公开(公告)号：HK1246650A1

公开(公告)日：2018-09-14

申请号：HK18106115

申请日：2018-05-10

Applicant: ACADEMIA SINICA

Inventor： WONG CHI-HUEY ,  MA CHE ,  WANG CHENG-CHI ,  CHEN JUINE-RUEY

IPC: A61K20060101 ,  A61P20060101

公开(公告)号：MX2011009930A

公开(公告)日：2012-05-08

申请号：MX2011009930

申请日：2010-03-26

Applicant: ACADEMIA SINICA

Inventor： WONG CHI-HUEY ,  MA CHE ,  WANG CHENG-CHI ,  CHEN JUINE-RUEY

IPC: A61K39/145 ,  A61K39/12 ,  A61K39/155 ,  A61K39/21 ,  A61K39/29 ,  A61P31/12 ,  A61P31/14 ,  A61P31/16 ,  A61P31/18 ,  C07K14/11 ,  C07K14/135 ,  C07K14/155 ,  C07K14/18 ,  C12P21/02

Abstract: Se proporcionan las composiciones inmunogénicas que comprenden glicoproteínas virales parcialmente glicosiladas para usar como vacunas contra virus. Las vacunas formuladas usando glicoproteínas de superficie viral mono-, di-, o tri- glicosiladas y polipéptidos proporcionan protección potente y amplia contra virus, aún a través de las cepas. Las composiciones farmacéuticas que comprenden polipéptidos de hemaglutinina monoglicosilados y vacunas generadas por los mismos y métodos de su uso para la profilaxis o tratamiento de infecciones virales se describen. Los métodos y composiciones se describen para virus de influenza HA, NA y M2, proteínas F, G y SH RSV, glicoproteínas M o E de virus de Dengue, glicoproteína E1 o E2 de virus de hepatitis C y glicoproteínas gp120 gp41 de VIH.

公开(公告)号：BRPI1012635A2

公开(公告)日：2016-06-21

申请号：BRPI1012635

申请日：2010-03-26

Applicant: ACADEMIA SINICA

Inventor： MA CHE ,  WANG CHI-CHENG ,  WONG CHI-HUEY ,  CHEN JUINE-RUEY

IPC: A61K39/12

公开(公告)号：AU2016203431A1

公开(公告)日：2016-06-16

申请号：AU2016203431

申请日：2016-05-25

Applicant: ACADEMIA SINICA

Inventor： WONG CHI-HUEY ,  MA CHE ,  WANG CHENG-CHI ,  CHEN JUINE-RUEY

IPC: A61K39/12

Abstract: METHODS AND COMPOSITIONS FOR IMMUNIZATION AGAINST Immunogenic compositions comprising partially glycosylated viral glycoproteins for use as vaccines against viruses are provided. Vaccines formulated using mono-, di-, or tri-glycosylated viral surface glycoproteins and polypeptides provide potent and broad protection against viruses, even across strains. Pharmaceutical compositions comprising monoglycosylated hemagglutinin polypeptides and vaccines generated therefrom and methods of their use for prophylaxis or treatment of viral infections are disclosed. Methods and compositions are disclosed for influenza virus HA, NA and M2, RSV proteins F, G and SH, Dengue virus glycoproteins M or E, hepatitis C virus glycoprotein El or E2 and HIV glycoproteins gp120 and gp4l.

公开(公告)号：CL2014002415A1

公开(公告)日：2015-01-02

申请号：CL2014002415

申请日：2014-09-12

Applicant: ACADEMIA SINICA

Inventor： WONG CHI-HUEY ,  MA CHE ,  WANG CHENG-CHI ,  CHEN JUINE-RUEY

IPC: A61K39/12 ,  A61K39/145 ,  A61K39/155 ,  A61K39/21 ,  A61K39/29 ,  C07K14/135 ,  C07K14/155 ,  C07K14/18

公开(公告)号：CA2756206A1

公开(公告)日：2010-09-30

申请号：CA2756206

申请日：2010-03-26

Applicant: ACADEMIA SINICA

Inventor： WONG CHI-HUEY ,  MA CHE ,  WANG CHENG-CHI ,  CHEN JUINE-RUEY

IPC: A61K39/145 ,  A61K39/12 ,  A61K39/155 ,  A61K39/21 ,  A61K39/29 ,  A61P31/12 ,  A61P31/14 ,  A61P31/16 ,  A61P31/18 ,  C07K14/11 ,  C07K14/135 ,  C07K14/155 ,  C07K14/18 ,  C12P21/02

Abstract: Immunogenic compositions comprising partially glycosylated viral glycoproteins for use as vaccines against viruses are provided. Vaccines formulated using mono-, di-, or tri-glycosylated viral surface glycoproteins and polypeptides provide potent and broad protection against viruses, even across strains. Pharmaceutical compositions comprising monoglycosylated hemagglutinin polypeptides and vaccines generated therefrom and methods of their use for prophylaxis or treatment of viral infections are disclosed. Methods and compositions are disclosed for influenza virus HA, NA and M2, RSV proteins F, G and SH, Dengue virus glycoproteins M or E, hepatitis C virus glycoprotein E1 or E2 and HIV glycoproteins gp120 and gp41.

公开(公告)号：WO2010111687A3

公开(公告)日：2012-07-05

申请号：PCT/US2010028968

申请日：2010-03-26

Applicant: ACADEMIA SINICA ,  WONG CHI-HUEY ,  MA CHE ,  WANG CHENG-CHI ,  CHEN JUINE-RUEY

Inventor： WONG CHI-HUEY ,  MA CHE ,  WANG CHENG-CHI ,  CHEN JUINE-RUEY

IPC: A61K39/12

CPC classification number: A61K39/145 ,  A61K39/12 ,  A61K2039/55505 ,  C07K16/1018 ,  C07K2317/76 ,  C12N7/00 ,  C12N2740/11034 ,  C12N2740/16034 ,  C12N2760/16122 ,  C12N2760/16134 ,  C12N2760/16171 ,  C12N2770/24134

Abstract: Immunogenic compositions comprising partially glycosylated viral glycoproteins for use as vaccines against viruses are provided. Vaccines formulated using mono-, di-, or tri-glycosylated viral surface glycoproteins and polypeptides provide potent and broad protection against viruses, even across strains. Pharmaceutical compositions comprising monoglycosylated hemagglutinin polypeptides and vaccines generated therefrom and methods of their use for prophylaxis or treatment of viral infections are disclosed. Methods and compositions are disclosed for influenza virus HA, NA and M2, RSV proteins F, G and SH, Dengue virus glycoproteins M or E, hepatitis C virus glycoprotein E1 or E2 and HIV glycoproteins gp120 and gp41.

Abstract translation: 提供了包含部分糖基化的病毒糖蛋白的免疫原性组合物，其用作抗病毒疫苗。 使用单糖，二糖或三糖基化的病毒表面糖蛋白和多肽配制的疫苗甚至可以跨毒株提供有效和广泛的防病毒保护。 公开了包含单糖基化血凝素多肽和由其产生的疫苗的药物组合物及其用于预防或治疗病毒感染的方法。 公开了用于流感病毒HA，NA和M2，RSV蛋白F，G和SH，登革病毒糖蛋白M或E，丙型肝炎病毒糖蛋白E1或E2和HIV糖蛋白gp120和gp41的方法和组合物。

公开(公告)号：ES2784189T3

公开(公告)日：2020-09-23

申请号：ES10756977

申请日：2010-03-26

Applicant: ACADEMIA SINICA

Inventor： WONG CHI-HUEY ,  MA CHE ,  WANG CHENG-CHI ,  CHEN JUINE-RUEY

IPC: A61K39/12 ,  A61K39/145

Abstract: Una composición inmunogénica que comprende: una glicoproteína hemaglutinina (HA) del virus de la gripe parcialmente glicosilada, en donde la glicoproteína HA comprende uno o más sitios de glicosilación a los que está unido un glicano, y en donde el glicano consiste en un residuo azúcar, dos residuos azúcar o tres residuos azúcar.

公开(公告)号：AU2016203431B2

公开(公告)日：2018-03-08

申请号：AU2016203431

申请日：2016-05-25

Applicant: ACADEMIA SINICA

Inventor： WONG CHI-HUEY ,  MA CHE ,  WANG CHENG-CHI ,  CHEN JUINE-RUEY

IPC: A61K39/12

Abstract: METHODS AND COMPOSITIONS FOR IMMUNIZATION AGAINST Immunogenic compositions comprising partially glycosylated viral glycoproteins for use as vaccines against viruses are provided. Vaccines formulated using mono-, di-, or tri-glycosylated viral surface glycoproteins and polypeptides provide potent and broad protection against viruses, even across strains. Pharmaceutical compositions comprising monoglycosylated hemagglutinin polypeptides and vaccines generated therefrom and methods of their use for prophylaxis or treatment of viral infections are disclosed. Methods and compositions are disclosed for influenza virus HA, NA and M2, RSV proteins F, G and SH, Dengue virus glycoproteins M or E, hepatitis C virus glycoprotein El or E2 and HIV glycoproteins gp120 and gp4l.

公开(公告)号：AU2010229675B2

公开(公告)日：2016-02-25

申请号：AU2010229675

申请日：2010-03-26

Applicant: ACADEMIA SINICA

Inventor： WONG CHI-HUEY ,  MA CHE ,  WANG CHENG-CHI ,  CHEN JUINE-RUEY

IPC: A61K39/12

Abstract: Immunogenic compositions comprising partially glycosylated viral glycoproteins for use as vaccines against viruses are provided. Vaccines formulated using mono-, di-, or tri-glycosylated viral surface glycoproteins and polypeptides provide potent and broad protection against viruses, even across strains. Pharmaceutical compositions comprising monoglycosylated hemagglutinin polypeptides and vaccines generated therefrom and methods of their use for prophylaxis or treatment of viral infections are disclosed. Methods and compositions are disclosed for influenza virus HA, NA and M2, RSV proteins F, G and SH, Dengue virus glycoproteins M or E, hepatitis C virus glycoprotein E1 or E2 and HIV glycoproteins gp120 and gp41.