a disease associated with oxidative stress), or inhibiting drug resistance of cancer cells.

Abstract translation: 本发明提供新的式（I）化合物及其药物组合物。 式（I）化合物是组蛋白脱乙酰酶（HDAC）和3-羟基-3-甲基戊二酰辅酶A（HMG-CoA）还原酶（HMGR）的抑制剂。 还提供了使用化合物和药物组合物抑制HDAC和HMGR的活性，治疗与HDAC或HMGR相关的疾病（例如癌症，高胆固醇血症，急性或慢性炎性疾病，自身免疫性疾病，过敏性疾病，病原体感染， 神经变性疾病和与氧化应激相关的疾病），或抑制癌细胞的耐药性。

公开(公告)号：WO2009102880A3

公开(公告)日：2009-11-19

申请号：PCT/US2009033940

申请日：2009-02-12

Applicant: ACADEMIA SINICA ,  WONG CHI-HUEY ,  FANG JIM-MIN ,  YANG WEN-BIN ,  CHENG TING-JEN RACHEL ,  HSEIH YVES SHANG-YI ,  CHENG CHIEN ,  LIN CHIH-CHIEN ,  WEN HAO-YU

Inventor： WONG CHI-HUEY ,  FANG JIM-MIN ,  YANG WEN-BIN ,  CHENG TING-JEN RACHEL ,  HSEIH YVES SHANG-YI ,  CHENG CHIEN ,  LIN CHIH-CHIEN ,  WEN HAO-YU

IPC: A61K36/8984 ,  A61K31/715 ,  A61K31/736 ,  A61P35/00

CPC classification number: A61K36/8984

Abstract: Compositions and methods are disclosed relating to use of fractions, polysaccharides, and oligosaccharides of Dendrobium huoshanese. The fractions, polysaccharides, and oligosaccharides are able to effect an increase in beneficial cytokines and chemokines.

Abstract translation: 公开了关于使用蛭石石斛的级分，多糖和寡糖的组合物和方法。 级分，多糖和寡糖能够影响有益的细胞因子和趋化因子的增加。

公开(公告)号：ES2645043T3

公开(公告)日：2017-12-01

申请号：ES10859431

申请日：2010-11-12

Applicant: ACADEMIA SINICA

Inventor： LIN YUN-LIAN ,  CHERN YIJUANG ,  FANG JIM-MIN ,  LIN JUNG-HSING ,  HUANG NAI-KUEI

IPC: C07H19/167 ,  A61K31/426 ,  A61K31/56 ,  A61P11/06

Abstract: Una composición que comprende una cantidad eficaz de un compuesto de fórmula:**Fórmula** en donde n es 1 a 3, el heterociclo (sustituido) contiene anillos de 5 o 6 miembros y el heterociclo fusionado contiene heteroátomos de nitrógeno, oxígeno o azufre y el sustituyente se selecciona del grupo que consiste en hidrógeno, flúor, cloro, bromo, yodo, hidroxi, alquilo C1-6, trifluorometilo y fenilo (sustituido), para usar en el tratamiento de una enfermedad neurodegenerativa en un sujeto que lo necesite.

公开(公告)号：HK1208598A1

公开(公告)日：2016-03-11

申请号：HK15109316

申请日：2015-09-23

Applicant: ACADEMIA SINICA

Inventor： CHEN CHIH-CHENG ,  LIN YUN-LIAN ,  FANG JIM-MIN ,  CHERN YIJUANG ,  LIN CHIA-CHING JOHN ,  CHEN WEI-NAN ,  LIN CHUN-JUNG

IPC: A61K20060101 ,  A01N20060101

Abstract: The invention provides a new use of adenosine analogs for the treatment of pain through activation of neurokinin 1 (NK1) receptor signaling pathway, thereby inducing the activation of activation of M-type potassium channel to induce outward currents. A method and pharmaceutical composition for treating pain comprising an adenonsine analog that activates NK1 receptor signaling, thereby inducing outward current are also provided.

公开(公告)号：DK2568976T3

公开(公告)日：2016-01-11

申请号：DK11731548

申请日：2011-05-10

Applicant: ACADEMIA SINICA

Inventor： WONG CHI-HUEY ,  FANG JIM-MIN ,  CHENG YIH-SHYUN ,  SHIE JIUN-JIE

IPC: A61K31/00 ,  A61K31/665 ,  A61K31/683

公开(公告)号：AU2013306098A1

公开(公告)日：2015-02-12

申请号：AU2013306098

申请日：2013-08-16

Applicant: WONG CHI-HUEY ,  FANG JIM-MIN ,  CHENG YIH SHYUN ,  ACADEMIA SINICA ,  TSAI CHARNG-SHENG

Inventor： WONG CHI-HUEY ,  FANG JIM-MIN ,  CHENG YIH-SHYUN E ,  TSAI CHARNG-SHENG

IPC: C07H7/00 ,  C12Q1/34

Abstract: Provided herein are novel irreversible sialidase inhibitors. These compounds can be conjugated with a detectable tagging moiety such as azide-annexed biotin via CuAAC for isolation and identification of sialidases. The provided compounds and the corresponding detectable conjugates are useful for detecting sialidase-containing pathogens and imaging

公开(公告)号：CA2880701A1

公开(公告)日：2014-02-27

申请号：CA2880701

申请日：2013-08-16

Applicant: ACADEMIA SINICA ,  WONG CHI-HUEY ,  FANG JIM-MIN ,  CHENG YIH-SHYUN E ,  TSAI CHARNG-SHENG

Inventor： WONG CHI-HUEY ,  FANG JIM-MIN ,  CHENG YIH-SHYUN E ,  TSAI CHARNG-SHENG

IPC: C07H7/00 ,  C12Q1/34

Abstract: Provided herein are novel irreversible sialidase inhibitors. These compounds can be conjugated with a detectable tagging moiety such as azide-annexed biotin via CuAAC for isolation and identification of sialidases. The provided compounds and the corresponding detectable conjugates are useful for detecting sialidase-containing pathogens and imaging in situ sialidase activities under physiological conditions.

公开(公告)号：CA2835489A1

公开(公告)日：2011-11-17

申请号：CA2835489

申请日：2011-05-10

Applicant: ACADEMIA SINICA

Inventor： WONG CHI-HUEY ,  FANG JIM-MIN ,  CHENG YIH-SHYUN ,  SHIE JIUN-JIE

IPC: A61K31/7024 ,  A61P31/16 ,  G01N33/573

Abstract: Methods and compositions for detection of drug resistant pathogens and treatment against infections thereof are provided. Methods for detection of oseltamivir-resistant influenza viruses by competitive binding assays utilizing non- oseltamivir influenza virus neuraminidase inhibitors and oseltamivir carboxylate are provided. Influenza virus neuraminidase inhibitors coupled to sensors and useful for employment in the methods of the invention are disclosed. Novel phosphonate compounds active as neuraminidase inhibitors against wild-type and oseltamivir-resistant influenza strains of H1N1, H5N1 and H3N2 viruses are disclosed. An enantioselective synthetic route to preparation of these phosphonate compounds via sialic acid is provided.

公开(公告)号：BR112016008901B1

公开(公告)日：2022-08-23

申请号：BR112016008901

申请日：2014-10-22

Applicant: ACADEMIA SINICA

Inventor： FANG JIM-MIN ,  LIN YUN-LIAN ,  LIN JUNG-HSIN ,  LIN CHUN-JUNG ,  CHERN YIJUANG ,  HUANG NAI-KUEI ,  WANG HUNG-LI ,  TU BENJAMIN PANG-HSIEN ,  CHEN CHIH-CHENG

IPC: C07D498/02 ,  C07D515/02

Abstract: COMPOSTOS PARA USO NA PREVENÇÃO E TRATAMENTO DE DOENÇAS NEURODEGENERATIVAS E DA DOR Descrevem-se compostos para uso na prevenção e tratamento de doenças neurodegenerativas e dor. Em uma forma de realização da invenção, o composto é selecionado dentre o grupo que consiste em N6-[(3-halotien-2-il)metila]adenosina, N6-[(4-halotien-2-il)metila]adenosina e N6-[(5-halotien-2-il)metila]adenosina. Em outra concretização da invenção, o composto é selecionado dentre o grupo que consiste em N6-[(2-bromotien-3- il)metila]adenosina, N6-[(4-bromotien-3-il)metila]adenosina, N6-[(5-bromotien-3-il)metila[adenosina, N6-[(2-clorotien-3-il)metilaladenosina, N6-[(4-clorotien-3-il)metila]adenosina e N6-[( 5t--clorotien-3-il) meti la ] adenosina . T'e elm-se também métodos para sua produção e utilização.

公开(公告)号：HUE035188T2

公开(公告)日：2018-05-02

申请号：HUE10859431

申请日：2010-11-12

Applicant: ACADEMIA SINICA

Inventor： LIN YUN-LIAN ,  CHERN YIJUANG ,  FANG JIM-MIN ,  LIN JUNG-HSING ,  HUANG NAI-KUEI

IPC: A61K31/56 ,  A61P11/06