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    Methods and compositions for immunization against virus
    11.
    发明专利
    Methods and compositions for immunization against virus 未知

    公开(公告)号：AU2016203431A1

    公开(公告)日：2016-06-16

    申请号：AU2016203431

    申请日：2016-05-25

    Applicant: ACADEMIA SINICA

    Inventor： WONG CHI-HUEY ,  MA CHE ,  WANG CHENG-CHI ,  CHEN JUINE-RUEY

    IPC: A61K39/12

    Abstract: METHODS AND COMPOSITIONS FOR IMMUNIZATION AGAINST Immunogenic compositions comprising partially glycosylated viral glycoproteins for use as vaccines against viruses are provided. Vaccines formulated using mono-, di-, or tri-glycosylated viral surface glycoproteins and polypeptides provide potent and broad protection against viruses, even across strains. Pharmaceutical compositions comprising monoglycosylated hemagglutinin polypeptides and vaccines generated therefrom and methods of their use for prophylaxis or treatment of viral infections are disclosed. Methods and compositions are disclosed for influenza virus HA, NA and M2, RSV proteins F, G and SH, Dengue virus glycoproteins M or E, hepatitis C virus glycoprotein El or E2 and HIV glycoproteins gp120 and gp4l.

    Methods and compositions for immunization against virus
    13.
    发明专利
    Methods and compositions for immunization against virus 未知

    公开(公告)号：AU2016203431B2

    公开(公告)日：2018-03-08

    申请号：AU2016203431

    申请日：2016-05-25

    Applicant: ACADEMIA SINICA

    Inventor： WONG CHI-HUEY ,  MA CHE ,  WANG CHENG-CHI ,  CHEN JUINE-RUEY

    IPC: A61K39/12

    Abstract: METHODS AND COMPOSITIONS FOR IMMUNIZATION AGAINST Immunogenic compositions comprising partially glycosylated viral glycoproteins for use as vaccines against viruses are provided. Vaccines formulated using mono-, di-, or tri-glycosylated viral surface glycoproteins and polypeptides provide potent and broad protection against viruses, even across strains. Pharmaceutical compositions comprising monoglycosylated hemagglutinin polypeptides and vaccines generated therefrom and methods of their use for prophylaxis or treatment of viral infections are disclosed. Methods and compositions are disclosed for influenza virus HA, NA and M2, RSV proteins F, G and SH, Dengue virus glycoproteins M or E, hepatitis C virus glycoprotein El or E2 and HIV glycoproteins gp120 and gp4l.

    Methods and compositions for immunization against virus
    14.
    发明专利
    Methods and compositions for immunization against virus 未知

    公开(公告)号：AU2010229675B2

    公开(公告)日：2016-02-25

    申请号：AU2010229675

    申请日：2010-03-26

    Applicant: ACADEMIA SINICA

    Inventor： WONG CHI-HUEY ,  MA CHE ,  WANG CHENG-CHI ,  CHEN JUINE-RUEY

    IPC: A61K39/12

    Abstract: Immunogenic compositions comprising partially glycosylated viral glycoproteins for use as vaccines against viruses are provided. Vaccines formulated using mono-, di-, or tri-glycosylated viral surface glycoproteins and polypeptides provide potent and broad protection against viruses, even across strains. Pharmaceutical compositions comprising monoglycosylated hemagglutinin polypeptides and vaccines generated therefrom and methods of their use for prophylaxis or treatment of viral infections are disclosed. Methods and compositions are disclosed for influenza virus HA, NA and M2, RSV proteins F, G and SH, Dengue virus glycoproteins M or E, hepatitis C virus glycoprotein E1 or E2 and HIV glycoproteins gp120 and gp41.

    Diagnóstico del cáncer según la concentración de anticuerpos contra Globo H y sus fragmentos
    15.
    发明专利
    Diagnóstico del cáncer según la concentración de anticuerpos contra Globo H y sus fragmentos 未知

    公开(公告)号：ES2477549T3

    公开(公告)日：2014-07-17

    申请号：ES09798419

    申请日：2009-06-16

    Applicant: ACADEMIA SINICA

    Inventor： WONG CHI-HUEY ,  WU CHUNG-YI ,  WANG CHENG-CHI ,  YU ALICE L

    IPC: G01N33/574 ,  G01N33/53

    Abstract: Procedimiento diagnóstico de cáncer para los cánceres que son positivos para Globo H y positivos para Gb5, que comprende el suministro de una muestra que contiene anticuerpos de un sujeto del cual se sospecha que tiene cáncer, en donde dicha muestra es suero, saliva o líquido de ganglio linfático, la incubación de la muestra con Gb5 y uno o varios de Globo H, Bb2 y Bb3 para permitir que los anticuerpos de la muestra se fijen a Gb5 y a uno o varios de Globo H, Bb2 y Bb3, la medición de la cantidad de anticuerpos fijados a Gb5 y la cantidad de anticuerpos fijados a Globo H, a Bb2 o a Bb3, y la determinación de si el sujeto tiene el cáncer basándose en la cantidad de los anticuerpos fijados, en donde una proporción significativamente más alta de la cantidad de anticuerpos fijados a Globo H, Bb2 o Bb3 por la cantidad de anticuerpos fijados a Gb5, en comparación con la del sujeto sin cáncer, indica que el sujeto tiene un cáncer que es positivo para Globo H y positivo para Gb5.

    CANCER DIAGNOSIS BASED ON LEVELS OF ANTIBODIES AGAINST GLOBO H AND ITS FRAGMENTS
    19.
    发明专利
    CANCER DIAGNOSIS BASED ON LEVELS OF ANTIBODIES AGAINST GLOBO H AND ITS FRAGMENTS 未知

    公开(公告)号：NZ590064A

    公开(公告)日：2012-05-25

    申请号：NZ59006409

    申请日：2009-06-16

    Applicant: ACADEMIA SINICA

    Inventor： WONG CHI-HUEY ,  WU CHUNG-YI ,  WANG CHENG-CHI ,  YU ALICE L

    IPC: G01N33/574 ,  G01N33/53

    Abstract: A cancer diagnostic method that comprises the steps: (a) Providing a sample containing antibodies from a subject suspected of having cancer; (b) Incubating the sample with Gb5 and one or more of Globo H, Bb2, Bb3 and Bb4 to allow binding of the antibodies in the sample to the Gb5 and the Globo H, Bb2, Bb3 and Bb4; (c) Measuring the amount of the GB-5-bound antibodies and the amount of the Globo H-bound, Bb2-bound, Bb3-bound and Bb4-bound antibodies; (d) Determining whether the subject has the cancer based on the amounts of Gb5-bound antibodies and the Globo H-bound, Bb2-bound, Bb3-bound and Bb4-bound antibodies; The cancer is Globo H-positive and GB5-positive; and a higher ratio of the amount of Globo H-bound, Bb2-bound, Bb3-bound and Bb4-bound antibodies to the amount of Gb5-bound antibodies compared to a cancer-free subject indicates the subject has cancer. The cancer can be breast cancer, skin cancer, liver cancer, prostate cancer, ovary cancer, colon cancer, stomach cancer or pancreas cancer.

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